Three Paths to Autonomy and Self-Actualisation

All people have a deep yearning for Self-Actualisation, Autonomy, finding their purpose, and reaching their full potential, albeit usually unconscious. On the conscious level, abundance, happiness, love, success, is strived for, which is fine, but the deeper level of being and connection to spirit is often lost. Many people don't know how to reach Self-Actualisation and Autonomy. They instead may experience fear of the 'Un-Sung -Song-Syndrome.' Fearing never reaching their full potential. Feelings of anxiety, depression, feeling lost, unhappy and feelings of being an orphan are often present.
The big question is, what stops people from reaching self-actualisation and connecting to their inner spirituality?