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Offering the coverage of nucleoside analog activity in oncology and hematology, this volume includes topics from pharmacology to unpublished clinical findings on the pivotal role of fludarabine, cladribine, and pentostatin in the management of diseases.

This volume provides a thorough overview of current knowledge of stress proteins in both normal and disease physiology. It draws upon current stress protein research to evaluate the potential for developing new diagnostic, prophylactic and therapeutic approaches to control human disease.

Providing coverage of the clinical, research, and therapeutic aspects of dermatological problems associated with bacteria, fungi, and viruses, this book introduces many antifungal, antibacterial, and antiviral agents. It highlights the molecular biology and risk-benefit ratios of new diagnostic and treatment modalities.

Presents an examination of Crohn's disease (CD), from an historical evolution of the field to developments of etiopathogenesis, diagnostic evaluation, and therapeutic management. This work reviews possible etiologic agents, the various ways CD progresses, novel diagnostic techniques, and standard and innovative therapies.

Offering a multidiciplinary approach to understanding functional gastrointestinal (GI) disorders, this work provides a survey of esophageal, gastric, and colonic diseases known to have a strong behavioral component. It details the technologies used to assess these disorders from both a gastroenterologic and a psychologic perspective.

Provides a systematic coverage on the application of materials science techniques to the pharmaceutical field, offering a comprehensive program for the physical characterization of raw materials, drug substances, and formulated products.

This reference presents a detailed overview of approaches and techniques in the management of pain caused by tissue, nerve and central nervous system injuries, categorizing pain into a variety of syndromes and underlying mechanisms to aid the development of interventional pharmacologic measures.

Provides coverage of every aspect of valvular heart disease, presenting aetiology, pathophysiology and symptomatology in detail, as well as current methods of diagnosis and treatment. Specific problem areas, such as endocarditis, pregnancy, arrhythmias and rheumatic disease are examined.

Covers advances in the field of respiratory diseases, reflecting the recent and dramatic expansion of knowledge regarding the determinants of respiratory health, screening tests for early pulmonary lesions, therapeutic interventions for respiratory infections and strategies for prevention.

A comprehensive overview of the state of health care and availability worldwide. It focuses on the approach to the provision of quality, cost-effective health-care systems.

Provides contemporary information on all aspects of Down syndrome, investigating health concerns by age group and by organ system. The text sets out to identify and correct problems before they interrupt developing skills. Appendices provide growth charts and financial checklists.

Drug Delivery to the Oral Cavity

Reveals the results from clinical trials conducted in Scandinavia, Scotland, Australia, Canada, and the United States. This book highlights historical studies of dietary trials designed to reduce CHD; covers tests of HMG COA reductase inhibitors for patients with and without CHD; and more. It is for cardiologists, pharmacologists, and others.

This book captures some of the essential developments, both historical and current, relating to the human retroviruses and the diseases they cause. It describes detailed molecular biology and epidemiology of human T-leukemia virus type 1 (HTLV-1).

Discusses three major classes of asthma therapies-bronchodilators, antiinflammatories, and antiallergics. This book addresses the treatment strategies for asthma, keying in on the genetics and molecular biology of asthma and pointing the way toward new, commercially viable therapies. It is for pulmonologists, pediatricians, allergists, and others.

Performing an study of one of the common yet less accurately understood causes of human illness. This book examines the epidemiology, pathophysiology, and treatment options for asthma and respiratory infections. It contains results from clinical trials of antiviral agents that explore avenues of therapy.

Summarizes the etiology, presentation, and treatment of the complex symptoms, infections, and opportunistic cancers of people living with HIV/AIDS. This book presents therapies that strike a balance between controlling and eliminating cancer and minimizing the damage to the immune system. It is for oncologists, immunologists, and others.

A resource which provides practical strategies and a foundation for designing and implementing cardiac rehabilitation services to relieve the symptoms of cardiovascular disease patients through exercise, training and risk reduction and secondary prevention, improve quality of life, and decrease mortality.

Explains pharmaceutical transport phenomena. This book focuses on practical applications of drug delivery from a physical and mechanistic perspective, highlighting biological systems. It demonstrates applications like drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes and others.

Ion Channels in the Pulmonary Vasculature

Anemia of Chronic Disease

Uterine Cancer

Acute and Chronic Cough

Highlights the impact of sleep deprivation on the well-being of the individual and society. This reference presents theories on the function of sleep, the effects of sleep deprivation on patients with medical and psychiatric conditions, and provides interpretative and methodological results in comparative studies of sleep deprivation.

Pediatric Heart Failure