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This volume addresses SDG 3 from a mathematical standpoint, sharing novel perspectives of existing communicable disease modelling technologies of the next generation and disseminating new developments in modelling methodologies and simulation techniques. These methodologies are important for training and research in communicable diseases and can be applied to other threats to human health. The contributions contained in this collection/book cover a range of modelling techniques that have been and may be used to support decision-making on critical health related issues such as: Resource allocation Impact of climate change on communicable diseases Interaction of human behaviour change, and disease spread Disease outbreak trajectories projection Public health interventions evaluation Preparedness and mitigation of emerging and re-emerging infectious diseases outbreaks Development of vaccines and decisions around vaccine allocation and optimization The diseases and public health issues in this volume include, but are not limited to COVID-19, HIV, Influenza, antimicrobial resistance (AMR), the opioid epidemic, Lyme Disease, Zika, and Malaria. In addition, this volume compares compartmental models, agent-based models, machine learning and network. Readers have an opportunity to learn from the next generation perspective of evolving methodologies and algorithms in modelling infectious diseases, the mathematics behind them, the motivation for them, and some applications to supporting critical decisions on prevention and control of communicable diseases. This volume was compiled from the weekly seminar series organized by the Mathematics for Public Health (MfPH) Next Generation Network. This network brings together the next generation of modellers from across Canada and the world, developing the latest mathematical models, modeling methodologies, and analytical and simulation tools for communicable diseases of global public health concerns. The weekly seminar series provides a unique forum for this network and their invited guest speakers to share their perspectives on the status and future directions of mathematics of public health.

This book analyzes cyberdefense from a novel and interdisciplinary perspective, offering solutions for problems that have long impeded a more efficient defense. It explains why cyberdefense organized and performed by humans is too slow, too cumbersome, and too ineffective. Combining the analytical capabilities of experts in operations research and management, international security studies, economics, risk analysis, and defense management, the volume addresses these problems of current cyberdefense. The authors present suggestions for the next generation of cyberdefense, explaining why the future defense must focus on speeding up responses, why a single response may not be enough, and why effectiveness requires foresight.This makes the book a must-read for scholars, researchers, intelligence analysts, homeland security staff, and professionals who are interested in learning more about the issues of current cyberdefense, as well assolutions for the next generation of cyberdefense.

In the automotive sector, digitalisation, connectivity and automation are rapidly expanding. In tomorrow¿s vehicles, human beings will merely be passengers ¿ which raises a host of complex legal issues regarding accidents involving self-driving vehicles. This book is the first to offer a comprehensive, global overview of civil liability regimes for all levels of vehicle automation in jurisdictions that represent some of the most important markets for the automotive industry. After a technical introduction to how self-driving cars work, the individual chapters analyse the liability for driving automation at SAE J3016 levels 0 through 5 from a country-specific perspective. All chapters were written by experts in the field and follow a uniform legal structure. Hence, the book offers an essential comparative analysis of similarities and differences in the jurisdictions examined, while also providing suggestions for future legislative changes at the national and international level. The book is not only relevant for legal scholars and practitioners but will also be of particular interest to anyone involved in the design, manufacture, distribution and operation of self-driving vehicles.

This book provides a unique, detailed, and cutting-edge guide to obstructive sleep apnea (OSA) and the epiglottis. It discusses in detail epiglottis collapse both as relevant for diagnosis (e.g., sleep studies, drug induced sleep endoscopy, imaging and sound analysis) and treatment of OSA.In addition to general information on OSA, the chapters explore the role of the epiglottis in evolution, swallowing function, pathophysiology and surgical anatomy. The central chapters deal with patient selection, diagnosis, indications, and contraindications. The last sections investigate non-surgical treatments, surgical techniques, their results, possible failures, and complications. A conclusive chapter discusses research and future perspectives. The volume offers a large number of high-quality photos and illustrations, and an extensive collection of educational videos that highlight all steps of the surgical procedures. The book will appeal to all caregivers working in the field of diagnosis and treatment of obstructive sleep apnea, in particular otolaryngologists, pulmonologists, neurologists, sleep doctors, maxillofacial surgeons, anesthetists, and also the personnel working in sleep labs, general nurses and scrub nurses, physician assistants, and sleep technicians.

Global Warming: Truth and Consequences is a guidebook for persons who are unfamiliar with the relevant details but want to know what anthropogenic global warming and its repercussions entail. The first chapter presents background material on the earth's climate system and some of the global warming rejecters' claims and their refutations, including the evidence underlying the reality of anthropogenic global warming. The next chapter examines in detail many of the global warming's contemporaneous and deleterious repercussions, while the final one considers some future scenarios and their likely consequences, some of which are from the latest IPCC Reports. It also presents a number of the proposed steps to avoid these consequences and the problems of implementing them.

Hansen¿s disease (leprosy) is endemic in more than 100 countries worldwide, with over 200,000 new diagnoses each year and more than 4 million people living with some form of HD-related impairment. The World Health Organization¿s ¿Global Leprosy Strategy¿ timeline for Hansen¿s disease elimination indicates that it will be encountered in clinical practice in endemic countries for at least another decade. Increasing north-to-south migration, global travel and overseas medical work mean that physicians in non-endemic countries will also encounter patients with Hansen¿s disease, which can affect people for many years before diagnosis and after treatment. For busy clinicians, it represents a challenge, in terms of disease learning and updating knowledge and skills.This book provides a concise, up-to-date, and comprehensive source of information on Hansen¿s disease clinical practice. It covers essential topics on all clinical aspects, complemented by history, epidemiology, paleopathology, and the social impact of the disease. Edited and written by contributors with decades of experience, it¿s divided into twenty-six chapters clarifying the genetics and neurological manifestations, physical disabilities and its prevention; oral, ophthalmological, and bone changes, among others.For the primary audience of practicing physicians, it is an affordable point of reference, whilst also being suitable for student and trainee doctors. It¿s also accessible to general practitioners and specialists in dermatology, neurology, pediatrics, infectious disease, family and community medicine, and orthopedics, as well as to non-specialists and other healthcare professionals.

This practical and handy textbook offers a succinct yet comprehensive overview of the main challenges, issues and solutions in global health in relation to the UN¿s Sustainable Development Goals (SDG) 2030 agenda.Subdivided into 11 parts, devoted each to a macro-topic, the book opens with an introduction to Global Health followed by an overview of the global burden of disease ¿ from child and maternal health to communicable and non-communicable diseases. The authors further examine the social determinants of health, health systems¿ features as well as innovations, governance and methods in Global Health. In consideration of the emerging discussions and ideas, and beyond the more traditional and essential elements of global health, the book also looks at the need to re-think the whole concept of global health and the importance of a ¿decolonized¿ approach that engages low and lower-middle countries fully. One entire part is then devoted to analyzing the major threats to the health of humanity such as climate change, the need for an ecological approach to health (including ¿One Health¿ approaches), and, ultimately, planetary health.Written by an international panel of more than 100 experts, this manual will be an excellent resource for students in a broad range of disciplines ¿ from medicine and other scientific studies to economics, social science, anthropology and international relations. Pragmatic and reader-friendly, it will further be a valuable tool for policymakers, program implementers and those wishing to build knowledge on the meaning, principles and practices of global health.

Analysis of the Sponge (Porifera) Gene Repertoire: Implications for the Evolution of the Metazoan Body Plan.- Sponge-Associated Bacteria: General Overview and Special Aspects of Bacteria Associated with Halichondria panicea.- Microbial Diversity of Marine Sponges.- Full Absolute Stereostructures of Natural Products Directly from Crude Extracts: the HPLC-MS/MS-NMR-CH 'Triad'.- Bioactive Natural Products from Marine Invertebrates and Associated Fungi.- Sustainable Use of Marine Resources: Cultivation of Sponges.- Sustainable Production of Bioactive Compounds from Sponges: Primmorphs as Bioreactors.-Approaches for a Sustainable Use of the Bioactive Potential in Sponges: Analysis of Gene Clusters, Differential Display of mRNA and DNA Chips.- Sorbicillactone A: a Structurally Unprecedented Bioactive Novel-Type Alkaloid from a Sponge-Derived Fungus.-

Sounds can be harmonic, number sequences too - a coincidence?This book deals with a musical theory of proportions, i.e. the ancient doctrine of proportions as the oldest and most important common anchorage of the two cultural sciences mathematics and music.The musical theory of tones, intervals, tetrachords, sounds and scales is in fact the exact musical image of the laws of arithmetic and its symmetries in the set of rules of playing with numbers, their proportions and their medievals. Alone the miracle of the so-called Harmonia perfecta maxima 6 - 8 - 9 - 12, whose proportions determine the fifth as well as the fourth, form the octave and have the brazen whole tone in their center, shaped the musical edifice of Pythagorean music for thousands of years. This elementary chain of proportions 6: 8: 9: 12 is, moreover, completely symmetrical and built up from the arithmetic as well as from the harmonic medieta of the octave numbers 6 and 12.This book develops the theory of proportions as a mathematical science and always contrasts it with the musical motivation by means of numerous examples. The main idea is the derivation of a theory of symmetry from the Harmonia perfecta maxima to the Harmonia perfecta infinita abstracta, a process of unlimited tone generations by Babylonian mean iterations. From this, both the classical-antique diatonic is simultaneously extracted and the path "from the monochord to the organ" is re-examined.Finally, the work contains a mathematically guided introduction to the ancient tetrachordics as well as to the church tonal scales and concludes with an excursion into the sound worlds of the organ. Here the "foot-number rule of the organ" leads us by means of examples into the world of the tonal dispositions of this instrument and shows the omnipresence of the ancient theory of proportions. This book is suitable for anyone with an interest in mathematics and music.This book is a translation of the original German 1st edition Proportionen und ihre Musik by Karlheinz Schüffler, Springer-Verlag GmbH Germany, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.

This book is a socio-legal interdisciplinary study on gender and diversity in multicultural societies of Europe. It uses secondary data to discuss the broad experiences of migrant single mothers/women in Europe. Second, it includes narratives of experiences across the life course of single Danish-Pakistani women, starting from their pre-migration background to their elderly lives. The author uses an analytical framework used of relational collectivism and individualism, the former referring to the understanding of oneself as connected and interdependent to the family, and the latter referring to values of independence, personal interest and achievements. She uses the term "mélange familism" to explain a new family type that combines both relational-collectivist and individualist elements. A major part of this work is its deliberation of mélange familism and processes of social and legal practices in the everyday lives of single mothers. Crucially, the book demonstrates that social and legal traditions are not static, but are a product of improvisation. It makes a significant contribution by providing an alternate picture of single women/mothers as against the stereotypical image of 'passive, subordinate Muslim women'. It also contributes to gender and family studies by showing the increasing establishment of single-mother-headed households as a source of new possibilities; a new type or form of family construction, and not just the tragic residue of a broken two-parent family.

For more than two decades, anesthesiologists and obstetricians have turned to this handbook as the definitive reference for obstetric anesthesia. Authoritative yet concise, it has been designed as a practical guide to all aspects of anesthesia for childbirth and related obstetric procedures, including perinatal pharmacology, relief of labor pain, fetal monitoring, anesthesia for cesarean delivery, high risk pregnancy, and in vitro fertilization.The sixth edition of Datta's Obstetric Anesthesia Handbook has been revised to update the content and help expedite the retrieval of the most pertinent information. It also acknowledges the unequaled contribution by the late Dr. Sanjay Datta to this popular reference and includes updated chapters on "Pain of Labor and Delivery," "High-Risk Pregnancy," and "Maternal Mortality and Morbidity." An appendix includes the most recent national guidelines for obstetric anesthesia and with numerous illustrations and tables throughout the text, as well as updates regarding new medications and techniques, this esteemed handbook is more valuable than ever before.

This book examines autism characteristics that may be different than expected (atypical), primarily found in females, but also in others and are likely to be missed or misdiagnosed when identification and support are needed. It follows a lifespan framework, guiding readers through comprehensive assessment processes at any age. The book integrates interpretations of standardized measures, information from scientific literature, and context from first-person accounts to provide a more nuanced and sensitive approach to assessment. It addresses implications for improved treatment and supports based on comprehensive assessment processes and includes case studies within each age range to consolidate and illustrate assessment processes. Key areas of coverage include: Interdisciplinary assessment processes, including psychology, speech and language pathology, education, and health care disciplines.Lifespan approach to comprehensive assessment of autism in females/atypical autism.Guide to interpretation of standardized measures in females/atypical autism.Additional assessment tools and processes to provide diagnostic clarity.Descriptions of barriers in diagnostic processes from first-person accounts.Intervention and support strategies tied to assessment data.In-depth explanations of evidence and at-a-glance summaries. Assessment of Autism in Females and Nuanced Presentations is a must-have resource for researchers, professors, and graduate students as well as clinicians, practitioners, and policymakers in developmental and clinical psychology, speech language pathology, medicine, education, social work, mental health, and all interrelated disciplines.

Bau und Funktion der Nebenniere in neuerer Betrachtungsweise.

Now in a thoroughly revised and expanded second edition, this classroom-tested text demonstrates and illustrates how to apply concepts and methods learned in disparate courses such as mathematical modeling, probability, statistics, experimental design, regression, optimization, parameter estimation, inverse modeling, risk analysis, decision-making, and sustainability assessment methods to energy processes and systems. It provides a formal structure that offers a broad and integrative perspective to enhance knowledge, skills, and confidence to work in applied data analysis and modeling problems. This new edition also reflects recent trends and advances in statistical modeling as applied to energy and building processes and systems. It includes numerous examples from recently published technical papers to nurture and stimulate a more research-focused mindset. How the traditional stochastic data modeling methods complement data analytic algorithmic approaches such as machine learning and data mining is also discussed. The important societal issue related to the sustainability of energy systems is presented, and a formal structure is proposed meant to classify the various assessment methods found in the literature. Applied Data Analysis and Modeling for Energy Engineers and Scientists is designed for senior-level undergraduate and graduate instruction in energy engineering and mathematical modeling, for continuing education professional courses, and as a self-study reference book for working professionals. In order for readers to have exposure and proficiency with performing hands-on analysis, the open-source Python and R programming languages have been adopted in the form of Jupyter notebooks and R markdown files, and numerous data sets and sample computer code reflective of real-world problems are available online.

Fluorescence Spectroscopy: New Approaches and Probes.- Advanced Luminescent Labels, Probes and Beads and their Application to Luminescence Bioassay and Imaging.Fluorescence Spectral Engineering- Biophysical and Biomedical Applications.Fluorescence Nanometrology in Sol-Gels.Integrated Supramolecular Systems: from Sensors to Switches.Ratiometric Probes: Design and Applications.Binding of Ethidium to Yeast tRNAPhe: A New Perspective on an Old Bromide.Experimental Aspects of DNA Computing by Blocking: Use of Fluorescence Techniques for Detection.- Fluorescence Spectroscopy of Single Molecules and Molecular Assemblies. Multiparametric Detection of Fluorescence Emitted from Individual Multichromophoric Systems.Fluorescence Intensity Distribution Analysis (FIDA) and Related Fluorescence Fluctuation Techniques: Theory and Practice.Single Molecule Reactions of the Enzyme LDH and of Restriction Endonucleases in the Fluorescence Microscope.- Application of Fluorescence in Biological Membrane and Enzyme Studies.Application of the Wavelength-Selective Fluorescence Approach to Monitor Membrane Organization and Dynamics.Fluorescence Approaches for the Characterisation of the Peripheral Membrane Binding of Proteins Applied for the Blood Coagulation Protein Prothrombin.Assessment of Membrane Fluidity in Individual Yeast Cells by Laurdan Generalised Polarisation and Multi-Photon Scanning Fluorescence Microscopy.Formation of Higher Order Signal Transduction Complexes as seen by Fluorescence Spectroscopy.Mechanisms of Modulation of the Modulation of Membrane Interfacial Enzyme Catalysis by Non-lamellar Forming Lipids: Comparison with the Behaviour of a Fluorescent Probe in Membranes.Emission Spectroscopy of Complex Formation between E. coli Purine Nucleoside Phosphorylase (PNP) and Identified Tautomeric Species of Formycin Inhibitors Resolves Ambiguities found in Crystallographic Studies.- Fluorescence Microscopic Imaging Techniques for the Study of Living Cells.Fluorescence Lifetime Imaging Implemented with Resonant Galvanometer Scanners.Spectral Imaging of Single CdSe/ZnS Quantum Dots Employing Spectrally- and Time-Resolved Confocal Microscopy.Imaging of Oxidative Stress in Plant Cells by Quantitative Fluorescence Microscopy and Spectroscopy.The Biomedical Use of Rescaling Procedures in Optical Biopsy and Optical Molecular Imaging.Looking into a living cell.Expression of Multicolor Fluorescent Fusion Proteins in Zebrafish Cell Cultures: A Versatile Tool in Cell Biology

This volume contains the proceedings of the 2022 iteration of the ISPGAYA meeting, titled ¿Multidimensional Sustainability: Transitions and Convergences¿ and held on September 29 and 30th, 2022 in Vila Nova de Gaia, Portugal. The conference and resulting book intend to explore the involvement of Portugal, a country on the semi-periphery of the world system, in developments regarding the understanding of and progress toward sustainability. The conference was organized by ISPGAYA, an institution belonging to the private polytechnic higher education system in Portugal, and brought together participants from around the world. This volume intends to establish a milestone in the multidimensional approach to the theme of sustainability, affirming the concept's multi- and interdisciplinary nature and bringing together scholars across disciplines.

In addition to complementary radiographic imaging, the physical exam is an essential diagnostic element for the orthopedic surgeon. As such, learning to perform this exam thoroughly is of utmost importance to medical students, residents and interns on an orthopedic rotation and in later practice.This practical text succinctly presents all of the necessary information regarding the physical examination of the lower extremity and lumbar spine. The lower spine, hip, knee, and foot and ankle are discussed in dedicated thematic sections, with each section comprised of three main chapters. The initial chapter describes the musculoskeletal anatomy and function of the joint, presenting the tests themselves along with the rationale for performing them. The second chapter presents the systematic examinations carried out in every case, and the third chapter describes examinations for specific conditions relating to the joint, including tendinopathies, osteoarthritis, neurological conditions, deformities and more. Plentiful bullet points and color images throughout the text describe and illustrate each test and physical sign.Convenient and user-friendly, Handbook of Lumbar Spine and Lower Extremity Examination is a valuable, portable guide to this all-important diagnostic tool for students and practitioners alike.

Ein Endocranialausguß von Hipparion sebastopolitanum aus dem Sarmat von P?un-Ja?i (Rumänien).

Eine Kennzeichnung der zweidimensionalen elliptischen Geometrie.

Über die Normalprojektionen von Vektorsystemen im n-dimensionalen euklidischen Raum.

Basic Aspects.- 1 The Epidermal Barrier and Strategies for Surmounting It: An Overview.- 2 Stem Cells, Differentiation and Renewal Kinetics of Keratinocytes: Implications for Cutaneous Gene Therapy.- 3 Relevant Animal Models for Skin Gene Therapy.- 4 Nonviral Gene Transfer into the Skin.- 5 Safety and Pharmacokinetics of Naked Plasmid DNA: Studies on Dissemination and Ectopic Expression.- 6 Uptake of DNA by Keratinocytes.- Treatment of Skin Diseases.- Gene Therapy of Inherited Skin Diseases.- Gene Transfer Strategies in Tissue Repair.- Systemic Effects of Skin Gene Therapy.- The Use of Skin-Directed Gene Therapy in the Treatment of Systemic Diseases.- Keratinocyte Gene Therapy Using Cytokine Genes.- Genetic Vaccination Using the Skin.- Principles of Genetic Immunization.- Systematic Modulation of Immune Responses by CpG DNA.- Genetic and Dendritic Cell Vaccination as a Novel Therapy for Melanoma.- Molecular Strategies Interfering with Tumor Progression of Melanoma and Improving Anti-Tumor Immunity.- Prophylactic and Therapeutic DNA Vaccines Against Infectious Diseases.

Provides a comprehensive discussion of nursing the frail older person with a fragility fracture across Europe Based on a two-day workshop of like-minded specialist and advanced nurses from over 20 countriesActs as the course text/reader for a Europe-wide education programme in all relevant settings (Emergency Department, Fracture Clinic, Trauma Unit, Orthopaedic Ward, Rehabilitation setting)Open Access

I. Die Objekte der Pharmakognosie.- II. Grundwissenschaften der Pharmakognosie.- III. Pflanzensäuren als Hauptwirkstoffe.- IV. Kohlenhydratdrogen.- V. Glykosiddrogen.- VI. Gerbstoffdrogen.- VII. Eiweiße und Enzyme.- VIII. Alkaloiddrogen.- IX. Fette, Öle und weitere Lipoide.- X. Ätherische Öle, Harze und Balsame.- XI. Arzneimittel aus Mikroorganismen.- XII. Drogen, deren spezifische Wirkstoffe nicht oder nur ungenügend bekannt sind. Volksmedizinisch verwendete Drogen und Arzneipflanzen.

This book combines the field of economics -especially monetary theory- with other disciplines like ecology, physics, humanities, social sciences and development theory. This transdisciplinary approach makes the book a unique contribution for researchers, students, policy makers and professionals working in governmental or nongovernmental institutions, as well as anyone interested in society's well-being and achieving a true social-ecological transformation. It is written in an accessible language in order to reach a broad audience. In 2015, more than 190 world leaders recognized that the world is on a "collision course" (Max-Neef) and committed to 17 Sustainable Development Goals (SDGs). Many conferences and high-level meetings have been held since then, and one of the most frequently discussed topics is how to finance these goals. There is a widespread belief that coming up with more money for sustainable development will "do the trick". Usually, the discussions focus on finding additional financial resources in order to achieve the goals faster. In this book it is argued that not only is more money needed, but it needs to be a different kind of money. The book demonstrates that ALL but one of the SDGs are directly linked to our monetary system, which -being completely unnatural- can be seen as the most important, but at the same time least recognized, reason for market failure. Many people think we just need to do more, faster, better. Very few say that we have done things fundamentally wrong and that the institutions and values which motivated us to do those things need to be changed. It will be concluded that only if we change our unnatural design of money to a more natural one, will we be able to reach these goals

Einige Beobachtungen im Nordteil der Weyerer Struktur (Nördliche Kalkalpen und Klippenzone).

This is the first comprehensive listing of Amazon fruits from an ethnobotanical perspective. This detailed book covers 50 botanical families, 207 species, in the Amazon including how the people of each region use them. It is lavishly illustrated with high-quality photographs taken by the author, an extensive list of references, and Dr. Smith's latest, meticulous research. This book should be a foundational work for scholars working in the plant sciences, researchers in ethnobotanical studies, and general interest scholars seeking more detailed information on the latest research by a leading scientist in the Amazon.

Über die Pflanzengesellschaften der Fels- und Mauerspalten Südfrankreichs.