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Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states.Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology.This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics.Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics

Focusing on innovation, these proceedings present recent advances in the field of mechanical design in China and offer researchers, scholars and scientists an international platform for presenting their research findings and exchanging ideas. Gathering outstanding papers from the 2019 International Conference on Mechanical Design (2019 ICMD) and the 20th Mechanical Design Annual Conference, the content is divided into six major sections: industrial design, reliability design, green design, intelligent design, bionic design and innovative design. Readers will learn about the latest trends, cutting-edge findings and hot topics in the field of design.

This handbook offers a comprehensive source for electrical power professionals. It covers all elementary topics related to the design, development, operation and management of power systems, and provides an insight from worldwide key players in the electrical power systems industry.Edited by a renowned leader and expert in Power Systems, the book highlights international professionals' longstanding experiences and addresses the requirements of practitioners but also of newcomers in this field in finding a solution for their problems.The structure of the book follows the physical structure of the power system from the fundamentals through components and equipment to the overall system. In addition the handbook covers certain horizontal matters, for example "Energy fundamentals", "High voltage engineering", and "High current and contact technology" and thus intends to become the major one-stop reference for all issues related to the electrical power system.

This book reviews all important aspects of anxiety disorders with the aim of shedding new light on these disorders through combined understanding of traditional and novel paradigms. The book is divided into five sections, the first of which reinterprets anxiety from a network science perspective, examining the altered topological properties of brain networks in anxiety disorders. The second section discusses recent advances in understanding of the neurobiology of anxiety disorders, covering, for example, gene-environmental interactions and the roles of neurotransmitter systems and the oxytocin system. A wide range of diagnostic and clinical issues in anxiety disorders are then addressed, before turning attention to contemporary treatment approaches in the context of novel bio-psychosocial-behavioral models, including bio- and neurofeedback, cognitive behavioral therapy, neurostimulation, virtual reality exposure therapy, pharmacological interventions, psychodynamictherapy, and CAM options. The final section is devoted to precision psychiatry in anxiety disorders, an increasingly important area as we move toward personalized treatment.Anxiety Disorders will be of interest for all researchers and clinicians in the field.

This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.

This volume comprises select proceedings of the 7th International and 28th All India Manufacturing Technology, Design and Research conference 2018 (AIMTDR 2018). The papers in this volume discuss simulations based on techniques such as finite element method (FEM) as well as soft computing based techniques such as artificial neural network (ANN), their optimization and the development and design of mechanical products. This volume will be of interest to researchers, policy makers, and practicing engineers alike.

This book on ¿Orchid Biology: Recent Trends & Challenges¿ reviews the latest strategies for the preservation and conservation of orchid diversity and orchid germplasm. It is an outcome of the Proceedings of the International Symposium on ¿Biodiversity of Medicinal Plants & Orchids: Emerging Trends and Challenges¿ held on 9-11 February 2018 at Acharya Nagarjuna University, India. In addition, eminent orchid experts from around the globe were invited to contribute to this book. All chapters were peer-reviewed by international experts. The Orchidaceae are one of the largest families of flowering plants, comprising over 700 genera and 22,500 species and contributing roughly 40 percent of monocotyledons. They also represent the second-largest flowering plant family in India, with 1,141 species in 166 genera, and contribute roughly 10% of Indian flora. Orchids comprise a unique group of plants and their flowers are among the most enchanting and exquisite creations of nature. Phylogenetically and taxonomically, the Orchidaceae are considered to be a highly evolved family among angiosperms. They show incredible diversity in terms of the shape, size and colour of their flowers, and are of great commercial importance in floriculture markets around the globe. Millions of cut flowers of Cymbidium, Dendrobium, Cattleya, Paphiopedilum, Phalaenopsis, Vanda etc., besides potted orchid plants, are sold in Western Countries and thus, the orchid cut flower industry has now become a multimillion-dollar business in Europe, the USA and South East Asia.Besides their ornamental value, orchids hold tremendous pharmaceutical potential. Root tubers of Habenaria edgeworthii form an important component of the ¿Astavargä group of drugs in Ayurvedic medicine. It is an established fact that tubers of some terrestrial orchids have been used to treat diarrhoea, dysentery, intestinal disorders, cough,cold and tuberculosis. Some orchids, particularly those belonging to the genera Aerides, Arachnis, Cattleya, Cymbidium, Dendrobium, Epidendrum, Oncidium, Paphiopedilum, Phalaenopsis, Renanthera, Vanda etc. have been extensively used to produce internationally acclaimed hybrids. Yet paradoxically, Indian orchids are victims of their own beauty and popularity. As a result, their natural populations have been declining rapidly because of unbridled commercial exploitation in India and abroad. In fact, some orchids are now at the verge of extinction, e.g. Renanthera imschootiana, Diplomeris hirsuta, Paphiopedilum fairrieanum, Cypripedium elegans, Taeniophylum andamanicum etc.Given the global importance of orchids in terms of securing human health and wealth, this comprehensive compilation, prepared by international experts, is highly topical. Its content is divided into five main sections: (I) Cryopreservation & Biotechnology,(II) Orchid Biodiversity & Conservation, (III) Anatomy & Physiology, (IV) Pollination Biology and (V) Orchid Chemicals & Bioactive Compounds. All contributions were written by eminent orchid experts/professors from around the world, making the book a valuable reference guide for all researchers, teachers, orchid enthusiasts, orchid growers and students of biotechnology, botany, pharmaceutical sciences and ethnomedicine. It will be equally valuable for readers from the horticultural industry, especially the orchid industry, agricultural scientists and policymakers.

This edited volume contains sixteen chapters by eminent scholars on one of the largest migration corridors in the world i.e., between South and South-East Asia and the Gulf region. Asiäs trade and cultural contact with the Gulf date back to ancient historical times. Since the 1970s, the economic rise of the Gulf Cooperation Council (GCC) countries owing to the discovery of oil has inspired a huge influx of migrant workers from Asia. At present, out of roughly 15 million expatriates in the Gulf region, Asians constitute around 12 million (80 percent). The chapters in this book look at migration from countries like India, Sri Lanka, Bangladesh, Pakistan, Indonesia and Philippines to the different GCC countries. A few chapters also focus on migration from the India state of Kerala- a state where migration to the Gulf is prominent and where remittances make up over 36 percent of the state GDP. Furthermore, the issues covered range from labour practices and policies, citizenshipand state protection, human rights, gender and caste as well as diaspora. This book explores the multifaceted nuances of the ¿Asia-Gulf migratory corridor¿ and unearths future prospects and strategic implications. The book examines remittance behaviour, changing gender roles of immigrants, social-spatial mobility, migrant policies, human rights, sense of belonging and identity and perception, and the interaction between nationals and non-nationals.The book will be of interest to researchers in the areas of demography, migration and gender studies as well as social science researchers, policy makers, human rights lawyers, civil society institutions working on migration, Gulf studies programmes and centres on South-Asian and Middle-Eastern studies.

The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the experts. The book would be a companion for both beginners, as well as established researchers in the field. It would be useful for science education, research, clinical approach and policy making.

This book is a work that focuses on the forest environmental tax. Forest resources have played a major role in preventing global warming by absorbing carbon dioxide and supplying oxygen. However, global economic growth has adversely affected the global environment and has exacerbated global warming due to excessive consumption of forest resources. The functions or ¿services¿ of forests are diverse, but the interest of the citizenry in forest cultivation is scarce since forests are public goods. Concurrently, Japanese forestry, which has played an important role in forest conservation, is steadily declining, and it is no longer possible for private forest operators to maintain the forest environment. Therefore, in order to realize sustainable economic growth, it is necessary to formulate policies for the conservation of appropriate forest environments. Forest conservation is an especially important policy issue for Japan, where two-thirds of the country is forested. In Japan, a forest environmental tax is being introduced as a forest conservation policy. As of 2021, the forest environmental tax has already been introduced in about two-thirds of the prefectures and soon will be introduced as a national tax. In this book, the significance and issues of the forest environmental tax will be sorted out, and the status of the introduction of the forest environmental tax in Japan will be compared with that of other countries. In addition, there is additional material regarding the water source conservation fund in Toyota City, Aichi Prefecture, a system similar to the forest environmental tax.