Bøker utgitt av Springer-Verlag New York Inc.

ERCP and EUS

This volume explores the application of Quality by Design (QbD) to biopharmaceutical drug product development.

Surgical prophylaxis is examined through discussions of carotid endarterectomy, prevention of stroke from cerebral vascular malformations, prevention of aneurysmal subarachnoid hemorrhage, balloon transluminal angioplasty of the carotid artery in the head and neck, and prevention of recurrent stroke.

The Color Atlas of "Xenopus laevis" Histology provides the first central source on the microscopic anatomy of cells, tissues, and major organs of the adult South African clawed frog, Xenopus laevis.

Presenting a vector treatment of the principles of mechanics, this work aims to help the student gain confidence in transforming problems into appropriate mathematical language that may be manipulated to give useful physical conclusions or specific numerical results.

Integrating all aspects of the fields of metacognition and learning technologies, this book describes features of the learning technologies and how they have been designed to study and support metacognitive processing and self-regulated learning.

Authors are widely recognized professors and researchers in Schools of Medicine and Information Systems from the University of Arizona, University of Washington, Columbia University, and Oregon Health & Science University.

Few syndromes in psychopathology generate as much popular curiosity and clinical exploration as does obsessive-compulsive disorder (OCD).

The Cloud Computing and Services Science book comprises a collection of the best papers presented at the International Conference on Cloud Computing and Services Science (CLOSER), which was held in The Netherlands in May 2011.

Molecular marker strategies will be of help in understanding some aspects of sucrose metabolism and its regulation in this crop, thus complementing the ongoing crop improvement programmes.

Surveying the empirical literature on the development of children's knowledge of cognitive activities from early childhood to adolescence, this title deploys a conceptual framework integrating children's introspection with social influences on development.

The ancient Chinese scholars are fond of applying the Yin and Yang diagram to correlate almost everything. This book continues that tradition and uses the model to study other non-dialectical theories and models.

Discovering, managing, and interpreting knowledge of new biomarkers are challenging and attractive problems in the emerging field of biomedical informatics.This volume is a collection of state-of-the-art research into the application of data mining to the discovery and analysis of new biomarkers.

¿¿The trend is your friend¿is a practical principle often used by business managers, who seek to forecast future sales, expenditures, and profitability in order to make production and other operational decisions.  The problem is how best to identify and discover business trends and utilize trend information for attaining objectives of firms.This book contains an Excel-based solution to this problem, applying principles of the authors¿ ¿profit system model¿ of the firm that enables forecasts of trends in sales, expenditures, profits and other business variables.  The program, called FIRM, which runs on Windows with Microsoft Excel 2010, useshistorical time series of total sales, total costs, and total assets of the firm from its financial statements (income statements and balance sheets), estimates relationships among these variables, and then employs the estimated relationships to forecasts trends in these vital business variables.  Featuring step-by-step case examples, the goalis to equip business managers and students with easy-to-use tools for understanding and forecasting trends in important business variables, thereby empowering them to make better business decisions.

Case Studies in Service Innovation provides the reader fresh insight into how innovation occurs in practice, and stimulates learning from one context to another.

A large international conference on Advances in Intelligent Control and Innovative Computing was held in Hong Kong, March March 16-18, 2011, under the auspices of the International MultiConference of Engineers and Computer Scientists (IMECS 2010).

This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices.

This highly illustrated book, complete with comprehensive clinical references and annotated images, will serve as a leading text to educate head and neck surgeons, endocrinologists, and radiologists on the basics and nuances of thyroid and parathyroid ultrasound.

Countering the tendency to remember great scientists for a single achievement, this book celebrates the lesser-known inventions of such versatile innovators as James Watt, Alexander Graham Bell and Edmond Halley. Includes detailed illustrations and much more.

Three-dimensional (3D) transesophageal echocardiography (TEE) is a powerful visual tool and this is the most current 3D TEE guide available. It provides a practical and illustrated step-by-step guide to the latest in 3D technology and image acquisition.

Providing a comprehensive presentation of the diagnosis, evaluation and management of nonunions, this generously illustrated text details the current principles, surgical techniques and approaches with these challenging clinical situations.

It uncovers the problems in medical investigations that can not be overcome no matter how much care and diligence medical researchers bring to a research project.

Social differences in health and mortality constitute a persistent finding in epidemiological, demographic, and sociological research.

Since the beginning of the 1980's, a lot of news approaches of biomimetic inspiration have been defined and developed for imitating the brain behavior, for modeling non linear phenomenon, for providing new hardware architectures, for solving hard problems.

The complete sequences of a number of plant genomes and the recent advances of high-throughput technologies has fueled research efforts in the field of Plant Nuclear Biology unveiling numerous insights about the mechanisms underlying genome regulation.

This book provides a detailed account of the most recent developments, challenges and solutions to seamlessly advance and launch a lyophilized biologics or vaccine product, based on diverse modalities, ranging from antibodies (e.g., monoclonal, fused), complex biologics (e.g., antibody drug conjugate, PEGylated proteins), and vaccines (e.g., recombinant-protein based). The authors adeptly guide the reader through all crucial aspects, from biophysical and chemical stability considerations of proteins, analytical methods, advances in controlled ice nucleation and quality-by-design approaches, alternate drying technology, to latest regulatory, packaging and technology transfer considerations to develop a stable, safe and effective therapeutic protein, vaccine and biotechnology products.Lyophilized Biologics and Vaccines: Modality-Based Approaches is composed of four sections with a total of 17 chapters. It serves as a reference to all critical assessments and steps from early pre-formulation stages to product launch: Provides recent understanding of heterogeneity of protein environment and selection of appropriate buffer for stabilization of lyophilized formulationsDetails the latest developments in instrumental analysis and controlled ice nucleation technology Explains in-depth lyophilized (or dehydrated) formulation strategies considering diverse modalities of biologics and vaccines, including plasmid DNA and lipid-based therapeuticsDetails an exhaustive update on quality-by-design and process analytical technology  approaches, illustrated superbly by case studies and FDA perspectiveProvides the latest detailed account of alternate drying technologies including spray drying, bulk freeze-drying and crystallization, supported exceptionally by case studiesProvides a step-by-step guide through critical considerations during process scale-up, technology transfer, packaging and drug delivery device selection, for a successful lyophilization process validation, regulatory submission and product launchChapters are written by one or more world-renowned leading authorities from academia, industry or regulatory agencies, whose expertise cover lyophilization of the diverse modalities of biopharmaceuticals. Their contributions are based on the exhaustive review of literature coupled with excellent hands-on experiences in laboratory or GMP setup, making this an exceptional guide to all stages of lyophilized or dehydrated product development.

Diffuse Malignant Mesothelioma

This book describes the emergence of landscape ecology, its current status as a new integrative science, and how distinguished scholars in the field of landscape ecology view the future regarding new challenges and career opportunities.

There are updates to cases such as advances in blepharoplasty techniques, advances in fillers and filler techniques, advances in periorbital fat grafting, advances in brow lifting techniques, and advances in midface rejuvenation .