Bøker utgitt av Springer Verlag, Japan

This book focuses on standard operative techniques for important diseases in pediatric surgery, especially in neonates and infants, while also offering a wealth of schematic drawings and photographs to help readers understand the surgical techniques.

This volume presents detailed information on surgically relevant anatomy and histology of the anterior cruciate ligament (ACL), biomechanics, diagnostics, and ACL reconstruction.

This book is a methodological source on mice models of vascular diseases. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease.

This book provides simplified principles of surgical anatomy for colorectal cancers with sophisticated drawings, standard laparoscopic procedures with striking photographs and illustrations, and advanced procedures such as lateral pelvic node dissection and "down to top" or "reverse" total mesorectal excision.Oncological safety as well as minimum invasiveness of laparoscopic surgery for colorectal cancer has been acknowledged worldwide, based on long-term outcomes of several randomized controlled trials comparing laparoscopic surgery and open surgery. Developments in optical devices have provided us with a magnified clear vision of fine anatomical structures, facilitating our understanding of surgical anatomy and surgical procedures have been refined and improved accordingly.All these topics are presented in this book-valuable for surgical residents and experts eager to learn more about laparoscopic colorectal surgery-and readers will be enlightened by a new paradigm for "lap-enhanced surgical anatomy". Therefore this volume will greatly benefit not only colorectal surgeons but also general surgeons as well as gastroenterologists and oncologists.

In this book, recognized anesthesiology experts present the latest findings on anesthesia for electro-convulsive therapy (ECT).

This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease.

This book offers a detailed review of the pathological and imaging features, diagnosis and treatment of IgG4-Related Kidney Disease (IgG4-RKD). IgG4-related disease (IgG4-RD), which is characterized by an elevated serum IgG4 level and infiltration of systemic organs by IgG4 positive plasma cells, is a newly recognized systemic disease.

This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressive management of pulmonary metastasis.

This book deals with the essential factors in the personalization of treatment for primary breast cancer.

This book offers a detailed review of the remarkable advances that have been made in research on the pathogenesis of a number of neuroimmunological diseases, as well as outlining novel treatments including the use of monoclonal antibodies. Written by renowned experts who have made major contributions in the field, such as identifying neuromyelitis optica as an immunopathological clinical condition, identifying the role of ganglioside and ganglioside-complex antibodies in Guillain-Barré syndrome, and developing a novel treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome, the book summarizes recent advances in basic and clinical research. Neuroimmunological Diseases is a useful resource for not only researchers but also neurologists who are engaged in the management of neuroimmunological diseases.

This book presents a comprehensive overview and outlook for the future of indocyanine green (ICG) fluorescence navigation surgery, which is attracting clinical interest as a safe and less invasive procedure not only in detecting cerebral vessels, coronary arteries, and biliary trees, but also in identifying sentinel lymph nodes in cancer.

This book provides a comprehensive review of diagnosis and treatments of renal cell carcinoma (RCC) for practitioners and researchers with an interest in this disease. A major aim of the book is to present the most important and most recent advances in molecular bases and targeted therapy for this neoplasm. The remarkable resistance to chemotherapy and radiotherapy and the minimum contribution of cancer genes that commonly mutate in other adult epithelial cancers have made RCC highly distinct from other types of solid neoplasms. In the past decade, however, treatment options for RCC have been expanding and moving quickly toward laboratory-based and molecular-targeted therapies. Advances in RCC therapy also have brought novel treatment options to other types of cancer, such as a TKI for hepatocellular carcinoma and gastrointestinal tumors, as well as mTOR inhibitors to progressive neuroendocrine tumors of pancreatic origin and to breast cancer, suggesting that RCC is no longer an "orphan disease" in the field of molecular oncology. Additional topics covered in the book include pharmacokinetics and pharmacodynamics in molecular-targeted agents and the putative mechanism of resistance to anti-angiogenic agents, such as intratumoral heterogeneity or cancer stem cell population. This volume provides the latest and most useful information for all readers who are eagerly devoted to curing renal cell carcinoma.

This book describes the fundamental biology and mechanics of the vasculature and examines how this knowledge has underpinned the development of new clinical modalities, including endovascular treatment and vascularization of reconstructed tissue for regenerative medicine.

This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy.

This volume focuses on the etiology and morphogenesis of congenitalheart diseases.

Filled with illustrations drawn from the surgeon's point of view, it the book will be useful not only to surgeons and students but also to paramedical personnel. These kind of modifications will become useful resources to surgeons in some part of world where the homograft is not available.

A new era for liver anatomy has dawned. Liver anatomy has since been reevaluated from the standpoint of portal segmentation and drainage veins and includes a reclassification of the liver.

It is against this background and in recognition of the importance and urgency of the problem that this book brings together new insights on the topic together with research published to date.

The authors are specialists in macroeconomics, public economics, environmental economics, transportation economics and spatial economics, all of which are important aspects of regional science.

This book sheds new light on neurodegenerative disorders as systemic diseases. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.

This book is a knowledge-based text that covers the anatomy, neurophysiology, and neuropharmacology needed to carry out the necessary management and cerebrospinal protection during neuroanesthesia.

This book clearly shows the importance, usefulness, and powerfulness of current optimization technologies, in particular, mixed-integer programming and its remarkable applications.

Many international experts collaborated in creating this groundbreaking work, a principal-coding system, and in developing reference films and imaging parameters for the International Classification of HRCT for Occupational and Environmental Respiratory Diseases.

This book provides new insights into the universality of biological systems in animal reproduction and development by a comparative study of a variety of mechanisms in animals ranging from basal invertebrates to vertebrates, including mammals.Animals accomplish genetic diversity through meiosis and fertilization, and during embryogenesis animals must produce specialized cell types, including germ cells, in accordance with their individual body plan. This series of phenomena is essential to the continuity of life in the animal kingdom, and animals show various reproductive and developmental strategies.This volume, comprising four parts, reviews animal kingdom diversity, including reproductive strategies and germ cell differentiation mechanisms (Part 1), sex determination and differentiation (Part2), the mechanisms of fertilization (Part 3), and body axis formation (Part 4). Readers will find descriptions of the reproduction or development of 180 species, 13 phyla, 35 classes, 74 orders, 117 families, and 151 genera in this book. Of particular interest is the diversity of molecules and mechanisms used to achieve the same biological purpose in different animals.Undergraduates, graduate students, and professional scientists who want a deeper understanding of animal reproductive and developmental mechanisms will find this book to be of great value.

This volume examines our current understanding of the biological effects of fibrous and particulate substances, including discussions on nanoparticles.

a

This book focuses on exploring the linkages between natural disasters and sustainable development at the global, regional, and national levels. Similarly, slow onset disasters-often associated with global climate change-pose threats to development, livelihoods, food security, and long-term sustainable development.