Bøker utgitt av Springer Nature Switzerland AG

This book discusses how UNIDROIT principles are viewed and interpreted in different countries, presenting various perspectives and practical lessons learned. Written by experts in the field, it provides insights into how the principles are being used and applied in their respective countries.

This book presents the outcomes from the 2nd International Conference on Marine and Advanced Technologies 2021 (Icmat2021) which was organized by the Research and Innovation section, University Kuala Lumpur - Malaysian Institute of Marine Engineering Technology.

This book focuses on the latest scientific and technological advancements in the field of railway turnout engineering. It offers a holistic approach to the scientific investigation of the factors and mechanisms determining performance degradation of railway switches and crossings (S&Cs), and the consequent development of condition monitoring systems that will enable infrastructure managers to transition towards the implementation of predictive maintenance.The book is divided into three distinct parts. Part I discusses the modelling of railway infrastructure, including switch and crossing systems, while Part II focuses on metallurgical characterization. This includes the microstructure of in-field loaded railway steel and an analysis of rail screw failures. In turn, the third and final part discusses condition monitoring and asset management.Given its scope, the book is of interest to both academics and industrial practitioners, helping them learn about the various challenges characterizing this engineering domain and the latest solutions to properly address them.

The conference represented one of the key events of the Practicing Universal Design Principles in Design Education through a CAD-Based Game (PUDCAD) project, which developed a design game on a CAD-based platform, enabling students and designers to learn about universal design principles and develop accessible and innovative design ideas.

Contributors situate the politics of translation in the theoretical and methodological landscape of International Relations, encompassing feminist theory, de- and post-colonial theory, hermeneutics, post-structuralism, critical constructivism, semiotics, conceptual history, actor-network theory and translation studies.

Authors presented a hierarchical system consisting of two-level management systems: first level-unsustainability reduction systems and second level-control system for transformations toward sustainability.

The five-volume set IFIP AICT 630, 631, 632, 633, and 634 constitutes the refereed proceedings of the International IFIP WG 5.7 Conference on Advances in Production Management Systems, APMS 2021, held in Nantes, France, in September 2021.*The 378 papers presented were carefully reviewed and selected from 529 submissions.

Collaboration among industry, universities and research institutes plays a vital role in stimulating open innovation, which in turn leads to new products, processes, services and business models. This book brings together a number of real-life examples of how to govern and manage open innovation collaboration projects more effectively, and provides timely insights that project consortia, governance boards and funding agencies can directly apply to implement and monitor projects and achieve greater impacts. All papers were written by recognized leading authorities with extensive experience in governance and management, and reveal how to capitalize on the potential of open innovation.This book shares multidisciplinary research perspectives on the potential benefits and challenges of collaboration, project management, and open innovation, as well as the management of complex organizational cultures and governance models.

In this book, comprehensive coverage is given to nanotechnology applications in synthetic membrane processes, which are used in different fields such as water treatment, separation of gases, the food industry, military use, drug delivery, air filtration, and green chemistry.

This volume provides conceptual syntheses of diverging multilingual contexts, research findings, and practical applications of integrating content and language (ICL) in higher education in order to generate a new understanding of the cross-contextual variation.

The topics range from C*-algebras and Banach *-algebras, Sturm-Liouville theory, integrable systems, dilation theory, frame theory, Toeplitz, Hankel, and singular integral operators, to questions from lattice, group and matrix theories, complex analysis, harmonic analysis, and function spaces.

This study adopts a dynamic capabilities perspective to explore the activities and processes through which business model innovations arise in established organisations.

This book explores four guiding themes - reduced order modelling, high dimensional problems, efficient algorithms, and applications - by reviewing recent algorithmic and mathematical advances and the development of new research directions for uncertainty quantification in the context of partial differential equations with random inputs.

The book explores technological advances in the fourth industrial revolution (4IR), which is based on a variety of technologies such as artificial intelligence, Internet of Things, machine learning, big data, additive printing, cloud computing, and virtual and augmented reality.

Building on the groundbreaking work Lifestyle Medicine (2016), this unique new book bridges the gap between theory and practice by providing detailed information on the real-world development and creation of a Lifestyle Medicine Center, whether independently or as part of an established medical program or department. Part one sets the stage by establishing the rationale for creating a Lifestyle Medicine Center as well as the medical and economic burden it seeks to alleviate. The construction of the physical facility and all of the myriad details of the program and its key players are covered in part two, from the structural to the aesthetic, including informatics, developing patient resources and education tools, current technologies and applications, the role of the dietitian and exercise physiologist, inpatient consultation, the importance of community engagement, and more. Part three is comprised of case studies of existing, successfulLifestyle Medicine Centers across the country, with detailed descriptions of their history, development, programs and challenges. Chapters are supported with plentiful figures, tables and useful links. The burden of chronic disease in the U.S. and globally is growing, with pervasive direct and indirect multi-scale adverse effects on health and well-being, economics, and quality of life. Notwithstanding the remarkable progress in biomedical technology, the role of lifestyle medicine in managing chronic disease in a preventive care model is paramount; however, the relevant and effective education in lifestyle medicine is lacking. Translating the theory into action steps, instantiated by case studies with critical interpretations and problem-solving tools, Creating a Lifestyle Medicine Center is the go-to resource for family and primary care physicians, internal medicine physicians, and all clinical specialties interested in planning and developing a lifestyle medicine program.

This book provides a detailed review of how oncology drug development has changed over the past decade, and serves as a comprehensive guide for the practicalities in setting up phase I trials. The book covers strategies to accelerate the development of novel antitumor compounds from the laboratory to clinical trials and beyond through the use of innovative mechanism-of-action pharmacodynamic biomarkers and pharmacokinetic studies.The reader will learn about all aspects of modern phase I trial designs, including the incorporation of precision medicine strategies, and approaches for rational patient allocation to novel anticancer therapies. Circulating biomarkers to assess mechanisms of response and resistance are changing the way we are assessing patient selection and are also covered in this book. The development of the different classes of antitumor agents are discussed, including chemotherapy, molecularly targeted agents, immunotherapies and also radiotherapy. Theauthors also discuss the lessons that the oncology field has learnt from the development of hematology-oncology drugs and how such strategies can be carried over into therapies for solid tumors. There is a dedicated chapter that covers the specialized statistical approaches necessary for phase I trial designs, including novel Bayesian strategies for dose escalation.This volume is designed to help clinicians better understand phase I clinical trials, but would also be of use to translational researchers (MDs and PhDs), and drug developers from academia and industry interested in cancer drug development. It could also be of use to phase I trial study coordinators, oncology nurses and advanced practice providers. Other health professionals interested in the treatment of cancer will also find this book of great value.

Subsequent chapters discuss possible combinations of laccases and further potentially collaborating enzymes, and offer in-depth insights into laccase immobilisation for wastewater treatment and environmental biosensor applications of laccases.

This book puts forward the concept of the Diameter-Transformed Fluidized Bed (DTFB): a fluidized bed characterized by the coexistence of multiple flow regimes and reaction zones, achieved by transforming the bed into several sections of different diameters.

This title introduces readers to the use of lasers in dermatology/aesthetic practice and focuses on the fundamentals of lasers and light-based devices and their clinical application.

Cardiac implantable device (CIED) infections are a key issue since they have serious consequences in terms of morbidity, mortality and associated costs for healthcare systems.

This conference proceedings presents the research papers in the field of mine planning and mining equipment including themes such as mine automation, rock mechanics, drilling, blasting, tunnelling and excavation engineering.

Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients.

This book is intended to help management and other interested parties such as engineers, to understand the state of the art when it comes to the intersection between AI and Industry 4.0 and get them to realise the huge possibilities which can be unleashed by the intersection of these two fields.

This book discusses the main tasks of Design Automation for Field-coupled Nanocomputing (FCN) technologies, in order to enable large-scale composition of elementary building blocks, that obtain correct systems from given function specifications.

This volume describes the identification of emerging organic pollutants, mainly from industrial sources, their associated toxicological threats, and the latest green methods and biotechnological solutions to abate harmful impacts on people and the environment.