Bøker utgitt av Springer Nature Switzerland AG

This volume argues for the development of a macro perspective within psychology that more effectively incorporates social structures, systems, policies, and institutions. The book emphasizes how social structures and systems can ultimately promote, or erode, psychological wellbeing. Macropsychology is concerned with ¿understanding up,¿ or how we can influence the settings and conditions of the society in which we live. Psychology has traditionally been more interested in ¿understanding down,¿ that is, with the behaviour of individuals and groups; in inter-psychic and intra-psychic and in neurological and biological processes. This volume argues that psychology can more effectively contribute at the macro or societa level, by addressing grand challenges and global goals, using big data, and intervening at the population level.Bringing together social, organizational, cultural, and health psychology research, the book demonstrates a broad range of areas benefitting from a macropsychology perspective, particularly areas integral to the realization of the Sustainable Development Goals (SDGs). Contributors address the value of macropsychological perspectives in addressing sub-topics such as: Mental healthPersonality traits and social structureDisability rightsFood systems Humanitarian work psychology Macropsychology: A Population Science for Sustainable Development Goals aims to recognise and give impetus to a neglected perspective within psychology, and to inspire a paradigm-widening within the field of psychology, facilitating greater involvement with social justice and human rights.

Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patientresponses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease.

Obesity is an independent risk factor for cardiovascular disease (CVD) in adults as well as in obese children. This book will provide a description of the impact of obesity on the cardiovascular system and increased predisposition to CVD. It will identify the major biochemical mechanisms that lead to the occurrence of myocardial abnormalities and vascular alterations in obesity. We will also have some discussion on the biochemistry of the so-called obesity paradox in relation to CVD. The contributors to this book are international experts on obesity and associated cardiovascular complications. This book is also uniquely positioned as it focuses on the biochemistry of obesity-induced cardiovascular dysfunction. There are 20 chapters in 2 different parts in this book, comprising of Part A: Pathophysiology of Cardiovascular Complications in Obesity (11 chapters) and Part B: Modification of Cardiovascular Dysfunction in obesity (9 chapters). Theintent of this volume is to provide current and basic understanding of the biochemical mechanisms of obesity induced cardiovascular dysfunction that will be of value not only to cardiologists and other allied health professionals, but will also stimulate and motivate biomedical researchers and scientists to find the way to prevent the epidemic of obesity associated cardiovascular abnormalities. Furthermore, this book will serve as a highly useful resource for medical students, fellows, residents and graduate students with an interest in the cardiovascular system.In summary, this book covers a broad range of biochemical mechanisms of obesity-induced cardiovascular complications. We hope that the reader will understand that obesity is linked to an increase in the risk and occurrence of fatal CVD. Furthermore, the underlying message presented in the book is that the cause of obesity related disorders is complex and that understanding the biochemistry of cardiovascular dysfunction may contribute to the development of novel interventions for the prevention and treatment of obesity associated comorbidities.