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Opioid analgesics are among the most effective medications for pain management but are associated with serious and increasing public health problems, including abuse, addiction, and death from overdose. Currently, there is an opioid epidemic in the United States with the rate of prescription opioid-related overdose deaths quadrupling over the last 15 years. Pediatric patients are particularly vulnerable to the devastating consequences of opioid misuse. Adolescents who are prescribed opioids are at a higher risk for abusing illicit drugs later in life. Clinicians managing pediatric pain must account for such issues while still delivering effective analgesia to young patients who suffer from both acute and chronic pain. Opioid Therapy in Children and Adolescents is designed to explore the unique aspects of opioid therapy in pediatric patients. An introductory framework provides historical context and describes the epidemiology of the opioid crisis with focus on pediatric implications. Subsequent chapters focus on pediatric opioid pharmacology, safe opioid prescribing practices, and non-opioid alternatives to managing pediatric pain states, including multimodal analgesic strategies, interdisciplinary approaches, and complementary medicine. Mitigation strategies against pediatric opioid diversion and misuse are addressed to help clinicians develop practice changes that protect pediatric patients from opioid-related morbidity and mortality. Clinical case examples are also utilized throughout the text to provide grounding for each chapter and a context within which to examine pertinent issues. This first of its kind book provides a comprehensive approach that will guide clinicians to appropriately and safely prescribe opioid analgesics to pediatric patients suffering from pain. It is an invaluable resource for pediatricians, family practitioners, anesthesiologists,pediatric oncologists, and other clinicians who manage pediatric pain.

This book provides a concise reference of the histologic and clinical findings of dermatologic conditions encountered in the inpatient setting. The text is divided into twenty chapters. Histopathologic images and corresponding clinical photographs facilitate clinical pathologic correlation of the conditions discussed in each chapter. Bulleted summaries for quick easy-to-read reference and diagnostic pearls are provided for each of the discussed entities. Each chapter ends with several case studies in which clinical presentation, histologic interpretation and work-up of these challenging scenarios are outlined. This book represents an international collaboration and a wealth of clinical expertise and years of experience of authors from Africa, Asia, Europe, North and South America.Hospital-Based Dermatopathology is a useful diagnostic guide for general pathologists, pathology and dermatology trainees, medical students, dermatopathologists,as well as dermatologists, hospitalists, and inpatient clinicians. It also serves as a useful guide in rendering histologic diagnosis for hospital-based or inpatient skin biopsies.

The second edition of this volume has been updated with chapters on scar treatment using laser, microneedling, tissue engineering, adipose tissue and lipofilling. It compiles the perspectives of a multi-author team, examining the entire spectrum of burn reconstruction and long-term treatment. Individual updated chapters cover basic aspects of wound healing and scarring, and plastic surgery relating to tissue rearrangement and the use of flaps, as well as the long-term use of skin and skin substitutes. Furthermore, it addresses topics such as rehabilitation and scar management in detail. It provides comprehensive reconstruction guidelines organized by anatomic region (e.g. face, hands, ...) as well as future trends and prospects in burn reconstruction, such as allotransplantation and bionics.Please also have a look at the volume "Handbook of Burns Volume 1 - Acute Burn Care 2nd edition"

The number of natural and man-made disasters has risen dramatically over the last decade. Natural disasters, industrial accidents and terrorist attacks represent major incidents, often involving multiple casualties. In such cases, health professionals face multiple challenges because the type of medical care required differs from what is taught and provided in their everyday hospital duties. The aim of this book is to inform and prepare healthcare professionals for the challenges posed by major incidents, so that they can act effectively in medical teams sent on humanitarian missions or into conflict zones. It offers a holistic and horizontal approach covering all stages of the disaster management cycle.The book is divided into 5 sections: section 1: prehospital emergency services; section ii: hospital response; section iii: management of incidents; section iv: after the disaster; and section v: evaluation, ethical issues, education and research. Healthcare providers will find essential information on the special medical considerations in both prehospital and hospital disaster settings, medical management of disaster response, recovery, mitigation and preparedness. The book offers an interdisciplinary and interprofessional approach, and was written by prominent researchers and experienced practitioners.

Comprehensive and practical, this book thoroughly addresses the full range of concerns related to food allergies in the pediatric patient. As food allergies in the pediatric population increase in number and severity, Pediatric Food Allergy: A Clinical Guide provides information on new guidelines and potential treatment options, as well as working to improve awareness, diagnosis, management and prevention practices. Written by experts in their respective fields, chapters are divided into five sections. Opening with an introduction and overview of particular concerns and issues specific to food allergy in the pediatric population, sections two and three address diagnosis and management of comorbid conditions in food allergy, along with development of food allergies and current prevention recommendations. Sections four and five cover food allergy management, prognosis, and therapeutic options with a look to future developments, whileall sections include a discussion of epidemiology, differential diagnoses of other potential food-related diseases. In Pediatric Food Allergy: A Clinical Guide, pediatricians and allergists alike will find an invaluable resource as they work with this vulnerable patient population.

This book, now in its third edition, examines the current treatment options for first-line, relapsed, and refractory Hodgkin lymphoma and the appropriate management in special clinical circumstances, including in the elderly, pregnant women, and those with nodular lymphocyte-predominant disease (NLPHL). Careful attention is devoted to the emerging individually tailored treatment strategies, including checkpoint inhibition, that are especially appealing given their potential to reduce early and late treatment side effects in this generally young patient population. In addition, clear guidance is provided on the management of Hodgkin survivors. Other topics addressed include epidemiology, pathogenesis, the role of the microenvironment, initial clinical evaluation, imaging diagnosis, use of staging systems, and prognostic factors. The new edition of Hodgkin Lymphoma: A Comprehensive Overview has been revised and updated by key opinion leaders to reflect recent progressin the field. It will be of great value to hematologists, oncologists, and all others with an interest in Hodgkin lymphoma.

A groundbreaking contribution to the literature now in its revised and expanded second edition, this textbook offers a comprehensive review of diagnostic and treatment techniques for male infertility. This state-of-the-art, evidence-based textbook incorporates new multidisciplinary and complementary medicine approaches to create a first-of-its-kind guide to treatment strategies for male infertility and beyond. While this new edition is primarily designed as a reference for students and residents in reproductive medicine and andrology, it will be equally useful as well for professionals in urology, reproductive endocrinology, embryology, and research fields who are interested in the role that antioxidants play in male infertility.World-renowned experts in these areas have been selected to participate in this work. Careful selection of the highest quality content will span the whole range of topics in the area of male infertility, providing a complete review of well-established and current diagnostic and treatment techniques for male infertility. The incorporation of 20 new chapters will enhance the book¿s appeal by including the most recent advances brought to the male infertility arena. Additionally, this edition incorporates new features, including bulleted key points, review criteria and select video clips demonstrating some of the most fascinating male infertility treatment modalities. A dedicated new section on current guidelines on male infertility will enlighten readers on how to most optimally manage male infertility clinical scenarios. Covering all aspects of diagnosis and management, ART, lifestyle factors and associated conditions for male infertility, Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants will be a readily accessible, high quality reference for medical students and residents, and will be of significant value to professionals working in the various fields treating this condition as well.

This book provides a step-by-step and practically applicable approach for the accurate and clinically relevant diagnosis of lymph node (LN) and bone marrow (BM) biopsies. Clinicians expect pathological guidance not only with accurate diagnosis, but also about disease progression, minimal residual disease, disease susceptibility to a particular therapy, effects of prior therapy on prognosis and subsequent therapy etc. This book provides brief but to the point guidance about the prognostic and therapeutic implications of key ancillary studies so that the pathologist is comfortable to answer clinician¿s questions over the entire arc of manifestations and management of the disease. The text follows the WHO (2016) classification in essence but the material is organized in a fashion most useful to a practicing surgical pathologist. This is achieved by focusing on the morphological findings as the starting point. Using this morphological ¿backbone¿ and several frequently asked questions(FAQs) the reader is guided to a rational list of differential diagnoses leading to a definitive diagnosis. The contents of each chapter are carefully selected so that the practically important and directly applicable information is available in an easy-to-find and easy-to-grasp format.Practical Lymph Node and Bone Marrow Pathology serves as a practical introduction and handbook for pathology trainees and hematopathology fellows and will remain a useful reference to practicing pathologists when they are signing out lymph nodes or bone marrow specimens.

This innovative book presents the latest insights into hamstring strain injuries (HSI), one of the most common problems in elite and recreational sport, with a unique focus on prevention and rehabilitation. The research within this area has evolved rapidly over the past 10 years and this text offers a comprehensive overview of the recent and most relevant advances. It fills a gap in the literature, since other books focus on muscle injuries in general and their surgical treatment.Structured around the current evidence in the field, it includes sections on functional anatomy and biomechanics; basic muscle physiology in relation to injury and repair; assessment of risk factors; and factors associated with hamstring strains. It also discusses considerations in relation to acute and chronic injuries and hamstring injury prevention, including pre-season and in-season interventions, as well as management strategies and rehabilitation protocols. The final chapter is devoted to additionalinterventions when conservative rehabilitation and injury prevention fail. Written by renowned experts in the field, this book will be of great interest to sports physiotherapists, sports physicians, physical trainers and coaches.