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This textbook provides a practical and board-driven resource to describe and define the emerging field of cardiorenal medicine. Covering all aspects of the topic with depth and relevance, this groundbreaking reference brings together experts at the nexus between cardiovascular and renal medicine to provide an exception reference to educate in this critical area of modern medicine. It describes how the heart and kidneys are inextricably linked via hemodynamic, neural, hormonal and cellular signaling systems and, concentrating on disease-based coverage, goes on to review emerging concepts in epidemiology, pathogenesis, screening, diagnosis and the management of cardiorenal syndromes, all extensively illustrated and containing features to support scholarship in the field.Textbook of Cardiorenal Medicine provides consistent chapter organization, clear design and engaging text to define the diagnosis, treatment, intervention and surgical aspects of the full range ofconditions encountered within this area of medicine. It is therefore an essential resource to all involved in the management of cardiorenal disease.

This book describes and discusses the available joint preservation techniques for maintaining the stability homeostasis of the lower extremity joints ¿ specifically the hip, knee, and ankle ¿ following injury. Readers will find detailed coverage of anatomy, pathology, techniques for repair, restoration, and regeneration, and rehabilitation strategies. Joint preservation is an emerging field in Orthopaedics that represents a response to the limitations of joint replacement technology. Using the techniques now available, surgeons can try to prevent or delay the onset of osteoarthritis or other degenerative conditions affecting the joints, particularly in young patients. Furthermore, modern tissue engineering offers the potential for whole-joint resurfacing, thereby achieving complete restoration. Optimal implementation of these techniques depends upon further refinement of methods and continuing improvements in knowledge of biomechanics, biology, and anatomy. Against this background,the present book is an ideal guide to the latest treatment modalities that will appeal to all who wish to learn more about indications, goals, procedures, and expected outcomes.

This book provides a thorough update on the management of infections in patients with hematologic malignancies, focusing particularly on prevention, diagnosis, and treatment. Detailed attention is devoted to the central roles that vaccination and anti-infective prophylaxis have gained in improving overall survival in this patient group, in accordance with the principle that prevention is better than cure. Careful consideration is also paid to risk stratification, which is crucial in ensuring that anti-infective prophylaxis is targeted to those at the highest risk. While preventive strategies reduce the prevalence of infections, optimized management strategies are vital to decrease infection-related morbidity and mortality in those who nevertheless develop infections. Here, readers will find in-depth, up-to-date knowledge on the diagnosis and treatment of bacterial, fungal, viral, and parasitic infections, according to the affected organ and the causative pathogen. Finally, treatment inintensive care units is reviewed. The book will be of high value for hematologists, oncologists, and infection specialists.

Over the course of the last decade, political and mental entities at large have embraced global mental health: the idea that psychiatric health is vital to improved quality of life. Physicians globally have implemented guidelines recommended by the National Institute of Mental Health (NIMH) in 2007, thereby breaking down barriers to care and improving quality of life in areas where these practices have been implemented. Programs for training and education have expanded as a result. Clinicians benefit more from both local resources in some regions as well as in international collaboration and technological advancements. Even amidst all of these positive outcomes, clinicians still face some stumbling blocks. With worldwide statistics estimating that 450 million people struggle with mental, neuropsychiatric, and neurological disorders¿25 percent of the world¿s non-communicable disease burden¿rising to these challenges prove to be no small feat, even in wealthy Western nations. Various articles and books have been published on global mental health, but few of them thoroughly cover the clinical, research, innovative, and social implications as they pertain to psychiatry; often, only one of these aspects is covered. A comprehensive text that can keep pace with the rapidly evolving literature grows more and more valuable each day as clinicians struggle to piece together the changes around the world that leave open the possibility for improved outcomes in care. This book seeks to boldly rectify this situation by identifying innovative models of service delivery, training, education, research funding, and payment systems that have proven to be exemplary in implementation and scalability or have potential for scalability. Chapters describe specific barriers and challenges, illuminating effective strategies for improved outcomes. This text is the first peer-reviewed resource to gather prestigious physicians in global mental health from around the world and disseminate their expertise in the medical community at large in a format that is updateable, making it a truly cutting-edge resource in a world constantly changed by medical, scientific, and technological advances. Innovations in Global Mental Health is the ultimate resource for psychiatrists, psychologists, primary care physicians, hospitalists, policy makers, and all medical professionals at the forefront of global mental health and its implications for the future.

This book provides a data-driven analysis of robotic assisted, laparoscopic, and endoscopic urological procedures in children, including renal surgery, ureteral surgery, oncology, and bladder surgery. Introductory chapters outline and describe the logistics of establishing a dedicated minimally invasive program at your institution, as well as the basics of anatomy, instrumentation, access, and trocar placement. Subsequent chapters are organized by anatomic compartment (upper tract and lower tract) and organ system. Each chapter also addresses advanced techniques and future directions, as well as common complications and case-based challenges. The final chapters review oncology and special considerations in infants. Minimally Invasive and Robotic-Assisted Surgery in Pediatric Urology provides a comprehensive, evidence-based text on pediatric urology robotic and minimally invasive surgery, allowing readers to implement the material presentedfor the improvement of their own practices and patient outcomes.

This book provides a data-driven analysis of robotic assisted, laparoscopic, and endoscopic urological procedures in children, including renal surgery, ureteral surgery, oncology, and bladder surgery. Introductory chapters outline and describe the logistics of establishing a dedicated minimally invasive program at your institution, as well as the basics of anatomy, instrumentation, access, and trocar placement. Subsequent chapters are organized by anatomic compartment (upper tract and lower tract) and organ system. Each chapter also addresses advanced techniques and future directions, as well as common complications and case-based challenges. The final chapters review oncology and special considerations in infants. Minimally Invasive and Robotic-Assisted Surgery in Pediatric Urology provides a comprehensive, evidence-based text on pediatric urology robotic and minimally invasive surgery, allowing readers to implement the material presentedfor the improvement of their own practices and patient outcomes.

This extensively revised textbook reviews the use of transesophageal echocardiography (TEE) in pediatric and young adult patients with cardiac disease. It reviews how TEE has made a vital contribution to these patients¿ successful and continually improving clinical outcomes, enabling them to live well into adulthood. The book details the evolving technology and applications of TEE (including three-dimensional TEE), describing how this imaging approach remains at the forefront of clinical practice for pediatric patients and those with congenital heart disease (CHD).Transesophageal Echocardiography for Pediatric and Congenital Heart Disease represents a unique contribution as the only contemporary text to focus exclusively on the clinical application of TEE in children and all patients with CHD. Written by numerous prominent specialists in the field, it presents a comprehensive, modern and integrated review of the subject. Specific chapter topics include the physics and instrumentation of TEE, structural and functional evaluation, and specialized aspects of the examination, with emphasis on the technical considerations pertinent to both pediatric and adult patients with a variety of congenital and acquired cardiovascular pathologies. Consequently, it serves as a comprehensive reference for the TEE evaluation of CHD, utilizing the segmental approach to diagnosis and discussing the TEE evaluation of the many anomalies encompassing the CHD spectrum. In addition, numerous other relevant topics are discussed, including application of TEE for perioperative and interventional settings. The book is richly illustrated, with many chapters supplemented by illustrative case studies and accompanying videos. A specific section with multiple-choice questions and answers is provided at the end of each chapter to reinforce key concepts. This textbook therefore provides an invaluable and indispensable resource for all trainees and practitioners using TEE in the management of CHD and pediatric patients.

This book brings together findings from research and clinical practice, with comprehensive coverage of the important aspects of mental health in ageing persons with intellectual and developmental disabilities. It is crucial for professionals involved in the care of persons with all intellectual and developmental disabilities to have a broad understanding of the essential range of issues, and therefore this book provides a truly multi-disciplinary perspective, complete with many figures and illustrations to underline the key points.Undoubtedly, research and clinical practice are much more advanced in the general ageing population than in persons with intellectual and developmental disabilities, and so professionals and academics must be made fully aware of commonalities and idiosyncrasies of older people with intellectual and developmental disabilities. This book presents the ongoing developments concerning mental health and aging, which will become relevant to the intellectually disabled population. Through experience, this book also acknowledges that the impact on the persons themselves and on their carers always needs to be taken into account, with treatment programs established with a multi-faceted team approach in mind.Avoiding the jargon of many titles in this area while maintaining the hands-on approach of clinical practice, this book meshes the practical and scientific worlds, with all chapters written by leading experts in the field.Beyond the US, the IASSIDD support expands the book message worldwide.

This comprehensive, case-based resource provides the state-of-the-art knowledge that can help readers improve access and optimize delivery of stroke thrombectomy. Improving access to stroke is of particular importance because patients often misinterpret their symptoms or cannot speak for themselves if they have aphasia. More importantly, access needs to be organized because stroke therapies are all extremely time-sensitive. Scalable, choreographed protocols are necessary for emergency medical systems to ¿capture¿ stroke patients and automatically transport and triage to time-sensitive treatments. Many of the chapters in the first section on Fundamentals and Systems provide valuable insight in improving access to stroke care. Replete with illustrative case studies and emphasizing that treatment approaches to stroke should not be comprised of a one-size-fits-all approach, this illuminating title provides the complete thought, detail, insight and organization that will help readers meet the needs of stroke patients with large vessel occlusions. 12 Strokes: A Case-based Guide to Acute Ischemic Stroke Management examines the primary technical principles that underlie the current thrombectomy approaches. Instead of continuing the conceptual dichotomy of stent vs. aspiration, many of the chapters look at underlying principles and then discuss ways in which the currently available devices and approaches can best exploit them. The variety, creativity and detail in many of these chapters will help the reader develop a deeper understanding that might assist their ability to successfully take care of their next patient that ¿doesn¿t follow the textbook.¿ In addition, the anatomic and pathophysiologic classification of the core Twelve Chapters will help readers organize their thinking and approach. This knowledge, particularly because it is organized based on common, challenging syndromes, will arm the reader to quickly recognize patterns and deftly adapt their management approaches to the needs of the patient. An invaluable contribution to the clinical literature, 12 Strokes: A Case-based Guide to Acute Ischemic Stroke Management will be of great interest to not only neurosurgeons and neurologists but other specialists, primary care providers, and trainees as well.

Immunology and Rheumatology in Questions, 2nd Edition addresses through short and concise questions-and-answers (Q&As) on one hand all major aspects of basic clinical and laboratory immunology necessary for understanding underlying immunological mechanisms of autoimmune rheumatic diseases. The majority however of Q&As in this book presents in a laconic way definitions, pathogenetic aspects, clinical and laboratory manifestations, differential diagnosis and the management of all categories of rheumatic diseases including systemic autoimmune, autoinflammatory, metabolic and degenerative. Furthermore, in separate sections of this manual Q&As addressing rheumatic manifestations from other organ systems are included. Finally, a chapter is devoted to treatment of rheumatic diseases analyzing indications and side-effects of different therapeutic modalities with illustrations and diagrams utilized throughout the book to present the information in a clear and schematic way. In this fully revised second edition, more than 120 new Q&As have been added and the answers to more than 90 Q&As has been modified after having critically incorporated all new knowledge generated in the past three years in the field of rheumatology, in an effort to bridge classical and current evidence-based knowledge and to present didactic and credible information. This book is valuable to test and acquire knowledge not only for rheumatologists but for every specialist in internal medicine, family practice, physical/rehabilitation medicine and orthopedic surgery.

The second edition of this important book provides an up-to-date and comprehensive overview of clinical lipidology. Brand new chapters focus on recent advances in the field including novel biomarkers and the microbiome, genomics of cardiovascular risks, PCSK9 inhibitors, imaging technologies, and epidemiology of atherosclerotic cardiovascular disease.The book describes new guidelines, novel therapeutic agents, and changes in the understanding of specific lipoproteins and subclasses with regard to their relationships to cardiovascular disease risk. The second edition contains more than thirty chapters covering such topics as the history of lipidology, lipoprotein metabolism and vascular biology, disorders of lipid metabolism, lifestyle/dietary and pharmacologic management for dyslipidemia, the management of dyslipidemia in certain subgroups (e.g., women, children, older patients) and lipid testing, as well as an examination of other biomarkers and testing procedures related toatherosclerosis and cardiovascular disease. The second edition of Therapeutic Lipidology is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in lipidology, cardiology, endocrinology, pharmacotherapy, and health promotion and disease prevention.

This book provides readers with a holistic approach to chronic pelvic pain which is an extremely complex condition with associated pelvic dysfunctions. This approach significantly facilitates and accelerates the clinical assessment and subsequent follow-up. The pathophysiologic mechanisms involving the nervous system, the pelvic organs and the pelvic floor are discussed, deepening the possible implications on mind, sexuality and pelvic dysfunctions.Evaluation and diagnosis are examined for different types of syndromes. Moreover, since the Bladder Pain Syndrome and the Interstitial Cystitis are main causes of pelvic pain, an original diagnostic approach is proposed specifically for these conditions. In order to deliver the best clinical outcomes, this new system provides a multidisciplinary approach, both in the diagnostic phase and in the therapeutic phaseThe most recent therapies for chronic pelvic pain following a multidisciplinary approach are described in detail. Due to its practice-oriented contents, the book will greatly benefit all professionals dealing with this debilitating disease, supporting them in their daily clinical routine.

This book systematically summarizes classic imaging signs' characteristics and theory for whole body imaging, serving as a clinical guide for the understanding, prevention, and diagnosis of miscellaneous entities. In recent years, with the rapid evolution of modern imaging modalities, radiology has secured an irreplaceable role in diagnosis within standard clinical practice and being familiar with radiological signs has become essential.The book provides a multimodality review of more than 300 commonly utilized radiologic signs in radiography, CT, MRI, US, angiography, and nuclear medicine, including PET-CT. It is designed to enhance recognition of specific imaging patterns and enable the image interpreter to confidently reach an accurate diagnosis. Divided into ten chapters dedicated to different anatomic areas, each sign includes detailed discussion that explains the history and meaning of the descriptive or metaphoric sign, alongside illustrative photos for memory aid andclarification. Uniquely written from a practical point of view, each case leads you through a radiology expert¿s thought process in analyzing the classic signs with considerations of common misinterpretations and imaging pitfalls. The cases then highlight clinical presentation, relevant pathology, anatomy, physiology, and pertinent imaging features of common disease processes. Key information is distilled into succinct, bulleted points with detailed illustrations and images.This book is an ideal reference and review for practicing radiologists, as well as trainees preparing for licensing examinations.

This book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach.Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed.This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.