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This book compiles a diverse and interdisciplinary range of scientific literature, laboratory developments, industrial implications and future prospects covering Entomophagy in 3D food printing to fight against hunger and nutritional deficiencies. Recent developments in Entomphagy in 3D printing of Drosophila based materials, and their nutritional, social, economic, scientific and environmental aspects. are comprehensively covered. Readers will also find shortcomings, guidelines, and industrial prospects for these materials, with emphasis on processing methods for the extraction of sustainable materials through 3D food printing. 3D Printing of Sustainable Insect Materials focuses on the methodology, technology and processing used for utilizing insects in 3D food printing applications, establishing technology-driven knowledge to fight against hunger. Chapters cover the principles for Entomophagy, insect processing methods, modern 3D food printing technologies, and the theoretical and practical aspects of Emtomophagy in 3D printing, with a special focus on future prospects and technologies. This ground-breaking book will serve knowledge to researchers and industry professionals across the food industry with broad coverage of emerging technologies, materials developed through Entomophagy, functional characterization and the technical details required to produce sustainable insect-based materials through 3D food printing.

In response to the increasing move by scholars to reference other fields of knowledge in the advancement of entrepreneurship studies, this book offers an interdisciplinary approach to the study of entrepreneurship.The author investigates five main issues about entrepreneurial processes:the origin of entrepreneurship, the purpose to achieve, the way decisions are made, the creation of entrepreneurial networks and ecosystems. Respectively, these issues are analysed from new perspectives related to other disciplines, such as mythology, philosophy, mathematics, chemistry, and biology. In this way, the book investigates pervading questions about entrepreneurial processes that are still unsolved. By adopting this novel interdisciplinary approach, the book opens up new avenues of research in entrepreneurship studies.

This book provides an overview of Data Monitoring Committees(DMC) - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotechnology and pharmaceutical company and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity.This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to expertly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the impact of DMC activity on safeguarding the trial is so important.This book provides the following:Provides thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation;Includes practical and hands-on information on DMC implementation;Discusses a wide range of clinical trial ¿ by phase and therapeutic area.

This book presents an international review of the modern geo-economy and a scientific take on the geo-economy of the future. It identifies the challenges of climate change and their impact on the modern geo-economy. Prospects for the geo-economy of the future are outlined based on sustainable agriculture and alternative energy. Policy implications are put forward to develop a geo-economy of the future in response to the challenges of climate change. The book presents management implications for the development of the geo-economy of the future in response to the challenges of climate change at the regional and global scale. It presents the lessons-learned through the COVID-19 pandemic, and applies experiences of countries with different environmental conditions for agriculture and the development of the energy sector. Based on these results, advanced practical recommendations and ready-made frameworks at the national, regional, and enterprise level are provided.

This volume discusses how the use of technology creates opportunities for effective teaching practice and illustrates ways to apply innovative and stimulating ways to engage and interact with students on-line. This research-led book brings together teaching practice and case studies and provides a comprehensive understanding of how technology can enhance teaching and learning through English as medium of instruction. It helps to further the understanding of challenges that language teachers and learners may experience, and provides suggested solutions to address these challenges. It also reflects on the use of technology trough case studies and practical tasks. This book brings theory and practice together and it informs research and classroom practices. It will therefore be of great value to teachers in training as well as to those already working or researching in the field.

The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans.The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development.

This book gives a comprehensive account of modern x-ray science, based on the use of synchrotron radiation and x-ray-free electron lasers (XFELs). It emphasizes the new capabilities of XFELs which extend the study of matter to the intrinsic timescales associated with the motion of atoms and chemical transformations and give birth to the new field of non-linear x-ray science. Starting with the historical understanding of the puzzling nature of light, it covers the modern description of the creation, properties, and detection of x-rays within quantum optics. It then presents the formulation of the interactions of x-rays with atomic matter, both, from semi-classical and first-principles quantum points of view. The fundamental x-ray processes and techniques, absorption, emission, Thomson, and resonant scattering (REXS and RIXS) are reviewed with emphasis on simple intuitive pictures that are illustrated by experimental results. Concepts of x-ray imaging and diffractive imaging of atomic and nano structures are discussed, and the quantum optics formulation of diffraction is presented that reveals the remarkable quantum substructure of light. The unique power of x-rays in providing atom and chemical-bond specific information and separating charge and spin phenomena through x-ray polarization (dichroism) effects are highlighted. The book concludes with the discussion of many-photon or non-linear x-ray phenomena encountered with XFELs, such as stimulated emission and x-ray transparency.

This book discusses all aspects infectious CNS pathology, including different bacterial, viral, fungal, mycoplasma and protozoan pathogens, accompanied by illustrations that show macro- and histopathological changes. It also presents microbiological, epidemiological and clinical data, with a particular focus on meningitis and encephalitis of different bacterial and viral aetiologies, influenza, COVID-19  and other viral and bacterial generalized infections. Further, the book explores the importance of mixed infections, including those in the late stages of HIV infection, as well as pathological changes in different age groups including newborns. A special chapter is devoted to the probable role of biological pathogens in noninfectious brain pathology.

This book offers a unique treatment of building insulating products and the integration of these products with building components. This book was written for all those involved in building design, specification, construction, and commissioning, providing them with an understanding of and appreciation for the wide variety of thermal insulation products and technologies available for use in all types of buildings. The book proceeds from basic definitions and discussion of heat-transfer topics and thermal insulation concepts, to the design and use of these products. The impact of thermal insulation on dynamic building performance, including factors other than heating and cooling, is also discussed.The book does not require an advanced mathematical background. The authors provide sufficient information to provide a qualitative understanding, with more mathematical sections included for those interested in modeling and analysis. The basic physics associated with heat transfer in buildings are presented, along with the steady-state and transient analysis techniques needed for the effective implementation of thermal insulation and assemblies.Modern building design involves the integration of comfort, safety, economics, durability and cost considerations, all of which impact the selection and use of thermal insulation materials in buildings. In addition to theoretical explanations of the underlying science, the book details the properties and application of new thermal insulation materials, including vacuum panels, gas-filled panels, aerogels, phase-change materials, and radiation control technologies.Given its scope, the book will be of interest to researchers and building engineers wishing to understand the latest technologies and materials available, so as to achieve reduced energy consumption in commercial and residential buildings.

In recent years, "clean label" has become a trendy term in the food industry, spurring innovations in food product development. While the concept of "clean label" is relatively new, without any legal definition, it has a high market appearance and industrial relevance. Consumer demands are leading food and beverage manufacturers toward removing synthetic additives (e.g., emulsifiers) and incorporating natural ingredients. Indeed, many big food companies have committed to eliminating artificial food additives from their products altogether. However, the substitution of chemical preservatives for natural ingredients without compromising food safety, convenience, and sensory quality is a challenge for food technologists.The Age of Clean Label Foods offers a guide to this approach with a thorough exploration of "clean label" ingredients in foods and the development of these food products. All aspects of clean label foods are covered in this essential reference, including recent developments in "clean label ingredients," technologies for producing or enhancing the functionality of ingredients, the interaction of ingredients with emerging food processing technologies, legislative frameworks, and consumer attitudes. Particular emphasis is given to trendy topics in the clean label industry, such as products with reduced-fat or reduced salt content, modified starches, natural emulsifiers, antioxidants, flavorings and antimicrobials, and fermented foods, as well as active and intelligent packaging for clean label foods. Through this text, the authors hope to promote a better understanding from which food technologists and food microbiologists can operate in the "clean-label" arena, taking into consideration all the key aspects of food quality, sensory characteristics, and food safety.

This monograph is devoted to the study of multiscale model reduction methods from the point of view of multiscale finite element methods. Multiscale numerical methods have become popular tools for modeling processes with multiple scales. These methods allow reducing the degrees of freedom based on local offline computations. Moreover, these methods allow deriving rigorous macroscopic equations for multiscale problems without scale separation and high contrast. Multiscale methods are also used to design efficient solvers. This book offers a combination of analytical and numerical methods designed for solving multiscale problems. The book mostly focuses on methods that are based on multiscale finite element methods. Both applications and theoretical developments in this field are presented. The book is suitable for graduate students and researchers, who are interested in this topic.

This text aims to provide a comprehensive review of general emergency surgery, the branch of medicine that treats patients presenting to the hospital with a wide variety of emergency conditions. It includes a section focusing on clinical aspects, management, logistics, patient cohorts and perioperative considerations in the context of general emergency surgery and trauma. Other sections describe various conditions and diseases in specific anatomical structures to enable readers to easily find the information they need. Written and edited by international experts and opinion leaders in the field, this book is a valuable reference resource for general and emergency surgeons, trauma surgeons, emergency physicians and nurses. It will also be of interest to residents, students and all other healthcare professionals involved in the management of emergency surgical patients.

This book contains reports made at the International Conference on Differential Equations, Mathematical Modeling and Computational Algorithms, held in Belgorod, Russia, in October 2021 and is devoted to various aspects of the theory of differential equations and their applications in various branches of science. Theoretical papers devoted to the qualitative analysis of emerging mathematical objects, theorems of the existence and uniqueness of solutions to the boundary value problems under study are presented, and numerical algorithms for their solution are described. Some issues of mathematical modeling are also covered; in particular, in problems of economics, computational aspects of the theory of differential equations and boundary value problems are studied. The articles are written by well-known experts and are interesting and useful to a wide audience: mathematicians, representatives of applied sciences and students and postgraduates of universities engaged in applied mathematics.

The ever-increasing population and the associated anthropogenic activities have imparted an adverse impact on the environment, resulting in an escalating pollution crisis and forcing the advancement of sustainable, green, and eco-friendly technologies. There is an expanding and flourishing activity in environmental research, specifically focusing on environmentally responsive approaches to combat xenobiotics, pollutants, and emerging contaminants discharged into the environment due to various anthropogenic activities. Bioremediation is an approach that can facilitate sustainable practices to mitigate various environmental pollutants. Alternative eco-friendly technologies involving the utilization of various industrial and agricultural residues could be sourced as economically viable sources for harnessing various tools and value-added products during their appliances in environmental remediation. This book focuses on the perception of the existing trends and recent developmentsin bioremediation and green technology usage in waste minimization, and pollution mitigation has been focused through research and review-type chapters. The encouraging conclusions of these research contributions could be incorporated for commercial-scale appliances on sustainable environmental solutions. This book appeals to scientists, academicians, and research scholars to gain inspiration and guidance for pursuing research on sustainable environmental applications.

This book explores the rich history of the keyword from its earliest manifestations (long before it appeared anywhere in Google Trends or library cataloging textbooks) in order to illustrate its implicit and explicit mediation of human cognition and communication processes. The author covers the concept of the keyword from its deictic origins in primate and proto-speech communities, through its development within oral traditions, to its initial appearances in numerous graphical forms and its workings over time within a variety of indexing traditions and technologies. The book follows the history all the way to its role in search engine optimization and social media strategies and its potential as an element in the slowly emerging semantic web, as well as in multiple voice search applications. The author synthesizes different perspectives on the significance of this often-invisible intermediary, both in and out of the library and information science context, helping readers to understand how it has come to be so embedded in our daily life.This book: Provides a thorough history of the keyword, from primate and proto-speech communities to current timesExplains how the concept of the keyword relates to human cognition and communication processesHighlights the applications of the keyword, both in and out of the library and information science context

The hotel industry has gone through important transformations, not only in terms of management and operation but also in terms of interaction with consumers. Technological development and adaptation to the digital era have been one of the greatest challenges for hotels. This book aims to fill the gap in the literature in this specific area of the tourism sector and contribute to a better understanding of trends and challenges in the hotel industry on a global scale.

This edited volume brings together leading international researchers in an attempt to disentangle and understand the multiple conflicts of sovereignty within the European polity in the aftermath of the 2008 economic crisis. While most research on sovereignty focuses on its international dimensions, what makes this volume distinctive is the focus on the mobilization of sovereignty discourses in national politics. Contrary to tired paradigms studying clashes between national and supranational sovereignty, the various chapters of the volume offer a provocation for the readers ¿ what if these old vertical conflicts of sovereignty are increasingly complemented by horizontal conflicts between executives and parliaments at both the national and international level?

This book is devoted to the emerging field of integrated visual knowledge discovery that combines advances in artificial intelligence/machine learning and visualization/visual analytic. A long-standing challenge of artificial intelligence (AI) and machine learning (ML) is explaining models to humans, especially for live-critical applications like health care. A model explanation is fundamentally human activity, not only an algorithmic one. As current deep learning studies demonstrate, it makes the paradigm based on the visual methods critically important to address this challenge. In general, visual approaches are critical for discovering explainable high-dimensional patterns in all types in high-dimensional data offering "e;n-D glasses,"e; where preserving high-dimensional data properties and relations in visualizations is a major challenge. The current progress opens a fantastic opportunity in this domain. This book is a collection of 25 extended works of over 70 scholars presented at AI and visual analytics related symposia at the recent International Information Visualization Conferences with the goal of moving this integration to the next level.  The sections of this book cover integrated systems, supervised learning, unsupervised learning, optimization, and evaluation of visualizations. The intended audience for this collection includes those developing and using emerging AI/machine learning and visualization methods. Scientists, practitioners, and students can find multiple examples of the current integration of AI/machine learning and visualization for visual knowledge discovery. The book provides a vision of future directions in this domain. New researchers will find here an inspiration to join the profession and to be involved for further development. Instructors in AI/ML and visualization classes can use it as a supplementary source in their undergraduate and graduate classes.