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This book offers readers an accessible and broad-ranging guide to Environmental Public Interest Litigation (EPIL), which has burgeoned in China over the past decade. The aim of this book is to provide a systematic review of Chinese experiences with EPIL in environmental matters, both with a view to gauging its success to date and well as discussing some more critical aspects. To this end, the book systematically examines the establishment and development of EPIL in China's legal, social, and political contexts. It examines particularly the significant role and functions of EPIL in China's environmental governance, and the far-reaching impacts on Chinese civil society and governments. It also offers readers an insiders' perspective in terms of procedural and substantive issues with respect to EPIL, by reviewing the institutional designs, theoretical underpinnings and specific mechanisms, the roles of various participants and stakeholders involved in this legal process. At the same time,it studies leading EPIL cases raised from environmental pollution, natural resource damage and ecological damage, and the effectiveness of environmental adjudication that sustains EPIL as a new form of judicial instrument. This book is written to remedy the gap between Chinese and English literature in this area of law. The analysis of these issues, through a historic and comparative perspective, reveals the strengths and weaknesses of the current legal regime and serves as a basis for recommendations for bringing about more effective EPIL in China.

Digital disruption in healthcare is generating new technologies, applications, and large data sets, and these are all precipitating significant changes in healthcare processes. Emerging applications due to digital disruption and their impact on healthcare delivery and quality are becoming some of the key focus areas of research. However, to date, systematic, generalizable, full-scale evaluation of these new technologies/applications is lacking. Little is known about the net short- or long-term health and wellness impacts of digital technologies. Similarly, the care-delivery and management process changes caused by digital disruption are forcing healthcare organizations to react rather than plan for them in advance. Given these gaps, this book addresses the technology, applications, data, and process aspects of digital disruption in healthcare.This volume is a collection of key areas in health and wellness impacted by digital disruption. It highlights the benefits, barriers, facilitators, and transformative forces that are shaping healthcare digital disruption. Topics explored in the chapters include:Towards Network Medicine: Implementation of Panomics and Artificial Intelligence for Precision MedicineTelehealth Implementation: A Synopsis of Patients' Experience of Clinical OutcomesRealising the Healthcare Value Proposition of Better Access, Quality and Value of Care by Incorporating the Social Determinants of Health with Digital HealthThe Internet Hospital in the Time of COVID-19: An Example from China Given the diverse interest in healthcare delivery solutions today, the need is broad across academia and the healthcare industry for a comprehensive resource for teaching, practice, and research. Digital Disruption in Healthcare is a point-of-entry resource for transferring theory into practice for heads of IT departments in hospitals, consultants, and academia, as well as scholars and researchers. Both graduate and undergraduate students as well as certificate-seeking health informatics and public health students would benefit from this book. Furthermore, it is useful for healthcare stakeholders including healthcare professionals, clinicians, medical administrators, managers, consultants, policy-makers, and IT practitioners within the healthcare space.

This book explores the constitutional debates of the Year 3 of the French Revolution (also known as Year 1 of the French Republic) and the drafts for the Declaration and the Constitution of 1793. It presents the revolutionaries¿ distinct view on human rights and the rights of the peoples, as well as their philosophical underpinnings. After discussing how contemporary legal history and theory, and political philosophy approached the revolutionary period, the book tackles the main topics covered during the debates and proposals. Starting with the issue of external relations and the sovereignty of the people and ending with natural rights and Republicanism, this book shows how apparently technical questions (such as what procedure should be implemented to declare a war) are intertwined with philosophical reflections on rights and with problems that were urgent at the time.

This book aims at filling a gap in relation to the pathophysiology of the inguinal region and the genesis of groin protrusions. While inguinal hernia is a widespread disease and hernia repair accounts for the most frequently performed surgical procedure, these two aspects have been unsatisfactorily investigated, so that to date there is no shared hypothesis on how visceral protrusion through inguinal barrier occur. Exact knowledge on the pathogenesis is fundamental for adequately managing a disease, otherwise all curative approaches would  not be  evidence-based, but merely empirically identified  and with uncertain outcomes carried out. Moreover, in absence of pathogenetic certainty, formulating guidelines simply results in an unjustified methodology harbinger of polemics and controversies. Previous studies concerning the pathogenesis of inguinal protrusions were mainly focused on the detection of biochemical changes, mostly related to collagen chains, metalloproteinase and similar elements. Nevertheless, despite decades of researches, a sure relationship between these ultrastructural modifications and visceral protrusion has not been proven. On the contrary, over the years very few investigations dealt with evidencing eventual modifications in the tissue structures of the herniated groin. An extensive research finalized to ascertain in patients and in cadavers structural changes of the tissue elements composing the groin was therefore carried out by the author and his researchers team. The findings of these studies resulted to be very useful for definitely evidencing the etiology of inguinal hernia disease. Overall, the proposed book scrutinizes and widens all emerging aspects related to pathogenesis, histology, physiology, surgical and functional anatomy of the inguinal area affected by hernia protrusion. It intends to be a reference guide to surgeons willing to better understand the structural modifications occurring in patients affected by this disease with the aim of improving treatment results.

This edited volume is written in memoriam of Professor Emeritus Ubiratan D¿Ambrosio (1932 ¿ 2021), who was a well-known Brazilian mathematics educator and historian of mathematics. This book explores the diverse facets of D¿Ambrosiös work as well as his legacy and the later adaptation of his ideas around the globe.It starts with a preface written by his son, Alexandre D' Ambrosio, who shares his personal experiences growing up with this father and his love for discovery. The book is then divided into four sections:Past and Future: Ubi¿s Way of Seeing Education in the PresentRoots of EthnomathematicsEthnomathematics in ActionTrends in Ethnomathematics It features diverse points of view and experiences that explore mathematics and culture from researchers in the Americas, Africa, Europe and South Asia. Chapters range from personal explorations of D¿Ambrosiös impact to broader views of his researchand work. This book forms part of the growing understanding of Ubiratan D¿Ambrosiös life, research, and the legacy he has left for millions of researchers, students and teachers worldwide. This book is appealing to anyone involved in mathematics education research as well as those interested in the history and future of mathematics education.

This book is a study of the forensic theatricality of human rights claims in literary texts about slavery in the sixteenth and the nineteenth century in the Spanish Empire. The book centers on the question: how do literary texts use theatrical, multisensorial strategies to denunciate the violence against enslaved people and make a claim for their rights? The Spanish context is particularly interesting because of its early tradition of human rights thinking in the Salamanca School (especially Bartolomé de Las Casas), developed in relation to slavery and colonialism. Taking its point of departure in forensic aesthetics, the book analyzes five forms of non-narrative theatricality: allegorical, carnivalesque, tragicomic, melodramatic and tragic.

This is a first book-long analysis showing how the notion of ¿hybrid warfare¿ was used to transform security policies and discourses in an EU/NATO country. Building on current debates in International Political Sociology, Critical Security Studies, and Critical Geopolitics, it provides a novel account of how crisis, geopolitics, uncertainty, and expertise are intertwined in the social construction of threats. Based on extensive and original empirical research of large textual archive and elite interviews in the Czech Republic and Brussels, the book shows how officials, bureaucrats, journalists, activists, and experts all participate in the reshaping of security in a new geopolitical environment. Zooming on the case of Czechia and its specific Central European context, it complements the predominantly Western-centric studies of insecurity with an account of how the liminal position on an East/West boundary influences security politics. As a first study of its kind and scope, it will be of interest to academics and students interested in Central European politics, practices and discourses of hybrid warfare, as well as critical approaches to security and geopolitics.

This book takes a comprehensive look at community engagement strategies in education to demonstrate the diverse nature of school-community relations and their value to promote their effective development. The author brings twenty years of experience in various educational settings in Ontario and California to examining community involvement policies and their interpretation, as well as school-community collaboration in practice. Chapters include recent research on school-community collaboration from the perspective of teachers, school district leaders, administrators, and support staff within two school districts in a low-income and culturally diverse urban community. The book also includes perspectives from community members involved in organizations across the city with a mandate to work with youth. In a time where students¿ academic, social, and emotional support needs are on the rise, this book offers a valuable resource for strengthening school-community relations and demonstrating the power of collaboration.

This book combines research on technology-driven and social-driven innovation in tourism destinations and the multifaceted concept of sustainability, providing an integrative understanding of the nexus between smartness and sustainability within destinations. It engages theoretically and empirically with the research question of how, and to what extent, smart technologies drive tourism innovation focussed on sustainability. Although innovation and technology are widely considered the way to sustainable tourism growth, further studies need to size the role of technology and critically address modalities, challenges, opportunities and pitfalls of technology deployment in rebalancing tourism disequilibria within local systems. Local, national, and supranational policymakers¿ attention to technology investments, the widening technological frontiers, and the enthusiasm for new technological opportunities to build, manage, and market destinations suggest the relevance of this research agenda. This book provides scholars, postgraduate students, and practitioners with conceptual and empirical insights into smart solutions and innovative destination models for multi-stakeholder engagement to manage and address tourism impacts and imbalances. The book outlines scenarios of sustainability-oriented innovation, encompassing and intertwining technological, social, human, and cultural co-drivers as the necessary conditions for smart technologies to enhance sustainable destinations effectively and improve human wellbeing and societal development.

Social media has become vital in Generation Z users' daily lives, as they are the most connected group through social media; however, studies have shown the negative side of using social media heavily, particularly loneliness. Furthermore, the COVID-19 pandemic has contributed to the significant growth of social media use with Generation Z users, which has shown to cause negative psychological effects. This book explores the behaviors of Generation Z consumers on various social media platforms (including interaction with brands as well as persons) and, using results from a Bergen Social Media Addiction Scale (BSMAS) analysis, explores the potential risks and causes of social media addiction in this generation. In particular, it offers an integrative model to help marketers understand social media addition and ways in which companies and associations can promote a more conscious use of social media by acknowledging that pathological use of social media has negative effects. This book isuseful for students, researchers, scholars interested in empirical research on consumer social media use and addiction.

This edited volume compiles a series of chapters written by experts of isotopic analysis in order to highlight the utility of various isotope systems in the reconstruction of past human behaviors. Rather than grouping contributions by specific isotopes or analytical techniques, as many isotope review articles are arranged, the volume organizes chapters by broadly defined themes of archaeological research. These include: paleodiet and life histories, human-animal interactions, and migration and mobility. In this sense, the book is arranged with the intent of being as much question based as method based. Chapters under these themes provide background information on the principles of the techniques and on the theoretical underpinnings of the research; yet they are written with the non-specialist in mind and attempt to convey these ideas clearly and succinctly. In addition to the case studies and reviews, three chapters provide greater context to the field of isotopicarchaeology, discussing its history, basic principles, and future potential. The volume aims to serve as a reference source for students and practicing archaeologists seeking to apply isotopic studies to their own research projects or to act as a reader for courses in archaeological science. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book is about the remarkable trade conflict between two agricultural superpowers with a focus on Brazil¿s rapid agricultural modernization in recent decades and its impact on trade policy formation and global economic governance. Previous research, including Black (2016), trace the origins and evolution of the cotton dispute up to the August 31, 2009 final arbitration ruling that authorized Brazil to impose retaliatory trade measures to compel U.S. compliance. Inside the Cotton Dispute offers a comprehensive examination of the bilateral relations and negotiations that culminated with the October 2014 mutual solution to one of the most important trade conflicts since the establishment of the World Trade Organization.

Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process.Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage.Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.

This book stands as a manual and ready reference for the range of professionals involved in industrial drying. It addresses problems connected with most industrial drying systems, too often designed by those with limited formal engineering training in an environment of minimal regulatory oversight. The author explains how many existing drying systems are dangerous and pose fire hazards, create unhealthy working conditions, are highly energy inefficient, and have very little to no primary modeling of key process variables. Equipping readers with the necessary competencies to contend with issues in conducting studies, developing new designs; manufacturing, installing, and servicing industrial drying systems, this volume is ideal for engineers, OEMS, contractors, service technicians, scientists; agriculture, food, wood products manufacturers; and insurance underwriters.

Blockchains and smart contracts are emerging technologies that pose unique challenges for legal systems. This book outlines the extent to which these new and innovative technologies could have potentially disruptive effects on contract law in Europe. It does so through a comparative, three-part analysis of the recognisability and effects of smart contracts in European legal systems. First of all, in light of the technologies¿ transboundary nature, the book employs a comparative approach, considering French law, German law, English law, and Dutch law to analyse the impact on the different systems of contract law. While doing so, it also addresses the formation, interpretation, and vitiation of contracts. Secondly, it analyses the impact of these technologies on European laws regarding unfair terms in consumer contracts and argues that the existing rules should be applied to smart legal agreements in business-to-consumer relations. Lastly, it analyses the current European rules of private international law on the basis of which jurisdiction and applicable law are developed. In this respect, the book concludes that the vast majority of these European rules are ¿smart contract-proof¿.

Our world is becoming ever more complex. Among the geopolitical and macroeconomic issues currently facing mankind, with serious ramifications for our future, are digitalization and technology, climate change, and globalization. Political upheaval, wars, natural disasters, economic recessions, and pandemics, have all had massive negative impacts on our society. In this new world, various governmental and organizational decisionmakers ¿ including managers, international agencies, NGOs, political leaders, economists, science & technology innovators, and medical professionals ¿ must all learn to anticipate and deal with these emergent risks, the integration of which, along with the management of ¿black swan¿ events, has assumed paramount importance. This is the huge challenge now facing us. This book, aimed at both academics and practitioners, shows how a framework for resilience can be created to help modern organizations to not only survive but to thrive. The author considers some of the organizations and bodies that can be said to be highly resilient and examines how ¿Resilience Thinking¿ affects different disciplines and environments. He addresses the question of how resilience works and how it is applied in practice. The relationship between resilience and other knowledge areas such as complexity theory, strategy, and risk management ¿ from both top-down and bottom-up perspectives ¿ is examined. Situations are identified where there is a particular need for resilience, and an overview of the best ways of implementing a resilience process is offered.

This book is based on the 18 tutorials presented during the 30th workshop on Advances in Analog Circuit Design. Expert designers present readers with information about a variety of topics at the frontier of analog circuit design, with specific contributions focusing on analog circuits for machine learning, current/voltage/temperature sensors, and high-speed communication via wireless, wireline, or optical links. This book serves as a valuable reference to the state-of-the-art, for anyone involved in analog circuit research and development.

This book provides a comprehensive overview of various thyroid disorders in pregnancy. Merging clinical evidence with their own professional experience, international experts in the field report on novel research and share insights on a broad range of topics, from addressing the normal physiology of the thyroid in pregnancy, to the safe treatment of disorders during pregnancy.Given its scope, the book is chiefly intended for internists, obstetricians, gynecologists, endocrinologists and related sub-specialists; however, it will also benefit general physicians.

Do you want to know how to integrate environmental, social, and governance (ESG) data into business valuation? This book will help you do so step-by-step.The book primarily aims at reaching two types of audiences: practitioners and students in finance (graduate and undergraduate level). Practitioners in finance will find interest in the book, as it will give them access to academic knowledge in a format that suits them. Academic research has made substantial advances in the field of business valuation and ESG. The book intends to transform this knowledge into practical and rigorous methodologies for taking ESG into account when valuing a company. Graduate and undergraduate courses have recently developed in business schools, universities, and engineering schools. These courses usually directly refer to academic articles or valuation companies' website documentation, but not to academic books. Therefore, the book will allow students to have access to centralized and organized information about business valuation and ESG.Readers without prior knowledge of business valuation will be guided through the ESG integration process. They will first be introduced to the concept of value and the reasons for incorporating ESG into the value. They will then learn simple financial methods to value firms and see step-by-step use cases. For instance, the reader will learn how to value a firm in the renewable energy sector using cash flow and multiple valuation methods. After building knowledge of standard business valuation, readers will better understand ESG data and ratings. The reader will then learn how to integrate ESG into business valuation using cash flow and multiples approaches. Again, the reader will be able to replicate these methods as the book will provide practical cases for integrating ESG data in business valuation. Finally, for the readers that intend to go a bit further, they will learn about the academic research advances in ESG and businessvaluation.

This book addresses the structural and biological properties of the extracellular matrix component and glycosaminoglycan polymer hyaluronan (or hyaluronic acid, HA).The book discusses various aspects of HA biology, e.g., HA synthesis and degradation, as well as the role of HA in embryogenesis, development, and cell maintenance. The reader will learn about the role of HA in different tissues as well as its biological activities triggered by the interaction with different HA receptors. A closer look is had at the involvement of HA in human pathologies such as cancer, kidney fibrosis and wound healing. Biotechnological and biomedical applications for HA such as scaffold generation and drug delivery, including the novel synthetic sulphated HA are explored.This work will appeal to a wide readership within the extracellular matrix and hyaluronan field. It can serve as an introduction to the field for junior scientists but can also help senior scientists to gain a broader view of the field beyond their area of specialization.The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

This book uses Karl Barth¿s Der Römerbrief (1922) as a prism through which to explore the role of religion and its interactions with cultural and political thought in the turbulent interwar period in Europe. One of the most influential books in twentieth-century protestant theology, Der Römerbrief found Barth arguing that the crisis of the time was grounded in an even more profound crisis that pertained to the human condition as such. While much research has been conducted on Der Römerbrief, most of it has focused on the book¿s explicit theology. The aim of the present volume is to mark the centenary of this seminal book with a broader investigation into the movements of thought within Der Römerbrief and its reception and impact within its cultural and intellectual context. This broader approach by a range of Northern European researchers brings attention to interconnections between cultural and theological movements intimes of crisis.