Bøker utgitt av Random House USA Inc

If you believe that the latest blockbuster medication is worth a premium price over your generic brand, or that doctors have access to all the information they need about a drug's safety and effectiveness each time they write a prescription, Dr. Jerry Avorn has some sobering news. Drawing on more than twenty-five years of patient care, teaching, and research at Harvard Medical School, he shares his firsthand experience of the wide gap in our knowledge of the effectiveness of one medication as compared to another. In Powerful Medicines, he reminds us that every pill we take represents a delicate compromise between the promise of healing, the risk of side effects, and an increasingly daunting price. The stakes on each front grow higher every year as new drugs with impressive power, worrisome side effects, and troubling costs are introduced.This is a comprehensive behind-the-scenes look at issues that affect everyone: our shortage of data comparing the worth of similar drugs for the same condition; alarming lapses in the detection of lethal side effects; the underuse of life-saving medications; lavish marketing campaigns that influence what doctors prescribe; and the resulting upward spiral of costs that places vital drugs beyond the reach of many Americans.In this engagingly written book, Dr. Avorn asks questions that will interest every consumer: How can a product judged safe by the Food and Drug Administration turn out to have unexpectedly lethal side effects? Why has the nation's drug bill been growing at nearly 20 percent per year? How can physicians and patients pick the best medication in its class? How do doctors actually make their prescribing decisions, and why do those decisions sometimes go wrong? Why do so many Americans suffer preventable illnesses and deaths that proper drug use could have averted? How can the nation gain control over its escalating drug budget without resorting to rationing or draconian governmental controls?Using clinical case histories taken from his own work as a practitioner, researcher, and advocate, Dr. Avorn demonstrates the impressive power of the well-conceived prescription as well as the debacles that can result when medications are misused. He describes an innovative program that employs the pharmaceutical industry's own marketing techniques to reduce use of some of the most overprescribed and overpriced products. Powerful Medicines offers timely and practical advice on how the nation can improve its drug-approval process, and how patients can work with doctors to make sure their prescriptions are safe, effective, and as affordable as possible. This is a passionate and provocative call for action as well as a compelling work of clear-headed science.

The Random House Webster's Rhyming Dictionary is an essential resource for writers, poets and songwriters. An expanded version of the RH Webster's Pocket edition, it includes:• Approximately 60,000 words• Comprehensive cross-referencing • A glossary of poetic terms• Contemporary proper names and foreign phrases

Norman Mailer's dazzlingly rich, deeply evocative novel of ancient Egypt breathes life into the figures of a lost era: the eighteenth-dynasty Pharaoh Rameses and his wife, Queen Nefertiti; Menenhetet, their creature, lover, and victim; and the gods and mortals that surround them in intimate and telepathic communion. Mailer's reincarnated protagonist is carried through the exquisite gardens of the royal harem, along the majestic flow of the Nile, and into the terrifying clash of battle. An extraordinary work of inventiveness, Ancient Evenings lives on in the mind long after the last page has been turned. Praise for Ancient Evenings "Astounding, beautifully written . . . a leap of imagination that crosses three millennia to Pharaonic Egypt."-USA Today "Mailer makes a miraculous present out of age-deep memories, bringing to life the rhythms, the images, the sensuousness of a lost time."-The New York Times "Mailer's Egypt is a haunting and magical place. . . . The reader wallows in the scope, depth, the sheer magnitude and-yes-the fertility of his imagination."-The Washington Post Book World "An enormous pyramid of a novel [reminiscent of] Thomas Pynchon's Gravity's Rainbow and Carlos Fuentes's Terra Nostra."-Los Angeles Herald Examiner Praise for Norman Mailer "[Norman Mailer] loomed over American letters longer and larger than any other writer of his generation."-The New York Times "A writer of the greatest and most reckless talent."-The New Yorker "Mailer is indispensable, an American treasure."-The Washington Post "A devastatingly alive and original creative mind."-Life "Mailer is fierce, courageous, and reckless and nearly everything he writes has sections of headlong brilliance."-The New York Review of Books "The largest mind and imagination [in modern] American literature . . . Unlike just about every American writer since Henry James, Mailer has managed to grow and become richer in wisdom with each new book."-Chicago Tribune "Mailer is a master of his craft. His language carries you through the story like a leaf on a stream."-The Cincinnati Post

Join Mr. Tiffin and his students on a trip to a natural history museum and learn all about dinosaurs and the scientists who discovered them!Mr. Tiffin and his students are back in another picture book, and this time the focus is on dinosaur-loving Kimmy. During a field trip to the natural history museum, Kimmy is thrilled to share what she knows about the Stegosaurus and the Archaeopteryx and even the ginormous Titanosaurus. That changes when one of her classmates questions whether girls can be paleontologists. Kimmy starts to feel shy. What if they can't? What if no one wants to hear what she has to say? It will take some help from Mr. Tiffin--and from a famous scientist--for Kimmy to find her voice again.Join Mr. Tiffin's class as they learn about dinosaurs big and small, feathered and scaly, winged and ocean-dwelling. And root for Kimmy, the dinosaur expert . . . who might just learn something about herself.

Recipes & stories from 100 of the most creative and inspiring women in food today It's the first-ever cookbook from the team behind Cherry Bombe, the hit indie magazine about women and food, and the Radio Cherry Bombe podcast. Inside are 100+ recipes from some of the most interesting chefs, bakers, food stylists, pastry chefs, and creatives on the food scene today, including: Mashama Bailey, chef of The Grey Jeni Britton Bauer, founder of Jeni's Splendid Ice Creams Melissa Clark, New York Times columnist and cookbook author Amanda Cohen, chef/owner of Dirt Candy Angela Dimayuga, executive chef of Mission Chinese Food Melissa & Emily Elsen, founders of Four & Twenty Blackbirds Karlie Kloss, supermodel and cookie entrepreneur Jessica Koslow, chef/owner of Sqirl Padma Lakshmi, star of Top Chef Elisabeth Prueitt, pastry chef and co-founder of Tartine and Tartine Manufactory Chrissy Teigen, supermodel and bestselling cookbook author Christina Tosi, chef and founder of Milk Bar Joy Wilson, of Joy the Baker Molly Yeh, of my name is yeh The Cherry Bombe team asked these women and others for their most meaningful recipes. The result is a beautifully styled and photographed collection that you will turn to again and again in the kitchen. 2018 IACP Cookbook Award nominee for Compilations.

The Wild Kratts go in search of creatures that come out at night in this full-color storybook! PBS's successful animated show Wild Kratts joins the adventures of zoologists Chris and Martin Kratt as they travel to animal habitats around the globe. Along the way, they encounter incredible creatures while combining science education with fun. Boys and girls 4 to 6 can learn all about bats, owls, deep-sea creatures, and other animals that come out at night or live in dark.

In the spring of 1884 Ulysses S. Grant heeded the advice of Mark Twain and finally agreed to write his memoirs. Little did Grant or Twain realize that this seemingly straightforward decision would profoundly alter not only both their lives but the course of American literature. Over the next fifteen months, as the two men became close friends and intimate collaborators, Grant raced against the spread of cancer to compose a triumphant account of his life and times—while Twain struggled to complete and publish his greatest novel, Adventures of Huckleberry Finn.In this deeply moving and meticulously researched book, veteran writer Mark Perry reconstructs the heady months when Grant and Twain inspired and cajoled each other to create two quintessentially American masterpieces.In a bold and colorful narrative, Perry recounts the early careers of these two giants, traces their quest for fame and elusive fortunes, and then follows the series of events that brought them together as friends. The reason Grant let Twain talk him into writing his memoirs was simple: He was bankrupt and needed the money. Twain promised Grant princely returns in exchange for the right to edit and publish the book—and though the writer's own finances were tottering, he kept his word to the general and his family.Mortally ill and battling debts, magazine editors, and a constant crush of reporters, Grant fought bravely to get the story of his life and his Civil War victories down on paper. Twain, meanwhile, staked all his hopes, both financial and literary, on the tale of a ragged boy and a runaway slave that he had been unable to finish for decades. As Perry delves into the story of the men's deepening friendship and mutual influence, he arrives at the startling discovery of the true model for the character of Huckleberry Finn.With a cast of fascinating characters, including General William T. Sherman, William Dean Howells, William Henry Vanderbilt, and Abraham Lincoln, Perry's narrative takes in the whole sweep of a glittering, unscrupulous age. A story of friendship and history, inspiration and desperation, genius and ruin, Grant and Twain captures a pivotal moment in the lives of two towering Americans and the age they epitomized.

A brand-new Berenstain Bears collection featuring six classic stories all about being the best you can be!Join the one and only Berenstain Bears in this bindup of classic books all about how to be your very best self. Featuring six beloved stories, young cubs will learn a variety of important lessons, such as telling the truth, using their manners, learning about strangers, and more! These timeless stories will now reach an entirely new generation, all the while introducing them to the joys of a visit to Bear County. Includes:The Berenstain Bears and the Homework HassleThe Berenstain Bears Learn About StrangersThe Berenstain Bears Forget Their MannersThe Berenstain Bears and Too Much TVThe Berenstain Bears' Messy RoomThe Berenstain Bears and the Truth

One of the great works of Western literature, from perhaps the most important thinker of Christian antiquity, in a revolutionary new translation by one of today’s leading classicists Sarah Ruden’s fresh, dynamic translation of Confessions brings us closer to Augustine’s intent than any previous version. It puts a glaring spotlight on the life of one individual to show how all lives have meaning that is universal and eternal. In this intensely personal narrative, Augustine tells the story of his sinful youth and his conversion to Christianity. He describes his ascent from a humble farm in North Africa to a prestigious post in the Roman Imperial capital of Milan, his struggle against his own overpowering sexuality, his renunciation of secular ambition and marriage, and the recovery of the faith his mother had taught him during his earliest years. Augustine’s concerns are often strikingly contemporary, and the confessional mode he invented can be seen everywhere in writing today.  Grounded in her command of Latin as it was written and spoken in the ancient world, Sarah Ruden’s translation is a bold departure from its predecessors—and the most historically accurate translation ever. Stylistically beautiful, with no concessions made to suit later theology and ritual, Ruden’s rendition will give readers a startling and illuminating new perspective on one of the central texts of Christianity.Praise for Confessions“[Ruden] has clearly thought deeply about what Augustine was trying to say.”—The Wall Street Journal“A translation of [Augustine’s] masterwork that does justice both to him and to his God . . . Repeated small acts of attention to the humble, human roots of Augustine’s imagery of his relations to God enable Ruden to convey a living sense of the Being before Whom we find him transfixed in prayer: ‘Silent, long-suffering and with so much mercy in your heart.’”—The New York Review of Books “Delightfully readable . . . In this lively translation filled with vivid, personal prose, Ruden introduces readers to a saint whom many will realize they only thought they knew. . . . Approaching her subject with deep religious and historical knowledge, [Ruden] chooses to translate Augustine as a performative, engaging storyteller rather than a systematic theologian.”—Publishers Weekly (starred review)“Ruden’s translation makes Augustine’s ancient text accessible to a new generation of readers with a real taste of the original Latin.”—Library Journal “[Ruden’s] record as a translator of ancient texts . . . clearly establishes her considerable talent.”—Christianity Today

The only English translation of “a masterpiece” (The Nation)—a stunning trilogy of novellas about the soul-crushing cost of life under a violent Haitian dictatorship, featuring an introduction by Edwidge Danticat Originally published in 1968, Love, Anger, Madness virtually disappeared from circulation until its republication in France in 2005. Set in the barely fictionalized Haiti of “Papa Doc” Duvalier’s repressive rule, Marie Vieux-Chauvet’s writing was so powerful and so incendiary that she was forced to flee to the United States. Yet Love, Anger, Madness endures. Claire, the narrator of Love, is the eldest of three daughters who surrenders her dreams of marriage to run the household after her parents die. Insecure about her dark skin, she fantasizes about her middle sister’s French husband, while he has an affair with the youngest sister, setting in motion a complicated family dynamic that echoes the growing chaos outside their home.        In Anger, the police terrorize a middle-class family by threatening to seize their land. The father insinuates that their only hope of salvation lies with an unspeakable act—his daughter Rose must prostitute herself—which leads to all-consuming guilt, shame, and rage.  And finally, Madness paints a terrifying portrait of a Haitian village that has been ravaged by militants. René, a young poet, is trapped in his family’s house for days with no food and becomes obsessed with the souls of the dead that surround him.

A moving cultural biography of abolitionist martyr John Brown, by one of the most important African-American intellectuals of the twentieth century. In the history of slavery and its legacy, John Brown looms large as a hero whose deeds partly precipitated the Civil War. As Frederick Douglass wrote: "When John Brown stretched forth his arm ... the clash of arms was at hand." DuBois''s biography brings Brown stirringly to life and is a neglected classic.

"One helluva read."-Newsweek • "Gripping."-Outside • "Spellbinding."-Associated Press • "Powerful."-New York In 1912, the Saint Anna, a Russian exploration vessel in search of fertile hunting grounds, was frozen into the polar ice cap, trapping her crew aboard. For nearly a year and a half, they struggled to stay alive. As all hope of rescue faded, they realized their best chance of survival might be to set out on foot, across hundreds of miles of desolate ice, with their lifeboats dragged behind them on sledges, in hope of reaching safety. Twenty of them chose to stay aboard; thirteen began the trek; of them all, only two survived. Originally published in Russia in 1917, In the Land of White Death was translated into English for the first time by the Modern Library to widespread critical acclaim. As well as recounting Albanov's vivid, first-person account of his ninety-day ordeal over 235 miles of frozen sea, this expanded paperback edition contains three newly discovered photographs and an extensive new Epilogue by David Roberts based on the never-before-published diary of Albanov's only fellow survivor, Alexander Konrad. As gripping as Albanov's own tale, the Epilogue sheds new light on the tragic events of 1912-1914, brings to life many of those who perished (including the infamous captain Brusilov and nurse Zhdanko, the only woman on board), and, inadvertently, reveals one new piece of information-about the identity of the traitors who left Albanov for dead-that is absolutely shocking."Poetic."-The Washington Post • "A lost masterpiece."-Booklist • "A jewel of polar literature."-Seattle Post-Intelligencer • "Vivid . . . [a work of] terrifying beauty."-The Boston Globe

As part of the Louis L'Amour's Lost Treasures series, this edition contains exclusive bonus materials! He was a white man as cunning as any Indian, a brooding man who trusted in nothing but his weapon and his horse. Shalako was determined to cross the bleak Sonoran Desert-the Apaches' killing ground-by himself. But then he came across a European hunting party, and a brave and beautiful woman, stranded and defenseless. Shalako knew that he had to stay and help them survive. For somewhere out there was a deadly Apache warrior . . . and he had the worst kind of death in mind for them all.Louis L'Amour's Lost Treasures is a project created to release some of the author's more unconventional manuscripts from the family archives. In Louis L'Amour's Lost Treasures: Volumes 1, Beau L'Amour takes the reader on a guided tour through many of the finished and unfinished short stories, novels, and treatments that his father was never able to publish during his lifetime. L'Amour's never-before-seen first novel, No Traveller Returns, faithfully completed for this program, is a voyage into danger and violence on the high seas. These exciting publications will be followed by Louis L'Amour's Lost Treasures: Volume 2. Additionally, many beloved classics will be rereleased with an exclusive Lost Treasures postscript featuring previously unpublished material, including outlines, plot notes, and alternate drafts. These postscripts tell the story behind the stories that millions of readers have come to know and cherish.

At the beginning of the twentieth century, the South Pole was the most coveted prize in the fiercely nationalistic modern age of exploration. In the brilliant dual biography, the award-winning writer Roland Huntford re-examines every detail of the great race to the South Pole between Britain''s Robert Scott and Norway''s Roald Amundsen. Scott, who dies along with four of his men only eleven miles from his next cache of supplies, became Britain''s beloved failure, while Amundsen, who not only beat Scott to the Pole but returned alive, was largely forgotten. This account of their race is a gripping, highly readable history that captures the driving ambitions of the era and the complex, often deeply flawed men who were charged with carrying them out. THE LAST PLACE ON EARTH is the first of Huntford''s masterly trilogy of polar biographies. It is also the only work on the subject in the English language based on the original Norwegian sources, to which Huntford returned to revise and update this edition.

"A California classic . . . California, it should be remembered, was very much the wild west, having to wait until 1850 before it could force its way into statehood. so what tamed it? Mr. Starr's answer is a combination of great men, great ideas and great projects."-The EconomistFrom the age of exploration to the age of Arnold, the Golden State's premier historian distills the entire sweep of California's history into one splendid volume. Kevin Starr covers it all: Spain's conquest of the native peoples of California in the early sixteenth century and the chain of missions that helped that country exert control over the upper part of the territory; the discovery of gold in January 1848; the incredible wealth of the Big Four railroad tycoons; the devastating San Francisco earthquake of 1906; the emergence of Hollywood as the world's entertainment capital and of Silicon Valley as the center of high-tech research and development; the role of labor, both organized and migrant, in key industries from agriculture to aerospace. In a rapid-fire epic of discovery, innovation, catastrophe, and triumph, Starr gathers together everything that is most important, most fascinating, and most revealing about our greatest state. Praise for California"[A] fast-paced and wide-ranging history . . . [Starr] accomplishes the feat with skill, grace and verve."-Los Angeles Times Book Review"Kevin Starr is one of california's greatest historians, and California is an invaluable contribution to our state's record and lore."-MarIa ShrIver, journalist and former First Lady of California "A breeze to read."-San Francisco

Introduction by China Miéville Long acknowledged as a master of nightmarish visions, H. P. Lovecraft established the genuineness and dignity of his own pioneering fiction in 1931 with his quintessential work of supernatural horror, At the Mountains of Madness. The deliberately told and increasingly chilling recollection of an Antarctic expedition's uncanny discoveries-and their encounter with untold menace in the ruins of a lost civilization-is a milestone of macabre literature. This exclusive new edition, presents Lovecraft's masterpiece in fully restored form, and includes his acclaimed scholarly essay "Supernatural Horror in Literature." This is essential reading for every devotee of classic terror.