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This book describes at the introductory level how modern technology has made the scenario of the classic science-fiction movie Fantastic Voyage about a submarine and its crew members being shrunk to microscopic size and ventured into the body, a reality. Exactly 50 years following the release of the film, such reality takes the form of a medical interventional room capable of mimicking this scenario. Based on 15 years of intensive research and development by the world-leading team in this specific field, the book goes through the scenes of the movie and while explaining how it is implemented in this first-of-a-kind interventional facility.

Chemical Exchange Saturation Transfer is a powerful Magnetic Resonance Imaging (MRI) contrast mechanism with unique features. This is the first authoritative textbook covering all aspects of CEST imaging. The rapid expansion that CEST imaging has seen over the past 16 years since the seminal Ward and Balaban paper in 2000 has created a need for a graduate-level handbook that describes the wide assortment of issues that come in to play when trying to apply CEST imaging to medicine.

This book covers almost all fields of cancer genetics and genomics for personalized medicine. Surely, the one-fits-all approach does not work anymore for disease treatment. Targeted therapy or precision medicine or personalized medicine is becoming a standard for many disease treatments including cancer. However, how much do we know about the personalized medicine approach? This book will help undergraduate/graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine.

This book contains information about advanced nanomaterials that can be produced without harming the environment or human health. This encompasses the production of nanomaterials without environmental toxicity, at room temperature and with the use of renewable energy sources. The book contains the descriptions and results of theoretical and experimental researches in the field of environment friendly nanotechnology carried out over the past decade by the scientific team of company Polymate Ltd.-International Nanotechnology Center (Israel) under the leadership of Prof. O. Figovsky.

This book provides an overview over compound semiconductor materials and their technology. After presenting some theoretical background, the relevant material preparation technologies for bulk and thin layer epitaxial growth are described. Then it briefly discusses the electrical, optical and structural properties of these semiconductors, complemented by a description of the most popular respective characterization tools before more complex hetero and low-dimensional structures are discussed.

Investors are often looked upon as one homogeneous group of people with money ready to invest; however, this group is very diverse. In some ways, investors are like car buyers who seek common denominators in a car, such as the engine, wheels, brakes and seats, but the car they end up buying depends on personal preferences, needs and the money available. For investors the common denominator is the good business case, the ''engine, wheels, brakes, seats'' being a comprehensive business plan. However, which business case they will prefer in the end depends on their personal preference and financial capacity. How to Attract Investors takes the reader into the minds of the investors, addressing many of the challenges connected to investor search and negotiation and living with investors as co-owners. Even the finest skills of the brightest entrepreneurs wouldn''t be complete without the knowledge of the investor''s mind. This is the book that unravels it, layer by layer.

This book is the first to give an exhaustive overview of the structures, properties, current and possible future applications of diamondoids. The first part introduces the structures of diamondoids and gives an overview of their principal chemical and physical properties and a brief historical account, from the discovery of the first diamondoid member to the isolation of higher diamondiods. Then, current synthesis approaches and challenges in obtaining diamondoids in higher quantities are shown. Finally, approaches to generating plasmas in high-pressure and supercritical media are described.

This book provides a comprehensive overview of the current progress in muscle contraction and cell motility research. It discusses structural, mechanical, and biochemical characteristics of skeletal, cardiac, and smooth muscles, and cell motility. The experimental objects of the studies described in this volume extend from humans to molecules. A distinct feature of this volume is that, in some chapters, evidence against the textbook view is presented, showing how well-established dogma can be denied by an unexpected discovery. This book is as interesting as it is informative for general readers and young scientists alike, and it is sure to inspire both to challenge the enticing mysteries that still remain in this exciting research field.

The discovery and fabrication of new materials have opened the gate for new research fields in science and technology. The novel method of fabricating graphene, a purely 2D carbon lattice, and the discovery of the phenomenon of giant magnetoresistance (GMR) in magnetic multilayers are not exceptions. The latter has brought about the creation of the new technological field of spintronics, which utilizes both spin and charge degrees of freedom of electrons. As for the former, many applications have been proposed; however, no practical devices have yet been developed in the field of spintronics. The aim of this book is to provide possible hints to overcome the difficulties in graphene applications in the field of spintronics by comparing the physical properties of graphene and magnetoresistive (MR) phenomena in spintronics. The book will be useful for advanced undergraduate students and graduate students of physics, chemistry, and materials science and young researchers in nanotechnology and the field of spintronics.

The literature so far has reviewed only single-crystal and, up to some extent, optical ceramic scintillators. This book introduces and describes in detail the research and development in thin-film scintillators, glass ceramics, as well as nanocomposite and optical ceramics prepared by spark plasma sintering. It also features an example of an in-depth study of a powder phosphor material. Both technology description and various characterization aspects are provided together with application hints.

Transport of pharmaceutical agents in the body is paramount to therapeutic efficacy. Advances in the past decades have rendered a remarkable improvement of drug delivery strategies, which has helped to increase the bioavailability of therapeutic agents by protecting them from degradation, targeting them to diseased sites, and controlling their circulation time and release rate. Additionally, for most therapeutics, reaching the targets of action require penetration across tissues and/or entry within cells. The design of strategies to control the transport of therapeutic compounds through these physiological barriers has become an imperative and a challenging need in the quest for better therapeutics. This book provides an overview of the current advances in this field, including considerations on the biological regulation and natural mechanisms overcoming these barriers, as well as drug delivery strategies facilitating the transport of drugs and their carriers at the tissue, cell, and subcellular levels.

Since the first report on alcohol oxidation in 1998, many studies have highlighted some peculiarity of gold with respect to other metals. Some analogies have been found between gas and liquid phases, but the big challenge to operate in a condensed phase lies in the role of the solvent in tuning the reactantΓÇôcatalyst contact. Liquid-phase oxidation has numerous applications. However, many studies on gold catalysts have been devoted to gas-phase reactions. Only recently has the scientific community approached gold-catalyzed liquid-phase oxidation. This complete, exhaustive book covers the topic of gold-based catalyst applications in selective oxidation in the liquid phase. It presents a rational state of the art and will be useful for researchers, even those not yet involved in the field.

GaAs processing has reached a mature stage. New semiconductor compounds are emerging that will dominate future materials and device research, although the processing techniques used for GaAs will still remain relevant. This book covers all aspects of the current state of the art of IIIΓÇôV processing, with emphasis on HBTs. It is aimed at practicing engineers and graduate students and engineers new to the field of IIIΓÇôV semiconductor IC processing. The bookΓÇÖs primary purpose is to discuss all aspects of processing of active and passive devices, from crystal growth to backside processing, including lithography, etching, and film deposition.

Liposomes have been widely explored in the drug delivery realm over the past decades. Many of the properties that made them well suited for drug delivery applications, such as the internal space to encapsulate a large payload of molecules and the inherent protection from exterior stresses, have also been exploited in various analytical techniques. Liposomes in Analytical Methodologies provides an extensive coverage of their utility, ranging from historic developments to actively researched techniques written by expert investigators. The introductory chapter serves as a primer on the fundamentals of liposomes for analytical purposes and provides an overview of various applications, while subsequent chapters provide in-depth coverage of selected areas. With techniques ranging from liposome PCR to electrophoretic separations, readers will gain an appreciation for the versatility that liposomes can add to the analytical toolbox.

This handbook is the first to be entirely devoted to FF-OCM. It is organized into four parts with a total of 21 chapters written by recognized experts and major contributors to the field. After a general introduction to FF-OCM, the fundamental characteristics of the technology are analyzed and discussed theoretically. The main technological developments of FF-OCM for improving the image acquisition speed and for endoscopic imaging are presented in part II. Extensions of FF-OCM for image contrast enhancement or functional imaging are reported in part III. The last part of the book provides an overview of possible applications of FF-OCM in medicine, biology, and materials science.

This book focuses on the most recent advances in the science and technology of nanostructured materials for direct alcohol fuel cells, including novel non-noble or low noble metal catalysts deposited on the graphene layer and metal-free doped carbon black for oxygen electro-reduction reaction, Sn-based bimetallic and trimetallic nanoparticles for alcohol electro-oxidation reaction, and novel nanomaterials for promoting proton transfer in electrolyte. In addition, the book includes chapters from not only experimentalists but also computational chemists who have worked in the development of advanced power systems for decades.

As computational hardware continues to develop at a rapid pace, quantitative computations are playing an increasingly essential role in the study of biomolecular systems. One of the most important challenges that the field faces is to develop the next generation of computational models that strike the proper balance of computational efficiency and accuracy, so that the problems of increasing complexity can be tackled in a systematic and physically robust manner. In particular, properly treating intermolecular interactions is fundamentally important for the reliability of all computational models. In this book, contributions by leading experts in the area of biomolecular simulations discuss cutting-edge ideas regarding effective strategies to describe many-body effects and electrostatics at quantum, classical, and coarse-grained levels. The goal of the book is to not only provide an up-to-date snapshot of the current simulation field but also stimulate exchange of ideas across different sub-fields of modern computational (bio)chemistry. The text will be a useful reference for the biomolecular simulation community and help attract talented young students into this exciting frontier of research.