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Reviews the molecular genetics of the thalassemia syndromes, inherited hemoglobin disorders that comprise the commonest monogenic disorders globally. Thalassemias are found in high frequencies in tropical regions corresponding to the malaria belt.

This book provides a general description of the search for and discovery of the Higgs boson (particle) at CERN's Large Hadron Collider. The goal is to provide a relatively brief overview of the issues, instruments and techniques relevant for this search; written by a physicist who was directly involved. The Higgs boson mat be the one particle that was studied the most before its discovery and the story from postulation in 1964 to detection in 2012 is a fascinating one. The story is told here while detailing the fundamentals of particle physics.

Waves are everywhere in our daily life. We all experience sound and light with our ears and eyes, we use microwaves to cook, and radio waves are transmitted from and are received by our cell phones. These are just some examples of waves that carry energy from point A to B. However, we may not know details of the physics underlying all these waves. It is important to understand the mechanisms that generate wave dynamics for a given system. It is not straightforward to explain how an electromagnetic ield becomes oscillatory and propagates as a wave. Waves sometimes represent the underlying dynamics of observed phenomena at a fundamental level of physics.This book is designed to explore these mechanisms by discussing various aspects of wave dynamics from as many perspectives as possible. The target audiences are undergraduate students majoring in engineering science and graduate students majoring in general engineering. Going beyond the typical approach to learning science, this book discusses wave dynamics and related concepts at various levels of mathematics and physics, sometimes touching on profound physics behind them. This book was written to help readers learn wave dynamics on a deep physical level, and develop innovative ideas in their own fields.

This book is both an introduction and a demonstration of how Visual Basic for Applications (VBA) can greatly enhance Microsoft Excel(R) by giving users the ability to create their own functions within a worksheet and to create subroutines to perform repetitive actions. The book is written so readers are encouraged to experiment with VBA programming with examples using fairly simple physics or non-complicated mathematics such as root finding and numerical integration. Tested Excel(R) workbooks are available for each chapter and there is nothing to buy or install.

This book is designed to help the non-specialist user of spectroscopic measurements and electronic structure computations to achieve a basic understanding of the underlying concepts of quantum chemistry. The book can be used to teach introductory quantum c

Weights and measures form an essential part of our ingrained view of the world. It is just about impossible to function effectively without some internalized system of measurement. This volume outlines a history of the science of measurement, and the origin of the International System of Units (SI).

Starting with the history and fundamentals of optical fiber communications, Optical Fiber Multiplexing and Emerging Techniques introduces existing optical multiplexing techniques, and it focuses on the spatial domain multiplexing (SDM) and orbital angular momentum (OAM) of photon-based multiplexing.

Lissajous figures are produced by combining two oscillations at right angles to each other. The figures, drawn by mechanical devices called harmonographs, have scientific uses, but are also enjoyed for their own beauty. The author has been working with harmonographs since his undergraduate days, building several of them, lecturing on them and has written articles about them. This book is intended for people who enjoy physics or art or both.

The invention of the semiconductor laser along with silica glass fiber has enabled an incredible revolution in global communication infrastructure of direct benefit to all. Development of devices and system concepts that exploit the same fundamental light-matter interaction continues. Researchers and technologists are pursuing a broad range of emerging applications, everything from automobile collision avoidance to secure quantum key distribution. This book sets out to summarize key aspects of semiconductor laser device physics and principles of laser operation.

Covers essential Microsoft EXCEL (R)'s computational skills while analysing introductory physics projects. Topics of numerical analysis include multiple graphs on the same sheet, calculation of descriptive statistical parameters, a 3-point interpolation, and the Euler and the Runge-Kutter methods to solve equations of motion.

Parkinson's disease is a neurological disorder with cardinal motor signs of resting tremor, bradykinesia and lead-pipe rigidity.In addition, many patients display non-motor symptoms, including a diminished sensation of smell, gastrointestinal problems, various disorders of sleep and some cognitive impairment. These clinical features - particularly the motor signs - manifest after a progressive death of many dopaminergic neurones in the brain. Although currently available, conventional therapies can reduce the signs of the disease, the progression of this neuronal death has proved difficult to slow or stop, and the condition is relentlessly progressive. Hence, there is a real need to develop a treatment that is neuroprotective, one that slows the pathology of the disease effectively. At present, there are several neuroprotective therapies in the experimental pipeline, but these are for the patients of tomorrow. This book focuses on two therapies that are readily available for the patients of today. They involve the use of exercise and light (i.e. photobiomodulation, the use of red to infrared light therapy (I =600-1070nm) on body tissues). The two therapies are tied together in several ways. First, in animal models of Parkinson's disease, they each have been shown to offer the key feature of neuroprotection, stimulating a series of built-in protective mechanisms within the neurones, that helps their survival, to self-protect and/or self-repair. There are also some promising indications of neuroprotection and many beneficial outcomes in parkinsonian patients. Further, both exercise and light therapies are similar in that they are non-invasive and safe to use, with no known adverse side-effects, making their combination with the conventional therapies, such as dopamine replacement drug therapy and deep brain stimulation, all the more feasible. Given the heterogeneity of Parkinson's disease in humans, tackling the condition from a range of different angles - with a number of different therapies - would only serve to enhance the positive outcomes. This book considers the use of exercise and light therapies, proposing that they have the potential to make a powerful "e;dynamic duo"e;, offering a most effective neuroprotective treatment option to patients.

Practically every display technology in use today relies on the flat, energy-efficient construction made possible by liquid crystals.These displays provide visually-crisp, vibrantly-colored images that a short time ago were thought only possible in science fiction. Liquid crystals are known mainly for their use in display technologies, but they also provide many diverse and useful applications: adaptive optics, electro-optical devices, films, lasers, photovoltaics, privacy windows, skin cleansers and soaps, and thermometers. The striking images of liquid crystals changing color under polarized lighting conditions are even on display in many museums and art galleries - true examples of 'science meeting art'. Although liquid crystals provide us with visually stunning displays, fascinating applications, and are a rich and fruitful source of interdisciplinary research, their full potential may yet remain untapped.

Optics has been part of scientific enquiry from its beginning and remains a key element of modern science.This book provides a concise treatment of physical optics starting with a brief summary of geometrical optics. Scalar diffraction theory is introduced to describe wave propagation and diffraction effects and provides the basis for Fourier methods for treating more complex diffraction problems. The rest of the book treats the physics underlying some important instruments for spectral analysis and optical metrology, reflection and transmission at dielectric surfaces and the polarization of light. This undergraduate-level text aims to aid understanding of optical applications in physical, engineering and life sciences or more advanced topics in modern optics.

The Outside the Research Lab series is a testament to the fact that the physics taught to high school and university students IS used in the real world.This book explores the physics and technology inherent to a selection of sports which have caught the author's attention and fascination over the years. Outside the Research Lab, Volume 3 is a path to discovering how less commonly watched sports use physics to optimize performance, diagnose injuries, and increase access to more competitors. It covers Olympic and Paralympic fencing, show jumping horses, and arguably the most brutal of motorsports - drag racing. Stunning images throughout the book and clear, understandable writing are supplemented by offset detail boxes which take the physics concepts to higher levels.Outside the Research Lab, Volume 3 is both for the general interest reader and students in STEM. Lecturers in university physics, materials science, engineering and other sciences will find this an excellent basis for teaching undergraduate students the range of applications for the physics they are learning. There is a vast range of different areas that require expertise in physics...this third volume of Outside the Research Lab shows a few with great detail provided by professionals doing the work.

Offers a rigorous, physics focused, introduction to set theory that is geared towards natural science majors. The authors present the science major with a robust introduction to set theory, focusing on the specific knowledge and skills that will unavoidably be needed in calculus topics and natural science topics in general.

Nanomaterials and nanostructures are the original product of nanotechnology, and the key building blocks for enabling technologies. In this context, this book presents a concise overview of the synthesis and characterization methods of nanomaterials and nanostructures, while integrating facets of physics, chemistry, and engineering.

Phase transformations are among the most intriguing and technologically useful phenomena in materials, particularly with regard to controlling microstructure.After a review of thermodynamics, this book has chapters on Brownian motion and the diffusion equation, diffusion in solids based on transition-state theory, spinodal decomposition, nucleation and growth, instabilities in solidification, and diffusionless transformations. Each chapter includes exercises whose solutions are available in a separate manual.This book is based on the notes from a graduate course taught in the Centre for Doctoral Training in the Theory and Simulation of Materials. The course was attended by students with undergraduate degrees in physics, mathematics, chemistry, materials science, and engineering. The notes from this course, and this book, were written to accommodate these diverse backgrounds.

The development of man's understanding of planetary motions is the crown jewel of Newtonian mechanics. This book offers a concise but self-contained handbook-length treatment of this historically important topic for students at about the third-year-level of an undergraduate physics curriculum.

Uses a hands-on approach to nonlinear dynamics using commonly available software, including the free dynamical systems software Xppaut, Matlab and the Maple symbolic algebra system. Detailed instructions for various common procedures, including bifurcation analysis using the version of AUTO embedded in Xppaut, are provided.

Gene therapy as a potential method for treatment of genetic disorders and other malignancies as well as treatment of many cancers has attracted a great amount of attention in recent years.Current research focuses on stable and smart drug/gene delivery systems, including controlled release. Smart nanostructures have been considered as a promising approach when applied to drug and gene delivery systems, and could solve the problems related to the inefficient transfer of medication to the affected cells.

One hundred years after gravitational waves were first predicted, their first real direct effects were observed in 2015. This is the story of that hunt, and the insight it is producing into an array of topics in modern science, from the creation of the chemical elements to insights into the properties of gravity itself.

In the last years there have been great advances in the applications of topology and differential geometry to problems in condensed matter physics. Concepts drawn from topology and geometry have become essential to the understanding of several phenomena in the area. Physicists have been creative in producing models for actual physical phenomena which realize mathematically exotic concepts and new phases have been discovered in condensed matter in which topology plays a leading role. An important classification paradigm is the concept of topological order, where the state characterizing a system does not break any symmetry, but it defines a topological phase in the sense that certain fundamental properties change only when the system passes through a quantum phase transition.The main purpose of this book is to provide a brief, self-contained introduction to some mathematical ideas and methods from differential geometry and topology, and to show a few applications in condensed matter. It conveys to physicists the basis for many mathematical concepts, avoiding the detailed formality of most textbooks.