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Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells.

Presents wideband RF technologies and antennas in the microwave band and millimeter-wave band This book provides an up-to-date introduction to the technologies, design, and test procedures of RF components and systems at microwave frequencies.

Wind Farm Noise: Measurement, Assessment and Control  Colin H Hansen, University of Adelaide, Australia Con J Doolan, University of New South Wales, Australia Kristy L Hansen, Flinders University, Australia   A comprehensive guide to wind farm noise prediction, measurement, assessment, control and effects on people   Wind Farm Noise covers all aspects associated with the generation, measurement, propagation, regulation and adverse health effects of noise produced by large horizontalΓÇôaxis wind turbines of the type used in wind farms. The book begins with a brief history of wind turbine development and the regulation of their noise at sensitive receivers. Also included is an introductory chapter on the fundamentals of acoustics relevant to wind turbine noise so that readers are well prepared for understanding later chapters on noise measurements, noise generation mechanisms, noise propagation modelling and the assessment of the noise at surrounding residences.   Key features: ΓÇó Potential adverse health effects of wind farm noise are discussed in an objective way. ΓÇó Means for calculating the noise at residences due to a wind farm prior to construction are covered in detail along with uncertainty estimates. ΓÇó The effects of meteorological conditions and other influences, such as obstacles, ground cover and atmospheric absorption, on noise levels at residences are explained. ΓÇó Quantities that should be measured as well as how to best measure them in order to properly characterise wind farm noise are discussed in detail. ΓÇó Noise generation mechanisms and possible means for their control are discussed as well as aspects of wind farm noise that still require further research to be properly understood.   The book provides comprehensive coverage of the topic, containing both introductory and advanced level material.

The first book to discuss robust aspects of nonlinear regression--with applications using R softwareRobust Nonlinear Regression: with Applications using R covers a variety of theories and applications of nonlinear robust regression. It discusses both parts of the classic and robust aspects of nonlinear regression and focuses on outlier effects. It develops new methods in robust nonlinear regression and implements a set of objects and functions in S-language under SPLUS and R software. The software covers a wide range of robust nonlinear fitting and inferences, and is designed to provide facilities for computer users to define their own nonlinear models as an object, and fit models using classic and robust methods as well as detect outliers. The implemented objects and functions can be applied by practitioners as well as researchers.The book offers comprehensive coverage of the subject in 9 chapters: Theories of Nonlinear Regression and Inference; Introduction to R; Optimization; Theories of Robust Nonlinear Methods; Robust and Classical Nonlinear Regression with Autocorrelated and Heteroscedastic errors; Outlier Detection; R Packages in Nonlinear Regression; A New R Package in Robust Nonlinear Regression; and Object Sets.* The first comprehensive coverage of this field covers a variety of both theoretical and applied topics surrounding robust nonlinear regression* Addresses some commonly mishandled aspects of modeling* R packages for both classical and robust nonlinear regression are presented in detail in the book and on an accompanying websiteRobust Nonlinear Regression: with Applications using R is an ideal text for statisticians, biostatisticians, and statistical consultants, as well as advanced level students of statistics.

The Earth's natural resources are finite and easily compromised by contamination from industrial chemicals and byproducts from the degradation of consumer products.

Performance of the Jet Transport Airplane: Analysis Methods, Flight Operations, and Regulations presents a detailed and comprehensive treatment of performance analysis techniques for jet transport airplanes.

A well-organized guide to mathematical modeling techniques for evaluating and solving problems in the diverse field of mathematics, Mathematical Modeling: Applications with GeoGebraTMpresents a unique approach to software applications in GeoGebra and WolframAlpha(R).

Anticipate, manage, and overcome the complex issues facing community colleges Practical Leadership in Community Colleges offers a path forward through the challenges community colleges face every day.

Examines the governance challenges of cybersecurity through twelve, real-world case studiesThrough twelve detailed case studies, this superb collection provides an overview of the ways in which government officials and corporate leaders across the globe are responding to the challenges of cybersecurity. Drawing perspectives from industry, government, and academia, the book incisively analyzes the actual issues, and provides a guide to the continually evolving cybersecurity ecosystem. It charts the role that corporations, policymakers, and technologists are playing in defining the contours of our digital world.Rewired: Cybersecurity Governance places great emphasis on the interconnection of law, policy, and technology in cyberspace. It examines some of the competing organizational efforts and institutions that are attempting to secure cyberspace and considers the broader implications of the in-place and unfolding efforts--tracing how different notions of cybersecurity are deployed and built into stable routines and practices. Ultimately, the book explores the core tensions that sit at the center of cybersecurity efforts, highlighting the ways in which debates about cybersecurity are often inevitably about much more.* Introduces the legal and policy dimensions of cybersecurity* Collects contributions from an international collection of scholars and practitioners* Provides a detailed "map" of the emerging cybersecurity ecosystem, covering the role that corporations, policymakers, and technologists play* Uses accessible case studies to provide a non-technical description of key terms and technologiesRewired: Cybersecurity Governance is an excellent guide for all policymakers, corporate leaders, academics, students, and IT professionals responding to and engaging with ongoing cybersecurity challenges.

Formation Control of Multi-Agent Systems: A Graph Rigidity Approach Marcio de Queiroz, Louisiana State University, USA Xiaoyu Cai, FARO Technologies, USA Matthew Feemster, U.S.

Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments.

Written by experienced and well-respected physicians and professors, this new all-color volume presents the ultrasonic topographical and pathotopographical anatomy of the body, including the head, neck, chest, anterolateral abdominal wall, abdominal organs, retroperitoneal space, male and female pelvises, and lower extremities. Specific and non-specific ultrasonic symptoms are suggested for normal and abnormal developmental variants, diffuse and local pathotopographical anatomy. This color atlas contains comparative topographical and pathotopographical data and is the first manual of its kind for students and medical specialists in different areas, including those specializing in medical sonography. The original technology was tested at clinics in patients subjected to ultrasonic monitoring. Because of early detection there were no false-positive or false-negative results. The therapy was effective, and, in some cases, the use of the original method of "seagalography" (optometry and pulsemotorgraphy) has made it possible to develop new methods of treatment and/or to determine the optimal doses of drugs, as well as to develop effective drug complexes for treatment of a given pathology. This important new volume will be valuable to physicians, junior physicians, medical residents, lecturers in medicine, and medical students alike, either as a textbook or as a reference. It is a must-have for any physician's library.

In Engineering theory and applications, we think and operate in terms of logics and models with some acceptable and reasonable assumptions. The present text is aimed at providing modelling and analysis techniques for the evaluation of reliability measures (2-terminal, all-terminal, k-terminal reliability) for systems whose structure can be described in the form of a probabilistic graph. Among the several approaches of network reliability evaluation, the multiple-variable-inversion sum-of-disjoint product approach finds a well-deserved niche as it provides the reliability or unreliability expression in a most efficient and compact manner. However, it does require an efficiently enumerated minimal inputs (minimal path, spanning tree, minimal k-trees, minimal cut, minimal global-cut, minimal k-cut) depending on the desired reliability. The present book covers these two aspects in detail through the descriptions of several algorithms devised by the "reliability fraternity" and explained through solved examples to obtain and evaluate 2-terminal, k-terminal and all-terminal network reliability/unreliability measures and could be its USP. The accompanying web-based supplementary information containing modifiable Matlab(R) source code for the algorithms is another feature of this book. A very concerted effort has been made to keep the book ideally suitable for first course or even for a novice stepping into the area of network reliability. The mathematical treatment is kept as minimal as possible with an assumption on the readers' side that they have basic knowledge in graph theory, probabilities laws, Boolean laws and set theory.

Artificial neural network (ANN) has proven to be a universal approximator for any non-linear continuous function with arbitrary accuracy. This book presents how to apply ANN to measure various software reliability indicators: number of failures in a given time, time between successive failures, fault-prone modules and development efforts. The application of machine learning algorithm i.e. artificial neural networks application in software reliability prediction during testing phase as well as early phases of software development process is presented as well. Applications of artificial neural network for the above purposes are discussed with experimental results in this book so that practitioners can easily use ANN models for predicting software reliability indicators.

A comprehensive guide to the fundamental concepts and development, digital implementation schemes, performance considerations, and applications of arithmetic circuits for DSPArithmetic Circuits for DSP Applications is a complete resource on arithmetic circuits for digital signal processing (DSP). The text covers the key concepts, developments, and applications for different types of arithmetic circuits, which can be used for improving the efficiency of implementation of a multitude of DSP applications. Each chapter includes various applications of the respective class of arithmetic circuits along with information on the future scope of research. Written for students, engineers, and researchers in electrical and computer engineering, this comprehensive text offers a clear understanding of arithmetic circuits for digital signal processing and covers the concepts, designs, and applications of different types of arithmetic circuits.The text includes contributions from noted researchers on a wide range of topics, including a review of circuits used in implementing basic operations like additions and multiplications; distributed arithmetic as a technique for the multiplier-less implementation of inner products for DSP applications; discussions on look up table-based techniques and their key applications; CORDIC circuits for calculation of trigonometric, hyperbolic and logarithmic functions; real and complex multiplications, division, and square-root; solution of linear systems; eigenvalue estimation; singular value decomposition; QR factorization and many other functions through the use of simple shift-add operations; and much more. This book serves as a comprehensive resource, which describes the arithmetic circuits as fundamental building blocks for state-of-the-art DSP applications and reviews in depth the scope of arithmetic circuits and their applications.

Not available anywhere else, this groundbreaking volume presents a novel and unique approach to understand the complex chemical network behind the internal network structure of plants, a valuable tool for students of physics, biological physics, chemistry and biology, but also for sociologists and economists as well as for scientists in any field. Photosynthesis and the complex network within plants is becoming more important than ever, because of the earth's changing climate. In addition, the concepts can be used in other areas, and the science itself is useful in practical applications in many branches of science, including medicine, biology, biophysics, and chemistry. This original, groundbreaking work by two highly experienced and well-known scientists introduces a new and different approach to thinking about living organisms, what we can learn from them, and how we can use the concepts within their scientific makeup in practice. This book describes the principles of complex signaling networks enabling spatiotemporally-directed macroscopic processes by the coupling of systems leading to a bottom-up information transfer in photosynthetic organisms. Top-down messengers triggered by macroscopic actuators like sunlight, gravity, environment or stress lead to an activation of the gene regulation on the molecular level. Mainly the generation and monitoring, as well the role of reactive oxygen species in photosynthetic organisms as typical messengers in complex networks, are described. A theoretical approach according to the principle of synergetics is presented to model light absorption, electron transfer and membrane dynamics in plants. A special focus will be attended to nonlinear processes that form the basic principle for the accumulation of energy reservoirs and large forces enabling the dynamics of macroscopic devices. This volume is a must-have for any scientist, student, or engineer working with photosynthesis. The concepts herein are not available anywhere else, in any other format, and it is truly a groundbreaking work with sure to be long-lasting effects on the scientific community. Reactive Oxygen Species: Introduces a groundbreaking approach for understanding hierarchical networks in plants Introduces Reactive Oxygen Species (ROS) as "messengers" within the complex network of the photosynthesis process Suggests how the presented concepts can be used to describe other biological principles and multiscale hierarchical systems in society, politics and economy Provides cutting-edge research not available anywhere else in any other format

This book examines the Internet of Things (IoT) and Data Analytics from a technical, application, and business point of view.

Practical Guide to International Standardization for Electrical Engineering provides a comprehensive guide to the purpose of standards organizations, their relationship to product development and how to use the standardization process for cost-effective new product launch.

An advanced, practical approach to the first and second laws of thermodynamics Advanced Engineering Thermodynamics bridges the gap between engineering applications and the first and second laws of thermodynamics.

Your introduction to Islamic accounting Principles of Islamic Accounting is the first and only text that covers the fundamentals of Islamic accounting in English. A comprehensive guide, this groundbreaking reference offers both insight into Islamic accounting best practices and disclosure for Shariah-compliant instruments.

Examining the implications and practical implementation of multi-disciplinary International Conference on Harmonization (ICH) topics, this book gives an integrated view of how the guidelines inform drug development strategic planning and decision-making, together with impact on marketed products.

A great fall cannot be understood apart from the rise that preceded it. Enron Ascending is the only book to date that examines in detail the first two-thirds of that iconic energy company's life. Thus, it is the only book to date that exposes the deepest causes of Enron's stunning collapse. Nobel economist Paul Krugman predicted that history would look upon Enron's plummet as a greater turning point than the fall of the Twin Towers. Enron Ascending explains the shock of the company's fall by recalling the astounding achievements of Enron's birth, childhood, adolescence, and early maturity. It sets forth the once-celebrated but now-forgotten industry and innovation that caused the company and its reputation to soar stratospherically. At the same time, always conscious of the company's fate, the book highlights throughout the developing habits of thought and behavior that later evolved into self-destructive acts of desperation and deceit. Written fifteen years after the firm's demise, Enron Ascending offers the long perspective of a uniquely positioned insider, Robert L. Bradley, Jr., the company's director of public-policy analysis and Chairman Ken Lay's personal speechwriter. The book also offers a library of previously unavailable information, drawn from Bradley's innumerable corporate documents and unrepeatable interviews, which he collected in his capacity as the company's prospective historian. Most important, however, Enron Ascending offers an antidote to the unending stories, studies, and books about Enron that are presented as just-the-facts but are in reality shaped decisively by the worldview of their authors. Bradley shows, beyond dispute, that the early habits which set precedents for Enron's history-making demise were directly contrary to the free-market behaviors and capitalist attitudes generally blamed for Enron's fall.

A collection of case studies from nonwestern countries that offers an analysis of the significant role culture plays in crisis communication Culture and Crisis Communication presents an examination of how politics, culture, religion, and other social issues affect crisis communication and management in nonwestern countries. From intense human tragedy to the follies of the rich, the chapters examine how companies, organizations, news outlets, health organizations, technical experts, politicians, and local communities communicate in crisis situations. Taking a wider view than a single country's perspective, the text contains a cross-cultural and cross-country approach. In addition, the case studies offer valuable lessons that organizations that wish to operate or are operating in those cultures can adopt in preparing and managing crises. The book highlights recent crisis events such as Syria's civil war, missing Malaysia Airline Flight MH370, and Japan's Fukushima Daiichi nuclear power plant disaster. Each of the case studies examines how culture impacts communication and responses to crises. Authoritative, insightful, and instructive, this important resource: Analyzes how nonwestern cultures respond to crises Covers the role of culture in crisis communication in recent news events Includes contributions from 18 international authors who provide insight on nonwestern cultures and crisis communication Written for communication professionals, academics, and students, Culture and Crisis Communication presents an insightful introduction to the topic of culture and crisis communication and then delves into illustrative case studies that explore intracultural and transboundary crisis communication.

Addressing a cutting-edge, multidisciplinary field, this book reviews nanomaterials and their biomedical applications. It covers regeneration, implants, adhesives, and biosensors and strategies for more efficient therapy, diagnosis, and drug delivery with the use of nanotechnology.

Provides the reader how to apply flexible glass applications that are not possible or practical to address with alternative substrate materials. Examples of technology areas include displays, touch sensors, lighting, backplanes, and photovoltaics. Built on more than 10 years of valuable discussions and collaborations focused on truly defining what flexible glass means in the context of the emerging electronic and opto-electronic applications, this book provides a broad overview as well as detailed descriptions that cover flexible glass properties, device fabrication methods, and emerging applications. It provides the basis for identifying new device designs, applications, and manufacturing processes for which flexible glass substrates are uniquely suited and encourages and enables the reader to identify and pursue advanced flexible glass applications that do not exist today and provides a launching point for exciting future directions. The chapters are grouped into three sections. The first focuses on flexible glass and flexible glass reliability and has three chapters with authors from Corning. The second section focuses on flexible glass device fabrication which includes chapters on roll-to-roll processing, vacuum deposition, and printed electronics. These chapters are authored by established experts in their respective fields that have extensive experience in processing flexible glass substrates in toolsets that range from research to pilot scale. The third section focuses on flexible glass device applications and includes chapters on photovoltaics, displays, integrated photonics, and microelectronics integration. These are authored by experts with direct experience in fabricating and characterizing flexible glass devices. The diverse list of authors and their depth of experience in working with a variety of material systems, processes, and device technologies significantly adds valuable context to the overall flexible glass discussion. "This book represents a major contribution to the field. The long-incubated flexible glass revolution is upon us".--Peter L. Bocko, from the Foreword AudienceThe core market for this book is scientists, engineers, professors and students working in the field of flexible electronics and opto-electronics. This includes personnel at university research labs, corporate research and development labs, and national labs.

Patents are a vital asset in the modern business world. They allow patent holders to introduce new products in to a market while deterring other market players from simply copying innovative features without making comparable investments in research and development. In years past, a few patents may have provided adequate protection.

Updated with color and gray scale illustrations, a companion website housing supplementary material, and new sections covering recent developments in antenna analysis and design This book introduces the fundamental principles of antenna theory and explains how to apply them to the analysis, design, and measurements of antennas.

Oh, all the amazing things your iPad and iPad 2 can do! Lightweight, powerful, and perfect for reading and staying in touch, iPads are fun and practical for today's seniors, as long as you know how to use all the bells and whistles. That's where this helpful guide comes in.

The first book-length treatment of an exciting new technology, this volume explains the principles behind induced plasmonic current.

The bestselling guide to the leading image-editing software, fully updated Previous editions of this For Dummies guide have sold more 650,000 copies. Richly illustrated in full color, this edition covers all the updates Photoshop CS5, the gold standard for image-editing programs.