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  • Spar 10%
    av Kerri A. (Towson University) Goodwin
    639,-

    An approachable, coherent, and important text, Research in Psychology: Methods and Design, 8th Edition continues to provide its readers with a clear, concise look at psychological science, experimental methods, and correlational research in this newly updated version. Helpful learning aids, stepΓÇôbyΓÇôstep instructions, and detailed examples of real research studies makes the material easy to read and studentΓÇôfriendly.

  • - Fundamental Requirements, Enabling Technologies, and Operations Management
    av A Al-Dulaimi
    1 694,-

    A reliable and focused treatment of the emergent technology of fifth generation (5G) networksThis book provides an understanding of the most recent developments in 5G, from both theoretical and industrial perspectives. It identifies and discusses technical challenges and recent results related to improving capacity and spectral efficiency on the radio interface side, and operations management on the core network side. It covers both existing network technologies and those currently in development in three major areas of 5G: spectrum extension, spatial spectrum utilization, and core network and network topology management. It explores new spectrum opportunities; the capability of radio access technology; and the operation of network infrastructure and heterogeneous QoE provisioning.5G Networks: Fundamental Requirements, Enabling Technologies, and Operations Management is split into five sections: Physical Layer for 5G Radio Interface Technologies; Radio Access Technology for 5G Networks; 5G Network Interworking and Core Network Advancements; Vertical 5G Applications; and R&D and 5G Standardization. It starts by introducing emerging technologies in 5G software, hardware, and management aspects before moving on to cover waveform design for 5G and beyond; code design for multi-user MIMO; network slicing for 5G networks; machine type communication in the 5G era; provisioning unlicensed LAA interface for smart grid applications; moving toward all-IT 5G end-to-end infrastructure; and more. This valuable resource:* Provides a comprehensive reference for all layers of 5G networks* Focuses on fundamental issues in an easy language that is understandable by a wide audience* Includes both beginner and advanced examples at the end of each section* Features sections on major open research challenges5G Networks: Fundamental Requirements, Enabling Technologies, and Operations Management is an excellent book for graduate students, academic researchers, and industry professionals, involved in 5G technology.

  • av John W. Leis
    1 526,-

    Discover the basic telecommunications systems principles in an accessible learn-by-doing formatCommunication Systems Principles Using MATLAB covers a variety of systems principles in telecommunications in an accessible format without the need to master a large body of theory. The text puts the focus on topics such as radio and wireless modulation, reception and transmission, wired networks and fiber optic communications. The book also explores packet networks and TCP/IP as well as digital source and channel coding, and the fundamentals of data encryption.Since MATLAB(r) is widely used by telecommunications engineers, it was chosen as the vehicle to demonstrate many of the basic ideas, with code examples presented in every chapter. The text addresses digital communications with coverage of packet-switched networks. Many fundamental concepts such as routing via shortest-path are introduced with simple and concrete examples. The treatment of advanced telecommunications topics extends to OFDM for wireless modulation, and public-key exchange algorithms for data encryption. Throughout the book, the author puts the emphasis on understanding rather than memorization. The text also:* Includes many useful take-home skills that can be honed while studying each aspect of telecommunications* Offers a coding and experimentation approach with many real-world examples provided* Gives information on the underlying theory in order to better understand conceptual developments* Suggests a valuable learn-by-doing approach to the topicWritten for students of telecommunications engineering, Communication Systems Principles Using MATLAB(r) is the hands-on resource for mastering the basic concepts of telecommunications in a learn-by-doing format.

  • - Malpractice, Misconduct and Manipulation
    av C Alexander
    910,-

    Identifying malpractice and misconduct should be top priority for financial risk managers todayCorruption and Fraud in Financial Markets identifies potential issues surrounding all types of fraud, misconduct, price/volume manipulation and other forms of malpractice. Chapters cover detection, prevention and regulation of corruption and fraud within different financial markets. Written by experts at the forefront of finance and risk management, this book details the many practices that bring potentially devastating consequences, including insider trading, bribery, false disclosure, frontrunning, options backdating, and improper execution or broker-agency relationships.Informed but corrupt traders manipulate prices in dark pools run by investment banks, using anonymous deals to move prices in their own favour, extracting value from ordinary investors time and time again. Strategies such as wash, ladder and spoofing trades are rife, even on regulated exchanges - and in unregulated cryptocurrency exchanges one can even see these manipulative quotes happening real-time in the limit order book. More generally, financial market misconduct and fraud affects about 15 percent of publicly listed companies each year and the resulting fines can devastate an organisation's budget and initiate a tailspin from which it may never recover.This book gives you a deeper understanding of all these issues to help prevent you and your company from falling victim to unethical practices.* Learn about the different types of corruption and fraud and where they may be hiding in your organisation* Identify improper relationships and conflicts of interest before they become a problem* Understand the regulations surrounding market misconduct, and how they affect your firm* Prevent budget-breaking fines and other potentially catastrophic consequencesSince the LIBOR scandal, many major banks have been fined billions of dollars for manipulation of prices, exchange rates and interest rates. Headline cases aside, misconduct and fraud is uncomfortably prevalent in a large number of financial firms; it can exist in a wide variety of forms, with practices in multiple departments, making self-governance complex. Corruption and Fraud in Financial Markets is a comprehensive guide to identifying and stopping potential problems before they reach the level of finable misconduct.

  • av Richard C. (University of California) Dorf
    671,-

    Dorf s Introduction to Electric Circuits, Global Edition, is designed for a one- to -three term course in electric circuits or linear circuit analysis. The book endeavors to help students who are being exposed to electric circuits for the first time and prepares them to solve realistic problems involving these circuits.

  • av Avner (Tel Aviv University) Engel
    1 582,-

    A guide to systems engineering that highlights creativity and innovation in order to foster great ideas and carry them outPractical Creativity and Innovation in Systems Engineering exposes engineers to a broad set of creative methods they can adopt in their daily practices. In addition, this book guides engineers to become entrepreneurs within traditional engineering companies, promoting creative and innovative culture around them.The author describes basic systems engineering concepts and includes an abbreviated summary of Standard 15288 systems' life cycle processes. He then provides an extensive collection of practical creative methods which are linked to the various systems' life cycle processes. Next, the author discusses obstacles to innovation and, in particular, how engineers can push creative ideas through layers of reactionary bureaucracy within non-innovative organizations. Finally, the author provides a comprehensive description of an exemplary creative and innovative case study recently completed.The book is filled with illustrative examples and offers effective guidelines that can enhance individual engineers' creative prowess as well as be used to create an organizational culture where creativity and innovation flourishes. This important book:* Offers typical systems engineering processes that can be accomplished in creative ways throughout the development and post-development portions of a system's lifetime.* Includes a large collection of practical creative methods applicable to engineering and other technological domains* Includes innovation advice needed to transform creative ideas into new products, services, businesses and marketing processes* Contains references and notes for further reading in every sectionWritten for systems engineering practitioners, graduate school students and faculty members of systems, electrical, aerospace, mechanical and industrial engineering schools, Practical Creativity and Innovation in Systems Engineering offers a useful guide for creating a culture that promotes innovation.

  • av K Donohue
    1 596,-

    A comprehensive review of behavioral operations management that puts the focus on new and trending research in the field The Handbook of Behavioral Operations offers a comprehensive resource that fills an important gap in the behavioral operations literature. This vital text highlights best practices in behavioral operations research and identifies the most current research directions and their applications. A volume in the Wiley Series in Operations Research and Management Science, this book contains contributions from an international panel of scholars from a wide variety of backgrounds who are conducting behavioral research. The handbook provides succinct tutorials on common methods used to conduct behavioral research, serves as a resource for current topics in behavioral operations, and acts as a guide to the use of new research methods. The authors review the fundamental theories and offer frameworks from a psychological, systems dynamics, and behavioral economic standpoint. They provide a crucial grounding for behavioral operations as well as an entry point for new areas of behavioral research. The handbook also presents a variety of behavioral operations applications that focus on specific areas of study and includes a survey of current and future research needs. This important resource: Contains a summary of the methodological foundations and in-depth treatment of research best practices in behavioral research. Provides a comprehensive review of research conducted over the past two decades in behavioral operations, including such classic topics as inventory management, supply chain contracting, forecasting, and competitive sourcing. Covers a wide-range of current topics and applications including supply chain risk, responsible and sustainable supply chain, health care operations, culture and trust. Connects existing bodies of behavioral operations literature with related fields, including psychology and economics. Provides a vision for future behavioral research in operations. Written for academicians within the operations management community as well as for behavioral researchers more broadly, The Handbook of Behavioral Operations offers a comprehensive resource for the study of how individuals make decisions in an operational context with contributions from experts in the field.

  • Spar 10%
    - Practical Options Theory
    av Adam S. Iqbal
    639,-

    Gain a deep, intuitive and technical understand of practical options theory The main challenges in successful options trading are conceptual, not mathematical.  Volatility: Practical Options Theory provides financial professionals, academics, students and others with an intuitive as well as technical understanding of both the basic and advanced ideas in options theory to a level that facilitates practical options trading.  The approach taken in this book will prove particularly valuable to options traders and other practitioners tasked with making pricing and risk management decisions in an environment where time constraints mean that simplicity and intuition are of greater value than mathematical formalism. The most important areas of options theory, namely implied volatility, delta hedging, time value and the soΓÇôcalled options greeks are explored based on intuitive economic arguments alone before turning to formal models such as the seminal BlackΓÇôScholesΓÇôMerton model.  The reader will understand how the model free approach and mathematical models are related to each other, their underlying theoretical assumptions and their implications to level that facilitates practical implementation. There are several excellent mathematical descriptions of options theory, but few focus on a translational approach to convert the theory into practice. This book emphasizes the translational aspect, while first building an intuitive, technical understanding that allows market makers, portfolio managers, investment managers, risk managers, and other traders to work more effectively withinΓÇöand beyondΓÇöthe bounds of everyday practice. Gain a deeper understanding of the assumptions underlying options theory Translate theoretical ideas into practice Develop a more accurate intuition for better timeΓÇôconstrained decision making This book allows its readers to gain more than a superficial understanding of the mechanisms at work in options markets. Volatility gives its readers the edge by providing a true bedrock foundation upon which practical knowledge becomes stronger.

  • Spar 29%
    - Practical Magic for Crafting Powerful Work Relationships
    av Kim Christfort
    241,-

    A guide to putting cognitive diversity to work Ever wonder what it is that makes two people click or clash? Or why some groups excel while others fumble? Or how you, as a leader, can make or break team potential? Business Chemistry holds the answers. Based on extensive research and analytics, plus years of proven success in the field, the Business Chemistry framework provides a simple yet powerful way to identify meaningful differences between peopleΓÇÖs working styles. Who seeks possibilities and who seeks stability? Who values challenge and who values connection? Business Chemistry will help you grasp where others are coming from, appreciate the value they bring, and determine what they need in order to excel. It offers practical ways to be more effective as an individual and as a leader. Imagine you had a more inΓÇôdepth understanding of yourself and why you thrive in some work environments and flounder in others. Suppose you had a clearer view on what to do about it so that you could always perform at your best. Imagine you had more insight into what makes people tick and what ticks them off, how some interactions unlock potential while others shut people down. Suppose you could gain peopleΓÇÖs trust, influence them, motivate them, and get the very most out of your work relationships. Imagine you knew how to create a work environment where all types of people excel, even if they have conflicting perspectives, preferences and needs. Suppose you could activate the potential benefits of diversity on your teams and in your organizations, improving collaboration to achieve the groupΓÇÖs collective potential. Business Chemistry offers all of thisΓÇôΓÇôyou donΓÇÖt have to leave it up to chance, and you shouldnΓÇÖt. Let this book guide you in creating great chem

  • av Ethirajan Rathakrishnan
    1 750,-

    In Applied Gas Dynamics, Professor Ethirajan Rathakrishnan introduces the high-tech science of gas dynamics, from a definition of the subject to the three essential processes of this science, namely, the isentropic process, shock and expansion process, and Fanno and Rayleigh flows.

  • - The Ultimate System for Building Lifelong Client Relationships in the Blink of an Eye
    av David V. Lorenzo
    265,-

    Every sale is made or lost in 60 seconds--make them countCold calling and pushing your way into an office or a living room creates an atmosphere of adversity and distrust you must overcome before you close the deal. With those tired tactics, you're swimming upstream, against a strong current, with a bag of rocks tied to your waist.Sales has changed.Legacy sales gimmicks destroy relationships right from the first minute.The 60 Second Sale is a turnkey system for building profitable, lifelong relationships. Whether you work with affluent consumers or sell to senior executives in FORTUNE 500 companies, this step-by-step guide will help you open doors, close deals, and make more money in a way that leverages your natural strengths. That's the magnificence of the 60 second sale system. You get to be yourself and build your business.In this book you will discover:* How to start a sales conversation in 60 seconds* Who to target for immediate income* A powerful yet easy-to-use system to generate relationship revenue* Five ways to initiate new relationships* What to say to make sure your business meetings result in money in the bank* The secret to getting a "yes" every time, even in the most competitive sales environment* The winning mindset that removes the stress, uncertainty, and fear from income generation* And so many other effective business growth strategies, your competition won't know what hit themBusiness relationships are built one minute at a time. From introduction to closing, every 60 seconds you have an opportunity to strengthen your relationship or destroy it. Isn't it time you started leveraging your expertise, demonstrating your value, and building trust with your clients? When you do, they buy into who you are and how you can help them - right from the first minute.The 60 Second Sale is a fail-proof system for succeeding in today's relationship-focused sales environment.

  • Spar 29%
    - How to Build Exceptional Schools Across Your District
    av Paul Bambrick-Santoyo
    270,-

    Build better schools by training better leadersA Principal Manager's Guide to Leverage Leadership answers the question that district leaders have been asking across the country: if Leverage Leadership is a roadmap for principals on how to lead great schools, what can principal managers and districts do to support them on that path? A Principal Manager's Guide to Leverage Leadership offers a step-by-step guide to coaching principals to the highest levels of achievement, and it is rooted in studying the most successful principal managers and districts across the country. It can be used by principal managers/supervisors, superintendents, district and state leadership, and principal training organizations to accelerate the growth of principals in your community. Used in conjunction with Leverage Leadership 2.0, this book identifies the key actions principal managers should take to create exceptional school leaders, integrating the seven levers of leadership into district culture from the principal manager on up. With a particular emphasis on the two "super-levers" of data-driven instruction and student culture, this book is packed with advice, professional development materials, and real-world videos of principal managers in action, offering principal managers a valuable resource for bringing about change.A Principal Manager's Guide to Leverage Leadership introduces a new unifying approach that is also highlighted in Leverage Leadership 2.0: See It, Name It, Do It. It gives you the tools to See it (see models of effective practice and identify gaps), Name it (name concrete actions for improvement) and Do it (provide means to practice these action steps until a principal masters them)With A Principal Manager's Guide to Leverage Leadership in hand, principal managers, superintendents and principal training organizations can facilitate district-wide and state-wide transformations and hasten the benefit to the students and community as a whole.

  • Spar 30%
    - A Practical Guide to Building Exceptional Schools
    av Paul Bambrick-Santoyo
    295,-

    Cut through the mystique to learn the real drivers of great school leadershipLeverage Leadership 2.0 answers the basic question: what do great school leaders do that separates them from the rest? Rooted in the observation and training of over 20,000 school leaders worldwide, Leverage Leadership 2.0 offers a practical, updated and easier-to-use follow-up to the original, with field-tested techniques and actionable advice. As educational leaders around the world implement Leverage Leadership ideas, their collective stories have revealed a simple framework by which the seven levers may be implemented: See It, Name It, Do It. This book aligns classic Leverage Leadership principles with this proven framework to streamline implementation and help good leaders become great. Expert discussion and real-life success stories prove that effective leadership is not about innate charisma, charm, or personality--it's about how a leader uses their time.Aimed at all levels of school leadership, this book shows you what to do, and how and when to do it. The companion DVD includes 30 real-world videos that showcase effective leadership happening in our schools right now, and all templates, tools, and other professional development materials have been fully refreshed with a renewed focus on real-world implementation. Informational, inspirational, and highly motivational, this book explores both the separate components of success and what it looks like as a whole.* Learn the core principles of effective leadership* Understand what success looks like on the ground* Practice the seven levers of leadership that allow transformational growth* Adopt the tools and techniques that facilitate a schoolwide transformationEducational leaders from a diverse array of schools around the world have found unprecedented success using the key principles detailed in Leverage Leadership, and this book is inspired -- and informed -- by their stories. Leverage Leadership 2.0 is the practical resource school leaders need to start making real change happen today.

  • - A Historical Perspective on Technological Development and Future Landscape
    av Roy
    2 306,-

    SUSTAINABLE WATER TREATMENT: ADVANCES AND INTERVENTIONSThis outstanding new volume is a compendium of reference material which will cover most of the relevant and state-of-art approaches in the field of water treatment, focusing on technological advances for water treatment in four categories: advanced oxidation technologies, nanoparticles for water treatment, membrane separations, and other emerging technologies or processes.Apart from this perspective, fundamental discussions on a wide variety of pollutants have also been included, such as acidic wastewater treatment, metallurgical wastewater, textile wastewater as well as groundwater. The editors have not only covered a wide range of water treatment techniques, but also focus on their applications, offering a holistic perspective on water treatment in general.Covering all of the latest advances, innovations, and developments in practical applications for sustainable water treatment, this volume represents the most comprehensive, up-to-date coverage of the issues of the day and state of the art. Whether for the veteran engineer or scientist or a student, this volume is a must-have for any library.Sustainable Water Treatment: Advances and Interventions covers:* Provides an insight into various sectors of water and wastewater treatment technologies, introducing key technical topics* Is a comprehensive guide to technological interventions for water and wastewater treatment* Is also a reference book for any elective course on water treatment for engineers, scientists, and students, at both the undergraduate and graduate levels* Presents the most current and up-to-date advances in sustainable water treatment* Covers key technical topics and gives readers a comprehensive understanding of the latest research findings* Includes perspectives on future trends and challenges

  • - A Self-Learning Approach
    av Mohammed F. Daqaq
    1 229,-

    A unique approach to teaching particle and rigid body dynamics using solved illustrative examples and exercises to encourage self-learningThe study of particle and rigid body dynamics is a fundamental part of curricula for students pursuing graduate degrees in areas involving dynamics and control of systems. These include physics, robotics, nonlinear dynamics, aerospace, celestial mechanics and automotive engineering, among others. While the field of particle and rigid body dynamics has not evolved significantly over the past seven decades, neither have approaches to teaching this complex subject. This book fills the void in the academic literature by providing a uniquely stimulating, "flipped classroom" approach to teaching particle and rigid body dynamics which was developed, tested and refined by the author and his colleagues over the course of many years of instruction at both the graduate and undergraduate levels.Complete with numerous solved illustrative examples and exercises to encourage self-learning in a flipped-classroom environment, Dynamics of Particles and Rigid Bodies: A Self-Learning Approach:* Provides detailed, easy-to-understand explanations of concepts and mathematical derivations* Includes numerous flipped-classroom exercises carefully designed to help students comprehend the material covered without actually solving the problem for them* Features an extensive chapter on electromechanical modelling of systems involving particle and rigid body motion* Provides examples from the state-of-the-art research on sensing, actuation, and energy harvesting mechanisms* Offers access to a companion website featuring additional exercises, worked problems, diagrams and a solutions manualIdeal as a textbook for classes in dynamics and controls courses, Dynamics of Particles and Rigid Bodies: A Self-Learning Approach is a godsend for students pursuing advanced engineering degrees who need to master this complex subject. It will also serve as a handy reference for professional engineers across an array of industrial domains.

  • - From Analogue to Digital, Pensions to Robo-Advice
    av Dan Tammas-Hastings
    430,-

    Understand the investment template that dominates the pension industryLiability-Driven Investment is the practitioner's guide to this increasingly popular investment template. Already the dominant framework for pension schemes in Europe and the UK, the LDI market is expected to grow significantly with the shift from Defined Benefit to Defined Contribution, and then into Digital Asset Management -- or Robo-Advice. With an aging population and significant under-saving globally, more and more finance professionals will need to know how to work within and around the LDI framework; this book provides clear explanations for the framework's usefulness and growing popularity to help practitioners find their bearings in and around the LDI space.The ultimate goal of LDI is to move beyond simple asset value maximisation and ensure that investors have sufficient funds to pay liabilities. This informative guide digs into that basic premise to show the various mechanisms, guidelines and practices that make up the framework's "working parts."* Discover the optimal investment strategies in multiple assets classes* Understand the key characteristics of the instruments used, including bonds, interest rate derivatives, and inflation linked products* Learn why pension companies and individual investors are moving toward LDI* Explore the ways in which the explosive growth of Robo-Advice will change retail investmentFinance professionals have long been accustomed to shifting landscapes -- it is taken as a given that prevailing thought and attendant practices will change over time -- but the rapid expansion of LDI has taken many by surprise. Having already been established as the dominant framework for pensions, it is clear that the emphasis on LDI will only continue to grow. Liability-Driven Investment tells you what you need to know in order to work effectively with LDI.

  • av L Li
    2 564,-

    Provides a comprehensive, yet practical source of reference, and excellent foundation for comparing the properties and performance of coatings and selecting the most suitable materials based on specific service needs and environmental factors. Coating technology has developed significant techniques for protecting existing infrastructure from corrosion and erosion, maintaining and enhancing the performance of equipment, and provided novel functions such as smart coatings greatly benefiting the medical device, energy, automotive and construction industries. The mechanisms, usage, and manipulation of cutting-edge coating methods are the focus of this book. Not only are the working mechanisms of coating materials explored in great detail, but also craft designs for further optimization of more uniform, safe, stable, and scalable coatings. A group of leading experts in different coating technologies demonstrate their main applications, identify the key bottlenecks, and outline future prospects. Advanced Coating Materials broadly covers the coating techniques, including cold spray, plasma vapor deposition, chemical vapor deposition, sol-gel method, etc., and their significant applications in microreactor technology, super(de)wetting, joint implants, electrocatalyst, etc. Numerous kinds of coating structures are addressed, including nanosize particles, biomimicry structures, metals and complexed materials, along with the environmental and human compatible biopolymers resulting from microbial activities. This state-of-the-art book is divided into three parts: (1) Materials and Methods: Design and Fabrication, (2) Coating Materials: Nanotechnology, and (3) Advanced Coating Technology and Applications. Audience Scientists, researchers, engineers and technologists in chemistry, physics, biotechnology, materials science, environmental and biomedical engineering involved with surface materials processing.

  • - Theory, Design, and Measurements
    av Qian Xu
    1 372,-

    A comprehensive review of the recent advances in anechoic chamber and reverberation chamber designs and measurementsAnechoic and Reverberation Chambers is a guide to the latest systematic solutions for designing anechoic chambers that rely on state-of-the-art computational electromagnetic algorithms. This essential resource contains a theoretical and practical understanding for electromagnetic compatibility and antenna testing. The solutions outlined optimise chamber performance in the structure, absorber layout and antenna positions whilst minimising the overall cost. The anechoic chamber designs are verified by measurement results from Microwave Vision Group that validate the accuracy of the solution.Anechoic and Reverberation Chambers fills this gap in the literature by providing a comprehensive reference to electromagnetic measurements, applications and over-the-air tests inside chambers. The expert contributors offer a summary of the latest developments in anechoic and reverberation chambers to help scientists and engineers apply the most recent technologies in the field. In addition, the book contains a comparison between reverberation and anechoic chambers and identifies their strengths and weaknesses. This important resource:* Provides a systematic solution for anechoic chamber design by using state-of-the-art computational electromagnetic algorithms* Examines both types of chamber in use: comparing and contrasting the advantages and disadvantages of each* Reviews typical over-the-air measurements and new applications in reverberation chambers* Offers a timely and complete reference written by authors working at the cutting edge of the technology* Contains helpful illustrations, photographs, practical examples and comparison between measurements and simulationsWritten for both academics and industrial engineers and designers, Anechoic and Reverberation Chambers explores the most recent advances in anechoic chamber and reverberation chamber designs and measurements.

  • - Strategies Directed at MET and RON Receptor Tyrosine Kinase Pathways
    av JW Janetka
    2 003,-

    International experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than nonΓÇôselective, toxic chemotherapy.  With contributions from an international panel of experts in the field, the book integrates diverse aspects of biochemistry, molecular biology, protein engineering, proteomics, cell biology, pharmacology, biophysics, structural biology, medicinal chemistry and drug development. A large class of proteins called kinases are enzymes required by cancer cells to grow, proliferate, and survive apoptosis (death) by the immune system. Two important kinases are MET and RON which are receptor tyrosine kinases (RTKs) that initiate cell signaling pathways outside the cell surface in response to extracellular ligands (growth factors.) Both kinases are oncogenes which are required by cancer cells to migrate away from the primary tumor, invade surrounding tissue and metastasize. MET and RON reside on both cancer cells and the support cells surrounding the tumor, called the microenvironment. MET and RON are activated by their particular ligands, the growth factors HGF and MSP, respectively. Blocking MET and RON kinase activation and downstream signaling is a promising therapeutic strategy for preventing tumor progression and metastasis. Written for cancer physicians and biologists as well as drug discovery and development teams in both industry and academia, this is the first book of its kind which explores novel approaches to inhibit MET and RON kinases other than traditional small molecule kinase inhibitors. These new strategies target key tumorigenic processes on the outside of the cell, such as growth factor activation by proteases. These unique strategies have promising potential as an improved alternative to kinase inhibitors, chemotherapy, or radiation treatment. 

  • - Improving Economy and Efficiency
    av RA Fernandes
    1 694,-

    Presents a comprehensive account of established protectingΓÇôgroupΓÇôfree synthetic routes to molecules of medium to high complexity This book supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an ΓÇ£ideal synthesisΓÇ¥ and back the global need of practicing green chemistry. The only resource of its kind to focus entirely on protectingΓÇôgroupΓÇôfree synthesis, it is edited by a leading practitioner in the field, and features enlightening contributions by top experts and researchers from across the globe. The introductory chapter includes a concise review of historical developments, and discusses the concepts, need for, and future prospects of protectingΓÇôgroupΓÇôfree synthesis. Following this, the book presents information on protectingΓÇôgroupΓÇôfree synthesis of complex natural products and analogues, heterocycles, drugs, and related pharmaceuticals. Later chapters discuss practicing protectingΓÇôgroupΓÇôfree synthesis using carbohydrates and of glycosyl derivatives, glycolΓÇôpolymers and glycoΓÇôconjugates. The book concludes with a chapter on latent functionality as a tactic toward formal protectingΓÇôgroupΓÇôfree synthesis. A comprehensive account of established protectingΓÇôgroupΓÇôfree (PGF) synthetic routes to molecules of medium to high complexity Benefits total synthesis, methodology development and drug synthesis researchers Supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an ΓÇ£ideal synthesisΓÇ¥ and support the global need of practicing green chemistry Covers a topic that is gaining importance because it renders syntheses more economical ProtectingΓÇôGroupΓÇôFree Organic Synthesis: Improving Economy and Efficiency is an important book for academic researchers in synthetic organic chemistry, green chemistry, medicinal and pharmaceutical chemistry, biochemistry, and drug discovery.

  • - Fundamentals of Digital Drawing, 3D Modeling, and Visual Programming in Architectural Design
    av Frank Melendez
    783,-

    Bridges traditional and contemporary methods of creating architectural design drawings and 3D models through digital tools and computational processes.Drawing from the Model: Fundamentals of Digital Drawing, 3D Modeling, and Visual Programming in Architectural Design presents architectural design students, educators, and professionals with a broad overview of traditional and contemporary architectural representation methods. The book offers insights into developments in computing in relation to architectural drawing and modeling, by addressing historical analog methods of architectural drawing based on descriptive geometry and projection, and transitioning to contemporary digital methods based on computational processes and emerging technologies.Drawing from the Model offers digital tools, techniques, and workflows for producing architectural design drawings (plans, sections, elevations, axonometrics, and perspectives), using contemporary 2D drawing and 3D modeling design software. Visual programming is introduced to address topics of parametric modeling, algorithmic design, computational simulations, physical computing, and robotics. The book focuses on digital design software used in higher education and industry, including Robert McNeel & Associates Rhinoceros® (Rhino 6 for Windows), Grasshopper®, Adobe Illustrator® CC, and Arduino, and features an appendix filled with 10 design drawing and 3D modeling exercises intended as educational and pedagogical examples for readers to practice and/or teach workflows that are addresses in the book.* Bridges analog hand-drawing and digital design drawing techniques* Provides comprehensive coverage of architectural representation, computing, computer-aided drafting, and 3D modeling tools, techniques, and workflows, for contemporary architectural design drawing aesthetics and graphics.* Introduces topics of parametric modeling, algorithmic design, computational simulation, physical computing, and robotics through visual programming environments and processes.* Features tutorial-based instruction using the latest versions of Rhinoceros® (Rhino 6 for Windows), Grasshopper®, Adobe Illustrator® CC, and Arduino.

  • - Technologies and Applications
    av QF Hassan
    1 694,-

    A comprehensive overview of the Internet of Things' core concepts, technologies, and applicationsInternet of Things A to Z offers a holistic approach to the Internet of Things (IoT) model. The Internet of Things refers to uniquely identifiable objects and their virtual representations in an Internet-like structure. Recently, there has been a rapid growth in research on IoT communications and networks, that confirms the scalability and broad reach of the core concepts. With contributions from a panel of international experts, the text offers insight into the ideas, technologies, and applications of this subject.The authors discuss recent developments in the field and the most current and emerging trends in IoT. In addition, the text is filled with examples of innovative applications and real-world case studies. Internet of Things A to Z fills the need for an up-to-date volume on the topic. This important book:* Covers in great detail the core concepts, enabling technologies, and implications of the Internet of Things* Addresses the business, social, and legal aspects of the Internet of Things* Explores the critical topic of security and privacy challenges for both individuals and organizations* Includes a discussion of advanced topics such as the need for standards and interoperability* Contains contributions from an international group of experts in academia, industry, and researchWritten for ICT researchers, industry professionals, and lifetime IT learners as well as academics and students, Internet of Things A to Z provides a much-needed and comprehensive resource to this burgeoning field.

  • - Metastability of Solutions and Melts
    av Keshra Sangwal
    2 508,-

    A unique text presenting practical information on the topic of nucleation and crystal growth processes from metastable solutions and meltsNucleation and Crystal Growth is a groundbreaking text thatoffers an overview and description of the processes and phenomena associated with metastability of solutions and melts. The author--a noted expert in the field--puts the emphasis on low-temperature solutions that are typically involved in crystallization in a wide range of industries. The text begins with a review of the basic knowledge of solutions and the fundamentals of crystallization processes. The author then explores topics related to the metastable state of solutions and melts from the standpoint of three-dimensional nucleation and crystal growth.Nucleation and Crystal Growth is the first text that contains a unified description and discussion of the many processes and phenomena occurring in the metastable zone of solutions and melts from the consideration of basic concepts of structure of crystallization. This important text:* Outlines an interdisciplinary approach to the topic and offers an essential guide for crystal growth practitioners in materials science, physics, and chemical engineering* Contains a comprehensive content that details the crystallization processes starting from the initial solutions and melts, all the way through nucleation, to the final crystal products* Presents a unique focus and is the first book on understanding, and exploiting, metastability of solutions and melts in crystallization processesWritten for specialists and researchers in the fields of materials science, condensed matter physics, and chemical engineering. Nucleation and Crystal Growth is a practical resource filled with hands-on knowledge of nucleation and crystal growth processes from metastable solutions and melts.

  • av Joe Hutsko
    253,-

    Green gadgets encompass everything from iPods to energy-efficient home entertainment devices to solar laptop chargers and crank-powered gizmos. This book explains how to research green gadgets, make a smart purchasing decision, use products you already own in a more environmentally friendly way, and say goodbye to electronics that zap both energy.

  • - A Realistic Appraisal of the Future of Our National Economy (Peter L. Bernstein's Finance Classics)
    av Peter L. Bernstein
    235,-

    Peter L. Bernstein's The Price of Prosperity was first published in 1962 and then again as a revised edition in 1966. With chapter titles like The Burden of Government and The Fear of Taxes , this book speaks to the future of the economy at the time and how this new economy may be affected by the government.

  •  
    2 014,-

    This book provides research on the human element in forecasting. It focuses on how we can improve our ability to accurately forecast.

  • av Andreas (University of Cyprus) Demetriou
    898,-

    Developmental psychology deals with psychological processes of development in infancy, childhood and adolescence, as well as aging and transitions in adulthood. This book focuses on processes rather than developmental stages and emphasizes theory and a critique of core research.

  • - Determining Strategic Capability
    av Per V. Jenster
    660,-

    The company appraisal is an essential part of the strategy process and is generally recommended as the first step in strategic planning. It is a subject that, although critical, is somewhat neglected in the literature. The appraisal of the company covers the assessment of strengths, weaknesses, capabilities, resources and vulnerabilities.

  • - Managing the Balance Between Cultural and Technical Change
    av George Eckes
    376,-

    "Making Six Sigma Last is the most practical and helpful resource that I have seen on this subject. George's charisma and charm spill over into this interesting and entertaining book. Using one of George's many analogies, 'this is an upper-deck shot,' and combined with his first book should become the benchmark for Six Sigma learning.

  • - Overcoming Founder's Syndrome, Fundphobia and Other Obstacles to Success
    av Stephen R. Block
    408

    In a time of increasing demands for accountability and effectiveness, many nonprofits stumble again and again over the same obstacles to effectiveness. These roadblocks are responsible for many of the failures and disappointments that plague well-meaning nonprofits.

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