Bøker utgitt av John Wiley & Sons Inc

Eine umfassende Betrachtung der Struktur, Pharmakologie, Funktion und Rolle von G-Protein-gekoppelten RezeptorenMit GPCRs as Therapeutic Targets legt die renommierte Forscherin Dr. Annette Gilchrist einen maßgeblichen, umfassenden Leitfaden für einen dynamischen, aktiven Bereich der akademischen und industriellen Arzneimittelforschung vor. Das Werk, in dem die molekulare Pharmakologie dieser wichtigen Zielklasse behandelt wird, ist ein wichtiges Referenzwerk für neue und erfahrene Forscher, die sich mit G-Protein-gekoppelten Rezeptoren beschäftigen. Es enthält außerdem aktuelle Daten zu GPCR-Strukturen und dem strukturbasierten Wirkstoffdesign.In diesem Werk wird die Rolle von GPCR bei der Behandlung von Krankheiten und für neue Ansätze in deren Erforschung analysiert. Dabei werden nicht nur Informationen über die Struktur, Pharmakologie und Funktion von GPCR dargestellt, sondern es wird auch deren Rolle bei Krankheitszuständen erörtert. Neue Methoden zur Messung der GPCR-Aktivität werden auf verständliche und ansprechende Weise präsentiert. Das Werk bietet:* Eine gründliche Einführung in die molekulare Pharmakologie G-Protein-gekoppelter Rezeptoren mit aktuellen Angaben zu GPCR-Strukturen und dem strukturbasierten Wirkstoffdesign* Ausführliche Erörterungen der entstehenden Pharmakologie von GPCR, des intrazellulären Transports und der subzellulären GPCR-Signalübertragung* Umfassende Betrachtung der allosterischen Modulation, Rezeptordimerisierung, Deorphanisierung und Ubiquitinierung* Ausführliche Besprechung der Rolle von GPCR bei der Behandlung von Krebs, Substanzmissbrauch, zerebrovaskulären Erkrankungen und StoffwechselkrankheitenAls ideales Referenzwerk für Forscher in den Bereichen Biochemie, Zellbiologie und Pharmakologie sollte GPCRs as Therapeutic Targets auch in den Bibliotheken von Fachleuten der Medizinischen Chemie, Strukturbiologie und klinischen Pharmakologie einen Platz finden.

The success or failure of a web site ultimately comes down tousability. Billions of IT dollars are spent annually on web sitedevelopment - for retail, customer service, intranet and otheruses- how much of this is wasted because of inferior design andusability? Gartner research indicates that 90% of all web siteshave some critical usability problems. And almost half ofe-commerce web sites lose up to 15% of potential revenue whileincurring 15% extra costs due to usability problems. Thus, in manyinstances, usability problems have not only frustrated users, buthave also undermined and led to the demise of many web sites-andwill continue to do so.Web Usability is a practical guide for managers and executiveson the importance of usability, dealing with issues such as;Understanding how to handle web usability problemsDetermining which usability problems are critical and which onesare trivialPlanning how much to spend on usability and what to expect inreturnMeasuring and justifying their usability effortsAligning user goals with their business goalsWeb Usability will teach readers how to:Dramatically increase their web revenue potentialEffectively reduce and eliminate extra, hidden, andspecial-handling costsEfficiently develop and mainatin web sitesSignificantly improve web development ROI (return oninvestment)Mend stressed or broken relationships between businesses and theirpartners and customersImprove competitive advantage

PHYSICS, OPTICS, AND SPECTROSCOPY OF MATERIALSBridges a gap that exists between optical spectroscopists and laser systems developersPhysics, Optics, and Spectroscopy of Materials provides professionals and students in materials science and engineering, optics, and spectroscopy a basic understanding and tools for stimulating current research, as well as developing and implementing new laser devices in optical spectroscopy. The author--a noted expert on that subject matter--covers a wide range of topics including: effects of light and mater interaction such as light absorption, emission and scattering by atoms and molecules; energy levels in hydrogen, hydrogen-like atoms, and many electron atoms; electronic structure of molecules, classification of vibrational and rotational motions of molecules, wave propagation and oscillations in dielectric solids, light propagation in isotropic and anisotropic solids, including frequency doubling dividing and shifting, solid materials optics, and lasers.The book provides a basic overview of the laser and its comprising components. For example, the text describes methods for achieving fast Q-switching in laser cavities, and illustrates examples of several specific laser systems used in industry and scientific research. This important book:* Provides a comprehensive background in material physics, optics, and spectroscopy* Details examples of specific laser systems used in industry and scientific research including helium/neon laser, copper vapor laser, hydrogen-fluoride chemical laser, dye lasers, and diode lasers* Presents a basic overview of the laser and its comprising components* Elaborates on several important subjects in laser beams optics: divergence modes, lens transitions, and crossing of anisotropic crystalsWritten for research scientists and students in the fields of laser science and technology and materials optical spectroscopy, Physics, Optics, and Spectroscopy of Materials covers knowledge gaps for concepts including oscillator strength, allowed and forbidden transitions between electronic and vibrational states, Raman scattering, and group-theoretical states nomenclature.

Modern Industrial StatisticsThe new edition of the prime reference on the tools of statistics used in industry and services, integrating theoretical, practical, and computer-based approachesModern Industrial Statistics is a leading reference and guide to the statistics tools widely used in industry and services. Designed to help professionals and students easily access relevant theoretical and practical information in a single volume, this standard resource employs a computer-intensive approach to industrial statistics and provides numerous examples and procedures in the popular R language and for MINITAB and JMP statistical analysis software. Divided into two parts, the text covers the principles of statistical thinking and analysis, bootstrapping, predictive analytics, Bayesian inference, time series analysis, acceptance sampling, statistical process control, design and analysis of experiments, simulation and computer experiments, and reliability and survival analysis. Part A, on computer age statistical analysis, can be used in general courses on analytics and statistics. Part B is focused on industrial statistics applications.The fully revised third edition covers the latest techniques in R, MINITAB and JMP, and features brand-new coverage of time series analysis, predictive analytics and Bayesian inference. New and expanded simulation activities, examples, and case studies--drawn from the electronics, metal work, pharmaceutical, and financial industries--are complemented by additional computer and modeling methods. Helping readers develop skills for modeling data and designing experiments, this comprehensive volume:* Explains the use of computer-based methods such as bootstrapping and data visualization* Covers nonstandard techniques and applications of industrial statistical process control (SPC) charts* Contains numerous problems, exercises, and data sets representing real-life case studies of statistical work in various business and industry settings* Includes access to a companion website that contains an introduction to R, sample R code, csv files of all data sets, JMP add-ins, and downloadable appendices* Provides an author-created R package, mistat, that includes all data sets and statistical analysis applications used in the bookPart of the acclaimed Statistics in Practice series, Modern Industrial Statistics with Applications in R, MINITAB, and JMP, Third Edition, is the perfect textbook for advanced undergraduate and postgraduate courses in the areas of industrial statistics, quality and reliability engineering, and an important reference for industrial statisticians, researchers, and practitioners in related fields. The mistat R-package is available from the R CRAN repository.

Learn how radio access network (RAN) slicing allows 5G networks to adapt to a wide range of environments in this masterful resourceRadio Access Network Slicing and Virtualization for 5G Vertical Industriesprovides readers with a comprehensive and authoritative examination of crucial topics in the field of radio access network (RAN) slicing. Learn from renowned experts as they detail how this technology supports and applies to various industrial sectors, including manufacturing, entertainment, public safety, public transport, healthcare, financial services, automotive, and energy utilities.Radio Access Network Slicing and Virtualization for 5G Vertical Industries explains how future wireless communication systems must be built to handle high degrees of heterogeneity, including different types of applications, device classes, physical environments, mobility levels, and carrier frequencies. The authors describe how RAN slicing can be utilized to adapt 5G technologies to such wide-ranging circumstances.The book covers a wide range of topics necessary to understand RAN slicing, including:* Physical waveforms design* Multiple service signals coexistence* RAN slicing and virtualization* Applications to 5G vertical industries in a variety of environmentsThis book is perfect for telecom engineers and industry actors who wish to identify realistic and cost-effective concepts to support specific 5G verticals. It also belongs on the bookshelves of researchers, professors, doctoral, and postgraduate students who want to identify open issues and conduct further research.

Statistical Issues in Drug DevelopmentThe revised third edition of Statistical Issues in Drug Development delivers an insightful treatment of the intersection between statistics and the life sciences. The book offers readers new discussions of crucial topics, including cluster randomization, historical controls, responder analysis, studies in children, post-hoc tests, estimands, publication bias, the replication crisis, and many more.This work presents the major statistical issues in drug development in a way that is accessible and comprehensible to life scientists working in the field, and takes pains not to gloss over significant disagreements in the field of statistics, while encouraging communication between the statistical and life sciences disciplines. In addition to new material on topics like invalid inversion, severity, random effects in network meta-analysis, and explained variation, readers will benefit from the inclusion of:* A thorough introduction to basic topics in drug development and statistics, including the role played by statistics in drug development* An exploration of the four views of statistics in drug development, including the historical, methodological, technical, and professional* An examination of debatable and controversial topics in drug development, including the allocation of treatments to patients in clinical trials, baselines and covariate information, and the measurement of treatment effectsPerfect for life scientists and other professionals working in the field of drug development, Statistical Issues in Drug Development is the ideal resource for anyone seeking a one-stop reference to enhance their understanding of the use of statistics during drug development.

Anthropology is defined as the study of humankind and their origins throughout different places and times. The study focuses on cultural, biological, linguistic, and archaeological research. Anthropology For Dummies helps students and other interested readers understand this fascinating science by examining its core principles and applications.

MOLECULAR MECHANISMS OF FUNCTIONAL FOODComprehensive resource for understanding state-of-the-art mechanisms behind food health effectsThis book provides information on the development and validation of functional foods towards their market and industrial application. It covers the available information on developments, efficacy, and testing and safety, while demonstrating the proven or potential effects of food on health and disease.With contributions from the foremost experts in the field, this book will bring readers up to speed on the state of the art in the mechanisms behind food health effects, from their physiological bases to their conception, current uses, and future developments. Sample topics covered by the authors include:* The molecular mechanisms of action of antioxidant fibers, prebiotics, ginger, and cinnamon* Saffron, a functional food with potential molecular effects* Pseudocereals, ancestral grains that can serve as a source of bioactive compounds for functional foods* Molecular effects of future functional foods - psychobiotics, chronobiotics, hempseed, opuntia, common and carioca beans, coffee and cocoa by-productsFood industry professionals, government workers involved in projects related to food, and students in programs of study related to food can use this book as an up-to-date reference to fully understand the effects that many common and uncommon foods have on humans.

Industry 4.0 Vision for the Supply of Energy and MaterialsExplore the impact of Industry 4.0 technologies on the supply chain with this authoritative text written by a leader in his fieldIn Industry 4.0 Vision for the Supply of Energy and Materials, distinguished researcher and editor, Dr. Mahdi Sharifzadeh, delivers thematic, analytic, and applied discussions of the Industry 4.0 vision for supply chain design and operation. The book compiles all current aspects and emerging notions of Industry 4.0 into clusters of "enablers" and "analytics" of Supply Chain 4.0. Their multifaceted and highly interconnected nature is discussed at length, as are their diverse range of applications.You will discover uses of these new technologies ranging from the supply of conventional energy networks to renewables, pharmaceuticals, and additive manufacturing. You will also learn about their implications for economic prosperity and environmental sustainability. For each sector, this book scrutinizes current industrial practice and discusses developing concepts. Finally, the book concludes with potential future research directions of interest to industry practitioners and academics alike.Readers will also benefit from the inclusion of:* A thorough introduction to connectivity through wireless communications and remote sensors* An exploration of blockchains and smart contracts, as well as robotics and automation and cloud computing* Practical discussions of supply chain analytics, including big data, machine-learning, and artificial intelligence, as well as supply chain modeling, optimization, and control* A concise treatment of Industry 4.0 applications in supply chain design and operation, including the circular economy and the power industry* An analysis of the oil, gas, and petrochemical industry, the pharmaceutical industry, and additive manufacturingPerfect for PhD-level and Postdoctoral researchers and industrial researchers, Industry 4.0 Vision for the Supply of Energy and Materials will also earn a place in the libraries of working professionals with an interest in the quantitative analysis of Supply Chain 4.0 concepts and techniques.

AHMM is a premier international architectural practice. Established over 30 years ago, it has won numerous awards including the Stirling Prize. Through the contributions of journalists, clients, fellow professionals and academics, this AD issue celebrates the practice's achievements in all areas of architectural production, featuring archive material, new works and unparalleled access to the AHMM organisation, revealing new insights into their work and urban philosophies.To get to this eminent position, the office has consistently responded in innovative and imaginative ways to the changing imperatives of art, science and economics that influence our built environment. These parameters have metamorphosed considerably since AHMM was founded, in terms of advances in digitisation, material science and changes to contract management, what constitutes sustainability, procurement routes, construction methods, collaboration and architectural education.Above all this AD will explore AHMM's practice as a holistic design project in itself, in terms of building buildings, but also in using a design ethos to cope with shifts in workload and the firm's varying business activities and its administration over the years, thus providing insight for a future generation of potentially successful architectural professionals.

Hailed by the reviews as an extremely wide-ranging, useful book, this book provides a modern introduction to the chemistry and physics of solids. It offers a unique integrated approach, equally accessible to scientists and engineers.

In light of current developments in modelling, and with the aim of reinvigorating debates around the potentiality of the architectural model - its philosophies, technologies and futures - this issue of AD examines how the model has developed to become an immersive worldbuilding machine. Worldbuilding is the creation of imaginary worlds through forms of cultural production. Although this discourse began with an analysis of imaginary places constructed in works of literature, it has evolved to encompass worlds from fields such as cinema, games, design, landscape, urbanism and architecture. Worldbuilding differs from the notion of worldmaking, which deals with how speculative thinking can influence the construction of the phenomenal world. As architects postulate ever-increasingly complex world models from which to draw inspiration and inform their practice, questions of scale, representation and collaboration emerge. Discussed through a range of articles from acclaimed international contributors in the fields of both architecture and media studies, this issue explores how the architectural model is situated between concepts of worldbuilding and worldmaking - in the creative space of worldmodelling.Contributors: Kathy Battista, Thea Brejzek and Lawrence Wallen, Pascal Bronner and Thomas Hillier, Mark Cousins, James A Craig and Matt Ozga-Lawn, Kate Davies, Ryan Dillon, Christian Hubert, Chad Randl, Theodore Spyropoulos, and Mark JP Wolf.Featured architects: Phil Ayres, FleaFolly Architects, Minimaforms, and Stasus.

Bioanalytical Aspects in Biological TherapeuticsDeepen your understanding of how critical data are generated from bioanalysisIn Bioanalytical Aspects in Biological Therapeutics, a team of renowned chemists, immunologists, and biologists delivers a timely and practical exploration of the diverse scientific and technical literature on the bioanalytical investigation of current biotherapeutics under development. The book discusses the challenges and considerations for bioanalytical support, covering a wide range of central topics in the field, including overview and basic immunology for testing of biological therapeutics, pharmacokinetic aspects, clinical immunogenicity prediction and testing, biomarker testing, biotransformation assessment for biologics, statistical aspects of bioanalytical testing, regulatory expectations, and more.Drug development and analysis professionals will learn how critical data are generated from bioanalysis and how proven tools and methods are applied to the development of biologics. Alongside coverage of topics like PK, immunogenicity, neutralizing antibody assays, and the importance of quality control for reagents, readers will benefit from:* A thorough overview of the development of biotherapeutics and the role played by bioanalytical tests, as well as basic immunology for bioanalytical testing of biological therapeutics* Comprehensive explorations of platform and instrument considerations in bioanalytical testing, pharmacokinetics assays, and biomarker analysis using LC-MS, LBA, and other technologies* Practical discussions of immunogenicity prediction, preclinical and clinical anti-drug antibody assays, and bioanalytical schemes for anti-drug neutralizing antibody assays* In-depth examinations of critical reagents in bioanalysis* Regulatory expectations for bioanalytical method development, validation, and sample testingPerfect for pharmaceutical scientists in industry, Bioanalytical Aspects in Biological Therapeutics will also earn a place in the libraries of pharmaceutical regulators and other professionals working in pharmaceutical companies, as well as graduate students studying bioanalytical assays for biological therapeutics.

Learn how AI and data science are upending the worlds of biology and medicineIn Silico Dreams: How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future delivers an illuminating and fresh perspective on the convergence of two powerful technologies: AI and biotech. Accomplished genomics expert, executive, and author Brian Hilbush offers readers a brilliant exploration of the most current work of pioneering tech giants and biotechnology startups who have already started disrupting healthcare. The book provides an in-depth understanding of the sources of innovation that are driving the shift in the pharmaceutical industry away from serendipitous therapeutic discovery and toward engineered medicines and curative therapies.In this fascinating book, you'll discover:* An overview of the rise of data science methods and the paradigm shift in biology that led to the in silico revolution* An outline of the fundamental breakthroughs in AI and deep learning and their applications across medicine* A compelling argument for the notion that AI and biotechnology tools will rapidly accelerate the development of therapeutics* A summary of innovative breakthroughs in biotechnology with a focus on gene editing and cell reprogramming technologies for therapeutic development* A guide to the startup landscape in AI in medicine, revealing where investments are poised to shape the innovation base for the pharmaceutical industryPerfect for anyone with an interest in scientific topics and technology, In Silico Dreams also belongs on the bookshelves of decision-makers in a wide range of industries, including healthcare, technology, venture capital, and government.

Mutual Coupling Between AntennasA guide to mutual coupling between various types of antennas in arrays such as wires, apertures and microstrip patches or antennas co-sited on platformsMutual Coupling Between Antennas explores the theoretical underpinnings of mutual coupling, offers an up-to-date description of the physical effects of mutual coupling for a variety of antennas, and contains techniques for analysing and assessing its effects. The book puts the topic in historical context, presents an integral equation approach, includes the current techniques, measurement methods, and discusses the most recent advances in the field.With contributions from noted experts on the topic, the book reviews practical aspects of mutual coupling and examines applications that clearly demonstrate where the performance is impacted both positively and negatively. Mutual Coupling Between Antennas contains information on how mutual coupling can be analysed with a wide range of methods from direct computer software using discrete methods, to integral equations and Greens function methods as well as approximate asymptotic methods. This important text:* Provides a theoretical background for understanding mutual coupling between various types of antennas* Describes the interaction that occurs between antennas, both planned and unplanned* Explores a key aspect of arrays in any wireless, radar or sensing system operating at radio frequencies* Offers a groundbreaking book on antenna mutual couplingWritten for antenna engineers, technical specialists, researchers and students, Mutual Coupling Between Antennas is the first book to examine mutual coupling between various types of antennas including wires, horns, microstrip patches, MIMO antennas, co-sited antennas and arrays in planar or conformal configurations.

Das Buch Chemometrics and Cheminformatics in Aquatic Toxicology befasst sich mit den bestehenden und neu auftretenden Problemen der Verschmutzung der aquatischen Umwelt durch verschiedene metallische und organische Schadstoffe, insbesondere Industriechemikalien, Pharmazeutika, Kosmetika, Biozide, Nanomaterialien, Pestizide, Tenside, Farbstoffe und viele weitere. Es werden verschiedene chemometrische und cheminformatische Instrumente für Laien beschrieben mitsamt ihrer Anwendung auf die Analyse und Modellierung der Toxizitätsdaten von Chemikalien in Bezug auf unterschiedliche aquatische Organismen.Eine Reihe von Datenbanken zur aquatischen Toxizität sowie chemometrische Softwaretools und Webserver werden vorgestellt und praktische Beispiele für die Modellentwicklung gegeben, einschließlich der entsprechenden Abbildungen. Darüber hinaus enthält das Werk Fallstudien und Literaturberichte, um das Verständnis des Themas abzurunden. Außerdem lernen die Leserinnen und Leser Werkzeuge und Protokolle wie maschinelles Lernen, Data Mining sowie Methoden des QSAR-basierten und ligandenbasierten chemischen Designs kennen.Darüber hinaus bietet das Werk:* Eine umfassende Einführung in chemometrische und cheminformatische Instrumente und Techniken, insbesondere maschinelles Lernen und Data Mining* Eine Darstellung von Datenbanken zur aquatischen Toxizität, chemometrischen Softwaretools und Webservern* Praktische Beispiele und Fallstudien zur Verdeutlichung und Veranschaulichung der im Buch enthaltenen Konzepte* Eine kompakte Erläuterung der chemometrischen und cheminformatischen Instrumente sowie ihrer Anwendung auf die Analyse und Modellierung von ToxizitätsdatenChemometrics and Cheminformatics in Aquatic Toxicology ist ideal für Forschende und Studierende der Chemie sowie der Umwelt- und Pharmawissenschaften und sollte auch in den Bibliotheken von Fachleuten in der chemischen Industrie sowie Aufsichtsbehörden, die sich mit Chemometrie beschäftigen, einen Platz finden.

Vor etwa 10 Jahren erschien die Originalausgabe von Conducting Psychological Assessment. Seitdem wird dieses Referenzwerk, insbesondere in der Lehre, eingesetzt, um Psychologen in der Erstellung psychologischer Gutachten zu schulen, vor allem im Hinblick auf die Integration von Daten und das Abfassen von Berichten. Das in der Originalausgabe vorgestellte Hypothesentestmodell ist heute das Standardmodell für eine ethische und in jeder Hinsicht umfassende Begutachtung. Die 2. Auflage greift auf grundlegende Modelle der ersten Auflage zurück, ergänzt um Nuancen und Details, die in Workshops über die letzten zehn Jahre erarbeitet wurden. Der Autor hat anerkannte Modelle zum Abgleich widersprüchlicher Daten aus unterschiedlichen Quellen entwickelt, die in das Kapitel zur Datenintegration einfließen können. Auch nutzt der Autor verschiedene andere Modelle zur Persönlichkeitsfunktion als Vorlage für die Erarbeitung von Daten, darunter das interpersonelle Circumplex-Modell. Diese Ansätze kommen in diesem Buch durchgängig zur Anwendung.

This book focuses on plastics process analysis, instrumentation for modern manufacturing in the plastics industry.Process analysis is the starting point since plastics processing is different from processing of metals, ceramics, and other materials. Plastics materials show unique behavior in terms of heat transfer, fluid flow, viscoelastic behavior, and a dependence of the previous time, temperature and shear history which determines how the material responds during processing and its end use. Many of the manufacturing processes are continuous or cyclical in nature. The systems are flow systems in which the process variables, such as time, temperature, position, melt and hydraulic pressure, must be controlled to achieve a satisfactory product which is typically specified by critical dimensions and physical properties which vary with the processing conditions.Instrumentation has to be selected so that it survives the harsh manufacturing environment of high pressures, temperatures and shear rates, and yet it has to have a fast response to measure the process dynamics. At many times the measurements have to be in a non-contact mode so as not to disturb the melt or the finished product. Plastics resins are reactive systems. The resins will degrade if the process conditions are not controlled. Analysis of the process allows one to strategize how to minimize degradation and optimize end-use properties.

Discover a comprehensive exploration of the foundations and frontiers of the optoelectronics technology of group-III nitrides and their ternary alloysIn Group III-Nitride Semiconductor Optoelectronics, expert engineer Dr. Choudhury J. Praharaj delivers an insightful overview of the optoelectronic applications of group III-nitride semiconductors. The book covers all relevant aspects of optical emission and detection, including the challenges of optoelectronic integration and a detailed comparison with other material systems.The author discusses band structure and optical properties of III-nitride semiconductors, as well as the properties of their low-dimensional structures. He also describes different optoelectronic systems such as LEDs, lasers, photodetectors, and optoelectronic integrated circuits.Group III-Nitride Semiconductor Optoelectronics covers both the fundamentals of the field and the most cutting-edge discoveries. Detailed appendices contain Maxwell's equations in dielectric media and descriptions of time-dependent perturbation theory and light-matter interaction.Readers will also benefit from:* A thorough introduction to the band structure and optical properties of group III-nitride semiconductors* Comprehensive explorations of growth and doping of group III-nitride devices and heterostructures* Practical discussions of the optical properties of low dimensional structures in group III-nitrides* In-depth examinations of lasers and light-emitting diodes, other light-emitting devices, photodetectors, photovoltaics, and optoelectronic integrated circuits* Concise treatments of the quantum optical properties of nitride semiconductor devicesPerfect for researchers in electrical engineering, applied physics, and materials science, Group III-Nitride Semiconductor Optoelectronics is also a must-read resource for graduate students and industry practitioners in those fields seeking a state-of-the-art reference on the optoelectronics technology of group III-nitrides.

MACHINE LEARNING PARADIGM FOR INTERNET OF THINGS APPLICATIONSAs companies globally realize the revolutionary potential of the IoT, they have started finding a number of obstacles they need to address to leverage it efficiently. Many businesses and industries use machine learning to exploit the IoT's potential and this book brings clarity to the issue.Machine learning (ML) is the key tool for fast processing and decision-making applied to smart city applications and next-generation IoT devices, which require ML to satisfy their working objective. Machine learning has become a common subject to all people like engineers, doctors, pharmacy companies, and business people. The book addresses the problem and new algorithms, their accuracy, and their fitness ratio for existing real-time problems.Machine Learning Paradigm for Internet of Thing Applications provides the state-of-the-art applications of machine learning in an IoT environment. The most common use cases for machine learning and IoT data are predictive maintenance, followed by analyzing CCTV surveillance, smart home applications, smart-healthcare, in-store 'contextualized marketing', and intelligent transportation systems. Readers will gain an insight into the integration of machine learning with IoT in these various application domains.

Innovation in healthcare is currently a "hot" topic. Innovation allows us to think differently, to take risks and to develop ideas that are far better than existing solutions. Currently, there is no single book that covers all topics related to microelectronics, sensors, data, system integration and healthcare technology assessment in one reference. This book aims to critically evaluate current state-of-the-art technologies and provide readers with insights into developing new solutions. With contributions from a fully international team of experts across electrical engineering and biomedical fields, the book discusses how advances in sensing technology, computer science, communications systems and proteomics/genomics are influencing healthcare technology today.

Discover how the NG-RAN architecture is, and isn't, ready for the challenges introduced by 5G5G Radio Access Network Architecture: The Dark Side of 5G explores foundational and advanced topics in Radio Access Network (RAN) architecture and why a re-thinking of that architecture is necessary to support new 5G requirements. The distinguished engineer and editor Sasha Sirotkin has included numerous works written by industry insiders with state of the art research at their disposal. The book explains the relevant standards and technologies from an academic perspective, but also explains why particular standards decisions were made and how a variety of NG-RAN architecture options could be deployed in real-life networks.All major standards and technologies associated with the NG-RAN architecture are discussed in this book, including 3GPP, O-RAN, Small Cell Forum, IEEE, and IETF. Readers will learn about how a re-design of the RAN architecture would ensure that 5G networks can deliver their promised throughput and low latency KPIs consistently and sustainably.The book is structured as follows:* An overview of the market drivers of the NG-RAN architecture, like spectrum models, 5G-relevant regulatory considerations, and 5G radio interface technical requirements* An overview of the 5G System, from the core network, to the RAN, to the radio interface protocols and physical layer, with emphasis on how these are different compared to 4G* Release-15 RAN architectures defined in 3GPP, O-RAN, and Small Cell Forum* RAN architecture evolution in Release-16 and Release-17* Enabling technologies, like virtualization, open source technologies, multi-access edge (MEC) computing, and operations, administration, and management (OAM)* NG-RAN deployment considerations, objectives, and challenges, like costs, spectrum and radio propagation considerations, and coveragePerfect for network designers and operators who require a solid understanding of the NG-RAN architecture, 5G Radio Access Network Architecture also belongs on the bookshelves of network engineers who aim to increase their understanding of the standards and technologies relevant to the NG-RAN architecture.

Learn how to achieve the highest levels of success without sacrificing who you areIn I Took the Only Path to See You, author and CEO Jon Fisher delivers an inspiring message that reminds readers that professional success does NOT have to come at the expense of personal happiness. Fisher is proof that professionals can achieve success on a grand scale without having to sacrifice their personal ethics, personal relationships, and more. The book's author shares the experiences of those who have risen to become leaders in their fields, some of whom are his close friends.This important book teaches readers:* How to achieve success without losing sight of being a good person* That, while not everyone makes it to the top of their chosen field, everyone can always work toward healthy personal relationships* That personal growth is the key to real and sustained personal happinessPerfect for young entrepreneurs and seasoned professionals alike, I Took the Only Path to See You will also earn a place in the libraries of anyone interested in achieving personal fulfilment while pursuing material success. The road to true success and happiness starts with personal happiness.

In a complex and uncertain world, we all need tools to understand and manage our most important asset - our own minds. Our minds are our brakes and our accelerators, and as we face the new world, we need to consider how we respond to change, how we enhance our adaptability and learn to be agile in an ever-changing world.Just like we go to the gym to exercise, to strengthen our bodies to get physically fit, we want people to be putting the same effort into their mental fitness to learn how to navigate thinking and emotions better, how to approach challenges with patience and empathy, overcome stress and anxiety and apply practical strategies to help cultivate a more positive growth mindset.The Hidden Edge is the rationale and the business case to why mental fitness is the only advantage that matters in business. The book provides the foundations of mental fitness, and is designed to:* Empower you and your people to skilfully navigate their thinking and emotions* To approach challenges and setbacks with agility and patience* Provide practical tools & techniques to overcome stress and anxiety* Apply practical strategies to help cultivate a more positive growth mindset to business and lifeThe Hidden Edge is designed with a specific focus on developing people's mental agility, emotional regulation and adaptability to help amplify their personal presence and impact both in life and in work.

A thoroughly up-to-date exploration of nutrient uptake in plantsIn Plant Ionomics: Sensing, Signaling, and Regulation, accomplished botanists and researchers Dr. Vijay Singh and Dr Manzer Siddiqui deliver an up-to-date discussion of the sensing, signaling, and regulation of nutrient uptake in plants under a variety of conditions. The book offers an accessible and easy-to-use reference for researchers with an interest in plant ionomics, combining the latest research from leading laboratories around the globe.The authors provide coverage of a variety of critical topics, including plant and soil nutrient stoichiometry, nutrient management and stress tolerance in crops, and the relationship between agricultural production and nutrient applications. Readers will also find:* A thorough introduction to nutrient regulation and abiotic stress tolerance in plants* In-depth discussions of nutrient uptake and transport in plants and the role of nutrients in ROS metabolism* Practical explorations of nutrient and sugar signaling and associated gene networks in plants* Extensive treatments of the role of nutrients in plant-microbe interactions and nutrient-use efficiency in plantsPerfect for students, researchers, academics, and scientists with an interest in plant nutrition, Plant Ionomics: Sensing, Signaling, and Regulation will also earn a place in the libraries of professionals in the agriculture and pharmaceutical industries.

Discover the hidden inner workings of your mind so you can break unhelpful habits and set yourself on the path to achieving your full potential.Beyond Emotional Intelligence reveals how our ingrained mental tendencies can either help or hinder us, depending on how conscious we are of their influence over our lives. Whether we seek to set and achieve our desired outcomes, improve our relationships, or live in alignment with what we value most, we need emotional intelligence (EI) to identify and overcome the mental patterns that may be keeping us stuck. In this book, you'll embark on 12 Self-Discoveries that will help you get to know yourself, so you can stop getting in your own way. You'll learn how, with practice, you can retrain your mind to develop new thought patterns that will serve you better as you work toward your life's aspirations.Each of the 12 Self-Discoveries offers unique clues and insights into who we are and why we do what we do. They function as an internal barometer for our triggers, emotional patterns, and mental habits. Ultimately, they provide a clear path to uncover and work with our habits of mind and patterns of action and reaction, giving us the possibility to exercise our own agency at key moments in our lives. Beyond Emotional Intelligence presents the 12 Self-Discoveries framework which provides you with a solid foundation from which you can begin to grow.* Discover how your hidden thought patterns are influencing your life and your relationships with others* Build Emotional Intelligence as you learn to recognize your reactions, perceptions, and value systems* Use the highly regarded 12 Self-Discoveries model to identify your mental roadblocks and remove them with new habits of mind* Learn proven methods for influencing your outcomes, de-cluttering your mind, and shift your own awarenessThis book will be your guide as you embark on a rigorous process of self-discovery as you learn to embrace your inner wisdom and take control of your results.

Delivering Safety ExcellenceDiscover how to overcome a culture of inadequately addressing risk and thereby achieve safe working practices from a leader in the fieldDelivering Safety Excellence: Engagement Culture At Every Level provides an in-depth and practical overview of how to energize frontline employees, supervisors, managers, and leaders to overcome and solve regularly occurring safety concerns. The book teaches readers how to resolve dysfunctional safety cultures by engaging employees at all levels. This cross functional engagement culture regularly builds safe and effective working practices that eliminate regulatory, financial, and personal risk shortfalls while encouraging profitability and efficiency.The distinguished author shows how culture improvement processes and models can be utilized to improve the performance all across an organization. The material is presented in dialogue format using case studies to highlight the relationship between the concepts discussed and their application in the real world.You'll discover how to implement real solutions in industries of all types and in organizations of all sizes using practical and concrete strategies tested by the author in regions and varying cultures around the world. Readers will also benefit from the inclusion of:* A thorough introduction to rapidly resolving the many common deficiencies in safety culture, including scarce regulatory and cultural materials and a lack of support, trust, and credibility for safety officers* Practical discussions of how urgency can obstruct a consistent culture of safety, performance, and prudence* Explorations of behavior-based safety, the injury plateau, the Occupational Health and Safety Act, and a dynamic model of safety weaknesses that lead to injuriesPerfect for safety officers at all levels of organizations of any size, Delivering Safety Excellence: Engagement Culture At Every Level will also earn a place in the libraries of executives, managers, leaders, supervisors, and employees who seek a one-stop reference for how to build a safe and profitable company.