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Dieses Werk vermittelt einen Überblick über die Grundlagen und die Weiterentwicklung von Nutrazeutika und Naturprodukten. Beschrieben werden die verschiedenen Arten von Synthese- und Extraktionsmethoden, die verschiedenen Charakterisierungstechniken sowie die klinische Validierung verschiedener Kategorien dieser Produkte. Dabei wird detailliert auf ihre Anwendung in der Präventivmedizin, als Nahrungsergänzungsmittel, in der Arzneimittelforschung und bei der Verabreichung von Arzneimitteln sowie auf die Rolle der Nanotechnologie bei der Umsetzung dieser Anwendungen eingegangen. Weitere wichtige Themen sind pharmazeutische Alternativen auf Grundlage von Kohlenhydraten, Proteinen, Aminosäuren, Kräutern, Flavonoiden, Phytochemikalien, marinen Quellen, GVO und GVO-freien Produkten. Der Schwerpunkt des Buches liegt weitgehend auf den Nanomaterialien und den nanochemischen Aspekten dieser Produkte. Dieses Werk ist eine unverzichtbare Lektüre für alle, die Nutrazeutika und Naturprodukte herstellen, sowie für alle, die sich mit der Entwicklung von Lebensmitteln, Kosmetika und Arzneimitteln unter Einbeziehung verschiedener Technologien und Mechanismen aus diesem Bereich beschäftigen.

Automation and Computational Intelligence for Road Maintenance and ManagementA comprehensive computational intelligence toolbox for solving problems in infrastructure managementIn Automation and Computational Intelligence for Road Maintenance and Management, a team of accomplished researchers delivers an incisive reference that covers the latest developments in computer technology infrastructure management. The book contains an overview of foundational and emerging technologies and methods in both automation and computational intelligence, as well as detailed presentations of specific methodologies.The distinguished authors emphasize the most recent advances in the maintenance and management of infrastructure robotics, automated inspection, remote sensing, and the applications of new and emerging computing technologies, including artificial intelligence, evolutionary computing, fuzzy logic, genetic algorithms, knowledge discovery and engineering, and more.Automation and Computational Intelligence for Road Maintenance and Management explores a universal synthesis of the cutting edge in parameters and indices to evaluate models. It also includes:* Thorough introductions to management science and the latest methods of automation and the structure and framework of automation and computing intelligence* Comprehensive explorations of advanced image processing techniques, recent advances in fuzzy, and diagnosis automation* Practical discussions of segmentation and fragmentation and different types of features and feature extraction methods* In-depth examinations of methods of classification along with various developed methodologies and models of quantification, evaluation, and indexing in automationPerfect for postgraduate students in road and transportation engineering, evaluation, and assessment, Automation and Computational Intelligence for Road Maintenance and Management will also earn a place in the libraries of researchers interested in or working with the evaluation and assessment of infrastructure.

Elevate your game in the face of challenging market conditions with this eye-opening guide to portfolio managementInvesting Amid Low Expected Returns: Making the Most When Markets Offer the Least provides an evidence-based blueprint for successful investing when decades of market tailwinds are turning into headwinds.For a generation, falling yields and soaring asset prices have boosted realized returns. However, this past windfall leaves retirement savers and investors now facing the prospect of record-low future expected returns. Emphasizing this pressing challenge, the book highlights the role that timeless investment practices - discipline, humility, and patience - will play in enabling investment success. It then assesses current investor practices and the body of empirical evidence to illuminate the building blocks for improving long-run returns in today's environment and beyond. It concludes by reviewing how to put them together through effective portfolio construction, risk management, and cost control practices.In this book, readers will also find:* The common investor responses so far to the low expected return challenge* Extensive empirical evidence on the critical ingredients of an effective portfolio: major asset class premia, illiquidity premia, style premia, and alpha* Discussions of the pros and cons of illiquid investments, factor investing, ESG investing, risk mitigation strategies, and market timing* Coverage of the whole top-down investment process - throughout the book endorsing humility in tactical forecasting and boldness in diversificationIdeal for institutional and active individual investors, Investing Amid Low Expected Returns is a timeless resource that enables investing with serenity even in harsher financial conditions.

Principles of Toxicology concisely and efficiently presents the scientific basis for toxicology as it applies to the workplace and the environment, covering diverse chemical hazards encountered in modern workplaces and natural environments and providing a practical understanding of these hazards for those concerned with protecting the health of humans and ecosystems. The work presents not only theory, but also practical information regarding chemical hazards to give the student and new professional a working knowledge of the practice of toxicology and the ability to solve problems in environmental and industrial settings.Case histories and examples from industrial and environmental exposures to chemicals are included to demonstrate the application of toxicological principles. To allow for seamless reader comprehension and further exploration of covered topics, the work is supplemented with numerous illustrations to clarify and summarize key points, as well as annotated bibliographies. In the 4th edition, all chapters and references have been updated to account for the latest scientific thinking, and new color figures have been added.New topics covered in 4th Edition of Principles of Toxicology include:* Regulatory toxicology, including the key regulatory framework in which much of the field of toxicology operates* Alternative methods in toxicology, including cutting-edge approaches to developing new information on the toxicity of drugs and chemicals* The dilemma of selecting safe exposure limits, guiding readers through practical considerations and pitfalls in developing and using safe exposure limits* Ecological risk assessment, with detailed discussion of methods and considerations when evaluating the effects of contaminants on plants and animals.Providing information on the principles of toxicology and the application of those principles to solve problems in environmental and industrial settings, Principles of Toxicology serves as an excellent textbook resource for advanced undergraduate, graduate, and professional students in a range of environmental and health fields. It is also valuable to health professionals who need toxicological information and assistance beyond what is found in an introductory text to general toxicology.

Provides practical and up-to-date coverage of all essential areas of building services design managementBuilding Services Design and Management offers clear and systematic guidance for building services engineers involved in the design, overseeing the installation, testing, and commissioning of building services systems. Written by a highly experienced building services design engineer and project director, this comprehensive volume covers key topics including design criteria, project execution, utilities infrastructure, construction management, regulatory compliance, safety testing and building handover. Detailed chapters feature many high-quality illustrations and examples to help readers fully understand the principles and processes of building services design.The author addresses changing practices and current technologies on construction sites as well as answering common questions about occupant subjectivity, end-user behavior, design life maintainability, design responsibility, construction documentation, post-construction reporting, risk management, dispute resolution, and more. Throughout the book, readers are presented with practical and relevant information about the distinct features of building services engineering and expert advice on how to approach management of both the design and construction stages.* Addresses common questions and issues practitioners encounter before, during, and after a building services engineering project* Explores the technical, legislative, and cultural aspects of global design delivery management* Discusses digitally enabled technologies such as 3D printing, off-site manufacturing, and autonomous equipment* Describes stakeholder interfaces including the design and construction teams, utility services providers, and regulatory enforcement authoritiesBuilding Services Design and Management is an invaluable one-stop resource for building services engineers, architectural design managers, and construction project managers, and an excellent textbook for courses in building services engineering, architecture, and construction project management.

This book is a detailed and step-by-step introduction to the mathematical foundations of ordinary and partial differential equations, their approximation by the finite difference method and applications to computational finance. The book is structured so that it can be read by beginners, novices and expert users.Part A Mathematical Foundation for One-Factor ProblemsChapters 1 to 7 introduce the mathematical and numerical analysis concepts that are needed to understand the finite difference method and its application to computational finance.Part B Mathematical Foundation for Two-Factor ProblemsChapters 8 to 13 discuss a number of rigorous mathematical techniques relating to elliptic and parabolic partial differential equations in two space variables. In particular, we develop strategies to preprocess and modify a PDE before we approximate it by the finite difference method, thus avoiding ad-hoc and heuristic tricks.Part C The Foundations of the Finite Difference Method (FDM)Chapters 14 to 17 introduce the mathematical background to the finite difference method for initial boundary value problems for parabolic PDEs. It encapsulates all the background information to construct stable and accurate finite difference schemes.Part D Advanced Finite Difference Schemes for Two-Factor ProblemsChapters 18 to 22 introduce a number of modern finite difference methods to approximate the solution of two factor partial differential equations. This is the only book we know of that discusses these methods in any detail.Part E Test Cases in Computational FinanceChapters 23 to 26 are concerned with applications based on previous chapters. We discuss finite difference schemes for a wide range of one-factor and two-factor problems.This book is suitable as an entry-level introduction as well as a detailed treatment of modern methods as used by industry quants and MSc/MFE students in finance. The topics have applications to numerical analysis, science and engineering.More on computational finance and the author's online courses, see www.datasim.nl.

A comprehensive and definitive guide to the Catholic faith Whether you're a member of the faith or just interested in it, Catholicism For Dummies, 3rd Edition offers a casual, straightforward introduction to the ins and outs of the contemporary church.

Your no-nonsense guide to making sense of Robert's Rules The classic Robert's Rules of Order has a proven track record of helping membership groups apply codes of conduct to serve as a parliamentary authority within a given assembly.

Take a bite out of your iMac with this bestselling guide Even if you're already in love with your iMac, it helps to have a little guidance to really get the most out of this ultimate all-in-one computer.

Open the books on accounting with this friendly guide Want to make sense of accounting basics but don't know where to begin? This new edition of Accounting For Dummies helps you speak your accountant's language with ease minimizing confusion as you maximize profits.

The most comprehensive coverage of search engine optimization In Search Engine Optimization All-in-One For Dummies, 3rd Edition, Bruce Clay whose search engine consultancy predates Google shares everything you need to know about SEO.

Master the markets and make wise investments. Investing in Shares For Dummies gives you the sound advice and proven tactics you need to play the markets and watch your profits grow.

Since the previous edition of World History For Dummies published in March of 2001, significant events have reshaped our world view, and the concept of "globalisation" is influencing everything from businesses to education to the environment.

Organic Chemistry has a long-standing reputation as being a difficult course at all universities. Organic Chemistry I Workbook For Dummies provides readers with opportunities to review material and practice solving problems based on the topics covered in Organic Chemistry I For Dummies and in a typical Organic Chemistry course.

With the housing bubble of the past few years bursting and interest rates on the rise, there has been an upsurge in the number of foreclosures across the country, creating many opportunities for profit. But investing in real estate foreclosure[s?] can be a tough job, especially when a negative stigma is attached.

One of the most amazing things about Hebrew is that, in less than a century, it has gone from an ancient language of prayer and ritual spoken by a few holy men to a modern language of sunbathing, dining, going to the movies, and countless other everyday activities, spoken by millions.

A guide to create a winning business plan from scratch. It gives you what you need to map out your business strategy and stay on course including a sample plan that you can easily adapt for your business. It also charts your course assess the advanced state of your business and where you'd like to take it, and establish achievable objectives.

Atomic-Scale Modelling of Electrochemical SystemsA comprehensive overview of atomistic computational electrochemistry, discussing methods, implementation, and state-of-the-art applications in the fieldThe first book to review state-of-the-art computational and theoretical methods for modelling, understanding, and predicting the properties of electrochemical interfaces. This book presents a detailed description of the current methods, their background, limitations, and use for addressing the electrochemical interface and reactions. It also highlights several applications in electrocatalysis and electrochemistry.Atomic-Scale Modelling of Electrochemical Systems discusses different ways of including the electrode potential in the computational setup and fixed potential calculations within the framework of grand canonical density functional theory. It examines classical and quantum mechanical models for the solid-liquid interface and formation of an electrochemical double-layer using molecular dynamics and/or continuum descriptions. A thermodynamic description of the interface and reactions taking place at the interface as a function of the electrode potential is provided, as are novel ways to describe rates of heterogeneous electron transfer, proton-coupled electron transfer, and other electrocatalytic reactions. The book also covers multiscale modelling, where atomic level information is used for predicting experimental observables to enable direct comparison with experiments, to rationalize experimental results, and to predict the following electrochemical performance.* Uniquely explains how to understand, predict, and optimize the properties and reactivity of electrochemical interfaces starting from the atomic scale* Uses an engaging "tutorial style" presentation, highlighting a solid physicochemical background, computational implementation, and applications for different methods, including merits and limitations* Bridges the gap between experimental electrochemistry and computational atomistic modellingWritten by a team of experts within the field of computational electrochemistry and the wider computational condensed matter community, this book serves as an introduction to the subject for readers entering the field of atom-level electrochemical modeling, while also serving as an invaluable reference for advanced practitioners already working in the field.

GREEN CHEMISTRY for Sustainable Water PurificationGreen Chemistry for Sustainable Water Purification provides systematic coverage of the most recent research and development in clean water treatment technologies based on green materials and nanocomposites.Providing safe drinking water is one of the top priorities for scientists and industrialists working on projects, and one particular problem is the contamination of groundwater with toxic organic and inorganic compounds released by various industries. The presence of contaminants or industrial effluents in drinking water systems has increasingly become a major environmental challenge. To address the problem, several methods, including ion exchange, membrane filtration, advanced oxidation, biological degradation, photocatalytic degradation, electro-coagulation, and adsorption, are in operation for removing or minimizing these wastes. The purification process of wastewater using conventional methods, however, has proved to be markedly ineffective, very difficult, and highly expensive.On the other hand, for the remediation of water resources, a concept like green chemistry, based on the application of biological agents including polymers, bacteria, and fungi, has received great scientific attention as it helps to avoid the toxic by-products of conventional techniques and enhances eco-friendly wastewater treatment approaches.This book discusses the different treatment technologies with a special focus on the green adsorption approach, using biological and hybrid biochemical treatment technologies to prevent water contamination and maintain the ecosystem. It discusses the analysis of organic and inorganic pollutants from industrial wastewater. It also focuses on the removal and recovery of organic and inorganic contaminants from the environment and several case studies describing the removal and recovery of environmental pollutants using green technology are given. The recycling of low-cost along with green adsorbent technology is explained in detail. Finally, the book highlights treatment technologies with effective pollutant removal capacities that are used in modern water treatment units.AudienceThe book will serve as an important resource for materials scientists, chemists, chemical engineers, biotechnologists, textile engineers and environmental scientists. It will also be valuable to industrial organizations, consulting engineering companies, etc. for the selection and implementation of the most sustainable wastewater treatment technologies.

Explore the dramatic changes brought on by the new manufacturing technologies of Industry 4.0In Smart Manufacturing, The Lean Six Sigma Way, Dr. Anthony Tarantino delivers an insightful and eye-opening exploration of the ways the Fourth Industrial Revolution is dramatically changing the way we manufacture products across the world and especially how it will revitalize manufacturing in North America and Europe.The author examines the role and impact of a variety of new Smart technologies including industrial IoT, computer vision, mobile/edge computing, 3D printing, robots, big data analytics, and the cloud. He demonstrates how to apply these new technologies to over 20 continuous improvement/Lean Six Sigma tools, greatly enhancing their effectiveness and ease of use.The book also discusses the role Smart technologies will play in improving:* Career opportunities for women in manufacturing* Cyber security, supply chain risk, and logistics resiliency* Workplace health, safety, and security* Life on the manufacturing floor* Operational efficiencies and customer satisfactionPerfect for anyone involved in the manufacturing or distribution of products in the 21st century, Smart Manufacturing, The Lean Six Sigma Way belongs in the libraries of anyone interested in the intersection of technology, commerce, and physical manufacturing.

GLOBAL EPIDEMIOLOGY OF CANCERCancer is the second highest cause of death in the United States, and a leading cause of death globally. Our goals are to discuss the global epidemiology of various cancers, with detailed information on their prevalence, incidence, and clinical considerations. Epidemiology is the key to understanding the mortality and morbidity of cancer, and how we can prevent, diagnose, and treat the disease. Prevention of cancer is essential for saving lives. Prevalence and incidence of cancer are key factors that each government and population must be aware of. Advances in the study of cancer occur on a regular basis, and this book provides the latest insights about relationships between the disease and stem cells, tumorigenesis, molecular interactions, pathways, channels, and immunity.Global Epidemiology of Cancer: Diagnosis and Treatment meets the needs of readers by providing current information about epidemiology (including molecular epidemiology), diagnosis, and treatment. Providing logical, step-by-step information on various cancers, this book consolidates all of the most up-to-date information and data from verified studies on all different types of cancers in the United States and throughout the world.Chapters are presented so that each includes an overview, clinical manifestations, epidemiology, pathophysiology, etiology and risk factors, diagnosis, treatment, prevention, and prognosis.Global Epidemiology of Cancer: Diagnosis and Treatment will be invaluable to graduate and postgraduate students, including medical students; nurses; physician assistants; residents in oncology; public health students and allied health students.

Explore how students are disrupting education by using digital resources to support self-direct learningFree Agent Learning: Leveraging Students' Self-Directed Learning to Transform K-12 Education explores an emerging cohort of students that are self-directing their learning around interest-driven topics, the tools they're using to scaffold these experiences, and their motivations for these out-of-school learning behaviors. Readers will find new insights and frameworks for effectively leveraging the lived experiences of their students and transforming their schools' cultures, norms and practices.In this book, readers will learn how education leaders can translate a newly emerged understanding about students' self-directed learning into actionable knowledge to improve teaching and learning Free Agent Learners also offers:* Info dispelling the myth that real learning only happens in a classroom* Discussions of how modern students are using digital tools, content, and resources for purposeful learning outside of teacher direction or sponsorship* Actionable tips and accessible strategies for the use of the Free Agent Learner Ecosystem to support school improvementPerfect for K-12 school and district administrators and decision-makers, Free Agent Learners is an eye-opening read for anyone involved in the education of primary and secondary school students.

An essential introduction to data analytics and Machine Learning techniques in the business sectorIn Financial Data Analytics with Machine Learning, Optimization and Statistics, a team consisting of a distinguished applied mathematician and statistician, experienced actuarial professionals and working data analysts delivers an expertly balanced combination of traditional financial statistics, effective machine learning tools, and mathematics. The book focuses on contemporary techniques used for data analytics in the financial sector and the insurance industry with an emphasis on mathematical understanding and statistical principles and connects them with common and practical financial problems. Each chapter is equipped with derivations and proofs--especially of key results--and includes several realistic examples which stem from common financial contexts. The computer algorithms in the book are implemented using Python and R, two of the most widely used programming languages for applied science and in academia and industry, so that readers can implement the relevant models and use the programs themselves.The book begins with a brief introduction to basic sampling theory and the fundamentals of simulation techniques, followed by a comparison between R and Python. It then discusses statistical diagnosis for financial security data and introduces some common tools in financial forensics such as Benford's Law, Zipf's Law, and anomaly detection. The statistical estimation and Expectation-Maximization (EM) & Majorization-Minimization (MM) algorithms are also covered. The book next focuses on univariate and multivariate dynamic volatility and correlation forecasting, and emphasis is placed on the celebrated Kelly's formula, followed by a brief introduction to quantitative risk management and dependence modelling for extremal events. A practical topic on numerical finance for traditional option pricing and Greek computations immediately follows as well as other important topics in financial data-driven aspects, such as Principal Component Analysis (PCA) and recommender systems with their applications, as well as advanced regression learners such as kernel regression and logistic regression, with discussions on model assessment methods such as simple Receiver Operating Characteristic (ROC) curves and Area Under Curve (AUC) for typical classification problems.The book then moves on to other commonly used machine learning tools like linear classifiers such as perceptrons and their generalization, the multilayered counterpart (MLP), Support Vector Machines (SVM), as well as Classification and Regression Trees (CART) and Random Forests. Subsequent chapters focus on linear Bayesian learning, including well-received credibility theory in actuarial science and functional kernel regression, and non-linear Bayesian learning, such as the Naïve Bayes classifier and the Comonotone-Independence Bayesian Classifier (CIBer) recently independently developed by the authors and used successfully in InsurTech.After an in-depth discussion on cluster analyses such as K-means clustering and its inversion, the K-nearest neighbor (KNN) method, the book concludes by introducing some useful deep neural networks for FinTech, like the potential use of the Long-Short Term Memory model (LSTM) for stock price prediction.This book can help readers become well-equipped with the following skills:* To evaluate financial and insurance data quality, and use the distilled knowledge obtained from the data after applying data analytic tools to make timely financial decisions* To apply effective data dimension reduction tools to enhance supervised learning* To describe and select suitable data analytic tools as introduced above for a given dataset depending upon classification or regression prediction purposeThe book covers the competencies tested by several professional examinations, such as the Predictive Analytics Exam offered by the Society of Actuaries, and the Institute and Faculty of Actuaries' Actuarial Statistics Exam.Besides being an indispensable resource for senior undergraduate and graduate students taking courses in financial engineering, statistics, quantitative finance, risk management, actuarial science, data science, and mathematics for AI, Financial Data Analytics with Machine Learning, Optimization and Statistics also belongs in the libraries of aspiring and practicing quantitative analysts working in commercial and investment banking.

Process Safety for EngineersFamiliarizes an engineer new to process safety with the concept of process safety managementIn this significantly revised second edition of Process Safety for Engineers: An Introduction, CCPS delivers a comprehensive book showing how Process Safety concepts are used to reduce operational risks. Students, new engineers, and others new to process safety will benefit from this book.In this updated edition, each chapter begins with a detailed incident case study, provides steps that help address issues, and contains problem sets which can be assigned to students.The second edition covers:* Process Safety: including an overview of CCPS' Risk Based Process Safety* Hazards: specifically fire and explosion, reactive chemical, and toxicity* Design considerations for hazard control: including Hazard Identification and Risk Analysis* Management of operational risk: including management of changeIn addition, the book presents how Process Safety performance is monitored and sustained. The associated online resources are linked to the latest online CCPS resources and lectures.

Prepare to serve your community with this easy-to-follow guide for future police officersOpen positions for police officers and detectives are expected to expand dramatically over the next decade. The time is right if you're looking to become a new police officer in your town or city. And whether you're hoping to become a local, county, state, or federal law enforcement official, the Police Officer Exam For Dummies has all the info you need to prepare for and pass the National Police Officer Selection Test or your local police officer exam with flying colors.From the low-down on physical ability testing and the personal background interview, to targeted reviews of judgment skills, map reading, memory, observation, and recall, this guide will whip you into shape for the police officer test in no time at all.In this book, you'll:* Get the instruction you need to find your confidence and banish test anxiety for good* Learn memory aids and tips so you can master the observation and recall test* Get actionable and practicable test-taking strategies that actually improve your performance on the examSo, stop rubbing that rabbit's foot and start preparing like the pros do, with the Police Officer Exam For Dummies!