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A comprehensive review of stress signaling in plants using genomics and functional genomic approachesImproving agricultural production and meeting the needs of a rapidly growing global population requires crop systems capable of overcoming environmental stresses. Understanding the role of different signaling components in plant stress regulation is vital to developing crops which can withstand abiotic and biotic stresses without loss of crop yield and productivity. Emphasizing genomics and functional genomic approaches, Protein Kinases and Stress Signaling in Plants is a comprehensive review of cutting-edge research on stress perception, signal transduction, and stress response generation.Detailed chapters cover a broad range of topics central to improving agricultural production developing crop systems capable of overcoming environmental stresses to meet the needs of a rapidly growing global population. This book describes the field of protein kinases and stress signaling with a special emphasis on functional genomics. It presents a highly valuable contribution in the field of stress perception, signal transduction and generation of responses against one or multiple stress signals.This timely resource:* Summarizes the role of various kinases involved in stress management* Enumerates the role of TOR, GSK3-like kinase, SnRK kinases in different physiological conditions* Examines mitogen-activated protein kinases (MAPKs) in different stresses* Describes the different aspects of calcium signaling under different stress conditions* Examines photo-activated kinases (PAPKs) in varying light conditions* Briefs the presence of tyrosine kinases in plants* Highlights the cellular functions of receptor?]like protein kinases (RLKs)* Possible implication of these kinases in developing stress tolerant cropsProtein Kinases and Stress Signaling in Plants: Functional Genomic Perspective is an essential resource for researchers and students in the fields of plant molecular biology and signal transduction, plant responses to stress, plant cell signaling, plant protein kinases, plant biotechnology, transgenic plants and stress biology.

This book contains both practical and theoretical aspects of groundwater resources relating to geochemistry. Focusing on recent research in groundwater resources, this book helps readers to understand the hydrogeochemistry of groundwater resources. Dealing primarily with the sources of ions in groundwater, the book describes geogenic and anthropogenic input of ions into water. Different organic, inorganic and emerging contamination and salinity problems are described, along with pollution-related issues affecting groundwater. New trends in groundwater contamination remediation measures are included, which will be particularly useful to researchers working in the field of water conservation. The book also contains diverse groundwater modelling examples, enabling a better understanding of water-related issues and their management.Groundwater Geochemistry: Pollution and Remediation offers the reader:* An understanding of the quantitative and qualitative challenges of groundwater resources* An introduction to the environmental geochemistry of groundwater resources* A survey of groundwater pollution-related issues* Recent trends in groundwater conservation and remediation* Mathematical and statistical modeling related to groundwater resourcesStudents, lecturers and researchers working in the fields of hydrogeochemistry, water pollution and groundwater will find Groundwater Geochemistry an essential companion.

Textbook of Lifestyle MedicineThe Textbook of Lifestyle Medicine provides foundational knowledge essential to students and scientists across various disciplines to better understand this new area of research and practice. Incorporating the latest evidence-based research on the relationships between lifestyle factors and disease, this unique book discusses the practical tools necessary to address growing public health crises such as obesity, cancer, diabetes, and cardiovascular disease using a holistic approach to physical, mental, and spiritual wellness.The book offers comprehensive and up-to-date coverage of how lifestyle medicine professionals can prevent and mitigate 'Lifestyle Diseases'. Clear and accessible chapters explore modifiable lifestyle factors that positively affect health, nutrition, exercise, sleep, stress control, and social support, and highlight the negative impact of smoking, alcohol abuse, and other unhealthy lifestyles. Topics include sleep physiology, the genetic background and development of noncommunicable diseases (NCDs), the characteristics and principles of healthy lifestyle, the clinical significance of physical activity, and the mechanisms connecting social interaction and health implications. This important resource:* Discusses the global burden and risk factors of the modern disease epidemic* Covers a variety of nutritional approaches including the Mediterranean Diet and the Dietary Approaches to Stop Hypertension (DASH) diet* Features in-depth coverage of the Mediterranean Lifestyle, a holistic approach to health and wellness* Includes a clinical practice section and appendices on preventive medicine and public health tools and recommendations* Contains key points, take-home messages, self-assessment questions, color artwork and numerous references, citations, internet links, and further reading suggestionsWritten by two world experts in this growing field, the Textbook of Lifestyle Medicine is a must-have volume for students and practitioners in nutrition, exercise physiology, psychology, addiction therapy, sleep therapy, as well as physicians, nurses, and other health professionals wanting to expand their knowledge and practice.

A Companion to American Legal History presents a compilation of the most recent writings from leading scholars on American legal history from the colonial era through the late twentieth century.* Presents up-to-date research describing the key debates in American legal history* Reflects the current state of American legal history research and points readers in the direction of future research* Represents an ideal companion for graduate and law students seeking an introduction to the field, the key questions, and future research ideas

How to Pass the FRACP Written Examination is an indispensable review and study guide for anyone preparing for the challenging Fellow of the Royal Australasian College of Physicians (FRACP) exam. This up-to-date resource fully aligns with the current FRACP core training curriculum, containing a wealth of traditional multiple-choice questions (MCQs) as well as extended-matching questions (EMQs). There are hundreds of questions for every major topic of the written examination, including critical care medicine, cardiology, infectious diseases, immunology and allergy, neurology, and pharmacology.More than a simple practice exam, this guide provides clear and complete explanations of each answer, a mini-review of the subject, and links to the most recent or relevant articles on the topic. Complementing the main body of questions are a number of 'teaching' and two-step questions--designed to strengthen clinical reasoning skills, highlight important issues, and expand knowledge of contemporary 'hot' topics. Written by an experienced team of physicians and educators, this must-have book:* Provides a thorough review of the latest FRACP basic training syllabus* Features QR codes embedded in the text to enable quick access to all references* Offers tips, hints, advice, and examination strategies from previous candidates* Provides numerous questions grounded in clinically relevant cases* Covers of areas of medicine that are new, contemporary, and evolvingCovering both the 'Basic Sciences' and 'Clinical Practice' of the latest exam, Passing the FRACP Written Examination is an essential companion for FRACP candidates as well as those looking to refresh, improve, or update their knowledge of the FRACP syllabus.

A comprehensive collection of original essays by leading medical sociologists from around the world, fully updated to reflect contemporary research and global health issuesThe Wiley Blackwell Companion to Medical Sociology is an authoritative overview of the most recent research, major theoretical approaches, and central issues and debates within the field. Bringing together contributions from an international team of leading scholars, this wide-ranging volume summarizes significant new developments and discusses a broad range of globally-relevant topics. The Companion's twenty-eight chapters contain timely, theoretically-informed coverage of the coronavirus pandemic and emerging diseases, bioethics, healthcare delivery systems, health disparities associated with migration, social class, gender, and race. It also explores mental health, the family, religion, and many other real-world health concerns.The most up-to-date and comprehensive single-volume reference on the key concepts and contemporary issues in medical sociology, this book:* Presents thematically-organized essays by authors who are recognized experts in their fields* Features new chapters reflecting state-of-the-art research and contemporary issues relevant to global health* Covers vital topics such as current bioethical debates and the global effort to cope with the coronavirus pandemic* Discusses the important relationship between culture and health in a global context* Provide fresh perspectives on the sociology of the body, biomedicalization, health lifestyle theory, doctor-patient relations, and social capital and healthThe Wiley Blackwell Companion to Medical Sociology is essential reading for advanced undergraduate and graduate students in medical sociology, health studies, and health care, as well as for academics, researchers, and practitioners wanting to keep pace with new developments in the field.

Clinical Nursing Skills at a Glance is the must-have study and revision guide for pre-registration nursing students and newly qualified practitioners alike, providing a visual summary of the essential aspects of clinical nursing skills and procedures. The core platforms of professional practice applicable to nursing adults in a variety of clinical settings are emphasised throughout the text, including care planning, assessment, management, prioritisation and co-ordination of care.Designed to allow rapid reference to critical information, the book is divided into 12 sections organised around systems of the body, with each chapter describing a specific clinical skill. With high-quality images throughout, applications to practice, a review quiz, 'red flags' highlighting important aspects to consider in the clinical environment, and reflecting current NMC standards of proficiency for registered nurses, this new evidence-based guide:* Allows easy access to the necessary knowledge and skills required by nurses to provide quality care* Discusses general principles of care applicable to all, including verbal and non-verbal communication, record keeping, and admission and discharge procedures* Covers mandatory skills such as basic life support, infection control, and medicine management* Includes access to a companion website featuring interactive multiple-choice questions, case studies, and links to additional resourcesOffering superb illustrations, up-to-date information, and a reader-friendly approach, Clinical Nursing Skills at a Glance is an invaluable resource for pre-registration nursing students as well as newly qualified nurses, healthcare assistants, and allied healthcare professionals looking to expand their knowledge of nursing skills and procedures.

The revised Second Edition of Physical Evaluation and Treatment Planning in Dental Practice has been expanded to include information pertinent when considering comprehensive treatment planning for a wide variety of dental procedures. Written by internationally recognized specialists and discipline experts in their field, the Second Edition offers new chapters on dental and oral diseases and disorders, including insights and diagnostics for each category. Readers will learn about diagnosis and planning considerations for orofacial pain, caries, periodontics, oral surgery, endodontics, restorative, prosthodontics and esthetic dentistry, and more.Beginning with a complete introduction of oral health and associated systemic health, the book incorporates discussions of patient history profiles, basic procedures in physical examinations, including examination of the head, neck, extraoral and intraoral tissues, radiographic examination and interpretation, as well as laboratory methods. Readers will also find:* A thorough introduction to the orofacial clinical processes, including the essential phases in treatment, quality management, patient-doctor communication, documentation, and management of critical patient information.* An exploration of basic procedures in physical examinations in dentistry, including inspection, palpation, percussion, auscultation, olfaction, and evaluation of function, form, and detailed analysis.* A thorough review of the head and neck complex.* An analysis of the examination and diagnosis of the intraoral and extraoral features, including all hard and soft tissues of the orofacial complex.Designed for general dental practitioners, periodontists, prosthodontists, dental residents and fellows, and dental students, Physical Evaluation and Treatment Planning in Dental Practice is a logically organized one-stop reference for patient evaluation and treatment.

Seit der Veröffentlichung der ersten Ausgabe von Infectious Disease Management in Animal Shelters 2009 haben Forschung und Praxis im Bereich der Tierheimmedizin beträchtliche Fortschritte gemacht. Diese aktualisierte zweite Auflage des bahnbrechenden Werks bildet den aktuellsten und umfassendsten Leitfaden in Bezug auf Vorbeugung von, Umgang mit und Behandlung von Infektionskrankheiten bei Katzen, Hunden und exotischen Kleinsäugern in Tierheimen.Über das gesamte Buch hinweg gelingt es den Autoren ? ausgewiesenen Experten auf dem Gebiet ? eine Brücke zwischen der medizinischen Behandlung (von Einzeltieren und Gruppen) und dem Umgang mit den Krankheiten zu schlagen. Das Werk enthält zahlreiche praktische Strategien, die auf den neuesten Ergebnissen der Forschung und der evidenzbasierten Medizin sowie auf der persönlichen Erfahrung der Autoren in diesem Bereich beruhen. Neben Strategien zur Vorbeugung von Krankheiten und zur Eindämmung ihrer Ausbreitung bietet das Buch auch praktische Informationen rund um die Behandlung und führt Faktoren auf, die bei der Adoption zu berücksichtigen sind. Dieser wichtige Band:* Ist das einzige Buch, das sich ausschließlich mit der Behandlung von Infektionskrankheiten in Tierheimen beschäftigt* Enthält Richtlinien für den allgemeinen Umgang mit Krankheiten bei Katzen und Hunden sowie zur Vorbeugung und Kontrolle der Krankheiten* Basiert auf den zentralen Grundsätzen der Tierheimmedizin in Bezug auf eine tierfreundliche Populationskontrolle unter Berücksichtigung der Ziele Einsatz für das Tierwohl, Rettung von Leben und Schutz der menschlichen Gesundheit* Enthält ein neues Kapitel über als Haustiere gehaltene exotische SäugetiereDie zweite Ausgabe von Infectious Disease Management in Animal Shelters richtet sich an Tierärzte, Tierheimleitungen und Mitarbeiter in Tierheimen und ist das einzige Werk, das sich ausschließlich mit Infektionskrankheiten in Tierheimen befasst, wobei die Betreuung von Einzeltieren mit einer einzigartigen Sicht auf die Herdengesundheit verbunden wird.

Auf internationaler Ebene, so seitens politischer Entscheidungsträger, Klinikern und Ärzten, Graduierten und Laien, wächst das Interesse an der Bindungstheorie. Dennoch werden die Publikationen führender Forscher und auch wichtige theoretische und empirische Abhandlungen häufig kaum gelesen oder verstanden. Grundsatztexte sind nicht direkt zugänglich. Die Theorie wird häufig missverstanden, auch von Praktikern in ihrer täglichen Arbeit. Hinzu kommt, dass die Bindungstheorie mitunter falsch angewandt wird. Zurückzuführen ist dies teilweise auf den Umstand, dass Grundsatztexte in Zeitschriften erscheinen, die nicht frei zugänglich ist, oder in Büchern veröffentlicht werden, die Klinikern und interessierten Lesern nicht präsent oder die zu teuer sind. Dieses Buch soll zum einen prägnant und zugänglich sein, zum anderen die Bindungstheorie auf interessante Weise, aktuell und mit all ihren Facetten präsentieren. Es enthält Nachdrucke sorgfältig ausgewählter Buchkapitel und Zeitungsartikel sowie bislang unveröffentlichtes Material des Begründers der Bindungstheorie.

TRANSCATHETER MITRAL VALVE THERAPIES An essential survey of the advancing field of transcatheter mitral valve repair and replacementMinimally invasive transcatheter therapies have revolutionized the treatment of structural heart disease. Greatly improving outcomes for higher-risk patients, transcatheter aortic valve replacement is now established as a safe and effective alternative to invasive surgery. The mitral valve, however, poses further challenges. Contending with one of the heat s most anatomically and pathologically complex components, practitioners and engineers have yet to perfect a stream-lined, widely deliverable therapy though they are getting closer and closer to this goal.Transcatheter Mitral Valve Therapies provides a far-reaching survey of the field of mitral interventions in its current state. Highlighting the stumbling blocks preventing transcatheter mitral valve replacement s widespread adoption, the book s international group of contributors discuss the improvements to be made in repair and replacement procedures, as well as the adjunctive use of imaging and pharmacologic therapies. This ground-breaking text:Provides detailed explanations of transcatheter repair, transcatheter replacement, and adjunctive proceduresFeatures chapters on the use of imaging to aid in patient selection, procedure planning, and intra-operative guidanceDiscusses the importance of minimally invasive approaches for mitral valve repairExamines anticoagulation following transcatheter mitral valve interventionsOutlines the possible future of transcatheter mitral valve therapyTranscatheter Mitral Valve Therapies is an important, up-to-date resource for interventional cardiologists, as well as all clinical researchers and practitioners seeking information on this vital and developing treatment.

Blood and Marrow Transplantation Long Term ManagementHematopoietic cell transplantation (HCT) provides curative therapy for a variety of diseases. Over the past several decades, significant advances have been made in the field of HCT, to the point where HCT has become an integral part of treatment modality for a variety of hematologic malignancies and some nonmalignant diseases. HCT remains an important treatment option for a wide variety of hematologic and nonhematologic disorders, despite recent advances in the field of immunologic therapies. Factors driving this growth include expanded disease indications, greater donor options (expanding unrelated donor registries and haploidentical HCT), and accommodation of older and less fit recipients.The development of less toxic pretransplant conditioning regimens, more effective prophylaxis of graft-versus-host disease (GVHD), improved infection control, and other advances in transplant technology have resulted in a rapidly growing number of transplant recipients surviving long-term free of the disease for which they were transplanted. The changes over decades in the transplant recipient population and in the practice of HCT will have almost inevitably altered the composition of the long-term survivor population over time. Apart from an increasingly older transplant recipient cohort, the pattern of transplant indications has shifted from the 1990s when chronic myeloid leukemia made up a significant proportion of allo-HCT indications. Changes in cell source, donor types, conditioning regimens, GVHD prophylaxis, and supportive care have all occurred, with ongoing reductions in both relapse and non-relapse mortality (NRM) have been demonstrated.These patients have increased risks for a variety of late complications, which can cause morbidity and mortality. Most long-term survivors return to the care of their local hematologists/oncologists or primary care physicians, who may not be familiar with specialized monitoring and management of long complications after HCT for this patient population. As HCT survivorship increases, the focus of care has shifted to the identification and treatment of long-term complications that may affect quality of life and long-term morbidity and mortality.Preventive care as well as early detection and treatments are important aspects to reducing morbidity and mortality in long-term survivors after allo-HCT. This second edition, Blood and Marrow Transplantation Long Term Management: Survivorship after Transplant, provides up-to-date information about diagnosis, screening, treatment, and long-term surveillance of long-term survivors after HCT.

FRESHNEY'S CULTURE OF ANIMAL CELLSTHE NEW EDITION OF THE LEADING TEXT ON THE BASIC METHODOLOGY OF CELL CULTURE, FULLY UPDATED TO REFLECT NEW APPLICATIONS INCLUDING IPSCS, CRISPR, AND ORGAN-ON-CHIP TECHNOLOGIESFreshney's Culture of Animal Cells is the most comprehensive and up-to-date resource on the principles, techniques, equipment, and applications in the field of cell and tissue culture. Explaining both how to do tissue culture and why a technique is done in a particular way, this classic text covers the biology of cultured cells, how to select media and substrates, regulatory requirements, laboratory protocols, aseptic technique, experimental manipulation of animal cells, and much more.The eighth edition contains extensively revised material that reflects the latest techniques and emerging applications in cell culture, such as the use of CRISPR/Cas9 for gene editing and the adoption of chemically defined conditions for stem cell culture. A brand-new chapter examines the origin and evolution of cell lines, joined by a dedicated chapter on irreproducible research, its causes, and the importance of reproducibility and good cell culture practice. Throughout the book, updated chapters and protocols cover topics including live-cell imaging, 3D culture, scale-up and automation, microfluidics, high-throughput screening, and toxicity testing. This landmark text:* Provides comprehensive single-volume coverage of basic skills and protocols, specialized techniques and applications, and new and emerging developments in the field* Covers every essential area of animal cell culture, including lab design, disaster and contingency planning, safety, bioethics, media preparation, primary culture, mycoplasma and authentication testing, cell line characterization and cryopreservation, training, and troubleshooting* Features a wealth of new content including protocols for gene delivery, iPSC generation and culture, and tumor spheroid formation* Includes an updated and expanded companion website containing figures, artwork, and supplementary protocols to download and printThe eighth edition of Freshney's Culture of Animal Cells is an indispensable volume for anyone involved in the field, including undergraduate and graduate students, clinical and biopharmaceutical researchers, bioengineers, academic research scientists, and managers, technicians, and trainees working in cell biology, molecular biology, and genetics laboratories.

Die vollständig überarbeitete 2. Auflage dieses Lehrbuchs spiegelt die Leitlinien des Curriculums angehender Pflegekräfte wider und enthält ein neues Kapitel zu Wachstum und Entwicklung von Kindern und Jugendlichen. Darüber hinaus werden u. a. soziale, politische und Umwelteinflüsse auf die Gesundheit und das Wohlergehen von Kindern betrachtet. Problem- und Fragenstellungen wurden aktualisiert. Jedes Kapitel bietet eine Vielzahl wirkungsvoller pädagogischer Handreichungen, darunter Lernziele, klinische Betrachtungen, Körperschemata und Fragen zur Selbstüberprüfung des Lernstoffes. Dieses führende Lehrbuch, das Studenten darauf vorbereitet, in ihrem zukünftigen Arbeitsalltag Kinder und Jugendliche wirkungsvoll zu betreuen,- beschäftigt sich mit den anatomischen und physiologischen Veränderungen mit Auswirkungen auf den Gesundheitszustand.- legt den Schwerpunkt durchgängig auf die klinische Anwendung und verbindet Anatomie und Physiologie mit häufigen Gesundheitsstörungen bei Kindern.- folgt einem strukturieren und umfassenden Ansatz in Zusammenhang mit den theoretischen Grundlagen der Anatomie und Physiologie bei Kindern und bereitet die Studenten auf die Praxis vor.- bietet zusätzliche Online-Materialien, wie Multiple-Choice-Fragen, interaktive Flashcards, durchsuchbare Glossare und Literaturverweise.Fundamentals of Children and Young People's Anatomy and Physiology ist ein Muss für angehende Pflegekräfte und Studenten medizinischer Fachrichtungen und ein nützliches Referenzwerk für Pflegekräfte, Pflegehelfer, Gesundheitsassistenten und weitere Berufsgruppen aus dem Fachgebiet.

Neonatal HaematologyThis unique handbook contains comprehensive coverage of neonatal haematology and aids diagnosis via high-quality images, diagnostic algorithms, case studies, and tables. With illustrations accompanying the diagnosis at each stage and clear explanations provided throughout, the book is ideal for trainees and experts alike.Authored by two of the world's leading haematologists, Professor Irene Roberts and Professor Barbara Bain, this book provides a depth of knowledge that is unequalled in other texts. To aid in reader comprehension, it is neatly organised by clinical problems and covers sample topics such as:* Red cells: morphology, membrane, enzymes, and changes over the first 4 weeks of life* Haemolytic anaemias: causes of neonatal haemolysis, diagnostic clues, and immune haemolysis (haemolytic disease of the newborn)* Neonatal anaemia due to blood loss: causes of blood loss, diagnostic clues, feto-maternal haemorrhage, and twin-to-twin transfusion* Haematological signs of neonatal infection: causes of neutrophil left shift, leucoerythroblastosis, and toxic granulationPaediatric haematologists, consultant haematologists, and trainees in haematology can use the succinct, well-written content in this book as a useful helping hand during consultation. Biomedical scientists will also value the work as a laboratory reference.

Presenting the correspondence of The Brodricks, who originated in Surrey and established themselves in Ireland, in County Cork, in the mid-17th century, and were among the most important Anglo-Irish political families in the reigns of the later Stuarts and early Hanoverians.* Comprises letters between Alan Brodrick (1656-1728) and his brother Thomas (1654-1730) who emerged as leading figures in the Irish parliament, at the forefront of a political interest which associated itself with the whig party in England* Includes correspondence with other members of their immediate family, providing a wealth of detailed commentary on political events in Ireland and England, both national and local* A collection largely untouched by historians until deposited with the Surrey Record Office (now the Surrey History Centre) in the 1970s, when its enormous value came to be appreciated by researchers seeking to understand Irish political history in the decades following the Glorious Revolution* Covers the immediate aftermath of the Hanoverian succession, with the establishment of a 'whig ascendancy' in Ireland and the growing divisions between whig factions in both Ireland and England* The crisis over the South Sea Bubble also forms a major theme, with Thomas Brodrick achieving national prominence in Britain as the chairman of the parliamentary committee of inquiry into alleged ministerial corruption

AN INTRODUCTION TO BEHAVIOR ANALYSISExplore a fascinating introductory treatment of the principles of behavior analysis written by three leading voices in the fieldAn Introduction to Behavior Analysis delivers an engaging and comprehensive introduction to the concepts and applications for graduate students of behavior analysis. Written from the ground up to capture and hold student interest, the book keeps its focus on practical issues.The book offers readers sound analyses of Pavlovian and operant learning, reinforcement and punishment, motivation and stimulus control, language and rule-following, decision-making and clinical behavior analysis. With fully up to date empirical research references and theoretical content, An Introduction to Behavior Analysis thoroughly justifies every principle it describes with empirical support and explicitly points out where more data are required.The text encourages students to analyze their own experiences and some foundational findings in the field in a way that minimizes jargon and maximizes engagement. Readers will also benefit from the inclusion of:* A clear articulation and defense of the philosophical assumptions and overarching goals of behavior analysis.* A thorough description of objective data collection, experimental methods, and data analysis in the context of psychology* An exploration of the core principles of behavior analysis, presented at a level comprehensible to an introductory audience* A broad array of principles that cover issues as varied as language, substance-use disorders, and common psychological disordersPerfect for students taking their first course in behavior analysis or behavior modification, An Introduction to Behavior Analysis will also earn a place in the libraries of students pursuing certification through the Behavior Analysis Certification Board or taking courses in the applied psychological sciences.