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Provides a timely update to a key textbook on human drug metabolismThe third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact.Human Drug Metabolism, 3rd Edition begins by covering basic concepts such as clearance and bioavailability, and looks at the evolution of biotransformation, and how drugs fit into this carefully managed biological environment. More information on how cytochrome P450s function and how they are modulated at the sub-cellular level is offered in this new edition. The book also introduces helpful concepts for those struggling with the relationship of pharmacology to physiology, as well as the inhibition of biotransformational activity. Recent advances in knowledge of a number of other metabolizing systems are covered, including glucuronidation and sulphation, along with the main drug transporters. Also, themes from the last edition are developed in an attempt to chart the progress of personalized medicine from concepts towards practical inclusion in routine therapeutics. The last chapter focuses on our understanding of how and why drugs injure us, both in predictable and unpredictable ways. Appendix A highlights some practical approaches employed in both drug metabolism research and drug discovery, whilst Appendix B outlines the metabolism of some drugs of abuse. Appendix C advises on formal examination preparation and Appendix D lists some substrates, inducers and inhibitors of the major human cytochrome P450s.* Fully updated to reflect advances in the scientific field of drug metabolism and its clinical impact* Reflects refinements in the author's teaching method, particularly with respect to helping students understand biological systems and how they operate* Illustrates the growing relationship between drug metabolism and personalized medicine* Includes recent developments in drug discovery, genomics, and stem cell technologiesHuman Drug Metabolism, 3rd Edition is an excellent book for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology. It will also appeal to professionals interested in an introduction to this field, or who want to learn more about these bench-to-bedside topics to apply it to their practice.

Presents comprehensive coverage of the many microvascular complications of diabetesDiabetes remains one of the main causes, in the western world, of legal blindness, end stage renal disease, and amputation, despite the implementation of tight glycemic control and the great progress in the management and care of our patients. This book provides a useful and handy tool to professionals and students in the field of diabetes and its microvascular complications by integrating information from clinical settings as well as from the frontlines of diabetic research. It provides readers with up-to-date diagnostic criteria, classifications, and therapeutic approaches. and recent discoveries on mechanisms of disease, experimental therapeutic agents, and biomarkers of disease.Written by top experts in the field, Microvascular Disease in Diabetes offers in-depth chapters covering pathophysiology; the genetics of diabetic microvascular disease; and the epigenetics of diabetic microvascular disease. It then provides sections featuring both clinical and research information on diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, and diabetic foot. It also looks at coronary microvascular dysfunction and cerebral microvascular disease.* Integrates new and accessible material on diabetic microvascular comorbidities* Covers all relevant microvascular systems* Provides a much-needed resource synthesizing research and clinical applications to treating microvascular complications of diabetes* Presents current diagnostic criteria, classifications, and therapeutic approaches, as well as recent discoveries on the mechanisms of disease, experimental therapeutic agents, and biomarkers of diseaseAssembled in an easily consultable manner, Microvascular Disease in Diabetes is an excellent text for investigators, clinicians, and students looking to improve their understanding of diabetic complications.

"In this highly accessible new introductory textbook, Pete Woodcock examines the fundamental questions of political theory. He takes students step-by-step through the most important answers given by history's most famous thinkers to the most essential questions in politics, on topics ranging from liberty and justice to gender and revolution"--

Patrik Wikstrom illuminates the workings of the music industry, and captures the dynamics at work in the production of musical culture between the transnational media conglomerates, the independent music companies and the public.

The definitive reference text on curation both inside and outside the museumA Companion to Curation is the first collection of its kind, assembling the knowledge and experience of prominent curators, artists, art historians, scholars, and theorists in one comprehensive volume. Part of the Blackwell Companion series, this much-needed book provides up-to-date information and valuable insights on the field of curatorial studies and curation in the visual arts. Accessible and engaging chapters cover diverse, contemporary methods of curation, its origin and history, current and emerging approaches within the profession, and more.This timely publication fills a significant gap in literature on the role of the curator, the art and science of curating, and the historical arc of the field from the 17th century to the present. The Companion explores topics such as global developments in contemporary indigenous art, Asian and Chinese art since the 1980s, feminist and queer feminist curatorial practices, and new curatorial strategies beyond the museum. This unique volume:* Offers readers a wide range of perspectives on curating in both theory and practice* Includes coverage of curation outside of the Eurocentric and Anglosphere art worlds* Presents clear and comprehensible information valuable for specialists and novices alike* Discusses the movements, models, people and politics of curating* Provides guidance on curating in a globalized worldBroad in scope and detailed in content, A Companion to Curation is an essential text for professionals engaged in varied forms of curation, teachers and students of museum studies, and readers interested in the workings of the art world, museums, benefactors, and curators.

In-depth scholarship on the central artists, movements, and themes of Latin American art, from the Mexican revolution to the presentA Companion to Modern and Contemporary Latin American and Latinx Art consists of over 30 never-before-published essays on the crucial historical and theoretical issues that have framed our understanding of art in Latin America. This book has a uniquely inclusive focus that includes both Spanish-speaking Caribbean and contemporary Latinx art in the United States. Influential critics of the 20th century are also covered, with an emphasis on their effect on the development of artistic movements.By providing in-depth explorations of central artists and issues, alongside cross-references to illustrations in major textbooks, this volume provides an excellent complement to wider surveys of Latin American and Latinx art. Readers will engage with the latest scholarship on each of five distinct historical periods, plus broader theoretical and historical trends that continue to influence how we understand Latinx, Indigenous, and Latin American art today. The book's areas of focus include:* The development of avant-garde art in the urban centers of Latin America from 1910-1945* The rise of abstraction during the Cold War and the internationalization of Latin American art from 1945-1959* The influence of the political upheavals of the 1960s on art and art theory in Latin America* The rise of conceptual art as a response to dictatorship and social violence in the 1970s and 1980s* The contemporary era of neoliberalism and globalization in Latin American and Latino Art, 1990-2010With its comprehensive approach and informative structure, A Companion to Modern and Contemporary Latin American and Latinx Art is an excellent resource for advanced students in Latin American culture and art. It is also a valuable reference for aspiring scholars in the field.

Are personal relationships deeper and more intimate than ever before or are they increasingly empty and structured by selfish individualism? This exciting new book examines the question in a wide--ranging discussion of the nature of intimacy, focusing on key relationships between parents and children, families, sexual partners, couples and friends.

"Among the most significant changes affecting journalism is the emergence of startup culture. Through case studies of journalism startups, this book provides insight into the promises and pitfalls of media entrepreneurship, ultimately recognizing new voices as legitimate participants in the discourse about what journalism is, can be and should be"--

PROVIDES AN IN-DEPTH LOOK AT SCIENCE, POLICY AND MANAGEMENT IN THE WATER SECTOR ACROSS THE GLOBE Sustainable water management is an increasingly complex challenge and policy priority facing global society. This book examines how governments, municipalities, corporations, and individuals find sustainable water management pathways across competing priorities of water for ecosystems, food, energy, economic growth and human consumption. It looks at the current politics and economics behind the management of our freshwater ecosystems and infrastructure and offers insightful essays that help stimulate more intense and informed debate about the subject and its need for local and international cooperation. This book celebrates the 15-year anniversary of Oxford University's MSc course in Water Science, Policy and Management. Edited and written by some of the leading minds in the field, writing alongside alumni from the course, Water Science, Policy, and Management: A Global Challenge offers in-depth chapters in three parts: Science; Policy; and Management. Topics cover: hydroclimatic extremes and climate change; the past, present, and future of groundwater resources; water quality modelling, monitoring, and management; and challenges for freshwater ecosystems. The book presents critical views on the monitoring and modelling of hydrological processes; the rural water policy in Africa and Asia; the political economy of wastewater in Europe; drought policy management and water allocation. It also examines the financing of water infrastructure; the value of wastewater; water resource planning; sustainable urban water supply and the human right to water. Features perspectives from some of the world's leading experts on water policy and management Identifies and addresses current and future water sector challenges Charts water policy trends across a rapidly evolving set of challenges in a variety of global areas Covers the reallocation of water; policy process of risk management; the future of the world's water under global environmental change; and more Water Science, Policy, and Management: A Global Challenge is an essential book for policy makers and government agencies involved in water management, and for undergraduate and postgraduate students studying water science, governance, and policy.

This 4th edition of Yamada's Handbook of Gastroenterology provides a portable, well-illustrated, rapid access handbook for gastroenterologists of all levels, perfect for quick and easy use while on the wards.Divided into 2 parts -- part 1 being symptom-focused and part 2 disease-focused, it gives 100% clinical assessment and practical management advice for the entire range of GI symptoms, complaints and conditions that patients present with. Every symptom you're likely to encounter is covered, every condition assessed.

"As people use self-tracking devices and other digital technologies, they generate increasing quantities of personal information online. Lupton develops a fresh and intriguing perspective on how people make sense of and use their personal data, and what they know about others who use this information"--

"This book argues that, as industrial capitalism enters a period of prolonged crisis, a new paradigm of "industrious modernity" is emerging. Based on small-scale, commons-based and market-oriented entrepreneurship, this industrious modernity is being pioneered by the many outcasts that no longer find a place within a crumbling industrial modernity"--

"Many of us wonder what we could possibly do to end oppression, exploitation, and injustice. This is the first book dedicated to prefigurative politics: a must-read both for students of radical politics, anarchism and social movements, as well as activists and concerned people everywhere"--

First published in German as Nach Gott: Glaubens- und Unglaubensversuche, Suhrkamp Verlag 2017.

"Communication and artificial intelligence (AI) are closely related. The first work of its kind, this timely textbook provides educators and students with a much-needed resource, connecting the dots between the science of AI and the discipline of communication studies"--

"The original - and often continuing - sin of countries with a settler colonial past is their brutal treatment of indigenous peoples. Duncan Ivison's book considers how these states can accommodate indigenous populations today, and contends that we need to move towards a historically and theoretically nuanced liberalism better suited to our times"--

This new edition of Language and Gender has been thoroughly revised and updated, including the addition of entirely new chapters that explore recent work in the field. A range of approaches is covered at an introductory level, presenting sometimes difficult and complex issues in an understandable way.

"Few economic phenomena provoke as much confusion as money. In this accessible book, Geoffrey Ingham cuts through this tangled web of debate to examine the fundamental debate over the nature of money and trace the import of these competing views for how we understand our contemporary monetary systems"--

"In this comprehensive introduction, Spencer presents a new story of the origins and development of American Pragmatism, from its emergence through the interaction of European and Indigenous American cultures to its contemporary status as a diverse, vibrant, and contested global philosophy. This is an indispensable guide for undergraduate students"--

"In a world of increasingly heated political debates on migration, this book radically shifts the focus to address migration through the lens of inequality. Mirna Safi shows migration to be a mechanism of inequality and shows how studying international migration can challenge current limited, nationally established paradigms of social justice"--

"The declaration of equal rights arguably created the modern political community. But this act of empowering individuals caused the disempowering of the political community. Exposing this, Menke opens up a new way of understanding rights that no longer involves the disempowering of the political community"--

"Tim Jordan deftly explores the workings of the trillion-dollar digital economy. He discusses the hype and significance surrounding its activities and practices in order to outline important concepts, theory, and policy questions. Rich with case studies, the book is an important reference for those getting to grips with this contemporary phenomenon"--

THIS VALUABLE TEXT INCLUDES REFLECTIONS AND PRACTICAL SUPPORT THAT WILL EQUIP PROFESSIONALS TO CONFIDENTLY HANDLE THE CHALLENGES INHERENT TO LEADERSHIP IN THE FIELD FOR DECADES TO COME Written by experienced educational psychologists (EPs) for other EPs in leadership positions and those aspiring to become leaders, this unique and practical book addresses a number of themes including the debate over the nature of leadership and the growing concern for equity and ethics in practice. Emphasising the importance of building and maintaining relationships at all levels, especially during challenging times, this text: Meets a need to support new and existing educational psychologists (EPs) in understanding a range of leadership models Provides useful frameworks to apply to the Local Authority contexts where leaders are working Offers chapters that can be read independently as stand-alone topics or in sequential order Is derived from decades of courses for leaders of educational psychology Leadership for Educational Psychologists: Principles & Practicalities offers chapters covering such topics as: managing educational psychology services (EPSs); past and present leadership frameworks; ethical leadership; change management; women in leadership; inspirational and outward-facing leadership; educational psychology within a Welsh context; appreciative enquiry; recruitment and retention; managing data and quality standards; selling educational psychology services; and more. The book finishes with a section on available support mechanisms for EPs in leadership positions. Leadership for Educational Psychologists will be of great benefit to educational psychologists in leadership, including existing principal and senior educational psychologists, as well as those planning to move into promoted posts within EPSs. It will also be of interest to policymakers in local government, public sector leaders who manage professionals within local authorities, and voluntary and community organisations.