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A timely primer on the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery.

Thirty-eight years after its introduction, affinity chromatography remains a key tool in the armory of separation techniques available to separation and interaction scientists.

This guide to the role of forensic anthropology in investigating fatal cases of child abuse will prove an essential resource in a contentious area of pathology. It illustrates the material with photographs from real-life investigations in Harris County, USA.

Diseases of the pancreas have been extremely difficult to study. The ch- ters have been organized to provide a comprehensive discussion of acute and chronic pancreatitis, with up-to-date discussions of pat- physiology, epidemiology, diagnostic strategies, treatment, and c- plications of disease.

The authors examine in detail the mechanisms of hypertension in the elderly, the lifestyle trials and outcomes trials that were conducted in older persons, as well as the problems of clinical evaluation, secondary hypertension, adherence, and target organ damage.

Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.

This timely edition of Cancer Cell Culture: Methods and Protocols covers the basic concepts of cancer cell biology and culture while expanding upon the recent shift in cell culture methods from the generation of new cell lines to the use of primary cells.

Male Sexual Function: A Guide to Clinical Management, Second Edition is a comp- hensive overview of the field of male sexual function and includes a chapter on female sexual dysfunction, an emerging field with a very high incidence in the population and an ever-growing following.

A collection of readily reproducible classic and emerging molecular methods for the laboratory isolation and identification of the pathogens, viruses, and parasites that cause food-borne disease. Among the pathogens covered are specific bacteria, including Salmonella spp, Campylobacter spp., Listeria spp., and Bacillus spp.;

Hands-on researchers review the principles behind successful miniaturization and describe the key techniques for miniaturizing large-scale biochemical and bioanalytical methods for microchip analysis.

A comprehensive survey by leading basic and clinical researchers of the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling.

A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS.

An authoritative collection of optimal techniques for producing and characterizing the immunologically active cells and effector molecules now gaining wide use in the clinical treatment of patients.

A comprehensive and practice-oriented resource guide to currently available diagnostic and treatment options for male infertility disorders.

Wilson (biology, Winona State University) and Temple (Athabasca University, Canada) present work by contributors from universities, research institutions, industry, and public advocacy and health care organizations, reviewing how beverages affect health and nutrition. Contributors discuss the health

The authors examine in detail the mechanisms of hypertension in the elderly, the lifestyle trials and outcomes trials that were conducted in older persons, as well as the problems of clinical evaluation, secondary hypertension, adherence, and target organ damage.

Shoulder Dystocia and Birth Injury: Prevention and Treatment, Third Edition, supplements the limits of personal experience with the accumulated experience of many talented clinicians. It contains the latest causation theories and reviews of the literature.

The author provides today's most current information covering the four categories of prostatitis. An international group of contributors including urologists, scientists, psychologists, and pain specialists offer the reader new approaches to helping patients.

Based on the GABAergic nature of these neurons and their synaptic contacts with other spiny neurons, several authors have proposed that the spiny projection neurons form a lateral inhibition type of neural network [3-5].

Elizabeth Rakcozy and a team of leading clinical and experimental scientists describe in step-by-step detail the key techniques essential to effective molecular biological research in ophthalmology and optometry.

In this updated handbook, a panel of well known and highly experienced geriatric physicians and infectious disease experts review the most important common infections affecting the elderly and delineate their well-proven techniques.

The frequency of reports concemmg the interface of biological reco- tion elements to signal transduction technologies has risen dramatically over the last decade. 7: Affinity Biosensors: Techniques and Protocols, describes a variety of classical and emerging transduction technologies that have been interfaced to bioaffinity elements (e.

Helicobacter pylori Protocols offers an outstanding collection of state-of-the-art protocols for the identification and molecular manipulation of H. pylori, for the isolation and restriction endonuclease digestion of H. pylori chromosomal DNA, and for the transformation and insertional mutagenesis of H.

Easy-to-use and up-to-date, Methods in Plant Electron Microscopy and Cytochemistry offers today's plant scientists a first class collection of readily reproducible light and electron microscopical methods that will prove the new standard for all working in the field.

This pocket guide is designed to help the primary care practitioner recognize, diagnose, and manage anxiety disorders in a busy clinical practice. The guide includes helpful chapters on psychopharmacology, psychopharmacotherapy, and psychologic treatment for the anxiety disorders.

The authors focus on each of the major psychiatric illnesses, including depression, anxiety disorder, bipolar disorder, schizophrenia, substance abuse, eating disorders, and mental illness, as well as on the potential impact of these illnesses on infants and children.

A compendium of scientific research on constructing a criminal profile for crimes that are not readily resolvable by conventional police investigative methods. It utilizes a distinct approach referred to as Crime Action Profiling (CAP), a technique that has its foundations in the disciplinary knowledge of forensic psychology.

The original edition of this text, Clinical Evaluation of Medical Devices: Principles and Case Studies, provided the first overview of key pr- ciples and approaches to medical device clinical trials, illustrated with a series of detailed, real-world case studies.

This innovative book addresses what has been missing in existing text books and ethics courses to date: clear-cut ethical and legal guidelines essential to the everyday practice of medicine. Ethical dilemmas are enlivened with age, gender and culture issues.

This book introduces the reader to the basic principles of handwriting and the factors that affect their development. The book discusses the basic concept of the characteristics of writing that are compared when making an identification or elimination of a writer.