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This Methods in Molecular Biology(TM) volume offers detailed protocols, with theoretical background, and step-by-step instructions on implementing synchronization, as well as current techniques for the enhanced study of regulatory mechanisms in cell cycle events.

Animal models of schizophrenia and other major psychiatric disorders have been sought for decades and we now face new vistas on pathophysiology. Covering the key areas of research, this book explores the use of animal models in this difficult area of study.

In this book, researchers update the classic methods and introduce new approaches that go beyond basic conjugation techniques. There is emphasis on the interplay of organic synthesis, molecular biology, surface biotechnology and biomaterials engineering.

Non-coding, inhibitory microRNAs have emerged as important modulators of cellular gene expression, through a process called RNA interference (RNAi).

The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection.

With the introduction of cardiac surgery more than five decades ago and the use of the heart-lung machine for open heart surgical procedures granting the surgeon unlimited time in which to operate inside the heart, a complex task has been given to the Perfusionist.

Comprehensive Cardiovascular Medicine in the Primary Care Setting provides an authoritative, detailed discussion of cardiovascular disease balanced with practical utility.

Protein misfolding is a key feature of many disorders in humans, given that over twenty proteins are known to misfold and cause disease.

Human Embryonic and Induced Pluripotent Stem Cells presents a comprehensive collection of protocols developed by leading scientists in the field. It contains practical laboratory guidance to promote successful results.

Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume provides readers with a comprehensive understanding of this important and evolving field.

This sixth volume of reviews in forensic pathology provides professionals working in the field with cutting-edge material on the latest key advances in the fields of traumatic death, sudden natural death and death time estimation.

Research into the field of stem cell biology has developed exponentially over recent years, and is beginning to offer significant promise for unravelling the molecular basis of a multitude of disease states.

This book presents a cutting-edge, in-depth investigation into new methods of health promotion. It is one of the first books to focus on the role of omega-3 polyunsaturated fatty acids in unhealthy diets. The book also contains reviews of the economic benefits of novel health promotion and disease prevention methods.

Horizontal gene transfer (HGT) events encompass processes as varied as the exchange of genetic material between microbes coexisting in the same environment, between symbiotic bacteria and their eukaryotic hosts, and the evolution of organelles by symbiosis, in which whole genomes are acquired.

Part VIII probes psychosocial and cultural factors affecting judgment and decisions about translational stem cell research, and Part IX explores problems and procedures raised by an examination of the evaluation of stem cell research projects in research ethics committees.

Nutrition Guide for Physicians is a desktop reference guide on nutrition and its clinical implications for health and disease through the lifecycle.

This volume serves as a manual to providers about the multidisciplinary nature of cardiac rehabilitation in the current era, the current state of cardiac rehabilitation, and the issues presenting to current CR programs.

Suitable for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. This book covers various findings relevant to cellular and molecular functions of polyamines. It also provides the underlying conceptual basis and knowledge regarding potential therapeutic targeting polyamines and polyamine metabolism.

Additional chapters describe cutting-edge noninvasive angiography and vascular flow studies, specific drug therapy for claudication, regression of atherosclerosis therapy, gene therapy, and drug eluting stents for peripheral arterial disease.

This book details current trends and state-of-the-art in cell and gene based therapies. Examples from various organs and diseases illustrate the potential benefit obtained when both therapeutic approaches are combined with delivery strategies.

A distinguished panel of world authorities reviews the current state of today's understanding, diagnosis, and treatment of pancreatic cancer.

A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors.

Cardiac Markers is a comprehensive, up-to-date summary of clinical information on serum cardiac markers for coronary artery disease. Anyone who needs to know how to examine, diagnose, treat, and manage patients with acute chest pain and heart attacks will find this book indispensable.

Authoritative and practical, this important new book not only spells out the advantages and limitations of the latest diagnostic tests, but also provides numerous algorithms for evaluating patients and treating the liver problems commonly encountered by primary care physicians.

Those who do not feel pain seldom think that it is felt. Our purpose in preparing The Pain Management Handbook is to provide the informa tion needed by clinicians to develop strategies that optimize pain management.

Authoritative experts in transfusion medicine describe in critical detail the most important procedures for obtaining, selecting, and transfusing red blood cells to patients.

The authoritative experts writing here explore the mechanistic aspects of such autoimmune diseases as lupus, rheumatoid arthritis, diabetes, and autoimmune thyroid disease, and where possible delineate how malfunctioning immunological mechanisms can lead to clinical symptoms.

This challenge is particularly difficult to meet in osteoporosis, not only because has been so much new knowledge generated in recent years, but also because this there disorder has not caught the attention of many practicing physicians.

In the four pages committed to a discussion of myocardial infarction in the first edition of Harrison's Principles of Internal Medicine, published in 1950, there was no mention of use of the laboratory for management of patients.