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Methods in Enzymology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology serials Updated release includes the latest information on Helicase Enzymes

Adoptive Cell Transfer, Volume 371 in the International Review of Cell and Molecular Biology series highlights advances in the field, with this new volume presenting interesting chapters written by an international board of authors who expound on topics such as the Impact of tumor microenvironment on Adoptive Cell Transfer activity, Dendritic Cell Transfer, CAR-T Cell dysfunction and exhaustion, NK Cell-based cancer immunotherapy, Enabling CAR-T cells for solid tumors: rage against the suppressive tumor microenvironment, Improving Adoptive T-Cell therapy with cytokines administration, and What will (and should) be improved in Immunotherapy with CAR? Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists and drawn from international sources Offers a wide range of perspectives on specific subjects

Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Vitamins and Hormones serials Updated release includes the latest information on Parathyroid Hormone

Advances in Virus Research serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Advances in Virus Research serials

Advances in Applied Microbiology, Volume 119 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topics of microbiology. Contains contributions from leading authorities in the field Informs and updates on the latest developments in the field of microbiology Includes discussions on the role of specific molecules in pathogen life stages, interactions, and much more

Advances in Agronomy, Volume 175, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors. Includes numerous, timely, state-of-the-art reviews on the latest advancements in agronomy Features distinguished, well recognized authors from around the world Builds upon this venerable and iconic review series Covers the extensive variety and breadth of subject matter in the crop and soil sciences

Advances in Immunology, Volume 154, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology, with this volume covering Regulatory T Cells in Infection and Factor H and Properdin and their regulation. Presents current developments and comprehensive reviews in immunology Provides the latest in a longstanding and respected serial on the subject matter

Brillouin Scattering, Part Two, Volume 110 in the Semiconductors and Semimetal series, marks the centenary of Leon Brillouin''s seminal 1922 paper which provided a detailed theory on the effect that now bears his name. Sections in this new release include Optical Fiber Sensors Based on Stimulated Brillouin scattering, Brillouin-based RF frequency sources, SBS for Microwave Photonics (MWP), Engineerable Brillouin processes for integrated photonics, SBS in optical communication systems - the good, the bad and the ugly, Slow light, dynamic gratings and light storage, Non-reciprocity in Brillouin scattering, Electromechanical Brillouin Scattering, and Brillouin light scattering for studying mechanics of biological systems. Stimulated Brillouin Scattering (SBS) is the strongest third order nonlinearity and plays an important role in contemporary science and applications, particularly lasers, communications, fiber optics and basic physics. This volume provides different perspectives on current technological contexts of SBS in a range of different application areas, including sensing, communications, radar, imaging and information storage. Presented by the leading researchers in the field Covers both scientific and technological perspectives Provides different perspectives on current technological contexts of SBS in a range of different application areas, including sensing, communications, radar, imaging and information storage

Handbook on the Physics and Chemistry of Rare Earths: Including Actinides, Volume 61 presents the latest release in this continuous series that covers all aspects of rare earth science, including chemistry, life sciences, materials science and physics. Presents up-to-date overviews and new developments in the field of rare earths, covering both their physics and chemistry Contains individual chapters that are comprehensive and broad, along with critical reviews Provides contributions from highly experienced, invited experts

Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies. Up-to date review of hepatobiliary cancers molecular genetics, novel predictive molecular biomarkers, and distinct mechanisms of inter-and intratumor heterogeneity Novel insights into the role of tumor microenvironment as a promoter of hepatobiliary cancer progression and therapeutic resistance, as well as an emerging therapeutic target Current and emerging approaches and strategies for advancing personalized molecular therapeutic targeting and immunotherapy of hepatobiliary cancers

International Review on Neurobiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in International Review on Neurobiology serials Updated release includes the latest information on Sex and Gender Differences in Neurological Disease

Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more. Additional section cover Atypical kinetics of cytochrome P450 enzymes in drug metabolism, Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, Use of engineered cytochrome P450s for accelerating drug discovery and development, Assessing cytochrome P450 function using genetically engineered mouse models, Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions, and much more. Research on many forms of P450s has been extended into different fields, from molecules to in vivo situations because pharmacologists and toxicologists appreciate and are attracted to the potential therapeutics. The purpose of this volume is to collect a comprehensive description of major progress to date, to discuss possible future directions, and to invite young researchers to join this important and exciting world of P450. Comprehensive coverage of major progress in the last 60 years on the P450 research in pharmacology and toxicology Discussion of possible future directions of the research on P450s, especially for improved pharmacotherapy in humans Encouragement to young scientists to join this important and exciting basic, translational, and advanced world of P450

This volume addresses key contemporary aspects in cycling policy, practice and research. Cycling has seen a sharp increase in scientific and policy attention in the past decade. The amount of research has surged over the past couple decades. Also, levels of cycling have increased substantially in many countries and cities, and many areas have seen increases in infrastructure investments. In addition, the last decade has seen innovations in bicycle technology, in particularly the rise of electric-assist (e-bikes) and dock-less bike sharing schemes. This volume reviews the state of the art on cycling from various angles. As such it explores planners'' (engineers'', policy makers'') provisions for cycling, of cyclists'' (and non-cyclists'') travel behaviour, and resulting consequences for individuals and society. One focus is on demand-side aspects, including the use of bicycles and their users including patterns and trends in cycling, determinants of cycling, and modelling of cycling. Another focus is on impacts of cycling, such as emissions, safety aspects, as well as changes during the COVID pandemic. Contemporary overview of key aspects in cycling research and bicycle planning A focus on design for cycling, behavior of cyclists and consequences of cycling

Power Generation Technologies: Foundations, Design and Advances provides a comprehensive introduction to the latest developments in renewable and non-renewable generation technologies considered at micro and large-scale, and for traditional facility scale and modern distributed power generation systems. Each chapter provides a foundation in the topic enriched with practical solved examples, end chapter exercises and technical references. Provided computer codes can be instrumentalized to investigate practical examples at a granular level. In addition to the fundamental and theoretical discussions, operational and maintenance guidelines for power equipment are provided to prepare students for work in power plants. The work provides new international standards and regulation for power generation as well as content devoted to the thermo-economics of power generation and power plants. It is supported by a solution manual for end-chapter exercises and a slide show presentation of the book for instructors and students.

Agricultural Soil Sustainability and Carbon Management presents long-term research in the field of sustainable soil use and management to guide in the prioritizing the multifunctional value of soil health and addressing interdisciplinary links between major issues such as biodiversity and climate change. As soil is the largest terrestrial carbon pool and a significant contributor of greenhouse gases, much progress can be made toward curtailing the climate crisis by sustainable soil management practices. The book provides valuable insight into the soil and carbon management, research gaps, and the methodological challenges for research into soil carbon management that will be important over the decades.

Nuclear Power Reactor Designs: From History to Advances analyzes nuclear designs throughout history and explains how each of those has helped to shape and inform the nuclear reactor designs of today and the future. Focused on the structure, systems and relevant components of each reactor design, this book provides the readers with answers to key questions to help them understand the benefits of each design. Each reactor design is introduced, their origin defined, and the relevant research presented before an analysis of its successes, what was learned, and how research and technology advanced as a result are presented. Students, researchers and early career engineers will gain a solid understanding of how nuclear designs have evolved, and how they will continue to develop in the future.

Effective use of Social Media in Public Health offers a well-organized and comprehensive review of social media and its impact on people's lives and the public health sector. Divided into sections, the book addresses the growing use (and importance) of social media in conducting and disseminating research findings and covers an array of issues from cyberbullying to diversity and inclusion. Written by health educators and practitioners for health educators and practitioners, this book is a timely resource on the topics discussed.

Oceans and Human Health: Opportunities and Impacts, Second Edition explores the inextricably interconnected and complex relationship between oceans and humans. Through the lens of the expanding oceans and human health meta-discipline, this work examines the many invaluable ecosystem services offered by oceans as well as the global anthropogenic impacts, and explores the associated risks and benefits to human health. Written and edited by an interdisciplinary team of experts, the book features international perspectives on the resources available to address these benefits and risks, including enhanced research, policy, and community engagement. The book concludes by examining the future of ocean stewardship and how global populations can unite to nurture and promote our life-enhancing relationship with oceans. This is an indispensable resource for students, researchers, communities, and industry specialists in marine sciences, public health, and international policy.Â

Aptamers for Food Applications: Safety, Authenticity, and Integrity outlines the main applications of aptamers to ensure food safety, quality and compliance that are crucial for food science, public health and human sustainability. Aptamers or aptamer-based analytical devices are comprehensively summarized to tackle various food contamination or food adulteration problems. Topics covered in this book include aptamers for foodborne microbial pathogens, pesticide or veterinary drug residues, heavy metals, biotoxins, abused food additives, illegal food adulterants, POPs, GMOs, food allergens and food contact material migrants. It is therefore of interest for not only analytical investigators and food safety inspectors, but also regulatory practitioners and risk assessors in various food science and research fields.

Building off the success of the first edition, Gut Microbiota: Interactive Effects on Nutrition and Health, Second Edition, details the complex relationship between diet, the gut microbiota, and health. This second edition expands its coverage of emerging practical applications in nutrition and medicine. Covering topics such as the ecological concepts that apply to the gut microbiota and the effects of aging on the gut microbiome, among others, this book is sure to be a welcome resource to microbiome science trainees, food and nutrition researchers working in academia, and industry and healthcare professionals giving dietary recommendations to the general public.

New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics provides a compendium of recent diagnostic and therapeutic advances in GBM, encompassing a pipeline of compounds and (bio) nanotechnology strategies that have stood out with potential increased antitumoral activity and capability to cross the blood-brain barrier. Issues and challenges related to their translation into the clinical practice and their contribution to the increase in survival rates and well-being of patients are addressed. This is a valuable resource for graduate students, oncologists, cancer researchers and members of the biomedical field who need to learn more on recent developments on the management of glioblastoma. The book is split in three parts: Diagnosis, focusing on biomarkers and techniques such PET/MRI, infrared thermography, and deep neural networks; Therapeutics, discussing new chemical entities, as natural products and repurposed drugs, and new formulation approaches, as nanotechnology-based and microRNA approaches; and Theranostics, explaining the role of omics, system-based approaches, and glioblastoma microenvironment.

Handbook of Child and Adolescent Psychology Treatment Modules: Personalized Care in Behavior and Emotion provides clinicians with modularized treatment strategies for commonly occurring child and youth mental health disorders. Divided into two sections, the first part of the book translates basic science into clinical practice, reviewing predictors, mediators and moderators of change, and an overview of evidence for best practices in treating disorders. The second section guides clinicians on how to implement treatment strategies. Chapters instruct what therapy is, how to introduce it to clients, step-by-step implementation, worksheets for use in practice, homework to send home with clients, and more.

Principles of Engineering Tribology: Fundamentals and Applications introduces readers to the core theories and fundamentals of the field, its basic terminology and concepts, as well as advanced topics such as the tribological properties of various engineering surfaces, roughness measurements, and the mechanics of surface contact. The fundamentals of friction and wear of metallic and non-metallic materials such as polymers, ceramics, rubbers, and composites are discussed, as are fluidic, gaseous, grease, and solid media lubrication techniques. In addition, the properties of lubricants and various types of additives incorporated are discussed, along with a methodology for conducting friction, wear and lubrication laboratory testing and an overview of simulation and modeling methods for various tribosystems. Case studies and applications are featured throughout, with a particular emphasis on analyzing failure modes of tribosystems.

Deprescribing and Polypharmacy in an Aging Population supports healthcare professionals across global healthcare institutions in reducing polypharmacy-related drug replated problems (DRPs) by working with patients, families, interprofessional healthcare professionals, and educational institutions to develop, implement, test, improve upon, and educate on strategies for deprescribing and optimizing patient safety. Polypharmacy, the use of multiple medications at the same time by one person, is very common in various patient populations, including those who lack primary physicians, patients with mental health conditions, patients with multiple chronic conditions, and in the aging population.

Distributed Computing to Blockchain: Architecture, Technology, and Applications provides researchers, computer scientists, and data scientists with a comprehensive and applied reference covering the evolution of distributed systems computing into blockchain and associated systems. Divided into three major sections, the book explores the basic topics in the blockchain space extending from distributed systems architecture, distributed ledger, decentralized web to introductory aspects of cryptoeconomics (cryptography and economics) of decentralized applications. The book further explores advanced concepts such as smart contracts; distributed token mining, initial coin offerings; proof of work; public, private, and other blockchains; cryptography; security; and blockchains. The book goes on to review byzantine fault tolerance, distributed ledgers versus blockchains, and blockchain protocols. The final section covers multiple use cases and applications of distributed computing and the future directions for blockchains.

Membrane Dehumidification and Cooling: Fundamentals and Applications presents the state-of-the-art on membrane dehumidifiers, highlighting their most recent advancements and providing key insights into global R&D interests. With a strong focus on applications, the book offers characterization techniques to evaluate the potential of hygroscopic materials, as well as experimental methods to study the dehumidifiers' performance. The book begins by highlighting the demerits of conventional cooling systems and then reviews electrically driven alternative cooling solutions. A comparative study between different dehumidification techniques is also given, along with sections on fundamental transport mechanisms and thermodynamic modeling. Finally, scaling, heat transfer and thermodynamic analysis are presented, along with a review of hybrid membrane-based air-conditioners. This book is a one-stop resource for recent advancements in membrane dehumidification and cooling applications. It is an essential read for students, researchers and engineers interested in thermal engineering, heat and mass transfer, alternative cooling, energy materials and dehumidification.

Advances in Nano and Biochemistry: Environmental and Biomedical Applications gives insights into this advanced interdisciplinary science that encompasses the principles of physics and physical chemistry for the investigation of various processes and problems in biological systems. The book is a concise culmination of biophysical chemistry knowledge acquired through core concepts and advanced technologies for addressing emerging challenges in environmental and biomedical applications. Sections cover early diagnostic techniques and accurate treatment strategies using bioinspired, sustainable technologies, including nanomaterials, nanoenzymes, biopolymers, electrochemical biomolecule sensors, biocompatible magnetic nanomaterials, quantum dots and hybrid structures, and DNA nanotechnology. Other sections discuss advanced technologies for sensing and remedying environmental pollutants, including but not limited to, photocatalytic oxidations, gum polysaccharides based nanostructured materials, bio-inspired and biocompatible nanomaterials, hydrogel nanocomposites, and contemporary enzymes and nanozymes based?technologies. Ultimately, the state-of-the-art chapters in this book will empower researchers to combine two complementary elements - chemical analysis use and biomedical applications.

Handbook of Organizational Creativity: Individual and Group Level Influences, Second Edition covers creativity from many perspectives in two unique volumes, including artificial Intelligence work, creativity within specific applied domains (e.g., engineering, science, therapy), and coverage of leadership. The book includes individual, team and organizational level factors and includes organizational interventions to facilitate creativity (such as training). Chapters focus on creative abilities and creative problem-solving processes, along with individual differences such as motivation, affect and personality. New chapters include the neuroscience of creativity, creativity and meaning, morality/ethicality and creativity, and creative self-beliefs. Sections on group level phenomena examine team cognition, team social processes, team diversity, social networks, and multi-team systems and creativity. Final coverages includes different types and approaches to leadership, such as transformational leadership, ambidextrous leadership leader-follower relations, and more.

Diagnostic Molecular Biology, Second Edition describes the fundamentals of molecular biology in a clear, concise manner with each technique explained within its conceptual framework and current applications of clinical laboratory techniques comprehensively covered. This targeted approach covers the principles of molecular biology, including basic knowledge of nucleic acids, proteins and chromosomes; the basic techniques and instrumentations commonly used in the field of molecular biology, including detailed procedures and explanations; and the applications of the principles and techniques currently employed in the clinical laboratory. Topics such as whole exome sequencing, whole genome sequencing, RNA-seq, and ChIP-seq round out the discussion. Fully updated, this new edition adds recent advances in the detection of respiratory virus infections in humans, like influenza, RSV, hAdV, hRV but also corona. This book expands the discussion on NGS application and its role in future precision medicine.

CRISPR-Cas System in Translational Biotechnology discusses applied and translational aspects of the CRISPR-Cas technology. The book bridges the gap between theoretical knowledge and practical solutions surrounding this emerging and impactful technology in several academic and industrial fields. It is split in five sections: CRISP-Cas fundamentals and advancements; CRISP-Cas in medical biotechnology; CRISP-Cas in environmental biotechnology; CRISP-Cas in food biotechnology; and biosafety, patents and commercialization of CRISP-Cas technology. Written by experts from diverse backgrounds, the content covers the subject and its impact in multiple fields. It is a valuable resource for graduate students and researchers on bioinformatics, systems biology, and members of the biomedical field and biotechnology industry who are interested in learning more about CRISP-Cas system and its applications.