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Pathophysiological Aspects of Proteases in Cancer provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. The book both gives insights on the general aspects of the role of proteases in cancer, their role as diagnostics and prognostics biomarkers, their impact on chemoresistance, and the future cutting-edge technologies like cocktail therapies and Cyber Knife technology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and working to identify targets for drug development.Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.

Artificial Intelligence and Multimodal Signal Processing in Human-Machine Interaction presents an overview of an emerging field that is concerned with exploiting multiple modalities of communication in both Artificial Intelligence and Human-Machine Interaction. The book not only provides cross disciplinary research in the fields of multimodal signal acquisition and sensing, analysis, IoTs (Internet of Things), Artificial Intelligence, and system architectures, it also evaluates the role of Artificial Intelligence I in relation to the realization of contemporary Human Machine Interaction (HMI) systems. In 23 chapters/sections "Artificial Intelligence and Multimodal Signal Processing in Human-Machine Interaction" covers different aspects of the multimodal signals, from the sensing to analysis using hardware/software, and making use of machine/ensemble/deep learning in the intended problem solving. The reader is introduced to the multimodal signals and their role in the identification of the intended subjects mental state and the realization of HMI systems are explored and the applications of signal processing and machine/ensemble/deep learning for HMIs are assessed. Each chapter starts with the importance, problem statement and motivation. The description of proposed methodology is provided, and related works are also presented. Each chapter can be read independently and therefore the book is a valuable resource for researchers, health professionals, postgraduate students, post doc researchers and faculty members in the fields of HMIs, Brain-Computer Interface (BCI), Prosthesis, Computer vision, and Mental state estimation, and all those who wish to broaden their knowledge in the allied field.

Exosome Communication: Advances in Research and Therapeutics for Health and Disease covers the key qualities of exosomes as drug delivery vehicles. The book provides a comprehensive exploration of exosomes, starting with their history and development and explaining extracellular vesicles and biogenesis and techniques for isolation and characterization. It also delves into cargo loading, release strategies, and their potential applications in diagnostics and various diseases, including antigen-specific delivery, gene delivery, and vaccine delivery, highlighting how engineering exosomes can enhance therapeutic efficacy.Finally, the book also addresses critical considerations like quality control, heterogeneity reduction, regulatory and ethical aspects, clinical trials, and scale-up manufacturing. By providing a comprehensive and detailed overview of exosome-based therapeutics' potential, this book serves as a valuable reference for those interested in exploring exosomes' applications in drug delivery and therapeutics.

Understanding Autism: Perspectives, Assessment, Interventions, and the Journey Toward Inclusion offers a multifaceted exploration, providing readers with a comprehensive understanding of autism spectrum disorder from both biological and social perspectives. From the role of bioactive lipids in the pathobiology of autism to the challenges faced by individuals with autism within the criminal justice system, this book delves into critical aspects of autism, assessment strategies, and innovative interventions. From a biological perspective, readers will unravel the mysteries of the gut-brain connection and the impact of vitamin D on the gut microbiota.Meanwhile, the social perspective sheds light on sensory processing, autonomic regulation, and socio-emotional development in autism, as well as the pressing issue of justice and representation. Through the assessment section, readers will explore the unique challenges faced by parents with autism spectrum disorder and delve into linguistic anomalies in autism. Finally, the interventions section introduces groundbreaking programs and strategies designed to improve the lives of individuals with autism.

Technological Advances and Innovations in the Treatment of Chronic Respiratory Disorders focuses on 3D printing, bioprinting, microfluidics, organ-on-a-chip systems, and molecular modeling. The book, written by a team of leading experts in the field, is an essential resource for anyone interested in the future of CRD treatment. Chapters discuss the emerging therapeutic approaches for CRDs, including biologicals and phytoceuticals. Core chapters of the book then cover the application of 3D printing, bioprinting, microfluidics, organ-on-a-chip systems, and molecular modeling to different CRDs. The book concludes with a discussion of the current clinical trials and future prospects for the management of CRDs.This is a valuable resource for researchers, clinicians, and other healthcare professionals who are interested in the latest technological advances in the field of CRDs. It will also be of interest to students and scientists working in the fields of pharmaceutical sciences, microfluidics, bioinformatics, drug design, drug delivery, and 3D printing.

Migraine Management: Current Pharmacological and Non-pharmacological Options is a comprehensive guide to established, recent, and ongoing pharmaceuticals and device development projects. The book provides detailed information on the historical developments of migraine pain management, druggable targets, drugs action mechanisms, drugs for acute treatment and preventive care of patients, administration routes, and alternative treatments. This is the ideal reference for academic researchers interested in anti-migraine pharmacology. It is also the perfect reference for physicians and care professionals involved in the well-being of migraine patients.

Hyperautomation in Precision Agriculture: Advancements and Opportunities for Sustainable Farming is the first book to focus on the integration of multiple techniques and technologies to create an ecosystem sustaining approach that doesn’t compromise soil health or environmental safety as it increases crop yield. The book highlights the integration of state-of-the-art tools and working models to address the various challenges in the field of agriculture. It also identifies and discusses the potential and challenges of hyperautomation in sustainable agriculture with respect to efficiency improvement and human enhancement of automated operations.Hyperautomation is a true digital transformation in sustainable agriculture utilizing advanced techniques such as robotic process automation (RPA), digital process automation (DPA), unmanned aerial vehicle (UAV), controlled-environment agriculture (CEA), remote sensing, internet of things (IoT), crop modeling, precision farming, sustainable yield, image analysis, data fusion, artificial intelligence (AI), machine learning (ML), and deep learning (DL).

Exploring the Metaverse: Challenges and Applications explores the various applications and challenges facing the metaverse, from privacy and security concerns to questions about the economy and ethical considerations. Drawing on insights from experts in technology, ethics, and economics, the book's authors provide a comprehensive overview of the metaverse and its potential implications. Through a series of engaging essays and thought-provoking case studies, they examine the complex issues facing the metaverse, such as the role of virtual identity, the impact on social interactions, and the potential for addiction. Finally, they explore potential solutions to these challenges, from technological innovations to policy interventions.

Quinone-Based Compounds in Drug Discovery: Trends and Applications provides a comprehensive and up-to-date overview of the latest advances in the field of drug discovery using quinone-based materials. The book covers various aspects of quinone-based materials such as their synthesis, characterization, and applications in drug discovery, consolidating current research. It introduces quinones in the pharmacology context and then describes current developments in drugs for key diseases and conditions. Final chapters deal with the regulatory and commercial framework to take quinone-based drugs to the market. This book will benefit a wide range of readers, including researchers, scientists, and graduate students in the field of drug discovery. Chemists and biochemists will also benefit from the contents of this book.

The multitasking molecular chaperone Hsp60: Structure, function, and impact on health and disease provides an overview of this key component of the Chaperone System (CS). Over the last several years, the importance of the CS as a physiological system has been brought to prominence and its roles in health and disease made clear. The molecular chaperones, including Hsp60, are the key components of the CS that are typically cytoprotective, but they can also be etiopathogenic factors, causing diseases named chaperonopathies. This book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and eukaryotic experimental models. The main goal is to provide information accessible to all healthcare professionals in a way that can be understood by nonspecialists and that would stimulate clinical and pathological detection of Hsp60 chaperonopathies. Molecular mechanisms are briefly described with the purpose of illuminating roads toward accurate diagnosis, treatment, and patient monitoring. Consequently, the possibility of developing/applying chaperonotherapy centered on Hsp60, as a therapeutic tool or target, is analyzed in many sections of this book, across a variety of medical specialties.This book is an invaluable reference for practitioners, researchers, and students in medicine, biology, molecular biology, biochemistry, biophysics, pharmacology, and related life sciences