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Landscape Evolution: Landforms, Ecosystems and Soils asks us to think holistically, to look for the interactions between the Earth's component surface systems, to consider how universal laws and historical and geographical contingency work together, and to ponder the implications of nonlinear dynamics in landscapes, ecosystems, and soils. Development, evolution, landforms, topography, soils, ecosystems, and hydrological systems are inextricably intertwined. While empirical studies increasingly incorporate these interactions, theories and conceptual frameworks addressing landforms, soils, and ecosystems are pursued largely independently. This is partly due to different academic disciplines, traditions, and lexicons involved, and partly due to the disparate time scales sometimes encountered. Landscape Evolution explicitly synthesizes and integrates these theories and threads of inquiry, arguing that all are guided by a general principle of efficiency selection. A key theme is that evolutionary trends are probabilistic, emergent outcomes of efficiency selection rather than purported goal functions. This interdisciplinary reference will be useful for academic and research scientists across the Earth sciences.

Constitutive Modeling of Engineering Materials provides an extensive theoretical overview of elastic, plastic, damage, and fracture models, giving readers the foundational knowledge needed to successfully apply them to and solve common engineering material problems. Particular attention is given to inverse analysis, parameter identification, and the numerical implementation of models with the finite element method. Application in practice is discussed in detail, showing examples of working computer programs for simple constitutive behaviors. Examples explore the important components of material modeling which form the building blocks of any complex constitutive behavior.

Macromolecular Engineering: Design, Synthesis and Application of Polymers explores the role of macromolecular engineering in the development of polymer systems with engineered structures that offer the desired combination of properties for advanced applications. This book is organized into sections covering theory and principles, science and technology, architectures and technologies, and applications, with an emphasis on the latest advances in techniques, materials, properties, and end uses ¿ and including recently commercialized, or soon to be commercialized, designed polymer systems. The chapters are contributed by a group of leading figures who are actively researching in the field.  This is an invaluable resource for researchers and scientists interested in polymer synthesis and design, across the fields of polymer chemistry, polymer science, plastics engineering, and materials science and engineering. In industry, this book supports engineers, R&D, and scientists working on polymer design for application areas such as biomedical and healthcare, automotive and aerospace, construction and consumer goods.

Demonstrates the basic principles underlying the use of common experimental, chemometric, and statistical tools. This work emphasises problem-solving applications and the proper use and interpretation of data used for scientific research.

With energy sustainability and security at the forefront of public discourse worldwide, there is a pressing need to foster an understanding of clean, safe alternative energy sources such as solar and wind power. This book illuminates the basic principles behind all key renewable power sources - solar, wind, biomass, hydropower & fuel cells.

Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students.

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.Recent Advances in iPSC-derived Cell Types, Volume 4 addresses how different cell types can be derived from induced pluripotent stem cells.Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to form different cell types which can be used in cell therapy as well as to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cellular populations, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs to derive different cell types, such as: erythroid cells, mucosal-associated invariant T cells, megakaryocytes, cerebral cortical neurons, inner ear cell types, airway epithelial cells, male germ cells, trophoblasts, cardiomyocytes, ßpancreatic cells, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation; and is contributed by world-renowned authors in the field.

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students.

Process Safety Calculations, Second Edition remains to be an essential guide for students and practitioners in process safety engineering who are working on calculating and predicting risks and consequences. The book focuses on calculation procedures based on basic chemistry, thermodynamics, fluid dynamics, conservation equations, kinetics and practical models. It provides helpful calculations to demonstrate compliance with regulations and standards, such as Seveso directive(s)/COMAH, CLP regulation, ATEX directives, PED directives, REACH regulation, OSHA/NIOSH and UK ALARP, along with risk and consequence assessment, stoichiometry, thermodynamics, stress analysis and fluid-dynamics. This fully revised, updated and expanded second edition follows the same organization as the first, including the original three main parts, Fundamentals, Consequence Assessment and Quantitative Risk Assessment. However, the latter part is significantly expanded, including an appendix consisting of five fundamental thematic areas belonging to the risk assessment framework, including in-depth calculations methodologies for some fundamental monothematic macro-areas of process safety.

Biomass, Biofuels, Biochemical: Circular Bioeconomy: Current Developments and Future Outlook presents the views of experienced academicians and researchers working in the area of the circular bioeconomy. This book presents an assortment of Resource recovery, Waste Biorefineries, Bio-electrochemical systems, Biopolymers and Green solvents, Bio-adsorbents, and Technology transfer topics. Environmental engineers, biotechnologists, science graduates, chemical engineers, industrial experts and policymakers working in these areas will find the information on the circular economy and its important part in developing low carbon and resource-productive economies very informative.  Methodologies and beneficial strategic approaches to address the usage of wastes from agriculture, co-products, and by-products are also discussed.

Climate Change: Observed Impacts on Planet Earth, Third Edition, brings together top global researchers across many disciplines to provide a comprehensive review on the complex issue of climate change and weather patterns. The third edition continues its tradition of focusing on the science and evidence on this highly politicized topic. Every chapter is updated, with this new edition featuring new chapters on topics such as glacier melt, the impacts of rising temperatures, extreme weather, modeling techniques, biodiversity, and more. This book is essential for researchers, environmental managers, engineers, and those whose work is impacted by, or tied to, climate change and global warming.

NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients. Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective.