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The study of one-shot devices such as automobile airbags, fire extinguishers, or antigen tests, is rapidly becoming an important problem in the area of reliability engineering. These devices, which are destroyed or must be rebuilt after use, are a particular case of extreme censoring, which makes the problem of estimating their reliability and lifetime challenging. However, classical statistical and inferential methods do not consider the issue of robustness. Statistical Modeling and Robust Interference for One-shot Devices offers a comprehensive investigation of robust techniques of one-shot devices under accelerated-life tests. With numerous examples and case studies in which the proposed methods are applied, this book includes detailed R codes in each chapter to help readers implement their own codes and use them in the proposed examples and in their own research on one-shot device-testing data. Researchers, mathematicians, engineers, and students working on accelerated-life testing data analysis and robust methodologies will find this to be a welcome resource.

Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology’s potential in revolutionizing drug delivery for colon-related ailments. Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges. Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein-peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system. Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors.

Generalized Quantum Calculus with Applications is devoted to the qualitative theory of general quantum calculus and its applications to general quantum differential equations and inequalities. The book is aimed at upper-level undergraduate students and beginning graduate students in a range of interdisciplinary courses including physical sciences and engineering, from quantum mechanics to differential equations, with pedagogically organized chapters that each concludes with a section of practical problems. Generalized quantum calculus includes a generalization of the q-quantum calculus and the time scale calculus. There are many open problems and difficulties in q-quantum calculus and time-scale calculus, and this book explores how to use the generalized quantum operators to solve difficulties arising in q-quantum calculus and time-scale calculus, including but not limited to generalized quantum integration, generalized quantum chain rules, and generalized quantum Taylor formula. Since generalized quantum calculus includes the q-quantum and time-scale calculus, this book can be utilized by a wide audience of researchers and students. This text is one of few foundational books on generalized quantum calculus and can be used for future discoveries in the area of integral transforms, variational calculus, integral equations, and inequalities in the language of generalized quantum calculus. This book also offers detailed proofs, exercises, and examples to aid instructors, researchers, and users in their studies.

Microbial Genomics: Host Adaptation, Virulence, and Evolution covers different aspects of microbial genomics, metagenomics, and functional studies of microbes that have provided a significant understanding of microbial-host interactions, virulence function, host adaptation mechanisms, including microbial evolution. Microbial Genomics: Host Adaptation, virulence, and Evolution is a comprehensive source on the latest updates and applications of microbial genomics information to understand the plant, microbe interaction, host adaptation, virulence nature of the infectious pathogen, microbial evolution, host-pathogen interactions contribute to shaping the genetic diversity of both organisms. Sections include an introduction to Microbial Genomics, followed by sections on Plant Microbiome, Genome Editing Prospecting and Approaches, Microbial virulanse and disease incidence. The final section of the book covers Microbial Genomics and evolutionary concepts. "Microbial Genomics: Host Adaptation, virulence, and Evolution" is a valuable resource for faculty members, researchers, and undergraduate and postgraduate students at universities, medical research labs, industries, and government agencies that are interested in the microbial science specific to the microbial genome, virulence function of pathogenic microbes, host adaptation, evolution of microbes, and all other disciplines related to molecular microbiology.

Cheese: Chemistry, Physics and Microbiology, Fifth Edition provides a comprehensive overview of the chemical, biochemical, microbiological, and physico-chemical aspects of cheese, taking the reader from the rennet and acid coagulation of milk to the role of cheese and related foods in addressing public health issues. This updated revision, the most comprehensive work on the science of cheese, addresses the basic definition of cheese, along with the diverse factors that affect its quality. Understanding these fermented milk-based food products is vital to a global audience. Divided in two volumes, this book contains by far the most comprehensive coverage of the scientific aspects of this important dairy product, covering all aspects of cheese manufacture and ripening from the standpoint of basic science (vol 1). In addition, coverage is included of all major families of cheese (vol 2).

The Auditory Cerebellum: Function and Dysfunction focuses on the sensory and cognitive aspects of the cerebellum, with an emphasis on hearing, speech, music, speaking, and singing. This book fills the gap for information needed in audiology and auditory neuroscience, tinnitus, and developmental disorders with a strong auditory component. This book starts with a general overview on the connectivity between the cerebellum and auditory subcortical and cortical areas, including general cortical networks. There are several chapters devoted to the timing aspects of the cerebellum underlying speech and music perception as well as motor aspects in speaking and singing.Also discussed is the role of the cerebellum in hearing impairment, tinnitus, developmental disorders with a strong auditory component, including dyslexia, autism, attention deficit, and hyperactivity disorder. Dr. Jos Eggermont, a leading researcher in the field, uses a systems analysis approach that covers electrophysiology and neural imaging, both in animals and humans.