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Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated with therapeutic failure. Cancer types discussed include breast, endocrine, hematologic, gastrointestinal, musculoskeletal, lung, skin and central nervous system cancers. The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology, pharmaceutical sciences, biomaterials and medical/clinical sciences that are interested in accessing a comprehensive compendium on efflux pumps in mechanisms of cancer resistance.

Wastewater Treatment Residues as Resources for Biorefinery Products and Energy reviews wastewater treatment processes and the use of residues. The viability of end use processes for residues, such as incineration, cement additives, agricultural fertilizers, and methane production are reviewed and analyzed, as are new processes for the use of residues within a fuels production system, such as pyrolysis, hydrothermal liquefaction and syngas. Specialized chapters discuss fractionation of biomass, the production of compounds from volatile fatty acids that conceptually proceed from the anaerobic acidogenesis of residues, and a final analysis of the overall productivity and viability that can be expected from these production schemes.

Escaping from Bad Decisions presents a modern conceptual and mathematical framework of the decision-making process. By interpreting ordinal utility theory as normative analysis examined in view of rationality, it shows how decision-making under certainty, risk, and uncertainty can be better understood. It provides a critical examination of psychological models in multi-attribute decision-making, and evaluates the constitutive elements of "good" and "bad" decisions. Multi-attribute decision-making is analysed descriptively, based on the psychological model of decision-making and computer simulations of decision strategies. Finally, prescriptive examinations of multi-attribute decision-making are performed, supporting the argument that decision-making from a pluralistic perspective creates results that can help "escape" from bad decisions. This book will be of particular interest to graduate students and early career researchers in economics, decision-theory, behavioral economics, experimental economics, psychology, cognitive sciences, and decision neurosciences.

Soil Health Assessment: Technology, Theory and Practice provides up-to-date coverage on the state- of-the-art in soil health assessment, outlining both the technology used in the field and the most effective methods for sample analysis and soil health quantification. Beginning with a review of the links between soil characteristics and soil health, the book outlines laboratory techniques for assessing soil chemistry, organic matter content assessment, soil structural assessment and soil biology indicators. Smartphone technology for soil health indicators, decision support methodologies for land management, and spatial datasets relevant for soil health are also discussed. Drawing on the experience of its expert editors and authors, this book presents a practical guide for soil scientists, environmental scientists, ecologists and all those who would benefit from rapid, innovative soil-assessment technologies and methods in their own work.

Life Cycle and Criticality Assessment of Platinum Extraction, Usage and Energy Applications discusses past, present and future research works on platinum and its applications to fuel cells. It examines the global trends of platinum mining, processing and its applications, with case studies from the Southern African region. The book offers a brief discussion on different types of fuel cells and a detailed description of platinum-based fuel cell technology. The environmental and socioeconomic impacts of the production chain of fuel cell technology are evaluated using lifecycle assessment, along with a critical assessment of platinum group metals that focuses on all aspects of its sustainability.

Incorporates industry changes, lessons learned and new approaches Explores various ways in which data analysts and managers can ensure consistent, accurate and reliable data across their organizations Includes new case studies which detail real-world situations Explores all of the capabilities an organization must adopt to become data driven Provides guidance on various approaches to data governance, to determine whether an organization should be low profile, central controlled, agile, or traditional Provides guidance on using technology and separating vendor hype from sincere delivery of necessary capabilities Offers readers insights into how their organizations can improve the value of their data, through data quality, data strategy and data literacy Provides up to 75% brand-new content compared to the first edition

The Urban Heat Island (UHI) is an area of growing interest for many people studying the urban environment and local/global climate change. The UHI has been scientifically studied for 200 years and, although it is an apparently simple phenomenon, there is considerable confusion around the different types of UHI and their assessment. The Urban Heat Island-A Guidebook provides simple instructions for measuring and analysing the phenomenon, as well as greater context for defining the UHI and the impacts it can have. Readers will be empowered to work within a set of guidelines that enable direct comparison of UHI effects across diverse settings, while informing a wide range of climate mitigation and adaptation programs to modify human behaviour and the built form. This opens the door to true global assessments of local climate change in cities. Urban planning and design strategies can then be evaluated for their effectiveness at mitigating these changes.

Spans two volumes, Radiation Physics and Detectors and Radioanalytical Applications Includes a much-expanded treatment of calculations required in the measurement of radionuclide decay, energy of decay, nuclear reactions, radiation attenuation, nuclear recoil, cosmic radiation, and synchrotron radiation Includesthe latest advances in liquid and solid scintillation analysis, alpha- and gamma spectrometry, mass spectrometric analysis, gas ionization and nuclear track analysis, and neutron detection and measurement Covers high-sample-throughput microplate techniques and multi-detector assay methods