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Effective guide for Parkinson's patients/caregivers and neurologists to optimise ON-OFF periods. Simple monitoring schemes are presented for patients to assess response to L-dopa-containing drugs, enabling doctors to personalise dosage and timing to reduce on-off periods. How to optimise cellular response and efficacy of drugs is clearly described

Parkinson's Disease Top Tips to Optimize Function The "Top Tips" offered in this user-friendly book, are distilled from the many years of successful clinical experience of the authors, directors of their pioneering Parkinson's Management Team, in London, UK. It is greatly comforting for people with Parkinson's to know that these really excellent tips can offer effective tools to optimize their function and wellbeing (abilities), at any stage This book is a MUST for people with Parkinson's, their Partners and Caregivers to confidently make informed choices within the constraints of the illness. The many positive tips include:  The Specific Timing of taking L-dopa and other Drugs with Food  Avoiding Drug-Nutrient and Inter-Nutrient Interactions  Movement Recommendations include Unfreezing, Getting up, Balance, Dance, Movement Therapy, Feet, Hands, Circulation and many others!  Understanding How Dopamine is made from Dietary Protein and other Nutrients  Dopamine, Adrenaline and the Stress Connection - Stress Management  Regulation of Intestinal Function  Sleep Improvement  Energy Production  Dental Health  Weight Control  Diet  Stress Relief  Reducing Free Radicals  Avoiding Excito-toxins  Food Hygiene, Kitchen Safety  Intimacy, Pregnancy  Having an Anaesthetic  Travel Tips  Partners and Caregivers  Speech Recommendations  Osteopathy, Physiotherapy  Swallowing and Chewing Problems  Music Therapy  Laboratory Tests  Nutritional Supplements  Simple, Delicious Recipes  Helpful Contacts

PARKINSON'S DISEASE DOPAMINE METABOLISM, APPLIED BIOCHEMISTRY & NUTRITION Authors: Lucille Leader and Dr Geoffrey Leader Foreword: by Dr Nicholas Miller This user-friendly monograph illustrates the various metabolic pathways implicated in Parkinson's disease, with their primary sources in protein, carbohydrates and fats. It describes the enzymes necessary for metabolic and biochemical progress with their dependence on coenzymes - which are specific nutrients. The text demonstrates that concomitant with dopaminergic pharmaceutical supplementation, dynamic support of the individual's biochemical, metabolic and nutritional status should be considered as essential adjuvant therapy during the degenerative journey. The aim is to optimise potential cellular and general functional health within the constraints of the disease. Dopamine, the neurotransmitter which is deficient in Parkinson's disease, is metabolised from dietary protein. The metabolic steps from protein ingestion in the diet to the production of dopamine in the brain - and further on to adrenaline, are best described by biochemistry. Contemporary nutritional management is the APPLICATION of biochemical principles. Medical tests as well as state of the art nutritional biochemical tests are presented which enable the medical and nutritional professions to up- or down- regulate the individual cellular environment. Subjects presented include: ¿ dopamine metabolism ¿ adrenal metabolism ¿ inflammation and prostaglandins ¿ oxidative stress and free radicals ¿ intestinal environment ¿ Krebs Cycle and cell energy ¿ drug-nutrient interaction ¿ nutritional supplements ¿ detoxification ¿ laboratory tests This "personalised" therapeutic approach does indeed complement the use of dopaminergic pharmaceuticals and may enhance their efficacy due to the support of biochemical pathways.