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This book will initiate and introduce the readers to the state-of-the-art developments and trends in this field of study and will largely cater the scientific need of scientists engaged in melatonin research across the globe.

This volume in the popular series, Drugs and the Pharmaceutical Sciences, begins with the history of cancer treatment, carcinogens, and molecular mechanisms involved in cancer pathogenesis. It incudes conventional and advanced cancer therapies ranging from oral and parenteral preparations to advanced fabricated systems such as nanoparticles, liposomes, antibodies, aptamers, poly(amidoamine) and photodynamic therapies. The preparation and mechanisms of molecular targeting of cancer are presented and the authors focus on a diverse audience including undergraduates and research students.Features Timely coverage of changes in process control technology for the phamaceutical industry, a dynamic area in terms of products and manufacturing processes Provides an update on the unique requirements of these industries and how they differ from others, for example the microelectronics or specialized chemicals industries Draws on the author's vast experience in the field of industrial hygiene and hazardous materials Presents a collection of unique situations in which industrial hygiene was implemented to resolve a variety of scenarios and did not interfere with quality issues Addresses current topics relating to industry evolution such as migration of therapies to higher potency, RiskMAP, new modalities in medicines and treatments, large molecule therapeutics and conjugates

Stem cell science has emerged as a novel discipline in biomedical research over the past decade. With advancements in this field, stem cells have demonstrated versatile applications ranging from basic research to clinical case studies. Recognizing the demand for knowledge in stem cell applications, this book aims to provide comprehensive information on stem cell technology and its application in biosystems. It covers fundamental culture methods, advanced stem cell-based biosystems, and clinical case studies of stem cell therapy. This book is intended for individuals with an interest in stem cell science, offering valuable insights into this rapidly evolving field.

Multiplicative Partial Differential Equations presents an introduction to the theory of multiplicative partial differential equations (MPDEs). It is suitable for all types of basic courses on MPDEs. The authors' aim is to present a clear and well-organized treatment of the concepts behind the development of mathematics and solution techniques. The text is presented in a highly readable, mathematically solid format. Many practical problems are illustrated, displaying a wide variety of solution techniques.Features Includes new classification and canonical forms of second-order MPDEs Proposes the latest techniques in solving the multiplicative wave equation such as the method of separation of variables and the energy method Useful in allowing for the basic properties of multiplicative elliptic problems, fundamental solutions, multiplicative integral representation of multiplicative harmonic functions, meant-value formulas, strong principle of maximum, multiplicative Poisson equation, multiplicative Green functions, method of separation of variables, and theorems of Liouville and Harnack

Abstract Algebra: An Inquiry-Based Approach not only teaches abstract algebra but also provides a deeper understanding of what mathematics is, how it is done, and how mathematicians think.

The main focus of this book is the examination of women's health issues and the role machine learning can play as a solution to these challenges. This book will illustrate advanced, innovative techniques/frameworks/concepts/machine learning methodologies, enhancing the future healthcare system. Combating Women's Health Issues with Machine Learning: Challenges and Solutions examines the fundamental concepts and analysis of machine learning algorithms. The editors and authors of this book examine new approaches for different age-related medical issues that women face. Topics range from diagnosing diseases such as breast and ovarian cancer to using deep learning in prenatal ultrasound diagnosis. The authors also examine the best machine learning classifier for constructing the most accurate predictive model for women's infertility risk. Among the topics discussed are gender differences in type 2 diabetes care and its management as it relates to gender using artificial intelligence. The book also discusses advanced techniques for evaluating and managing cardiovascular disease symptoms, which are more common in women but often overlooked or misdiagnosed by many healthcare providers.The book concludes by presenting future considerations and challenges in the field of women's health using artificial intelligence. This book is intended for medical researchers, healthcare technicians, scientists, programmers and graduate-level students looking to understand better and develop applications of machine learning/deep learning in healthcare scenarios, especially concerning women's health conditions.

This book presents methods for the summation of infinite and finite series and the related identities and inversion relations. The summation includes the column sums and row sums of lower triangular matrices. The convergence of the summation of infinite series is considered. The author's focus is on symbolic methods and the Riordan array approach. In addition, this book contains hundreds summation formulas and identities, which can be used as a handbook for people working in computer science, applied mathematics, and computational mathematics, particularly, combinatorics, computational discrete mathematics, and computational number theory. The exercises at the end of each chapter help deepen understanding.Much of the materials in this book has never appeared before in textbook form. This book can be used as a suitable textbook for advanced courses for high lever undergraduate and lower lever graduate students. It is also an introductory self-study book for re- searchers interested in this field, while some materials of the book can be used as a portal for further research.

This monograph presents a coherent and elementary introduction to Gauge theories of the fundamental interactions and their applications to high-energy physics. It deals with the logic and structure of local Gauge symmetries and Gauge theories, from quantum electrodynamics through unified theories of the interactions among leptons and quarks. Many explicit calculations provide the reader with practice in computing the consequences of these theories and offer a perspective on key experimental investigations. First published in 1983, this text is ideal for a one-semester course on Gauge theories and particle physics. Specialists in particle physics and others who wish to understand the basic ideas of Gauge theories will find it useful as a reference and for self-study.

Social media provides a new way for aesthetic practitioners to connect with consumers and to differentiate their clinics; however, to most clinic managers and practitioners, digital media represents a sea of confusion that they cannot even begin to know how to navigate. With over 25 years of experience in medical aesthetics, Lewis offers a unique understanding of the challenges clinics face every day to market their products and services ethically, manage patients, and stay profitable. This updated text serves as an expert user's guide written specifically for healthcare professionals in need of an in-depth introduction and comprehensive actionable program for digital marketing, social media, and aesthetic clinic management. It is a must-read for practitioners who want to keep up with the latest developments in this hotly competitive field.This second edition features: NEW chapters on hot topics you need to know MORE tips, charts, tables, and resources UP TO THE MINUTE strategies for success

Nanomaterials are becoming ubiquitous; microbes similarly are everywhere. This book focuses on various ways the diverse nanomaterials interact with microbial communities and implications of such interactions. Both toxicity and beneficial effects of nanomaterial-microbe interactions have been covered. This includes areas such as fate and bioavailability of nanomaterials in environments, microbial synthesis of nanomaterials and antimicrobial action of nanomaterials. Fairly comprehensive but with narrow focus, the book provides useful insights into these interactions which need to be factored in while designing nanoscience based new technologies.

This book deals with an interdisciplinary approach towards present-day practical challenges and recent developments in algal biotechnology and covers a broad spectrum of issues ranging from diverse algae and its applications in agriculture, human food, animal feed, wastewater treatment, and industry to algal metabolites. Major themes covered in this volume include algae-based processes for the treatment of industrial effluents, algal biorefinery, and industrial trends, and applications of algae in food, feed, nutraceuticals, and pharmaceuticals.Features: Explores the possibility of utilization of algae in human food and pharmaceutical compounds. Presents recent state of the art of design and tools in algal biorefineries. Reviews concepts of membrane bioreactors and microbial fuel cells, including their process and performance. Algae-based technologies for safe and eco-friendly processes to promote a sustainable bio-economy. Discusses algae as a source for potential aquafeed. This book is aimed at graduate students and researchers in biotechnology, bioenergy, renewable energy, energy, fuel and petrochemicals, wastewater, novel technologies, clean technologies, bioremediation environmental biotechnology, functional foods and nutraceuticals, marine and aquatic science.

This book contains a foreword by Maurice Conlon, Associate Director, Appraisal and Revalidation Lead, NHS Clinical Governance Support Team. This is an invaluable, detailed guide offering practical resources for medical professionals in the challenging role of appraiser. It assists with confidence, professionalism and competency and contains a comprehensive, up-to-date summary of the 'state of play' for appraising doctors. It also includes sample forms, contracts for guidance and links to web resources. "The Appraiser's Handbook" provides vital information for all those involved in continuing professional development in primary and secondary care. Appraisal leads and managers in primary and secondary care trusts will find it of great interest, as will clinical tutors, GP tutors and deanery educational teams. "This book aims to support appraisers in developing their skills in order to ensure that the doctor whom they appraise, gains the maximum possible benefit from the time spent in, and preparing for, the appraisal. The appraiser will find appraisees who enthusiastically embrace appraisal and those who doubt its use and place in their professional development. Different approaches may be needed to support and understand different individuals." - Nick Lyons, Susanne Caesar and Abayomi McEwen. "This book, written by a trio steeped in appraisal, is a valuable resource for appraisers. It will help doctors learning to be appraisers, and experienced appraisers. It will also help those organising appraisal, to remind them of the aims of the process. Teachers of appraisal will be able to use it to supplement and support their curricula. I believe revalidation, when it arrives, will be the single biggest step towards improvement taken by the profession, since the introduction of the medical register. I also believe this depends upon the inclusion of appraisal within the revalidation package. Putting high-quality, developmental appraisal 'in the water' for the medical profession will bring about a whole-profession shift in terms of lifelong professional development. This book will support that aim." - Maurice Conlon, in the Foreword.

This concise, practical text covers the essential information veterinary students and nurses, new graduates and practitioners need to succeed in equine medicine, focussing on respiratory and gastrointestinal diseases. Written for an international readership, the book conveys the core information in an easily digestible, precise form with extensive use of bullet-points, lists, diagrams, protocols and extensive illustrations (over 200 full colour, high-quality photographs).Part of a five-book series that extracts and updates key information from Munroe's Equine Surgery, Reproduction and Medicine, Second Edition, the book distils best practice in a logical straightforward clinical-based approach. It details relevant clinical anatomy, physical clinical examination techniques, normal parameters, aetiology/pathophysiology, clinical examination findings, differential diagnosis, diagnostic techniques, management and treatment, and prognosis. The emphasis is on information tailored to general equine clinicians with just enough on advanced techniques to make the practitioner aware of what is available elsewhere. The respiratory system is split into sections on surgical and medical conditions of the upper and lower respiratory tract. The gastrointestinal system is divided into the upper tract, including the oral cavity and dentistry, and the lower tract and peritoneal cavity. Ideal for veterinary students and nurses on clinical placements with horses as well as practitioners needing a quick reference 'on the ground'. The spiralbound format allows the book to lie open during practice.

Mathematical Methods for Life Sciences introduces calculus, and other key mathematical methods, to students from applied sciences (biology, biotechnology, chemistry, pharmacology, material science, etc). Special attention is paid to real-world applications, and for every concept, many concrete examples are provided. The book does not aim to enable students to prove theorems and construct elaborate proofs, but rather to leave students with a clear understanding of the practical mathematics behind the power of optimization, dynamical systems, and all the predictive tools these theories give rise to. Features: No prerequisites beyond high school algebra and geometry. Could serve as the primary text for a first-year course in mathematical methods for biology, biotechnology, or other life sciences. Easy to read: the students may skip all the proofs and go directly to key examples and applications.

Nanotechnology has the potential to drastically transform the agri-food sector with its significant applications to improve agricultural productivity and the efficiency of agrochemicals. The food sector has benefitted from the inclusion of nanoparticles in food matrixes and the nanoencapsulation of nutraceuticals. Smart packaging materials designed with the help of nanotechnology have been used for increasing the shelf life of stored food products. Nanomaterials have been extensively used for the delivery of important agrochemicals to enhance their bioefficacy, prevent their degradation, and control their release. Various nanomaterials have been explored for remediation of arising environmental issues. Nanotechnology has also made a useful contribution to the utilization of huge agricultural and food wastes for production of valuable products. The existing and emerging applications of nanotechnology will contribute to environmental sustainability.Nanotechnology for Sustainable Agriculture, Food and Environment has been structured to provide a widespread coverage and up-to-date progress of nanotechnology and its applications in the agri-food sector and environmental remediation. Synthesis of value-added nanomaterials from agri-food wastes and their potential applications in environmental remediation have been explored. In addition, toxicity issues with nanomaterials have also been discussed.Features: Elaborated information on the use of nanotechnology for sustainable agriculture In-depth study about valorization of agri-food waste An overview of applications of nanotechnology in environmental remediation Toxicity analysis of nanotechnology-based products We aim to satisfy the need for a reference book for scientists, researchers, academicians and students in nanotechnology, agricultural, food, nutraceuticals, environmental and material sectors.

One of the world's foremost authorities on magnetism, Professor Louis Neel was the recipient of the 1970 Nobel Prize in Physics. With all but ten of Neel's 150 original papers being written in French, the aim of this English edition is to bring this important work to a wider readership.

Those affected by cancer or receiving cancer treatment have often been more susceptible to infections due to coexisting chronic diseases, overall poor health status, and systemic immunosuppressive states caused by both cancer and anticancer treatments. This pioneering text is an introduction to the key topics in the relationship between infection, pollution, and cancer and is an invaluable resource for residents and junior faculty in Oncology facing the practical problems arising and for those still in training. *Looks at the lessons to be learned for future Oncology patients from a series of studies. *Presents relevant international experience from Oncology clinicians and researchers. *Brings together input from different countries, systems, and specialties.

This is a concise and quick reference guide, clinically oriented, based on experience underpinned by published research data. The systems-based approach emphasizes the problem list process utilized by most practitioners when faced with a patient presenting with a single or variety of clinical symptoms. This allows generation of a complete list of infectious disease differentials, and the ability to include or exclude those indicated based on patient risk assessment. Pathogen specific information enables rational choice of diagnostics, therapy, and prognostication for a complete list of small animal infectious disease that includes bacterial, viral, parasitic/protozoal and fungal.

Xavier Goodarzian, MD(Hons), MRCGP, PGDiplClinDerm, PGCertCosMed, MBCAM, is the medical director of the Dr Xavier Clinic in Southampton and London, UK, where he has performed chemical peels since 2006. A medical graduate of the University of Louvain (Leuven) in Belgium, he obtained member status of the Royal College of General Practitioners and has postgraduate degrees in Clinical Dermatology (Queen Mary University of London) and Cosmetic Medicine (University of Leicester) in the UK. A full member of the British College of Aesthetic Medicine, he is an officially recognised trainer and Key Opinion Leader for SkinTech in the UK, holds training and mentoring sessions internationally, and has spoken at many live events in conferences in various countries. He is passionate about skincare, skin health, and chemical peels.This book has been written with the aim of making a practitioner's peeling experience easier and more practical. It contains sample patient forms, over 250 illustrations, and a wealth of tips for patient guidance and safe clinical practice.

Following tenets set out by Milton Erickson, Therapeutic Interventions in Three Sentences: Reshaping Ericksonian Hypnotherapy by Talking to the Brain and Body presents an array of short, effective commands which have been developed for use in connection with a wide range of mental and psychosomatic disorders.Examining in detail the basic building blocks which must be in place in order for someone to send an effective command to his or her sub-conscious mind, the book presents an elegant way of using informal variations of Ericksonian hypnotherapy in awake states and transferring these principles to a variety of therapeutic settings. The methods described follow specific rules derived from hypnotherapy but can be integrated into any other form of counselling or therapy and can be used in short sessions, in telephone consultations and with patients in critical states, as well as conversations of a therapeutic nature by non-therapeutic professionals. The book explains why and how these interventions work, their general structure, and how they can be used to tackle specific needs such as trauma, depression, and anxiety disorders.The book will be of great interest to counsellors, doctors and therapists of different orientations who are looking for therapeutic methods that can be used in short sessions or with patients in critical states, as well as non-therapeutic professionals who engage in conversations of a therapeutic nature, such as social workers, pastors, nurses, carers and teachers (including SEN teachers).

A biofilm is a collection of microbial cells that have adhered to biotic surfaces such as plant cuticles or animal epithelia, as well as abiotic surfaces such as rocky substratum or catheter exteriors. The life cycle of a microorganism includes the fundamental process of biofilm formation for survival in diverse and harsh environments since it is a protected mode of growth allowing colonisation of new habitats by dispersal of microbes from the microbial clusters. The biofilm bound microorganisms remain embedded in an extracellular polymeric matrix that protects the indwelling cells from surfactants, biocides, several invaders like protozoans, and defences offered by the hosts like phagocytic cells. The biofilm bound recalcitrant microbes induce chronic and nosocomial diseases, posing a serious threat to public health. It has been observed that various antimicrobial drugs are able to successfully remove the planktonic (freely suspended) states of microbes as compared to the sessile (substrate-bound) forms, thus resulting in the development of antimicrobial resistance.Modern pharmacological strategies targeting the biofilm matrix differ from the conventional methods of antibiotic usage. This includes the use of natural compounds such as plant bioactive molecules, antimicrobial peptides, green synthesised nanoparticles, or secondary metabolites from other organisms that not only prevent the rise of antimicrobial resistance but are also safe for the host tissues.Biofilm Associated Antimicrobial Resistance and Its Recovery provides a detailed and systematic review of alternative pharmacological developments in the field of biofilm research.Features: A narrative overview of the mechanism of biofilm formation and its role in the emergence of antimicrobial resistance Recent research in the development of antibiofilm remedies involving biogenic compounds Advancements in biofilm detection methodologies with cutting-edge technologies This book serves as a resource for researchers who need to understand and analyze the progression of events during microbial biofilm formation, as well as design safer methodologies for its successful eradication. It may also be used as a textbook for a graduate level course in microbiology or microbial biotechnology.

Relativism can be found in all philosophical traditions and subfields of philosophy. It is also a central idea in the social sciences, the humanities, religion and politics. This is the first volume to map relativistic motifs in all areas of philosophy, synchronically and diachronically. It thereby provides essential intellectual tools for thinking about contemporary issues like cultural diversity, the plurality of the sciences, or the scope of moral values.The Routledge Handbook of Philosophy of Relativism is an outstanding major reference source on this fundamental topic. The 57 chapters by a team of international contributors are divided into nine parts: Relativism in non-Western philosophical traditionsRelativism in Western philosophical traditions Relativism in ethicsRelativism in political and legal philosophyRelativism in epistemologyRelativism in metaphysics Relativism in philosophy of scienceRelativism in philosophy of language and mindRelativism in other areas of philosophy.Essential reading for students and researchers in all branches of philosophy, this handbook will also be of interest to those in related subjects such as politics, religion, sociology, cultural studies and literature.

Advanced Mathematical Analysis and its Applications presents state-of-the-art developments in mathematical analysis through new and original contributions and surveys, with a particular emphasis on applications in engineering and mathematical sciences. New research directions are indicated in each of the chapters, and while this book is meant primarily for graduate students, there is content that will be equally useful and stimulating for faculty and researchers.The readers of this book will require minimum knowledge of real, complex, and functional analysis, and topology.Features Suitable as a reference for graduate students, researchers, and faculty Contains the most up-to-date developments at the time of writing.

Sustainable Uses and Prospects of Medicinal Plants presents information on less known and underexplored medicinal plant species in various regions of the world. The book investigates current advances in medicinal plant science and includes detailed information on the use of green nanotechnology, characterization of plants, conservation, revitalization, propagation, and pharmacological activities of selected plants. A volume in the Exploring Medicinal Plants series, it collects information on less known medicinal plant species in various regions of the world for documentation profiling their ethnobotany, developments in their phytochemistry, and pharmacological activities and provides an in-depth look at some specific herbal medicines of importance, threatened and less known species and addresses sustainable utilization and conservation of medicinal plants to ensure existence and use.Appropriate for plant and biodiversity conservation organisations, community leaders, academicians, researchers, and pharmaceutical industry personnel, the book comprises innovative works with information of what is expected to address sustainability in the future.

The book examines how global technological advances shape the way we work and allocate work today and how we might do so in the future, exploring advances in robotics, artificial intelligence, green technology, and implications for workforce skills and future welfare. It uses Australia as a case study, contrasting the country's experience to those elsewhere.The book is a cross-disciplinary collaboration that brings together the expertise of engineers, data scientists, economists and sociologists. The reader is offered an overview of the current uses of advanced digital technologies and what it means for today's workforce, society and economy. The book also looks to the future. Current uses of advanced technology lag its already existing capability. The contributions note potential future application of technology and the economic, social and workplace implications of technological change.The book should be of interest to anyone studying and wishing to better understand what work might look like in the future and how we might prepare for likely changes.

First published in 1992, Environmental Particles describes properties, roles, and methods for the characterization of environmental particles in air, water, sediment, and soil. This book emphasizes modern methods for sampling, instrumental characterization methods, and physical/chemical principles for describing the properties and roles of particles in the environment (particularly their influence on the transport of toxic compounds). It will be an excellent reference source for environmental chemists and physicists, limnologists, oceanographers, air and soil scientists, analytical chemists, environmental engineers, scientists involved in environmental protection, and students.

This up-to-date book compiles both basic and advanced laboratory techniques of mammalian cell culture. It is divided into four major sections encompassing the basics of cell culture, nucleic acid and protein isolation, cell-staining techniques, and cell transfection and single-cell analysis. The topics include aseptic handling, media preparation, and passaging of cells. The book also outlines downstream assays such as nucleic acid and protein isolation from in-vitro cell cultures.Key Features: Covers cellular staining using fluorescent dyes, genetic manipulation of cells via transfection, and an introduction to single-cell analyses Discusses basics in cell culture and downstream applications including gene and protein expression analysis Includes the principles underlying each of the techniques and provides a detailed methodology to practice Explores the whole range of techniques - from basic to downstream applications and advanced methods The book is essential for students and researchers in the field of life sciences, biotechnology, genetics, and molecular biology.

'The MRCS Clinical Examination is the final requirement to obtain the professional qualification for the Intercollegiate Membership of the Royal College of Surgeons. This Membership allows the transition from doctor to surgeon and a career in higher surgical training. This standardised clinical examination requires candidates to demonstrate their ability in examining patients, with effective and clear communication. 'The authors should be commended on producing a book that covers all clinical sections of the Examination, in such a concise, comprehensive and structured manner.This study guide will serve as your personal tutor working closely with you, prompting and providing pointers to improve your examination technique. It includes dozens of clinical scenarios, demonstrating how to examine the system and avoid common mistakes. In addition, the candidates can improve their communication skills, which is an integral part of this Examination. This book complements the "Insider Medical MRCS Clinical Course". It simulates the actual test conditions by providing sample cases and answers, coupling identification of weaknesses and strengths. This book will also prove to be extremely valuable for the new-style MRCS OSCE' - Nigel Mendoza in his Foreword.

Healthy behaviours, at the individual and community levels, are imperative to improving and sustaining better public health. With a strong focus on prevention, health promotion strategies are crucial to improving quality of life, while taking into account the various determinants of health. This book provides a global perspective, with an emphasis on contextual issues with health promotion in South Asia for understanding challenges and related strategies. Readers will be comprehensively introduced to healthy behaviours through case studies, covering theories, interventions, and approaches to promote healthy behaviour, the impact of policy and how behaviour change can be sustained.Key features -- Covers existing and emerging issues in health promotion - Inputs from globally renowned public health experts with a multi-disciplinary approach in content and audience - Connects with health systems and relevant sustainable development goals - Provides case studies for enabling readers to understand and apply evidence-based solutions to key public health issues

While there are several texts that focus on forensic science techniques and applications, there are few to no quality books that adequately address the judicial interpretation of forensic legal and scientific principles. The field of forensic science and law has long been in need of a historic casebook.Forensic Law Casebook: Judicial Reasoning and the Application of Forensic Science in Criminal Cases fills the current void by reviewing actual case law and translating the practical application of science to the courtroom. Each chapter represents a unique forensic discipline, providing a short introduction to the subject matter, the relevant case law and court cases that pertain to that subject area and posing a variety of questions and issues to the student. All cases provided contain a sufficient portion of the legal decision - and its implications to the evidence and analytical practices of that discipline - in order to then pose critical and analytical questions to the student, once they have fully read the case material and the decision and considered its implications.Each chapter ends its theoretical examination with real-world experience encountered by those laboring in the investigative and collection processes - as well as problems or challenges encountered by those employed in the office of the prosecutor, public defender, medical examiner or other aligned office. This last section of each chapter gives true meaning and impact as to how forensic law decision-making impacts forensic practitioners, and a true understanding of the responsibility placed on law enforcement, investigators and scientists tasked with collecting, preserving and analyzing the evidence.Forensic Law Casebook provides the reader with an array of legal cases and decisions that lay out the parameters of forensic law and its evidentiary value. In the end, what emerges from this are the bedrock principles that guide current forensic evidence and the admissibility of various practices common to the field applications of forensic science. Practitioners, law students, undergraduate and graduate students in compatible majors - as well as law and university libraries - will benefit from this essential reference and adjunct to anyone studying forensic science, criminalistics and the law.