Bøker utgitt av American Society for Microbiology

A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistanceAntibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics.Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:* What are antibiotics?* Where do antibiotics come from?* How do antibiotics work?* Why do antibiotics stop working?* How should our limited inventory of effective antibiotics be addressed?Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.

An exploration of the raw power of genetic material to refashion itself to any purpose...Virtually all organisms contain multiple mobile DNAs that can move from place to place, and in some organisms, mobile DNA elements make up a significant portion of the genome. Mobile DNA III provides a comprehensive review of recent research, including findings suggesting the important role that mobile elements play in genome evolution and stability.Editor-in-Chief Nancy L. Craig assembled a team of multidisciplinary experts to develop this cutting-edge resource that* covers the specific molecular mechanisms involved in recombination, including a detailed structural analysis of the enzymes responsible* presents a detailed account of the many different recombination systems that can rearrange genomes* examines the tremendous impact of mobile DNA in virtually all organismsMobile DNA III is valuable as an in-depth supplemental reading for upper level life sciences students and as a reference for investigators exploring new biological systems. Biomedical researchers will find documentation of recent advances in understanding immune-antigen conflict between host and pathogen. It introduces biotechnicians to amazing tools for in vivo control of designer DNAs. It allows specialists to pick and choose advanced reviews of specific elements and to be drawn in by unexpected parallels and contrasts among the elements in diverse organisms.Mobile DNA III provides the most lucid reviews of these complex topics available anywhere.

Presenting the latest molecular diagnostic techniques in one comprehensive volumeThe molecular diagnostics landscape has changed dramatically since the last edition of Molecular Microbiology: Diagnostic Principles and Practice in 2011. With the spread of molecular testing and the development of new technologies and their opportunities, laboratory professionals and physicians more than ever need a resource to help them navigate this rapidly evolving field.Editors David Persing and Fred Tenover have brought together a team of experienced researchers and diagnosticians to update this third edition comprehensively, to present the latest developments in molecular diagnostics in the support of clinical care and of basic and clinical research, including next-generation sequencing and whole-genome analysis. These updates are provided in an easy-to-read format and supported by a broad range of practical advice, such as determining the appropriate type and quantity of a specimen, releasing and concentrating the targets, and eliminating inhibitors.Molecular Microbiology: Diagnostic Principles and Practice* Presents the latest basic scientific theory underlying molecular diagnostics* Offers tested and proven applications of molecular diagnostics for the diagnosis of infectious diseases, including point-of-care testing* Illustrates and summarizes key concepts and techniques with detailed figures and tables* Discusses emerging technologies, including the use of molecular typing methods for real-time tracking of infectious outbreaks and antibiotic resistance* Advises on the latest quality control and quality assurance measures* Explores the increasing opportunities and capabilities of information technologyMolecular Microbiology: Diagnostic Principles and Practice is a textbook for molecular diagnostics courses that can also be used by anyone involved with diagnostic test selection and interpretation. It is also a useful reference for laboratories and as a continuing education resource for physicians.

Groundbreaking thinking on how bacterial metabolism is foundational to pathogenesisFor too long, bacterial metabolism and bacterial pathogenesis have been studied as separate entities. However, the scientific community is beginning to realize that not only are bacterial nutrient acquisition and utilization essential for pathogenesis, but that interfering with the pathogen-specific metabolic pathways used during infection can regulate virulence factor expression and might lead to effective breakthroughs in a variety of treatments.Editors Paul Cohen and Tyrrell Conway, who pioneered the use of metabolic mutants in competitive colonization assays, an approach now widely used to investigate the nutrition of pathogens in vivo, are uniquely qualified to advance our knowledge of this integrative field of research. They convened a group of contributors who are breaking new ground in understanding how bacterial metabolism is foundational to pathogenesis to share their expert perspectives and outlook for the future.Beginning with overviews, Metabolism and Bacterial Pathogenesis covers* a wide range of diseases and both Gram-positive and -negative bacteria that serve as model systems for in vitro and in vivo investigations* intracellular, respiratory, and enteric pathogens* pathogen-specific nutrient acquisition in hosts* mechanisms of host-driven metabolic adaptation by pathogens* metabolic regulation of virulence gene expressionUseful for specialists in bacterial pathogenesis and specialists in metabolism as well as molecular biologists, physicians, veterinarians, dentists, graduate and undergraduate students, and laboratory technicians, Metabolism and Bacterial Pathogenesis is also essential reading for scientists studying the microbiome.

A comprehensive introduction to this exciting and developing field.

State-of-the-art reviews covering major aspects of antibodies and intervention against infectious diseasesThe connection between antibodies and infectious diseases has spawned entire related fields of study. Antibodies for Infectious Diseases presents perspectives from leading research scientists and summarizes the amazing progress in this area into a single definitive source.Providing a broad survey of the most important aspects of the field of antibodies for infectious diseases, this book* presents general features pertaining to structure, function, isotype, and the role of complement in antibody function* examines the role of antibodies in antimicrobial immunity with specific targets* details new methods for expression of monoclonal antibodies, in plants or by transfer of antibody genes for in vivo expression in treated subjectsAntibodies for Infectious Diseases is a comprehensive reference for researchers, pharmaceutical developers, and health care professionals on the status of the development of antibody-based therapies for treating infectious diseases. It is also useful as supplemental reading for upper level life sciences students.

An excellent textbook for upper-level undergraduate and graduate courses in the biosciences that features a series of chapters describing the latest advances in the basic knowledge of plasmid biology, the specialized functions plasmids confer to the host cell, and the practical utilization of plasmids for discovery, medicine, and agriculture.

A comprehensive collection of perspectives by experts in mycobacterial molecular biologyMycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. Tuberculosis was named a global health emergency by the World Health Organization, a distinction no other disease has received. Although the study of mycobacterial genetics has expanded dramatically, with new investigations into mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 remain today.Advances in our understanding of mycobacterial genetics have been reflected in exciting recent developments. New diagnostic approaches can identify drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge.Written by leading experts in the field, Molecular Genetics of Mycobacteria, Second Edition,* Discusses key areas of current research in mycobacterial genetics* Explains the genetics of the physiology, metabolism, and drug sensitivities of M. tuberculosis* Presents genetic approaches for manipulating M. tuberculosisThis book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.

Written by scientists working in the field, this book will provide a series of "stories" about how disruption of the environment and transmission from animal hosts is responsible for emerging human and animal diseases.

The future is now--this groundbreaking textbook illustrates how biotechnology has radically changed the way we think about health careBiotechnology is delivering not only new products to diagnose, prevent, and treat human disease but entirely new approaches to a wide range of difficult biomedical challenges. Because of advances in biotechnology, hundreds of new therapeutic agents, diagnostic tests, and vaccines have been developed and are available in the marketplace.In this jargon-free, easy-to-read textbook, the authors demystify the discipline of medical biotechnology and present a roadmap that provides a fundamental understanding of the wide-ranging approaches pursued by scientists to diagnose, prevent, and treat medical conditions.Medical Biotechnology is written to educate premed and medical students, dental students, pharmacists, optometrists, nurses, nutritionists, genetic counselors, hospital administrators, and individuals who are stakeholders in the understanding and advancement of biotechnology and its impact on the practice of modern medicine.Hardcover, 700 pages, full-color illustrations throughout, glossary, index.

Every speck of dust, drop of water, and grain of soil and each part of every plant and animal contain their own worlds of microbes.Designed as a key text for upper-level undergraduates majoring in microbiology, genetics, or biology, Principles of Microbial Diversity provides a solid curriculum for students to explore the enormous range of biological diversity in the microbial world. Within these richly illustrated pages, author and professor James W. Brown provides a practical guide to microbial diversity from a phylogenetic perspective in which students learn to construct and interpret evolutionary trees from DNA sequences. He then offers a survey of the "tree of life" that establishes the necessary basic knowledge about the microbial world. Finally, the author draws the student's attention to the universe of microbial diversity with focused studies of the contributions that specific organisms make to the ecosystem.Principles of Microbial Diversity fills an empty niche in microbiology textbooks by providing an engaging, cutting-edge view of the "microbial zoo" that exists around us, covering bacteria, archaea, eukaryotes, and viruses.

Written by practicing scientists on the front lines of ethical issues, Scientific Integrity presents core topics for graduate and postdoctoral trainees and professional researchers.

A comprehensive overview of clinically important infections of the urinary tract Urinary tract infections (UTIs) continue to rank among the most common infectious diseases of humans, despite remarkable progress in the ability to detect and treat them. Recurrent UTIs are a continuing problem and represent a clear threat as antibiotic-resistant organisms and infection-prone populations grow.Urinary Tract Infections: Molecular Pathogenesis and Clinical Management brings the scientific community up to date on the research related to these infections that has occurred in the nearly two decades since the first edition. The editors have assembled a team of leading experts to cover critical topics in these main areas:* clinical aspects of urinary tract infections, including anatomy, diagnosis, and management, featuring chapters on the vaginal microbiome as well as asymptomatic bacteriuria, prostatitis, and urosepsis* the origins and virulence mechanisms of the bacteria responsible for most UTIs, including uropathogenic Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae* the host immune response to UTIs, the rise of antibiotic-resistant strains, and the future of therapeuticsThis essential reference serves as both a resource and a stimulus for future research endeavors for anyone with an interest in understanding these important infections, from the classroom to the laboratory and the clinic.

A valuable physician's reference that covers zoonotic pathogens as agents of emergence and reemergence of zoonotic diseases, opportunistic zoonotic infections, risks of iatrogenic transmission and xenotransplantation, imported zoonotic infections, food-borne zoonoses, and transmissible spongiform encephalopathies.

Over the past decade, there has been explosive growth in the U.S. artisan cheese industry. The availability of artisan cheeses, made using traditional practices, has ignited renewed consumer interest in cheese making and cheese consumption.

This book offers a balanced presentation of the microbial world to children in the early school-age years. Using vivid micrographs that show microorganisms shaped as letters of the alphabet, this book teaches children that microorganisms are fascinating life forms that carry out essential activities in our ecosystems to sustain life on Earth.

Diseases have significantly shaped the course of the world's history. From the fourteenth-century plague to HIV/AIDS today, diseases have fundamentally altered the shape of society, politics, and culture.