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Based during the Industrial Revolution in a small, rural Pennsylvania town, "A Sign of the Times" is designed for Young Adult readers to teach them history and the importance of education in an ever-changing world.

★★ Fall in love with cozy small-town romance filled with delightful characters and brimming with holiday joy.★★ He's been all over the world. She's a home-town girl. Can a holiday wish bridge the gap?In Cora Carpenter's small California hometown, Christmas is tailor-made for couples. Unfortunately, Cora is a party of one, thanks to a con man who stole her heart, then bilked her out of thousands of dollars.What's on her Christmas wish list this year? Nothing whimsical. She'll take a new vacuum cleaner, thanks-and no dating for the foreseeable future. But when she meets a stranger with a broken-down car, his warm smile and perilously blue eyes almost make her want to tweak that list. If only she could get over the pain and humiliation of her past.A double whammy of betrayal and a broken heart sent anchorman Patrick Gervez thousands of miles west looking for a fresh start. But the pretty child care provider's unforgettable amber eyes and deft hand with a set of jumper cables does funny things to his heart-and makes him wonder if she's a forgotten dream come true.Except she's as skittish as a piece of tinsel in a windstorm. And the only way to help her forget her heartbreak, is to convince her to forgive. Especially herself.This heartwarming, sweet and wholesome contemporary holiday romance will rekindle your belief in love, Christmas, and Happily-Ever-After. Perfect for fans of Debbie Macomber, RaeAnne Thayne, and Susan Mallery. This story celebrates the joy, blessings, and true meaning of Christmas. Readers are saying: "Cora's story is sweet and touching," and "Whether you're short on time or not, this wholesome, inspirational holiday story is sure to lighten your heart and put a smile in your soul, so don't miss it." A Chocolate-Box Christmas Wish is the perfect gift to yourself. Scroll up and order today!

Birthday girl Ryder gets everything she doesn't want and nothing she really wants for her birthday. One failed wish after another, Ryder begs God to grant her just one wish. Will Ryder get the one thing she really wants for her birthday? Read this short fun story and you will see.

Detective Atticus Ware gave up Idaho to start again in the California mountains, close to his imprisoned brother. Although he's found good friends, the experienced Dominant wants more than the "do me" submissives flocking around him. He needs a woman to give her heart as well as her body.After Virginia Cunningham exhausts herself propping up a failing relationship, she accepts a social worker job far, far away in a California prison. Invited to observe BDSM classes on a wilderness camping trip, she's shocked-her fiancé had insisted BDSM was a fabrication to sell books. But when Atticus lures her into participating, she learns submission under the hands of a powerful Dom is beyond anything she'd imagined. Nonetheless, she can't permit a relationship-she'd just lose herself again.Finally, Atticus has found the woman he wants in his life. In his bed. In his cuffs. Only she keeps backing away. Well...if he has to help a little counselor get her head on straight, he's just the Dom for the job.

The best part of being a parent are those moments you get to engage and have fun with your children. Spurring great conversation and engagement are some of the most treasured moments that will last a lifetime. This book helps parents and their children to discover those moments.This father-and-daughter team holds double black belts in the "Art of the Special Day." They truly believe what the little plaque says on Breton's great-nanny's bathroom wall: "We don't remember days, we remember moments." This little sign's tattered patina relays a message that has seemingly been delivered through the ages, again and again, the reminder that our journey through life is made of brief memories, and those brief memories enrich our life and shape our legacy. Breton (age 9) and Tyler (age 42) have put together three of their favorite games that will get you started on maxing-out your adventure. Some random fun things to do...if you and your teammate are up for an adventure! Coffee Talk: Project Special Day offers a host of fun adventures that will enrich and deepen your most special relationship between a parent and child.Looking for a fun group of activities to do with your child on your next adventure CLICK BUY and take Coffee Talk Special Day with you.

'Take off your clothes, ' he commanded. She shivered and bent to unlace her boots. 'No, ' he said slowly, 'start with your blouse. I want to see what it is I've won...' The New Year sky is heavy with snow on the night Helen surrenders her body to a stranger. She loses her virtue on the roll of a dice and the wager sets tongues wagging. Though there are many illicit goings-on in the Fens in the 1920s, for the squire's sister-in-law to run off with a boatman is a scandal. But brave and beautiful Helen doesn't care. If she finds winter warmth and steamy romance in the strong arms of Jack Hartman then that, so she thinks, is a private affair...

Julie Danner has been running away from home for nine years. She hoped leaving small-town Hopes Ridge and starting a career in journalism would silence the voices in her head causing her to question her own sanity. But when her wheelchair-bound dad calls, asking for help with her unraveling mother, she's forced to go back home and confront the woman she hoped to never see again. If returning home weren't bad enough, the house Julie moves back to may be haunted. At first, she tries to ignore the signs. But Julie soon discovers that she has an ability more powerful than mere intuition - the other side is desperately trying to send her a message. The clues start to add up, to reveal a horrible truth about what happened inside Julie's house long ago, and just how connected to the violent and evil past she might be. While a serial killer still lurks, Julie moves from skeptic to believer, and from journalist to cold-case investigator, enlisting her retired cop father to hunt down a murderer who may be closer than she thinks. Inside Powder House hides the stink of betrayal, lust, and a love twisted beyond anything natural - but will Julie uncover it all before it's too late?

How do you feel when you- Accomplish a task with speed, efficiency and finesse?- Achieve something that you thought you could not?- Keep getting consistently better in what you do?You will feel proud, happy and experience a sense of accomplishment, right? You get a kick and feel high and mighty about yourself, don't you? So, when you achieve what you want to, you surely "Get High"!That is what this book is about. To enable you to get to a higher version of yourself in whatever work you do. It has short stories that you can learn from and activities that will enable you to achieve your goals to maximize your growth potential.Go ahead. Be your own coach for high performance. Achieve what you want.Because YOU CAN.

Old Man Smith is sitting on a one thousand acre run down horse ranch that is prime ground. He finds himself in a war to keep it. Both the city of Sedalia Missouri and the Mob in Detroit and New York want it, and both use Eminent Domain as their vehicle to take it. Smith being a World War II Veteran and a sharp shooter in the war is no stranger to war. The Tobin boys who grew up around the old man have their own ranch and side with Smith. Ben Tobin is standing behind Old Man Smith while he's looking towards the city of Sedalia and he says to him. "Ben, I've never been no hand with words, I'm no politician. The only thing I was ever real good with was a gun. I'm just going to fight 'em with what I know. Yeah, Ben, I'll be waiting on those hi-tech sophisticated sunzabitches." The greatest generation in American History has no back down to him, and his principals and values will not waver or bend.Before it's over the eyes of the nation and the world would be on Sedalia Missouri. Old Man Smith is full of surprises and just when you think you have it all figured... well, not so fast, maybe not.

The Most Dangerous and Powerful thing in this world is love. - D. WibisonoNia Wright, a bourgeois corporate executive for one of the biggest cyber security firms in the world, is living the life of her dreams. She has the big house, dream job, fancy car and the heart of Terence Deveraux, one of the most eligible bachelors in Atlanta. Her journey continues when a shocking secret rocks her world.Nia awakens to her entire life is turned upside down, when she discovers she was given the lungs of Marco Silver, the man killed in the other car. Riled with guilt, Nia goes on a journey to learn more about Marco, the mystery man who saved her life. In a twist of fate, she uncovers Marco's secret love letters. Love letters, he wrote to his wife while he was off on the other side of the world, defending the country. Starving for romance, Nia secretly reads Marco's love letters and falls dangerously in love with her fantasy man. Was It Marco's charm or the mystery of his letters that captured Nia's heart? Marco's words became the cure for Nia's ailing heart, as she is unknowingly led down a pathway to a deadly secret.Caught in a love triangle with the fantasy man of her dreams and a changed Terence, Nia goes on a journey to uncover Marco's deadly secret, a secret that will eventually put her life in danger. Was her car accident real or an attempt on her life? And who is the creepy freckled man stalking Nia? Is he trying to kill her? If Nia is to get out of this alive, she must let her fantasy man go, but she can't... Marco has her smitten. How do you choose between the man you're engaged to marry and a ghost? Will Nia choose to live life on the run, following the scent of Marco...or will the simple life with Terrence guide her heart? Follow Nia as she heads down the slippery slope of love, murder, espionage, lies, scandal, confessions and forgiveness. Nia is Dangerously in Love.

Take one secret, add intimacy and regret. Toss in a billionaire. What will happen?Caroline hasn't had a date in years. So what if she is lonely? Caroline is determined to build her branding business into a success, even if it means staying single and living with her Grandma to save on rent.But investing all her time into building her business means she's lost contact with the outside world, except the owners of the local café where she picks up her morning coffee. In exchange for a branding package, Caroline agrees to accept a lifetime of free coffee and pastries from Annie and Dan. She decides an upside to not dating is not caring about the extra padding to her hips from the extra treats.Her business is beginning to succeed, and she's hitting her stride when she meets Jolan at the café. Jolan is everything Caroline doesn't think she deserves. Still, his unexpected insecurities, sweet nature, and warm laugh make her want to get closer. Jolan is sexy enough to make her even say yes to attending one of his yoga classes, despite all her fears that the last place someone who looks like her belongs is in a yoga studio.When Jolan starts arriving to eat lunch with her and Gran every day, then Caroline can't help but begin to fall for him. How can she turn their friendship into romance? Then comes the chance of a lifetime: Jolan invites her to visit New York City with him.Caroline doesn't want to confide that she's scared to go. She's lived her entire life in a small rural town and has never been more than a few miles away from home.New York City. Perfect guy. A growing business. With everything finally beginning to go so right, what could go wrong?New York City is where Caroline plans on confessing her love to Jolan and turning their friendship into courtship. But a secret revelation and sequence of events will cause Caroline to gather enough courage to step out into New York City alone. For anyone else, it would be easy, but for Caroline going to dinner on her own is the small act of bravery that changes the rest of her life.Take one secret, add intimacy and regret. Toss in a billionaire. What will happen? Hit the 'Look Inside' or download a sample to your kindle to start reading now.

Fascinating look into the early 20th century world of adoption in Kansas City, Missouri. "More Voices of The Willows" is a follow up to "Mansion on a Hill: The Story of The Willows Maternity Sanitarium and the Adoption Hub of America." Adoptees and birth mothers share heartwarming and sometimes heart wrenching reunion stories. Ranging from 1908 until 1969, these twenty-two voices express the common threads of needing to know who am I, what is my family background and medical history, fear of hurting adoptive parents' feelings, and guilt for being forced to give up a baby under difficult circumstances.One voice is a past Kansas governor who was a Willows baby and wrote about his being chosen by his adoptive parents. Another is an adoptee finding her ninety-year-old biological parents and learning they had eloped after finding out the young woman was pregnant. Upon telling their parents, the young bride was forced to go to The Willows and give up their baby for adoption. Readers will be amazed at the incredible story of a man who was born at The Willows, adopted multiple times, lived at Boys Town, was homeless, and eventually became a merchant marine at sixteen. These are just three of the amazing stories. New details about The Willows that has been discovered since the release of "Mansion on a Hill" is shared. In addition, there is information about other maternity homes and homes for infants that resided in Kansas City in the early 1900s. These include The Fairmount Maternity Hospital, Florence Crittenton Homes, St. Vincent's Maternity Home, St. Anthony's Home for Infants, East Side Maternity Hospital, Kansas City Cradle, and The Veil Maternity Hospital. There were dozens of homes for pregnant, unwed women that led to Kansas City being tagged the Adoption Hub of America.

Vascularization in Tissue Engineering presents a comprehensive picture of blood vessel development and the recent developments on the understanding of the role of angiogenesis in regenerating biological tissues. The first-half of this book, consists of three chapters, emphasizing the fundamental knowledge about cell pathways, growth factors, co-culture strategies, cell interactions, and vascularization in pathological scenarios. The second half takes this knowledge a step further and explains the vascular microenvironment, scaffolds, and related applications in regenerative medicines. This section also provides information about biomaterial scaffolds and stem cell cultures for wound-healing and tissue regeneration. Readers will learn about cutting edge technologies in this field. This volume is a handy reference for students and researchers seeking information about the angiogenic processes and applied biotechnology in tissue engineering.

Multidisciplinary research involving crystallography, kinetic studies, molecular docking, genetics and other techniques in biochemistry has yielded a wealth of knowledge about the reaction mechanisms in cellular processes. This knowledge has allowed researchers to understand, in a better way, the normal functioning of the cell process, which is used as a reference point for learning about and preventing or correcting pathologies that cause diseases.This enzymology reference is a thorough compendium about reaction mechanisms occurring between the major enzymes related to the biosynthetic pathways of 3 important types of biological compounds - 6-carbon carbohydrates, fatty acids and amino acids - and their substrates, cofactors and residues. Readers will gain an understanding of the interaction between substrates or ligands with specific amino acid residues in biosynthetic enzymes. This understanding builds a foundation for learning about the biochemistry of different inhibitors used in the treatment of several diseases such as cancer, infectious diseases, and metabolic syndrome alterations such as diabetes and obesity.Enzymes covered in the book include aldolases, isomerases, kinases, mutases, synthases, dehydrogenases, reductases, transferases, hydrolases, lyases among others, all of which are wide spread in biochemical transformations. This reference, with its insights on common biochemical enzymes serves as a handy guide for students, researchers and professionals involved academia or industry related to pharmaceutical development, healthcare, food chemistry and other disciplines.

Canceris driven by numerous genetic and epigenetic changes occurring at the cellular level.These changes drive normal cells to proliferate and escape processes thatusually regulate their survival and migration. Many of these alterations areoften associated with signaling pathways which regulate cell growth anddivision, cell death, survival, invasion and metastasis, and angiogenesis.Almost all cancer cells show high expression of signaling components includinggrowth factor receptor tyrosine kinases (RTKs), small GTPases, serine/threoninekinases, cytoplasmic tyrosine kinases, lipid kinases, estrogen receptor, activation of transcription factors Myc and NF-κB, etc. Updated knowledge aboutthese signaling components is highly desirable for researchers involved indeveloping therapies against cancer.Signal TransductionResearch for Cancer Therapy covers advancements in research on the signalingpathways in the human body, especially in some types of cancers, such asbreast cancer, pancreatic cancer and colon cancer. Keyfeatures of this volume include 8 focused topical reviews on signaling pathwaysin a specific cancer type, coverage of multiple cancer types (breast cancer, colon cancer, hepatocellular cancer, multiple myeloma, acute myeloid leukemia, and pancreatic cancer), and coverage of a wide array of signaling pathways (bothreceptor mediated and non receptor mediated pathways). Thisvolume is essential reading for researchers in pharmaceutical R&D andpostgraduate research programs in pharmacology and allied disciplines.Clinicians involved in oncology will also benefit from the information providedin the chapters.

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance - many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians.The fifth volume brings together reviews on the following topics: - Targeted therapy for tumor vasculature- Anti-angiogenic therapy for breast and prostate cancers (including information updates on clinical trials)- Microbe-based and other novel antiangiogenesis therapies, including chromene-based agents

Catalysis is an area of chemical sciences which has fascinated a wide range of academicians, researchers, chemical technologists and industries throughout the world. Progress in this field has been made owing to the thrust provided by this research and commercial interest. The field of catalysis is interdisciplinary by its nature, as it requires knowledge of organic synthesis, coordination and organometallic chemistry, reaction kinetics and mechanisms, stereochemical concepts and materials science. Fundamentals and Prospects of Catalysis highlights many important topics and sub-disciplines in catalysis by presenting 7 chapters on different but varied catalytic processes. This volume presents the following topics: - Organocatalytic Asymmetric Synthesis of Spiroacetals and Bridged Acetals- Design and Development of Bimetallic Enantioselective Salen Co Catalysts for The Hydrolytic Kinetic Resolution of Terminal Epoxides- Recent Trend in Asymmetric Heterogeneous Flow Catalysis- Ball Milling: A Green Tool in Synthetic Organic Chemistry- Recent Advances in the Developments of Enantioselective Electrophilic Fluorination Reactions via Organocatalysis- Green and Sustainable Biocatalytic Routes to Prepare Biobased Polyols as Precursors for Polyurethanes with Comparison of Existing Biobased Polyol Technology- Polymers Used as Catalysts

This marvelous little guide provides the beginning novelist with a step-by-step plan for writing fiction. An experienced editor takes you through the various forms of outlines that will help you to start - and finish - your first or even your second or third novel, whether it's a mystery, spy thriller, sci fi or a romance. There are sections on: Plots, Locale, Characters, Dialogue, Sex Scenes, Writing Technology and Developing Your Style, as well as Editing and Marketing. Sample outlines are included that you can use as the basis for planning your book. If you're an aspiring writer, this will get you started constructing something readable - maybe not The Great American Novel, but at least a serviceable beach read and maybe even a series of works that can bring you a steady income stream.

Halogenated pyridines can be used as interesting starting materials in a wide range of organic synthesis methods. Substituted pyridine compounds are used generally as starting materials in the nucleophilic substitution reactions and have unique scaffolds for the construction of other heterocyclic and macrocyclic compounds. They also have important medicinal properties. Due to synthetic difficulties in the synthesis of the highly substituted pyridine derivatives from pyridine itself, perhalopyridines have a special importance in this regard. This book covers the synthetic reactions and applications of perhalopyridines. An introductory chapter introduces the reader to the physical and chemical properties of halopyridines, followed by 3 chapters which focus on pentafluoropyridine, pentachloropyridine and pentabromopyridine, respectively. The focused chapters provide information about synthetic methods and relevant nucleophilic reactions for each of the listed perhalopyridines and their derivatives. The book is a quick reference on perhalopyridines for students of applied chemistry, organic chemistry and chemical engineering.

Las crónicas de Melanie Márquez Adams te sumergenen el ensueño y los colores del paisaje norteamericano fuera de las grandes ciudades, un panorama diferente que nos es más lejano e inaccesible. Cada historia desenreda con maestríalas fibras más profundas de los problemas sociales que enfrenta todo escritora mujer, migrante y latina, en constante lucha con su entorno y consigo misma. Los lectores van a encontrar belleza y profunda reflexión en cada palabra. --Jennifer Thorndike Asumirse como latinoamericana en Estados Unidos es, sin dudas, un gesto político. Gracias a su escritura precisa, Melanie Márquez-Adams convierte ese gesto en un acto público de rebeldía. No es casual que, para contar sus querencias, la autora elija el lenguaje diáfano de la crónica, un género al que tanto el periodismo como la literatura del continente deben sus mejores páginas. --Dainerys Machado Vento Divertida, incisiva y cálida, Melanie Márquez Adams revela a una escritora que se encuentra a sí misma en el más extranjero de los entornos. --Teresa Dovalpage ¿Cómo resiste una mujer del siglo 21? Emigrando, observando, recordando, escribiendo. Con Querencia, Melanie Márquez Adams se desdobla para inventar una nueva manera de protestar, de resistir. Una manera cuya pancarta es la belleza precisa de una narrativa capaz de reflejarnos, de mirar de frente tanto los momentos difíciles como los hermosos de nuestras vidas como mujeres en este país.-Anjanette DelgadoEditora, Home in Florida: Latinx Writers and the Literature of Uprootedness

Bacterial Diseases provides readers an overview of a broad variety of bacterial infections. Chapters cover the description of specific disease and its causative agent, followed by information about symptoms, diagnosis and clinical management. This easy-to-read resource is a suitable introductory textbook for pharmacy, medical, and dental students, as well as M Phil, and Ph.D. candidates for Pharmacology, Botany, Zoology, Microbiology, Pharmacy, Biotechnology and allied health science programs. Readers interested in a simple clinical summary of bacterial diseases can also benefit from the information provided. Key Features: - Coverage of a broad spectrum of bacterial infections over 41 topical chapters- Easy-to-read presentation which provides a basic description of diseases covered to clinical diagnosis and management- Emphasis on the route of infection- References for further reading