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Infections of the liver and biliary system are not uncommon, while most of the infections are viral in nature. Globally, viral hepatitis is a major public health problem and parallels infections such as HIV and tuberculosis and is associated with significant morbidity and mortality. Rapid advances have been made with HCV therapy at a time when the community focus has shifted to global elimination. This issue highlights some of the areas of considerable advances and challenges in viral hepatitis B and C. In addition, Hepatitis E is resurfacing as an infection of significance, particularly in the Western World where there is a prevalence of chronic infections. Gastroenterologists and hepatologists often think of viral hepatitis as the sole cause of hepatic infections, but there are other infections caused to bacteria, fungi and parasites; this issue highlights these infections as well. Articles are devoted to the following topics: Global epidemiology of viral hepatitis; Update on diagnostics in viral hapatitis; Heptatitis B: Immunization and impact on natural history and cancer incidence; Heptatitis B: Current status of therapy and future therapies; Hepatitis Delta: Prevalence, natural history, and treatment options; Hepatitis C: How good is real-life data and do  generics work: Hepatitis C: Does successful treatment alter the natural history and quality of life; Hepatitis E: Epidemiology,clinical course, prevention, and treatment; CMV and EBV infections of the liver; Extrahepatic manifestations of viral hepatitis; Pyogenic and amebic infections of the liver; and Fungal and parasitic infections of the liver.

In collaboration with the Consulting Editors, Ranjan K. Thakur and Andrea Natale, Drs. David R. Holmes Jr., Saibal Kar, Dhanunjaya Lakkireddy, and Vivek Reddy have assembled an issue of Cardiac Electrophysiology Clinics on Left Atrial Appendage. Topics include, but are not limited to, why we have an atrial appendage, thromboembolism in AF, role of LAA in systemic homeostasis, history of LAA closure, impact of LAA closure on systemic thromboembolization, perirprocedural imaging, anatomical considerations for epicardial and endocardial appendage closure, epicardial vs endocardial closure, technical considerations of endocardial and epicardial closure, surgical LAA occlusion, post procedural management, AF patients undergoing ablation, and more.

This issue of Foot and Ankle Clinics, guest edited by Dr. Sudheer Reddy, will discuss Current controversies in the approach to complex hallux valgus deformity correction. This issue is one of four selected each year by long time series Consulting Editor, Dr. Mark Myerson. Topics in this issue will include: Hypermobility in Hallux Valgus; Cost-effectiveness of Surgical Techniques in Hallux Valgus; Current trends in anesthesia management in hallux valgus; Management of Hallux Valgus in Metatarsus Adductus; Role of coronal plane malalignment in hallux valgus correction; Evolution of MIS in hallux valgus; Current trends in fixation techniques; The evolution of thinking of fixation in the Lapidus procedure; Intraoperative and Postoperative evaluation of Hallux Valgus Correction; Postoperative Management of Hallux Valgus; Management of Complications; And Management of complications Arthritis of MTP joint Malunion/Nonunion.

The objective of the book is to document best practices in managing the major irrigation canal systems to maximise the benefits to farmers in terms of increase in utilization of irrigation potential created under the major irrigation projects. The main emphasis on how best we can manage local canal systems to increase farmers incomes in a sustainable way in a multi-stakeholder perspectives which include farmers, water users associations, irrigation department officials, agricultural officers and local non-governmental organisations involved in farmers welfare.