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Os heterociclos são uma importante classe de compostos, constituindo mais de metade de todos os compostos orgânicos conhecidos. Têm sido frequentemente encontrados como uma unidade estrutural chave na química sintética... O livro consiste na síntese de diferentes anéis heterocíclicos a partir dos derivados da hidrazina ou da hidrazida. O livro também tentou cobrir as actividades biológicas destes sistemas de anéis heterocíclicos. O livro vai ser de grande ajuda para os estudantes de pós-graduação, bem como para os estudantes de doutoramento.

A pirazolona é um anel de cinco membros de lactam (anel heterocíclico), contendo dois grupos de azoto e um grupo cetónico na sua estrutura. Devido à sua vasta gama de acção biológica e à sua ampla utilidade como ferramentas sintéticas na concepção de diferentes moléculas bioactivas, têm um valor específico na indústria farmacêutica. Têm actividade antimicrobiana, antifúngica, antimicobacteriana, antibacteriana, anti-inflamatória, antitumoral, estimulante da secreção gástrica, antidepressiva e antifilária. As elevadas propriedades terapêuticas dos medicamentos relacionados com a pirazolona têm incitado os cientistas terapêuticos a sintetizar inúmeros novos agentes quimioterápicos. Este livro dá uma breve perspectiva sobre a síntese e perfil biológico, juntamente com a estrutura da molécula activa da série de trabalhos particulares das pirazolonas e seus derivados. É uma tentativa de compilar o trabalho de diferentes cientistas terapêuticos num só local. Esperamos que este nosso esforço ajude os estudantes não só no início do seu trabalho de investigação mas também na concepção de novos derivados das pirazolonas e na avaliação do seu potencial terapêutico.

Heterocycles are an important class of compounds, making up more than half of all known organic compounds. They have been frequently found as a key structural units in synthetic chemistry. The book consists of the synthesis of different heterocyclic rings from the hydrazine or hydrazide derivatives. The book has also tried to cover the biological activities of these heterocyclic ring systems. The book is going to be of great help to the students of postgraduate as well as doctoral students.

This book is going to be very helpful for the post graduate scholars and the research scholars at the beginning of their research carrier and will help them in selection of their research projects if based on pyrazole moiety. This gives a brief outlook on the Pyrazole- a five membered heterocyclic ring and its importance from the chemistry as well as medicinal aspect. This includes general information, different synthetic procedures and medicinal activity of pyrazole bearing active compounds. The medicinal activity was described along with brief literature and the structure of the active compounds showing different biological activities viz., antimicrobial, anticancer, antiviral, antimalarial, anti-inflammatory and analgesic activities. And while discussing the medicinal activity of different compounds containing pyrazole nucleus we have given the structures of starting materials as well which makes this book a unique and different from others. We hope our readers will find this book as an introductory tool in designing the new molecules and will be of widespread use which will further help in learning and become a reference for the medicinal chemist.This book is going to be very helpful for the post graduate scholars and the research scholars at the beginning of their research carrier and will help them in selection of their research projects if based on pyrazole moiety. This gives a brief outlook on the Pyrazole- a five membered heterocyclic ring and its importance from the chemistry as well as medicinal aspect. This includes general information, different synthetic procedures and medicinal activity of pyrazole bearing active compounds. The medicinal activity was described along with brief literature and the structure of the active compounds showing different biological activities viz., antimicrobial, anticancer, antiviral, antimalarial, anti-inflammatory and analgesic activities. And while discussing the medicinal activity of different compounds containing pyrazole nucleus we have given the structures of starting materials as well which makes this book a unique and different from others. We hope our readers will find this book as an introductory tool in designing the new molecules and will be of widespread use which will further help in learning and become a reference for the medicinal chemist.