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Proceedings of the EFMI 2019 Special Topic Conference. Information and Communications Technology ICT is used in healthcare and health science research in application domains such as clinical trials and the development of drug and medical devices, as well as in translational medicine, with the aim of improving prevention, diagnosis, and interventions in health and care.This book presents accepted papers from the 2019 European Federation of Medical Informatics conference EFMI STC 2019, held in Hanover, Germany, from 710 April 2019. More than 90 submissions were received, from which, after review, the Scientific