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Thus, we gain a picture of a complex regulatory interaction, fine tuned in normal circumstances to provide each system with necessary information about the status of the other systems and the basis to respond appropriately to changes in each other.

There was once an old Chinese man working on a hill with a boy. Suddenly, the old man noticed that a huge wave, far distant in the sea, was approaching the shore endangering all. The villagers were too busy with their own work and paid little heed to the old man, who was considered a bit eccentric.