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This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy.

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature¿s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the sixth volume of a continuing series.

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease.

This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including Cathepsin D, galectins, iron, oxygen, Phospholipase D1, leptin, extracellular vesicles, and more.

Amy Zarzeczny The future of stem cell research and its clinical translation in Canada: Exploring questions of governance and policy options. Ali Mobasheri  Future cell and gene therapy for osteoarthritis (OA): potential for using mammalian protein production platforms, irradiated and transfected protein packaging cell lines for over-production of therapeutic proteins and growth factors Babak Arjmand Bagher Larijani Motahareh Sheikh Hosseini Moloud Payab Kambiz Gilany  Parisa Goodarzi Peyvand Parhizkar Roudsari Mobina Amanollahi Baharvand; Negin sadat Hoseini Mohammadi The Horizon of Gene Therapy in Modern Medicine:  Advances and Challenges. Neslihan Meric, Gulen Guney Esken, Fatih Kocabas Developments in Artificial Platelet and Erythroid Transfusion Products. Ali Golchin, Forough Shams, Farshid Karami  Advancing mesenchymal stem cell therapy with CRISPR/Cas9 for clinical trial studies. Tunc AKKOC Mesenchymal Stem Cells in Asthma.  Toka A. Ahmed, Sara M. Ahmed, Zaynab El-Gammal,Shaimaa Shouman, Ashrakat Ahmed, Ragaa Mansour, and Nagwa El-Badri Oocyte Aging: the Role of Cellular and Environmental Factors and Impact on Female Fertility. Esra Aydemir ├çoban, Didem Tecimel, Fikrettin ┼₧ahin, Ay┼ƒen Asl─▒ H─▒zl─▒ Deniz Targeting Cancer Metabolism and Cell Cycle by Plant-derived Compounds. Safa AYDIN, Derya SA─₧RA├ç, Fikrettin ┼₧AH─░N DIFFERENTIATION POTENTIAL OF MESENCHYMAL STEM CELLS INTO PANCREATIC ╬▓-CELLS. Ezgi Av┼ƒar Abdik, Ay┼ƒen Asl─▒ H─▒zl─▒ Deniz, H├╝seyin Abdik, Safa Ayd─▒n, Fikrettin ┼₧ahin, Pakize Neslihan Ta┼ƒl─▒ Zooming in across the Skin: A Macro-to-Molecular Panorama. 

In collaboration with the Breast Cancer Research Foundation (BCRF), this timely volume provides a comprehensive review on all areas of breast cancer survivorship research, highlighting research that is underway or in development.

The book discusses new concepts and findings in the field of pulmonary function. Pulmonary function goes far beyond spirometry. Chapters contribute to the latest thinking on molecular mechanisms underpinning pulmonary function, on patient care and attempt to keep up-to-date with current clinical and research progress.

The chapters of this book deal with the preventable drivers of poor respiratory health, the role of health information technology, the improvement in health care delivery and the integration of respiratory health and behavioral health services.

This unique publication explores diverse themes relating to thrombosis and embolism, from basic research at cell and molecular level to the actual care, prevention, and treatment of diverse categories of patients suffering from such diseases.

Nearly 30 years ago, a number of scientists working on the Enteric Nervous System (ENS) gathered at Flinders University, in Adelaide, Australia to discuss the advances and future of their research. It was a friendly and stimulating meeting, attended by most of the major players, in what was to become the discipline of ΓÇÿNeurogastroenterology''.In 2014, the main Australasian Neuroscience Society meeting was held in Adelaide, Australia, providing the perfect opportunity to recreate a follow-up ENS meeting. As such, the ΓÇÿENS II 2014 meetingΓÇÖ aimed to identify how far the field of enteric neuroscience had developed, where the future was heading, and what technological advances had been made to address current and future unresolved questions. 30 speakers from around the world were invited to give talks and revisit the original expectations, the advances made since, and the future directions of ENS research. These discussions included three generations of investigators from 7 different countries. This publication represents the majority of proceedings from the ΓÇÿThe Enteric Nervous System II 2014ΓÇÖ conference, which was held on February 1st - 2nd 2014 at the National Wine Centre of Australia, Adelaide. This meeting was an Official satellite meeting of the 34th Annual Meeting of Australasian Neuroscience Society, which was also held in Adelaide. The 20 contributions contained within this submission are from international researchers in the field of the ENS, who reviewed the advances made since the first meeting in the early 1980s and summarizes the present and future perspectives of neuro-gastroenterology. Some colleagues could not attend but did send greetings and their messages are included in these proceedings.

This Series will provide microbiologists, hygienists, epidemiologists and infectious diseases specialists with well-chosen contributed volumes containing updated information in the areas of basic and applied microbiology involving relevant issues for public health, including bacterial, fungal and parasitic infections, zoonoses and anthropozoonoses, environmental and food microbiology.The increasing threat of the multidrug-resistant microorganisms and the related host immune response, the new strategies for the treatment of biofilm-based, acute and chronic microbial infections, as well as the development of new vaccines and more efficacious antimicrobial drugs to prevent and treat human and animal infections will be also reviewed in this series in the light of the most recent achievements in these fields.Special attention will be devoted to the fast diffusion worldwide of the new findings of the most advanced translational researches carried out in the different fields of microbiological sciences, with the aim to promote a prompt validation and transfer at clinical level of the most promising experimental results.

Good health and medical care in childhood and adolescence are essential for the ability to neutralize health threats later in life and to extend longevity.

Lung ventilation is driven by a complex neural regulatory network, and apart from conditions typically observed during a disease state, it is sensitive to functional dysregulation.

The Advances in Microbiology, Infectious Diseases and Public Health Series will provide microbiologists, hygienists, epidemiologists and infectious diseases specialists with well-chosen contributed volumes containing updated information in the areas of basic and applied microbiology involving relevant issues for public health, including bacterial, fungal and parasitic infections, zoonoses and anthropozoonoses, environmental and food microbiology.The increasing threat of the multidrug-resistant microorganisms and the related host immune response, the new strategies for the treatment of biofilm-based, acute and chronic microbial infections, as well as the development of new vaccines and more efficacious antimicrobial drugs to prevent and treat human and animal infections will be also reviewed in this series in the light of the most recent achievements in these fields.Special attention will be devoted to the fast diffusion worldwide of the new findings of the most advanced translational researches carried out in the different fields of microbiological sciences, with the aim to promote a prompt validation and transfer at clinical level of the most promising experimental results.

The impairment of lung function caused by environmental exposure to pollutants and toxicants is a rising health problem, particularly in highly industrialized parts of the world.

The successful prophylaxis and treatment of ubiquitous respiratory infections is essential for the enhancement of public health. The chapters provide new insights into the biology of causative pathogens, tackle the epidemiological aspects, and present an update on diagnostics, prevention and therapy of infections.

This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. Gene therapy applications for virus infections have been discussed since the early 1990's.

The chapters in this topical volume of Advances in Microbiology, Infectious Diseases and Public Health present exciting, insightful observations on emerging viral infections like influenza, Middle East respiratory syndrome, or mosquito-transmitted diseases, as well as the potential of social media in preventing and fighting infectious diseases.

This book aims at unraveling the mechanisms and improving the treatment of pulmonary pathologies, ranging from such common conditions like influenza and related viral infections, functional lung dysfunction, to lung lesions and others.

This book examines a range of contemporary ideas and arguments concerning the core yet unsettled clinical issues. Important aspects of pulmonary disorders are tackled such as occupational and environmental respiratory health hazards, the role of vitamin D supplementation in airway allergy, or nutritional aspects of care for lung cancer patients.

Diseases of the respiratory system often cause multisystem dysfunction and morbidity.

The book endeavors to provide a stimulating and thought provoking scientific content to share and exchange new clinical studies and advancements in dealing with pulmonary diseases.

Clinical investigation plays an essential role in the differential diagnosis, biomarker development, and therapy and cure of diseases. The book presents a bench-to-bed approach, with broad empirical coverage by experienced practitioners. The articles include topics like cytokine receptors in lung cancer, conduciveness of oxidative stress to carcinogenesis, safety and effectiveness of surgical correction of deformed chest, diagnostic and treatment regimens in inflammation-ridden obstructive lung conditions, alterations in growth hormone secretion leading to disorders of growth and metabolism, microbiota transplantation in pediatric patients, and the promising markers of renal epithelial injury. Yet another issue concerns the restructuring of chronic pain management by establishing the community-based specialized pain clinics. The book aims to disseminate and deliberate on the latest interdisciplinary medical knowledge to enhance clinical outcomes. Being a blend of clinical investigation and practice the book is addressed to physicians, scientists, and allied health care professionals.

Other issues pertain to quality of life, disease preventive measures, and the move toward personal health care in chronic sufferers from multiple conditions in later life. The book is addressed to researchers and practitioners, and allied health care professionals engaged in effective patient care and therapy.

Pulmonary diseases are the major cause of human morbidity, taxing the health care system due to disease prevalence, chronicity, and social and fiscal costs. Inflammation also is an essential component of non-communicable lung diseases, including asthma and respiratory allergies, and smoking-related or granulomatous diseases.

The book recognizes that throughout the scientific, medical, and economic communities, new tests incorporating biomarkers are needed to improve the diagnosis of patients suffering from metabolic disorders.

Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies.

This book focuses on recent advances regarding clinical conditions and ailments whose mechanisms remain unclear, limiting our ability to treat them.The respective chapters address a range of multidisciplinary topics related to timely or emergent research areas, such as osteoporosis in postmenopausal women, the optimal surgical procedures for vertebral compression fractures, novel rehabilitative approaches in pelvic muscle training in case of urinary incontinence, and a rational approach to balneotherapy not only for the skin but also other organ systems disorders. Alterations in the endocrine function during strenuous physical activity at high altitude ¿ a multi-stressor environment comprising hypobaric hypoxia, exercise, and nutritional changes ¿ are presented as well. Other articles provide evidence-based insights into the diagnosis, mechanisms, and clinical course of respiratory infections in children such as bronchiolitis, pneumonia, and influenza. Finally, the pros and cons of e-health are discussed; a rapidly growing area based on the use of information and communication technology to streamline the flow of health information and patient-healthcare provider connections.The content is a well-structured blend of research and practical aspects, as well as updates on cutting-edge developments. All these essential topics are presented in a format suitable for medical professionals engaged in day-to-day patient care and therapy, as well as researchers, academics, and physiotherapists.

This book addresses several burning issues concerning diseases involving the lungs and respiratory tract. It discusses the epidemiology, mechanisms, prevention, and diagnosis of chest conditions such as chronic obstructive pulmonary disease, sleep apnea and respiratory infections.

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development.