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This text discusses the roles of p53 and ATM in cell cycle progression and cell death in response to DNA damage and how this information may lead to improved cancer therapies. Other areas of study covered include the methodological advantages and limitations to localizing tumour suppressor genes.

Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book''s chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process. Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality.Provides information on the timely nature of the included topics, which represent the most current concepts and approaches in cancer researchOffers outstanding and original reviews on colorectal cancer researchProvides the authority and expertise of the authors, all of whom are highly recognized and conducting state-of-the-art investigations in cancer, with this release focusing on colorectal cancer

Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more.Addresses the relationship between autophagy and senescence in cancer therapyCovers autophagy and senescence in tumor dormancyExplores autophagy and senescence in disease recurrence

Cancer Disparities, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. This latest volume presents a broad introduction to a spectrum of factors contributing to cancer disparities that include ancestral informative markers'' role in properly identifying race based on genetic ancestry, basic biological pathways contributing to cancer disparities, epidemiological factors linked to cancer disparities, and social/behavioral factors influencing cancer disparities.Describes the complex interplay of contributors to cancer disparities, ranging from the micro to macro level, and based on the social, environmental, and biological determinants of healthProvides a range of chapters reflecting the unique expertise of the authors in these diverse topic areas

Applications of Mass Spectrometry Imaging to Cancer, the latest volume in the Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on applications of mass spectrometry imaging to cancer.Provides information on cancer researchOffers outstanding and original reviews on a range of cancer research topicsServes as an indispensable reference for researchers and students alike

Molecular and Cellular Basis of Metastasis: Road to Therapy, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, with this volume covering the molecular and cellular basis of metastasis.Presents groundbreaking information on the molecular and cellular basis of metastasisProvides information on cancer researchOutstanding and original reviewsSuitable for both researchers and students

Provides information on the field of cancer research. This title presents reviews on a variety of topics.

This series provides coverage of all aspects of the molecular basis of human cancer, functions of oncogenes, and research strategies for cancer drug development and treatment. This volume includes a chapter on effectors of signal transduction and GI progression,

This volume comprises the cumulative subject index covering volumes 50-72 of the series "Advances in Cancer Research". It includes references to specific articles on topics such as breast cancer, prostrate cancer, Kaposi's sarcoma, Burkitt's lymphoma, leukemias, oncogenes and tumour genetics.

Provides information on the field of cancer research. This title presents original reviews on a variety of topics.

GPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapters included in this volume cover several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential. Specific chapters address the Role of GRKs and beta-arrestins in cancer, Atypical GPCRs in cancer, the Role of a chemokine receptor (CCR) 5 in cancer, Targeting G protein-coupled receptors for therapeutics in cancer, Emerging GPCR signaling pathways in cancer, and more. G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors which are involved in nearly every cellular and physiological event. These receptors can recognize a broad array of ligands and they are targeted by nearly one third of the currently prescribed drugs including anti-cancer therapeutics. Covers the latest concepts in GPCR signaling and their relevancy to cancer biologyPresents new indications for anti-cancer therapeutic programsIncludes sections on cross-talk and signaling networks of GPCRs and effectors in molecular oncology and therapeutics

Advances in Cancer Research, Volume 144, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research. Chapters in this new release include Gene-Environment-Microenvironment Interactions in Melanomagenesis, PP2A and the Cell Cycle, Current Progress Defining Calcium Signals as Therapeutic Targets in Cancer Cells, and much more. Provides the latest information on cancer researchOffers outstanding and original reviews on a range of cancer research topicsServes as an indispensable reference for researchers and students alike

Provides information on the field of cancer research. This title presents reviews on a variety of topics.

Provides information on the field of cancer research. This title presents original reviews on a variety of topics.

Provides information on the field of cancer research. The key features of this work include: The Yin Yang of TCF/b-Catenin Signalling; Biochemical and Clinical Implications of the Erb/HER Signaling Network of Growth Factor Receptors; p53 and Human Cancer: The First Ten Thousand Mutations; Macrophage Stimulating Protein; and more.